American Journal of Otolaryngology最新文献

筛选
英文 中文
Toasted: Is burnout affecting otolaryngology trainee career decisions? Toasted:职业倦怠会影响耳鼻喉科实习生的职业选择吗?
IF 1.7 4区 医学
American Journal of Otolaryngology Pub Date : 2025-11-01 Epub Date: 2025-10-21 DOI: 10.1016/j.amjoto.2025.104735
Brandon D. Abell , Victoria Fischman , Laylaa Ramos Arriaza , Cristina Cabrera-Muffly , Anne Getz , Andrew P. Johnson
{"title":"Toasted: Is burnout affecting otolaryngology trainee career decisions?","authors":"Brandon D. Abell ,&nbsp;Victoria Fischman ,&nbsp;Laylaa Ramos Arriaza ,&nbsp;Cristina Cabrera-Muffly ,&nbsp;Anne Getz ,&nbsp;Andrew P. Johnson","doi":"10.1016/j.amjoto.2025.104735","DOIUrl":"10.1016/j.amjoto.2025.104735","url":null,"abstract":"<div><h3>Objective</h3><div>Burnout is prevalent in the medical field, including within Otolaryngology – Head and Neck Surgery. To date, no study has focused on the impact burnout plays on the future career choices of otolaryngology residents and fellows. Additionally, this study aimed to assess how perceptions of burnout among subspecialty teaching faculty impacted trainees' future career choices.</div></div><div><h3>Methods</h3><div>An anonymous, cross-sectional survey was distributed nationally to program directors and coordinators of all ACGME-accredited Otolaryngology—Head and Neck Surgery residency programs in the United States during the 2022 academic year, with a request to forward the survey to current residents and fellows.</div></div><div><h3>Results</h3><div>A total of 82 trainees (72 resident physicians and 10 fellows) responded to the survey, with an estimated resident physician response rate of 4 %. 35 of the 72 residents (49 %) were planning to or were in the process of applying for a fellowship position. Burnout was cited as a factor in whether or not to pursue fellowship training for 41.3 % of respondents, and as a factor in whether or not to pursue academic medicine in 46.9 % of respondents. Witnessed or perceived burnout among faculty members also played a role in future career decisions for 61 % of respondents. Qualitative analysis revealed themes including negotiating current and future comfort/ burnout, seeking balance, and the influence of perceived burnout.</div></div><div><h3>Conclusions</h3><div>Personal burnout and observed burnout among faculty impacts career decision-making in a significant percentage of otolaryngology residents and fellows. Efforts to mitigate burnout are crucial to avoid determent of career choices within otolaryngology.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 6","pages":"Article 104735"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A randomized clinical trial of peritonsillar abscess treatment comparing drainage and tonsillectomy 扁桃体周围脓肿的随机临床试验比较引流和扁桃体切除术。
IF 1.7 4区 医学
American Journal of Otolaryngology Pub Date : 2025-11-01 Epub Date: 2025-10-20 DOI: 10.1016/j.amjoto.2025.104745
François Voruz , Rebecca Revol , Maxime Mermod , Pascal Senn , Yan Monnier , Nicolas Dulguerov
{"title":"A randomized clinical trial of peritonsillar abscess treatment comparing drainage and tonsillectomy","authors":"François Voruz ,&nbsp;Rebecca Revol ,&nbsp;Maxime Mermod ,&nbsp;Pascal Senn ,&nbsp;Yan Monnier ,&nbsp;Nicolas Dulguerov","doi":"10.1016/j.amjoto.2025.104745","DOIUrl":"10.1016/j.amjoto.2025.104745","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the efficacy, safety, and tolerance of drainage under local anesthesia compared to immediate tonsillectomy to treat uncomplicated unilateral peritonsillar abscess (PTA) in adults.