American Journal of Otolaryngology最新文献

{"title":"Optimal combination treatment for Locally Advanced Nasopharyngeal Carcinoma: A systematic review and Bayesian Network Meta-Analysis","authors":"Zexin Song ,&nbsp;Likai Chen ,&nbsp;Qi Zhang ,&nbsp;Yueyue Huang ,&nbsp;Hao Pan","doi":"10.1016/j.amjoto.2025.104692","DOIUrl":"10.1016/j.amjoto.2025.104692","url":null,"abstract":"<div><h3>Purpose</h3><div>To identify the optimal therapeutic strategy for Locally Advanced Nasopharyngeal Carcinoma (LA-NPC).</div></div><div><h3>Methods</h3><div>Herein, four databases (PubMed, Web of Science, Embase, and Cochrane Library) were systematically searched for pertinent articles from inception to May 24, 2024. Risk of Bias (ROB) was assessed using Cochrane's risk of bias tool 2.0. Statistical analyses were performed using Stata 16.0 and R 4.4.0.</div></div><div><h3>Results</h3><div>The final analysis included 46 studies involving 15,667 patients. Compared to the Concurrent Chemoradiotherapy (CCRT) + Adjuvant Chemotherapy (AC) combination therapy, the Induction Chemotherapy (IC) + CCRT + Epidermal Growth Factor Receptor Antibody (anti-EGFR) combination treatment demonstrated better efficacy in improving Overall Survival (OS) (Hazard Ratio [HR]: 0.52; 95 % Confidence Interval [CI]: 0.33–0.83). The Surface Under the Cumulative Ranking (SUCRA) analysis revealed that the IC + CCRT + AC + anti-EGFR combination ranked the highest in terms of OS, with a SUCRA score of 87.49 %. It also ranked the highest in terms of Distant Metastasis-Free Survival (DMFS), with a SUCRA score of 85.90 %. Additionally, the CCRT + anti-EGFR combination therapy ranked the highest in terms of PFS, with a SUCRA score of 77.21 %, while the IC + RT combination had the fewest Adverse Effects (AEs) (3–4 grade), with a SUCRA score of 86.20 %.</div></div><div><h3>Conclusion</h3><div>The IC + CCRT + AC + anti-EGFR combination therapy significantly improved OS, DMFS, and LRFS, highlighting its great promise in LA-NPC treatment. However, owing to the relatively few studies on immunotherapy and targeted therapy, more well-designed studies will be required to validate this deduction.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104692"},"PeriodicalIF":1.8,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of AI-generated study guides in otolaryngology education","authors":"Evan A. Patel ,&nbsp;Pierce T. Herrmann ,&nbsp;Lindsay Fleischer ,&nbsp;Peter Filip ,&nbsp;Stephanie Joe ,&nbsp;Rijul S. Kshirsagar ,&nbsp;Edward C. Kuan ,&nbsp;Peter Papagiannopoulos ,&nbsp;Zara M. Patel ,&nbsp;Sanjeet Rangarajan ,&nbsp;Pete S. Batra ,&nbsp;Bobby A. Tajudeen","doi":"10.1016/j.amjoto.2025.104693","DOIUrl":"10.1016/j.amjoto.2025.104693","url":null,"abstract":"<div><h3>Introduction</h3><div>Resident physicians training in otolaryngology frequently utilize dense traditional textbooks like “Cummings: Otolaryngology Head and Neck Surgery,” widely regarded as the gold standard for educational content in the field. However, integrating artificial intelligence (AI) into educational methods offers potential enhancements to traditional methods of trainee learning. This study evaluates the accuracy, relevance, and clarity of AI-generated study guides for otolaryngology residents and their efficacy in graduate level education.</div></div><div><h3>Methods</h3><div>Study guides for four rhinology chapters of “Cummings Otolaryngology Head and Neck Surgery” were generated using ChatGPT-4 by a non-expert in otolaryngology to ensure replicability. Multiple board-certified Rhinologists evaluated the study guides with a structured assessment form. The guides were rated on accuracy, relevancy, and clarity using a 4-point scale. The item-level content validity index (I-CVI) was calculated for each parameter.</div></div><div><h3>Results</h3><div>The mean scores for accuracy, relevancy, and clarity across all chapters were 3.45 ± 0.19, 3.64 ± 0.17, and 3.36 ± 0.08, respectively. I-CVI scores for accuracy, relevancy, and clarity ranged from 0.8 to 1.0, signifying that the content was valid. Reviewers praised the comprehensive nature and clear formatting, although they suggested incorporating more detailed explanations and visual aids.</div></div><div><h3>Discussion</h3><div>The findings demonstrate the potential of Large Language Models (LLMs) in generating high-quality content. AI-generated resources can reduce the burden on educators and provide tailored resources for residents. Future research is necessary to explore refined AI models and multimodal inputs to enhance educational outcomes. LLM's, such as OpenAI's GPT-4, have revolutionized the opportunity for personalized learning experiences for graduate level trainees.