Histopathology of superior turbinate mucosal contact in migraine: Preliminary findings

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

American Journal of Otolaryngology Pub Date : 2025-04-22 DOI:10.1016/j.amjoto.2025.104623

Dean Clerico, Benjamin Keiser, Jordon Wagner

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引用次数: 0

Abstract

Objective

To describe the histopathology of migraine-inducing mucosal compression between the superior turbinate and septum.

Study design

Observational case control series.

Setting

Primary author's private practice.

Methods

Superior turbinates in contact with the nasal septum in four migraine patients were excised, variously stained, and examined histologically. Superior turbinates free of contact with septum from three patients without migraine served as controls.

Results

Compared to control turbinates, we found epithelial denudation, fibrosis, calcification, fewer glands, and nerve fiber hypertrophy in the mucosa of superior turbinates of migraine patients. All four of these patients improved substantially after superior turbinate resection.

Conclusion

Areas of mucosal contact/compression from superior turbinates of migraine patients show pathologic changes that are apparently responsible for migraine symptoms. This is the first study we know of that demonstrates pathologic changes in the turbinates of patients with mucosal contact headaches.

Level of Evidence: 4

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偏头痛患者鼻甲上黏膜接触的组织病理学：初步发现

目的探讨偏头痛致上鼻甲与鼻中隔粘膜压迫的病理组织学特征。研究设计：观察性病例对照系列。主要作者的私人执业。方法对4例偏头痛患者鼻中隔接触的上鼻甲进行切除、染色和组织学检查。3例无偏头痛患者的上鼻甲与鼻中隔无接触作为对照。结果与对照组相比，偏头痛患者上鼻甲粘膜上皮脱落、纤维化、钙化、腺体减少、神经纤维肥大。所有4例患者在切除上鼻甲后均有显著改善。结论偏头痛患者上鼻甲粘膜接触/压迫区表现出明显的病理改变，这是偏头痛症状的原因。这是我们所知道的第一个证明粘膜接触性头痛患者鼻甲病理变化的研究。证据等级：4

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来源期刊

American Journal of Otolaryngology 医学-耳鼻喉科学

CiteScore

4.40

自引率

4.00%

发文量

378

审稿时长

41 days

期刊介绍： Be fully informed about developments in otology, neurotology, audiology, rhinology, allergy, laryngology, speech science, bronchoesophagology, facial plastic surgery, and head and neck surgery. Featured sections include original contributions, grand rounds, current reviews, case reports and socioeconomics.