</div></div><div><h3>Methods</h3><div>A randomized clinical trial was conducted in a tertiary care university hospital. Adults with PTA radiologically confirmed as ≥1 cm and uncomplicated were randomly assigned to two groups using block randomization. They immediately underwent either tonsillectomy under general anesthesia or drainage under local anesthesia. The primary outcome was treatment success at 48 h, defined as a reduction in swelling and restoration of swallowing function, allowing hospital discharge. Secondary outcomes included pain and anxiety levels, along with postoperative bleeding.</div></div><div><h3>Results</h3><div>A total of 41 patients were included (66 % male; age range 18—77 years). Twenty-one patients underwent tonsillectomy, while 20 underwent drainage. The success rate was higher in the tonsillectomy group (100 %) than in the drainage group (75 %, <em>p</em> = 0.02). Pain and anxiety levels were significantly higher in the drainage group (<em>p</em> &lt; 0.01). Postoperative bleeding occurred in 33 % of the tonsillectomy group, while no bleeding was reported in the drainage group (<em>p</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>Immediate tonsillectomy for treating PTA offers definitive management with high efficacy, albeit with an increased risk of postoperative bleeding. Drainage under local anesthesia is associated with a higher failure rate and increased patient discomfort but demonstrates a better safety profile. Treatment decisions should be tailored based on patient preferences, clinical presentation, and available resources.</div></div><div><h3>Trial registration</h3><div><span><span>ClinicalTrial.gov</span><svg><path></path></svg></span> protocol record <span><span>NCT04543708</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 6","pages":"Article 104745"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145450653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Objective diagnosis of Patulous Eustachian Tube following bariatric surgery using dynamic tympanometry 目的应用动态鼓室测量法诊断减肥手术后咽鼓管扩张。
IF 1.7 4区 医学
American Journal of Otolaryngology Pub Date : 2025-11-01 Epub Date: 2025-10-20 DOI: 10.1016/j.amjoto.2025.104742
Servet Erdemes , Hasan Elkan , Mehmet Çiftçi
{"title":"Objective diagnosis of Patulous Eustachian Tube following bariatric surgery using dynamic tympanometry","authors":"Servet Erdemes ,&nbsp;Hasan Elkan ,&nbsp;Mehmet Çiftçi","doi":"10.1016/j.amjoto.2025.104742","DOIUrl":"10.1016/j.amjoto.2025.104742","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to evaluate Patulous Eustachian Tube (PET) dysfunction developing after bariatric surgery using objective audiological tests, and to investigate the effect of rapid weight loss on the development of PET.</div></div><div><h3>Methods</h3><div>This prospective study was conducted between January and December 2024. A total of 64 patients with a body mass index (BMI) ≥ 40 who underwent bariatric surgery were included. Patients underwent otorhinolaryngological examination and audiological tests preoperatively and postoperatively (six-month postoperative). The diagnosis of PET was made objectively using the Patulous Eustachian Tube program of the Interacoustics AT235 device.</div></div><div><h3>Results</h3><div>68.8 % of the patients included in the study were female (<em>n</em> = 44) and 31.3 % were male (<em>n</em> = 20), with a mean age of 32.47 ± 5.11 years. While PET was not detected in any of the patients in the preoperative period (0 %), it developed in 25 % (<em>n</em> = 16) of the patients in the postoperative period. Greater weight loss was observed in patients who developed PET; however, this difference was not statistically significant (<em>p</em> &gt; 0.05). Symptoms such as autophony, ear fullness, and hearing their own breath sounds were observed in patients diagnosed with PET.</div></div><div><h3>Conclusion</h3><div>Rapid weight loss after bariatric surgery may trigger the development of PET. In this study, PET was reliably diagnosed through objective tympanometric tests. It is important that the diagnosis of PET be supported not only by subjective symptoms but also by objective tests. Patients with otological complaints after surgery should be carefully evaluated for PET.