</div></div><div><h3>Level of evidence</h3><div>Level 5</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104693"},"PeriodicalIF":1.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid-eluting stents in challenging frontal sinus surgery: A critical real world experience","authors":"Sven Beckmann ,&nbsp;Davina Gut ,&nbsp;Raffael Fink ,&nbsp;Marco Caversaccio ,&nbsp;Urs Borner ,&nbsp;Lukas Anschuetz","doi":"10.1016/j.amjoto.2025.104685","DOIUrl":"10.1016/j.amjoto.2025.104685","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigates the impact of placing steroid-eluting stents in the frontal sinus outflow tract on the need for postoperative interventions and postoperative changes in symptoms.</div></div><div><h3>Methods</h3><div>We performed a retrospective case-control study between January 2018 and December 2022 in 21 patients in each group with and without a steroid-eluting stent placed in the frontal sinus outflow tract. The outcome between the two groups was investigated regarding the need for revision surgery and changes in pre- and postoperative symptoms.</div></div><div><h3>Results</h3><div>Comparison between the two groups in the postoperative course revealed no statistically significant differences with respect to postoperative interventions. Further analysis of the postoperative symptoms demonstrated statistically significant reduced hyposmia, rhinorrhea, and nasal obstruction in the group with stenting after surgery than before surgery, whereas pain and rhinorrhea were reported significantly less frequently in the group without stenting in the postoperative course.</div></div><div><h3>Conclusions</h3><div>This study revealed no statistically significant differences in the postoperative course between the stenting and no-stenting group regarding early postoperative interventions (local intervention, revision surgery). Accordingly, this study is the first to show no significant difference in the postoperative intervention rates, whereas previous studies have all shown a significant difference in the need for postoperative interventions.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104685"},"PeriodicalIF":1.8,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning curves in endoscopic thyroidectomy: A literature review of different surgical approaches","authors":"Wenkai Li ,&nbsp;Xiaowei Peng ,&nbsp;Aiping Wang","doi":"10.1016/j.amjoto.2025.104691","DOIUrl":"10.1016/j.amjoto.2025.104691","url":null,"abstract":"<div><h3>Objective</h3><div>This review analyzes the learning curves of various endoscopic thyroidectomy approaches, aiming to guide surgeons in improving training efficiency, reducing learning time, and enhancing surgical safety and outcomes.</div></div><div><h3>Methods</h3><div>A literature search in PubMed and Web of Science for studies published from January 2014 to April 2024 on the learning curves of endoscopic thyroidectomy was conducted. Studies involving human subjects with specific case data were included; duplicates, non-English publications, animal studies, reviews, and unrelated thyroid conditions were excluded.</div></div><div><h3>Results</h3><div>A total of 47 studies were reviewed, covering various endoscopic thyroidectomy techniques. The trans-axillary procedure showed a learning curve peak between 30 and 90 cases (average 45.5 for endoscopic, 34.17 for robotic). The trans-breast/chest approach peaked between 25 and 60 cases (average 34.88). Transoral procedures peaked between 12 and 71 cases (average 37 for endoscopic, 28.63 for robotic). The bilateral axillo-breast approach (BABA) peaked at 30 cases for endoscopic surgeries and 15-51 cases for robotic-assisted surgeries (average 36.44).</div></div><div><h3>Conclusion</h3><div>This study highlights the learning curve differences among various approaches to endoscopic thyroidectomy, providing valuable insights for improving training and increasing the adoption of these techniques.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104691"},"PeriodicalIF":1.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of inpatient treatment in children with orbital cellulitis","authors":"Amani Kais,&nbsp;Erica McArdle,&nbsp;John Behnke,&nbsp;Ruifeng Cui,&nbsp;Chadi A. Makary,&nbsp;Hassan H. Ramadan","doi":"10.1016/j.amjoto.2025.104686","DOIUrl":"10.1016/j.amjoto.2025.104686","url":null,"abstract":"<div><h3>Background</h3><div>Orbital cellulitis in children can lead to serious complications and necessitate hospitalization for management.