Trans-oral robotic surgery in the management of malignant oropharyngeal minor salivary gland tumors: A systematic review

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

American Journal of Otolaryngology Pub Date : 2025-04-19 DOI:10.1016/j.amjoto.2025.104616

Gian Marco Pace , Camilla Zimello , Andrea Costantino , Elena Russo , Antonella Polimeni , Antonio Greco , Giannicola Iannella , Armando De Virgilio

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引用次数: 0

Abstract

Objective

The aim of this study is to evaluate trans-oral robotic surgery (TORS) in the treatment of oropharyngeal minor salivary glands (OPMSG) malignancies.

Methods

This study was performed according to the PRISMA statement. A systematic review was performed following a comprehensive electronic search in PubMed, Google Scholar and ScienceDirect databases for studies published until April 21st, 2024.

Results

Eleven studies were included in our analysis. A total of 180 patients (males: 44.8 %, n = 78/174) with a median age of 59.6 years (n = 174; IQR 53–72) who underwent OPMSG malignant tumor TORS resection were included. The most common histology was mucoepidermoid carcinoma (n = 76/161, 47.2 %), followed by adenoid cystic carcinoma (n = 42/161, 26.1 %) and polymorphous low-grade adenocarcinoma (n = 17/161, 10.6 %). 87.9 % of OPMSG were classified as T1-T2 (n = 153/174). The median hospitalization time was 4 days (n = 154; IQR 2–6.5). The median initiation of oral diet following surgery occurred on post-operative day 1 (n = 15; IQR 1–4). Post-operative complications, occurring within 30 days from the TORS procedure, presented in 5.8 % of cases (n = 10/172). Negative margins after resection of primary tumor were obtained in 80.4 % of cases (n = 139/173).

Conclusions

This systematic review confirms the safety and feasibility of TORS in the treatment of OPMSG malignancies. However, due to the low quality of included studies, further evidence is needed to establish clinical guidelines.

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经口机器人手术治疗口咽小涎腺恶性肿瘤：系统综述

目的探讨经口机器人手术（TORS）治疗口咽小唾液腺（OPMSG）恶性肿瘤的效果。方法本研究按照PRISMA标准进行。在PubMed、b谷歌Scholar和ScienceDirect数据库中进行全面的电子检索，检索到2024年4月21日之前发表的研究，并进行系统评价。结果6项研究纳入我们的分析。共180例患者（男性44.8%,n = 78/174），中位年龄59.6岁(n = 174；纳入IQR 53-72)行OPMSG恶性肿瘤切除术的患者。最常见的组织学为粘液表皮样癌（n = 76/161, 47.2%），其次为腺样囊性癌（n = 42/161, 26.1%）和多形性低级别腺癌（n = 17/161, 10.6%）。87.9%的OPMSG分为T1-T2 （n = 153/174）。中位住院时间为4天(n = 154；差2 - 6.5)。术后开始口服饮食的中位时间为术后第1天(n = 15；差1 - 4)。术后并发症发生在TORS手术后30天内，5.8%的病例（n = 10/172）出现。原发肿瘤切除后阴性切缘占80.4% （n = 139/173）。结论本系统评价证实了tor治疗OPMSG恶性肿瘤的安全性和可行性。然而，由于纳入的研究质量较低，需要进一步的证据来建立临床指南。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Otolaryngology 医学-耳鼻喉科学

CiteScore

4.40

自引率

4.00%

发文量

378

审稿时长

41 days

期刊介绍： Be fully informed about developments in otology, neurotology, audiology, rhinology, allergy, laryngology, speech science, bronchoesophagology, facial plastic surgery, and head and neck surgery. Featured sections include original contributions, grand rounds, current reviews, case reports and socioeconomics.