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 6","pages":"Article 104742"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145353361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on “Assessment of TISA ‘Transcutaneous Implant Skin Anomalies’ scale for cutaneous complications related to bone conduction hearing implants” by Hernández et al. American Journal of Otolaryngology-Head and Neck Medicine and Surgery 46 (2025) 104554 Hernández等人对“骨传导听力植入物相关皮肤并发症的TISA‘经皮植入物皮肤异常’评分评估”的评论。美国耳鼻咽喉头颈医学和外科学杂志46 (2025)104554
IF 1.7 4区 医学
American Journal of Otolaryngology Pub Date : 2025-11-01 Epub Date: 2025-09-17 DOI: 10.1016/j.amjoto.2025.104723
C. Hajema , I.J. Kruyt , M.K.S. Hol
{"title":"Comment on “Assessment of TISA ‘Transcutaneous Implant Skin Anomalies’ scale for cutaneous complications related to bone conduction hearing implants” by Hernández et al. American Journal of Otolaryngology-Head and Neck Medicine and Surgery 46 (2025) 104554","authors":"C. Hajema ,&nbsp;I.J. Kruyt ,&nbsp;M.K.S. Hol","doi":"10.1016/j.amjoto.2025.104723","DOIUrl":"10.1016/j.amjoto.2025.104723","url":null,"abstract":"","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 6","pages":"Article 104723"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editor letter 编辑的信。
IF 1.7 4区 医学
American Journal of Otolaryngology Pub Date : 2025-11-01 Epub Date: 2025-09-29 DOI: 10.1016/j.amjoto.2025.104724
Halime Sümeyra Sevmez
{"title":"Editor letter","authors":"Halime Sümeyra Sevmez","doi":"10.1016/j.amjoto.2025.104724","DOIUrl":"10.1016/j.amjoto.2025.104724","url":null,"abstract":"","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 6","pages":"Article 104724"},"PeriodicalIF":1.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative outcomes between endoscopic and microscopic approaches in pediatric type-1 tympanoplasty 儿童1型鼓室成形术的内窥镜和显微镜比较结果
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2025-09-01 Epub Date: 2025-05-23 DOI: 10.1016/j.amjoto.2025.104677
Nicole Kim , Evette A. Ronner , Angela S. Zhu , Matthew P. Partain , Ryan A. Bartholomew , Krish Suresh , Daniel J. Lee , Michael S. Cohen
{"title":"Comparative outcomes between endoscopic and microscopic approaches in pediatric type-1 tympanoplasty","authors":"Nicole Kim ,&nbsp;Evette A. Ronner ,&nbsp;Angela S. Zhu ,&nbsp;Matthew P. Partain ,&nbsp;Ryan A. Bartholomew ,&nbsp;Krish Suresh ,&nbsp;Daniel J. Lee ,&nbsp;Michael S. Cohen","doi":"10.1016/j.amjoto.2025.104677","DOIUrl":"10.1016/j.amjoto.2025.104677","url":null,"abstract":"<div><h3>Objectives</h3><div>Type-1 tympanoplasty is a surgical procedure employed to repair the tympanic membrane, when ossicular reconstruction is not required. Historically, this was performed via a microscopic approach utilizing either a transcanal, endaural, or postauricular incision. Recently, there has been a growing shift toward the use of transcanal endoscopic ear surgery (TEES), eliminating the need for an endaural or postauricular incision. This study seeks to evaluate and compare outcomes between TEES and non-TEES type-1 tympanoplasty in a pediatric population, specifically tympanic membrane closure rates and post-operative audiometric results.</div></div><div><h3>Methods</h3><div>A retrospective review of all pediatric patients who underwent type-1 tympanoplasty at a tertiary care hospital between 2016 and 2020 was performed. Differences in tympanic membrane perforation closure rates and audiometric results between patients who underwent TEES vs. non-TEES were tested using Fisher's Exact and Mann-Whitney <em>U</em> tests. Logistic regression with stepwise selection and linear regression were used to compare factors among groups.