</div></div><div><h3>Objective</h3><div>This study investigated predictors of inpatient hospitalization among pediatric patients receiving medical treatment for orbital cellulitis.</div></div><div><h3>Methods</h3><div>A retrospective cohort study of children treated for orbital cellulitis at West Virginia University Children's Hospital from January 2012–July 2022 was conducted. Patient characteristics, treatment setting (inpatient vs outpatient), orbital cellulitis type (preseptal vs postseptal), etiology of the orbital cellulitis (acute rhinosinusitis vs other), and presence of subperiosteal abscess were reviewed.</div></div><div><h3>Results</h3><div>The sample consisted of 100 pediatric patients with mean age of 7.0 years old (SD = 4.9). Inpatient treatment was required for 70 patients with a mean length of stay of 3.0 (SD = 1.7) days. In univariate regressions, acute rhinosinusitis (ARS), postseptal cellulitis, and subperiosteal abscess predicted necessitating inpatient treatment (<em>p</em> &lt; 0.05 for all). In multivariate regressions, only ARS predicted treatment setting (<em>p</em> = 0.016) and no variables predicted length of stay (<em>p</em> &gt; 0.05 for all).</div></div><div><h3>Conclusion</h3><div>In children who were treated medically for orbital cellulitis, ARS as the etiology was the main predictor necessitating inpatient treatment.</div></div><div><h3>Level of evidence</h3><div>4</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104686"},"PeriodicalIF":1.8,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous vocal fold steroid injections: a current reappraisal of indications and techniques","authors":"Leonardo Franz,&nbsp;Giovanna Baracca,&nbsp;Alessandro Matarazzo,&nbsp;Cosimo de Filippis,&nbsp;Gino Marioni","doi":"10.1016/j.amjoto.2025.104688","DOIUrl":"10.1016/j.amjoto.2025.104688","url":null,"abstract":"<div><h3>Objective</h3><div>Vocal fold steroid injections have been proposed for benign lesions (e.g. vocal nodules, polyps, cysts and Reinke's edema), based on their inflammatory background. Although several studies reported the trans-nasal fiber-endoscopic techniques, evidence regarding transcervical percutaneous approaches is limited. This review aimed to critically analyze the available evidence on percutaneous steroid injections for benign laryngeal lesions, providing an updated summary of indications, surgical techniques and results.</div></div><div><h3>Methods</h3><div>The Pubmed and Scopus databases were searched, according to the following keywords: percutaneous AND (steroid OR corticosteroid) AND injection AND (larynx OR laryngeal OR vocal fold). Articles were screened according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Original reports, in English, describing treatment with percutaneous vocal fold steroid injection were included. Articles lacking relevant reported data, single case reports, non-original studies, or preclinical studies were excluded.</div></div><div><h3>Results</h3><div>603 papers were retrieved. After duplicates removal and exclusion of studies not complying with the inclusion/exclusion criteria, 16 articles were included. The treated benign lesions were pre-nodular swelling/nodules, polyps, granulomas, fibrosis/scars, laryngeal stenosis and Reinke's edema. The described percutaneous approaches included the trans-thyrohyoid, trans-cricothyroid and trans-thyroid cartilage routes.</div></div><div><h3>Conclusion</h3><div>The available evidence describes percutaneous vocal fold steroid injection as feasible and effective in benign laryngeal lesions. In terms of clinical effectiveness, nodules and polyps seemed to show potentially more benefit compared to other lesion types. However, the heterogeneity of the available studies may prevent generalizability. To obtain more conclusive data, further studies, preferably in a prospective multicenter setting, are advocated.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104688"},"PeriodicalIF":1.8,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular free tissue transfer repair of pharyngoesophageal perforation following anterior cervical discectomy and fusion","authors":"Danielle M. Gillard ,&nbsp;Karolina A. Plonowska-Hirschfeld ,&nbsp;Chase Heaton ,&nbsp;Rahul Seth ,&nbsp;Andrea M. Park ,&nbsp;P. Daniel Knott","doi":"10.1016/j.amjoto.2025.104687","DOIUrl":"10.1016/j.amjoto.2025.104687","url":null,"abstract":"<div><h3>Background</h3><div>There are no current best practice guidelines for management of pharyngoesophageal perforation (PEP), a rare complication of anterior cervical discectomy and fusion (ACDF). We describe our institution's experience with free flap reconstruction of PEP after ACDF.