</div></div><div><h3>Results</h3><div>118 patients underwent type-1 tympanoplasty (85 TEES, 33 non-TEES). Rate of closure was higher for patients who underwent TEES (91.76 %, 78/85) compared to non-TEES (69.7 %, 23/33) (Fisher's exact <em>p</em> = 0.006). Patients who underwent TEES had a greater reduction in post-operative PTA (median = −9 dB, IQR = −15 to −3 dB, <em>n</em> = 74) than those who underwent non-TEES (median = −5 dB, IQR = −11 to 3 dB, <em>n</em> = 31) (Mann Whitney <em>p</em> = 0.015).</div></div><div><h3>Conclusion</h3><div>In the study population, closure rates and audiometric outcomes were superior in patients who underwent type-1 tympanoplasty using TEES compared to non-TEES.</div></div><div><h3>Level of evidence</h3><div>III.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104677"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymph node ratio as an independent prognostic factor in cN0 floor of mouth squamous cell carcinoma: A single-institution retrospective cohort analysis 淋巴结比例作为口腔鳞状细胞癌cN0底的独立预后因素:一项单机构回顾性队列分析
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2025-09-01 Epub Date: 2025-04-28 DOI: 10.1016/j.amjoto.2025.104644
Duy Quoc Ngo , Thang Manh Hoang , Trong Van Nguyen , Quy Xuan Ngo
{"title":"Lymph node ratio as an independent prognostic factor in cN0 floor of mouth squamous cell carcinoma: A single-institution retrospective cohort analysis","authors":"Duy Quoc Ngo ,&nbsp;Thang Manh Hoang ,&nbsp;Trong Van Nguyen ,&nbsp;Quy Xuan Ngo","doi":"10.1016/j.amjoto.2025.104644","DOIUrl":"10.1016/j.amjoto.2025.104644","url":null,"abstract":"<div><h3>Background</h3><div>To analyze the influence of lymph node ratio (LNR) in survival of clinically node-negative (cN0) patients with floor of mouth squamous cell carcinoma (FMSCC).</div></div><div><h3>Materials and methods</h3><div>Clinicopathologic data from 48 patients with cN0 FMSCC who underwent curative surgery and selective neck dissection from 2015 to 2020 was retrospectively assessed. The impact of LNR and other variables on overall survival (OS) and disease-free survival (DFS) was analyzed in univariate and multivariate analyses.</div></div><div><h3>Results</h3><div>Occult nodal metastases were identified in 11 patients (22.9 %). The mean lymph node yield was 13.94 ± 7.11 nodes. ROC curve analysis identified an optimal LNR threshold of 0.034, with an area under the curve of 0.691 (<em>p</em> = 0.03). In the multivariate analysis, LNR was an independent prognostic factor for both OS (HR 9.018, 95 % CI 3.214–25.306, <em>p</em> &lt; 0.001) and DFS (OR 12.889, 95 % CI 2.426–68.473, <em>p</em> = 0.002). Patients with LNR &gt;0.034 demonstrated significantly inferior 5-year OS rates (26.7 % versus 89.1 %).</div></div><div><h3>Conclusions</h3><div>The LNR is an independent prognostic factor in cN0 FMSCC patients. An LNR threshold of 0.034 effectively stratifies risk and may guide adjuvant therapy decisions.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104644"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary study on classification and treatment of type I variant preauricular fistula 变异型耳前瘘分型及治疗的初步探讨
IF 1.7 4区 医学
American Journal of Otolaryngology Pub Date : 2025-09-01 Epub Date: 2025-07-25 DOI: 10.1016/j.amjoto.2025.104709
Liang Liu , Haigang Zhang , Xunwu Dou , Xinghe Zhao , Mingyue Fan
{"title":"Preliminary study on classification and treatment of type I variant preauricular fistula","authors":"Liang Liu ,&nbsp;Haigang Zhang ,&nbsp;Xunwu Dou ,&nbsp;Xinghe Zhao ,&nbsp;Mingyue Fan","doi":"10.1016/j.amjoto.2025.104709","DOIUrl":"10.1016/j.amjoto.2025.104709","url":null,"abstract":"<div><h3>Objective</h3><div>To classify and manage Type I Variant Preauricular Fistulas (Type I VPFs) based on clinical manifestations, evaluate the efficacy of individualized surgical approaches, and provide a reference for their treatment.</div></div><div><h3>Methods</h3><div>From January 2016 to December 2023, our department treated 34 cases of Type I VPFs, including 19 males and 15 females, aged 11 months to 12 years (mean age: 5 years and 5 months). Sixteen cases involved the left ear, and 18 involved the right ear, with 4 cases presenting double fistulas. All cases had recurrent infections, and 7 cases had a history of incision and drainage. Based on clinical features, the fistulas were classified into Simple Type I VPFs, Conchal Type I VPFs, Retroauricular Groove Type I VPFs, External Auditory Canal Type I VPFs, and Hybrid Type I VPFs. Surgical management included complete fistula excision with adjacent crus helicis cartilage removal. Auxiliary incisions were made to debride granulation tissue based on its location, and primary flap reconstruction was performed for skin defects.</div></div><div><h3>Results</h3><div>The distribution of cases was as follows: Simple Type I VPFs (20.59 %, 7/34), Conchal Type I VPFs (35.29 %, 12/34), Retroauricular Groove Type I VPFs (29.41 %, 10/34), External Auditory Canal Type I VPFs (11.76 %, 4/34), and Hybrid Type I VPFs (2.94 %, 1/34). Approximately 29.41 % (10/34) of patients required flap reconstruction for defect repair, with these cases exclusively involving the conchal typeI VPFs.</div></div><div><h3>Conclusion</h3><div>Classification of Type I VPFs facilitates tailored surgical planning, achieving optimal functional and cosmetic outcomes.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104709"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between vitamin D deficiency and residual dizziness in idiopathic BPPV: Focus on otolith dysfunction and regression insights 特发性BPPV中维生素D缺乏与残留头晕之间的关系:耳石功能障碍和回归见解的重点
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2025-09-01 Epub Date: 2025-07-20 DOI: 10.1016/j.amjoto.2025.104704
Xuanchen Zhou , Tao Lin , Qiang Zhang , Changle Li , Ling Ding
{"title":"Association between vitamin D deficiency and residual dizziness in idiopathic BPPV: Focus on otolith dysfunction and regression insights","authors":"Xuanchen Zhou ,&nbsp;Tao Lin ,&nbsp;Qiang Zhang ,&nbsp;Changle Li ,&nbsp;Ling Ding","doi":"10.1016/j.amjoto.2025.104704","DOIUrl":"10.1016/j.amjoto.2025.104704","url":null,"abstract":"<div><h3>Background</h3><div>Residual dizziness (RD) following successful canalith repositioning maneuvers (CRMs) in idiopathic benign paroxysmal positional vertigo (BPPV) is multifactorial, with vitamin D (VD) deficiency hypothesized to influence otolith-mediated vestibular pathways.</div></div><div><h3>Objective</h3><div>To determine the impact of VD deficiency severity on RD incidence and vestibular dysfunction, and to evaluate the effects of VD supplementation on vestibular dysfunction.</div></div><div><h3>Methods</h3><div>A cross-sectional study enrolled 138 idiopathic BPPV patients with different VD level. Participants were stratified by deficiency severity: normal (&gt;20 ng/mL), insufficiency (10–20 ng/mL), and deficiency (&lt;10 ng/mL). RD risk factors (gender, age, times of CRMs, involved semicircular canals) were recorded. Otolith function was assessed via cervical/ocular vestibular-evoked myogenic potentials (cVEMP/oVEMP), and vestibular function via bithermal caloric testing. RD severity was measured using the Dizziness Handicap Inventory (DHI) at 1 week post-CRM. A subgroup (<em>n</em> = 30) with deficiency/insufficiency received 12-week VD3 supplementation (0.25 μg of oral calcitriol twice daily). Binary regression analysis was used to analyze predictors of RD.