</div></div><div><h3>Methods</h3><div>Retrospective review of patients who underwent free flap reconstruction of PEP after ACDF.</div></div><div><h3>Results</h3><div>Thirteen patients underwent 13 microvascular free tissue transfers. There was 1 partial flap failure and no complete flap losses. One patient (7.7 %) had a persistent salivary leak following PEP repair. Ten (77 %) patients were able to resume oral intake. Five (38 %) developed esophageal diverticula and 2 (15.4 %) developed esophageal stenosis an average of 7.4 months after repair.</div></div><div><h3>Conclusions</h3><div>PEP after ACDF poses a unique reconstructive challenge. While majority of these patients can successfully achieve oral diet following microvascular repair, clinically significant esophageal diverticula and stenoses may require long-term follow-up and management.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104687"},"PeriodicalIF":1.8,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of Eustachian tube balloon dilation: Impact on resource utilization and cost","authors":"Robert M. Conway,&nbsp;Masanari Kato,&nbsp;Seilesh C. Babu","doi":"10.1016/j.amjoto.2025.104689","DOIUrl":"10.1016/j.amjoto.2025.104689","url":null,"abstract":"<div><h3>Importance</h3><div>Eustachian tube balloon dilation (ETBD) is a novel treatment option for adult patients with ETD, with superior efficacy to medical therapy. However, appropriate timing of performing ETBD hasn't been thoroughly examined.</div></div><div><h3>Objective</h3><div>This study compared healthcare resource utilization among patients with ETD that are treated early with ETBD (i.e., within 3 months of ETD diagnosis) versus those treated later (i.e., 3–12 months of ETD diagnosis).</div></div><div><h3>Design</h3><div>Retrospective cohort study.</div></div><div><h3>Setting</h3><div>Utilizing Optum Clinoformatics Socio-Economic Status (SES) Database.</div></div><div><h3>Participants</h3><div>Patients aged 18 and older who had ETBD procedure between January 2017 to June 2021.</div></div><div><h3>Interventions</h3><div>Patients were classified into two groups based on the treatment timing of their incident diagnosis of ETD: early treated and late treated.</div></div><div><h3>Main outcomes and measures</h3><div>Outcomes including 12-month ETD-related surgical procedure rate, number of office visits, medication use, and total cost were assessed and compared among the study cohorts. Study outcomes were assessed using generalized linear regression.</div></div><div><h3>Results</h3><div>Two hundred seventy-seven patients were identified, with 173 patients in the early ETBD cohort and 104 patients in the late ETBD cohort. Early treated patients had significantly lower ETD-related surgical procedure rates (8.7 % vs. 17.3 %) lower rates (28.9 % vs. 48.1 %) and fewer (0.47 vs. 1.12) ETD-related office visits, and fewer medication claims (2.19 vs. 3.06). The early treated cohort had significantly lower ETD-related costs ($212.15 vs. $551) compared to patients treated later after diagnosis.</div></div><div><h3>Conclusions and relevance</h3><div>Among ETD patients undergoing ETBD, those treated early had significantly lower healthcare resource utilization and cost in comparison to those treated later. These results will hopefully add evidence to promote the early use of ETBD for purposes of patient benefit and decreased costs.</div></div><div><h3>Level of evidence</h3><div>IV</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104689"},"PeriodicalIF":1.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling complex relationships in laryngeal pathologies: A structural equation analysis of dysphonia in Saudi Arabian patients","authors":"Omar Ibrahim Alanazi ,&nbsp;Sameer Al-bahkaly ,&nbsp;Feras Alkholaiwi ,&nbsp;Yousef Aljathlany ,&nbsp;Mohammed Khalid Alhussaini ,&nbsp;Omar Ahmed Alrashood ,&nbsp;Ahmed Ibrahim Alanazi ,&nbsp;Faisal A. Althwiny ,&nbsp;Khaled Eid Alotibi ,&nbsp;Alwaleed Abdullah Altamimi ,&nbsp;Abdulaziz Saleh Alobaid ,&nbsp;Abdullah Ahmed Alzamil ,&nbsp;Faisal Abohelaibah ,&nbsp;Faisal Alhussaini ,&nbsp;Ahmed Y. Azzam","doi":"10.1016/j.amjoto.2025.104690","DOIUrl":"10.1016/j.amjoto.2025.104690","url":null,"abstract":"<div><h3>Introduction</h3><div>Dysphonia is a prevalent laryngological condition that impairs communication and quality of life in several cases, however the interplay between risk factors and specific laryngeal pathologies remains poorly understood. Previous studies often lack structured modeling of these multifactorial interactions. We utilized structural equation modeling (SEM) in a large Saudi-based cohort to investigate the direct and indirect pathways linking demographic factors, behavioral variables, as well as the types of laryngeal pathologies.</div></div><div><h3>Methods</h3><div>Our retrospective cohort study retrieved and analyzed the relevant data from dysphonia patients at a tertiary-care hospital in Riyadh, Saudi Arabia. Laryngeal pathologies were categorized into structural, inflammatory, neurological, and functional types. Our proposed SEM framework has assessed both of the direct and indirect pathways from risk factors to these categories, including cross-pathology links and moderation effects.</div></div><div><h3>Results</h3><div>Our study cohort has included a total of 998 eligible dysphonia patients. Structural pathologies were most prevalent (33.9 %). The SEM demonstrated excellent fit (CFI = 0.961, RMSEA = 0.049) and identified significant pathways: female gender strongly predicted structural (β = 0.412) and functional pathologies; increasing age associated positively with inflammatory, neurological, and functional types; smoking strongly predicted inflammatory pathologies (β = 0.338); occupational voice use predicted structural (β = 0.356) and functional (β = 0.297).</div></div><div><h3>Conclusions</h3><div>This SEM-based etiological model reveals peculiar and significant important dysphonia pathways with clear demographic signatures in a Saudi-based population. Findings highlight specific high-risk groups (as female voice professionals, older smokers) and important progression patterns (inflammatory-to-neurological, structural-to-functional). This framework helps to offer a more precise risk profiling, supporting targeted screening protocols and tailored preventive interventions based on specific risk factors and interconnected pathology development.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104690"},"PeriodicalIF":1.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between ultra-high-resolution computed tomography score of oval window region involvement and audiometry in otosclerosis","authors":"Heyu Ding ,&nbsp;Wei Wei ,&nbsp;Ning Xu ,&nbsp;Ruowei Tang ,&nbsp;Zhengyu Zhang ,&nbsp;Chen Yang ,&nbsp;Jing Xie ,&nbsp;Shusheng Gong ,&nbsp;Zhenchang Wang ,&nbsp;Pengfei Zhao","doi":"10.1016/j.amjoto.2025.104684","DOIUrl":"10.1016/j.amjoto.2025.104684","url":null,"abstract":"<div><h3>Purpose</h3><div>To assess the relationship between the ultra-high-resolution computed tomography (U-HRCT) score of oval window region (OWR) involvement and audiometry in otosclerosis.</div></div><div><h3>Methods</h3><div>This study enrolled patients with clinically suspected otosclerosis who underwent U-HRCT examination. The analysis included 71 ears from 50 patients (mean age, 38.0 [34.0–49.8] years). The ears were divided into the conductive hearing loss group (group A, 20 ears) and mixed hearing loss group (group B, 51 ears). The CT scores of bone involvement around the oval window (0, none; 1, &lt;25 %; 2, 25 %–50 %; 3, 50 %–75 %; 4, &gt;75 %) and stapes footplate involvement (0, none; 1, &lt;50 %; 2, &gt;50 %) were evaluated and summed to obtain the CT score of OWR involvement. The Mann–Whitney <em>U</em> test was used to compare the difference in the distribution of the CT score of OWR involvement between groups A and B. Spearman's rank correlation analysis was performed to evaluate the association between the CT score of OWR involvement and the mean air conduction (AC), bone conduction (BC) and air-bone gap (ABG).</div></div><div><h3>Results</h3><div>The CT score of OWR involvement in group B was significantly higher than that in group A (<em>p</em> = .014). The correlation coefficients between the CT score of OWR involvement and the mean AC, BC, and ABG threshold were 0.74 (<em>p</em> &lt; .001), 0.52 (p &lt; .001), and 0.48 (p &lt; .001).</div></div><div><h3>Conclusion</h3><div>U-HRCT possesses the ability to clearly depict the OWR in otosclerosis. The U-HRCT-derived OWR involvement score of otosclerosis could reflect the type and degree of hearing loss.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104684"},"PeriodicalIF":1.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}