</div><div><em>Results:</em> A moderate positive correlation emerged between serum VD and DHI scores (<em>r</em> = 0.365, <em>P</em> &lt; 0.001). cVEMP abnormalities were the only otolith parameter associated with RD (χ<sup>2</sup> = 9.75, <em>P</em> = 0.002). The degree of VD deficiency, cVEMP, and age emerged as significant predictors of RD. There was a significant increase in VD levels before and after treatment (13.29 ± 2.99 vs. 23.24 ± 4.78, P = 0.00) in the treatment group. Both groups showed significant shortening of cVEMP N23 wave latency after three months (<em>P</em> = 0.01 and <em>P</em> = 0.02), but only the treatment group showed significant reduction in oVEMP N10 wave latency (P = 0.01), with DHI scores reduced by 48.2 % (<em>P</em> = 0.008).</div></div><div><h3>Conclusions</h3><div>We confirmed that VD enhances otolith function and neural integrity. CVEMP, age, and VD levels predict RD likelihood. This research is the first to show VD supplementation improves saccule function and transmission pathways.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104704"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploration of risk factors affecting hearing loss in patients with granulomatosis with polyangiitis: A single-center retrospective study 肉芽肿合并多血管炎患者听力损失的危险因素探讨:一项单中心回顾性研究
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2025-09-01 Epub Date: 2025-05-19 DOI: 10.1016/j.amjoto.2025.104679
Chen Li , Zhijin Han , Mengyao Xie , Qi Tang , Shuyi Wang , Zhiyuan Wu , Shu Wang , Hua Yang
{"title":"Exploration of risk factors affecting hearing loss in patients with granulomatosis with polyangiitis: A single-center retrospective study","authors":"Chen Li ,&nbsp;Zhijin Han ,&nbsp;Mengyao Xie ,&nbsp;Qi Tang ,&nbsp;Shuyi Wang ,&nbsp;Zhiyuan Wu ,&nbsp;Shu Wang ,&nbsp;Hua Yang","doi":"10.1016/j.amjoto.2025.104679","DOIUrl":"10.1016/j.amjoto.2025.104679","url":null,"abstract":"<div><h3>Introduction</h3><div>Granulomatosis with polyangiitis (GPA) commonly affects the ears, leading to irreversible hearing loss and impacting patients' quality of life. This study aims to explore and summarize the risk factors associated with hearing loss in GPA patients, providing value for early diagnosis and improved prognosis.</div></div><div><h3>Materials and methods</h3><div>We collected information from patients during their hospitalization at this center from 2013 to 2023, including 19 patients with normal hearing and 89 patients with hearing impairment which is divided into four groups furtherly. Information on basic characteristics, laboratory tests, clinical manifestations, and treatment methods was collected. Initial univariate analysis was conducted for variable selection, followed by multivariate analysis to further verify if the selected factors are risk factors causing hearing impairment and to explore further.</div></div><div><h3>Results</h3><div>In different subgroups of hearing loss, it was found that age, levels of p-ANCA, ear involvement, eye involvement, and concurrent facial paralysis significantly exacerbate the level of hearing loss. Conversely, the levels of proteinase 3 anti-neutrophil cytoplasmic antibodies (PR3-ANCA), treatment with rituximab (RTX), and the level of hearing loss are negatively correlated. Through multifactor analysis, age, ear involvement, eye involvement, and facial palsy were identified as risk factors for more severe hearing loss. Furthermore, we analyzed the distribution of types of hearing loss in different severity groups and observed that the more severe the hearing loss, the higher the proportion of sensorineural hearing loss.</div></div><div><h3>Conclusion</h3><div>This study found that age, ear involvement, eye involvement, and facial palsy are four factors that contribute to irreversible hearing loss in patients with granulomatosis with polyangiitis (GPA). The occurrence of hearing loss in GPA patients appears to progress from conductive hearing loss to sensorineural hearing loss, indicating some mechanisms behind the hearing loss in GPA patients.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104679"},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书