American Journal of Otolaryngology最新文献

{"title":"Mepolizumab in chronic rhinosinusitis with nasal polyps: Real life data in a multicentric Sicilian experience","authors":"Cosimo Galletti ,&nbsp;Federico Sireci ,&nbsp;Giovanna Stilo ,&nbsp;Maria Antonietta Barbieri ,&nbsp;Giuliano Messina ,&nbsp;Riccardo Manzella ,&nbsp;Daniele Portelli ,&nbsp;Andrea Guglielmo Zappalà ,&nbsp;Mariut Diana ,&nbsp;Silvia Frangipane ,&nbsp;Angelo Immordino ,&nbsp;Francesco Lorusso ,&nbsp;Francesco Dispensa ,&nbsp;Francesco Ciodaro ,&nbsp;Francesco Freni ,&nbsp;Francesco Galletti ,&nbsp;Salvatore Gallina ,&nbsp;Ignazio La Mantia ,&nbsp;Bruno Galletti","doi":"10.1016/j.amjoto.2024.104597","DOIUrl":"10.1016/j.amjoto.2024.104597","url":null,"abstract":"<div><h3>Background</h3><div>Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a type 2 pattern of inflammation. Mepolizumab was approved for the treatment of CRSwNP in 2021. However, there is a lack of real-life studies.</div></div><div><h3>Aim</h3><div>This work aimed to evaluate the effectiveness and safety profile of Mepolizumab during the first year of treatment in a real-life setting.</div></div><div><h3>Methods</h3><div>A multicentric observational cohort study was carried out. A total of 67 patients were enrolled in the Otorhinolaryngology Unit of the three University Hospitals and considered for Mepolizumab therapy. All recorder characteristics were age (at the first Mepolizumab application visit), sex, smoke habits, previous local and systemic corticosteroid therapy, history of endoscopic sinus surgery, number of previous endoscopic sinus surgery, concomitant asthma, history of an allergic condition, immunoglobulin E (IgE), allergy to nonsteroidal anti-inflammatory drugs (NSAIDs), Aspirin Exacerbated Respiratory Disease (AERD), other comorbidities associated, blood eosinophils, nasal polyp score, sinonasal outcome test 22 (SNOT 22), sniffin' stick test, the start date of Mepolizumab therapy and number of doses of Mepolizumab and eventually, Mepolizumab's adverse events related to administration. The Wilcoxon test for dependent samples was performed to compare variables. Statistical significance was assumed for <em>p</em> values &lt; 0.05.</div></div><div><h3>Results</h3><div>A statistically significant reduction in SNOT-22 and NPS was shown in the 6th and 12th month compared to baseline values (p &lt; 0.001 for both comparisons). A statistically significant increase value at the Sniffin' sticks test was shown in the 6th and 12th month compared to baseline values (<em>p</em> &lt; 0.001 for both comparisons).</div><div>At the 12-month follow-up, according to EUFOREA indications, all patients were considered to remain in treatment with Mepolizumab and continued the treatment because of a reduced NPS, improved quality of life, and a reduced need for system corticosteroids.</div></div><div><h3>Conclusions</h3><div>This multi-centric real-life study supported the effectiveness of Mepolizumab in patients with severe uncontrolled CRSwNP in the improvement of quality of life, the severity of symptoms, polyp size reduction, and smell function. Our data also support the safety profile of monoclonal therapy with Mepolizumab.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104597"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of increased screen time on post-surgical pain and pain memory among children with sleep-disordered breathing","authors":"Pengcheng Ma ,&nbsp;Gang Li ,&nbsp;Dongdong Meng ,&nbsp;Ruijia Gan ,&nbsp;Ping Fang ,&nbsp;Chaobing Gao ,&nbsp;Dong Wang","doi":"10.1016/j.amjoto.2024.104550","DOIUrl":"10.1016/j.amjoto.2024.104550","url":null,"abstract":"<div><div>Adenotonsillectomy procedures can provide effective relief to children affected by sleep-disordered breathing (SDB), but the post-adenotonsillectomy pain management remains challenging, and the most effective approach to managing postoperative pain in these cases remains uncertain. The use of electronic media as a form of distraction therapy aimed at mitigating postoperative pain in children, it is unknown whether increases in screen time can effectively reduce persistent postoperative pain intensity or the incidence of negatively biased pain memories. A total of 107 SDB children undergoing adenotonsillectomy were enrolled and divided into two groups. Children in the intervention group were allowed to increase their screen time, while screen time was restricted for children in the control group. Child-reported pain intensity and negatively biased pain memories, pain-related fear were analyzed. The results indicated that no significant differences in initial postoperative pain intensity or fear were observed among groups. However, children in the intervention group did exhibit significantly reduced remembered Day 1 postoperative pain intensity (ηp² = 0.043, <em>p</em> = 0.035), memory of worst pain intensity (ηp² = 0.047, <em>p</em> = 0.027), and memory of worst pain-related fear (ηp² = 0.042, <em>p</em> = 0.036) as compared to controls. Subgroup analyses based on age and gender indicated that males and school-aged children presented with lower scores for negatively biased pain memories. Our study exhibited the association between screen time and post-surgical pain intensity and negatively biased pain memories, These findings suggest that increasing screen time represents an effective approach to the postoperative management of negatively biased pain memories in certain subsets of children with SDB.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104550"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of glucocorticoids combined with antiviral drugs versus glucocorticoids alone in the management of Bell's Palsy: A systematic review and meta-analysis of randomized clinical trials","authors":"Yan Zhu ,&nbsp;Tiantian Liang ,&nbsp;Sha Liu ,&nbsp;Jiasen Xu ,&nbsp;He Zhao ,&nbsp;Yan Wang ,&nbsp;Jingjing Qiu ,&nbsp;Dawei Liu ,&nbsp;Yan Sun","doi":"10.1016/j.amjoto.2024.104583","DOIUrl":"10.1016/j.amjoto.2024.104583","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to compare the efficacy of glucocorticoids combined with antiviral drugs (GA) versus glucocorticoids alone (GO) in the treatment of Bell's Palsy.</div></div><div><h3>Database reviewed</h3><div>According to the PRISMA2020 guidelines, we searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials for English articles from their inception to August 10, 2023, and performed a secondary search on October 31, 2024.</div></div><div><h3>Methods</h3><div>Studies describing the efficacy of (GA) for Bell's Palsy versus (GO). Patient demographics, cure rates, and results of subgroup analysis were collected. Stata 17.0 was used to perform the calculation and to draw relevant meta-analysis pictures. RevMan 5.4 was used to determine the source of bias and to summarize the risk of bias. Heterogeneity was assessed using Q-tests and I² statistics.</div></div><div><h3>Results</h3><div>A total of 10 RCTs enrolling 2893 participants were finally included in the meta-analysis. The treatment rate in the group of GA and the group of GO was 88.7 % and 83.2 %, respectively. The difference in the treatment rate between the two groups for Bell's Palsy was significant (relative risk (RR) = 1.09, 95 % confidence interval (CI) = 1.03–1.15), and significant heterogeneity was (I² = 63.6 %, <em>p</em> = 0.003 &lt; 0.1).</div></div><div><h3>Conclusions</h3><div>This review suggests that GA may be an effective treatment for Bell's palsy. Compared with GO, GA can improve the cure rate of Bell's palsy.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104583"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with new-onset of mental health disorders in Bell's palsy patients: A MarketScan database study","authors":"Shaun Edalati ,&nbsp;Sujay Ratna ,&nbsp;Parul Agarwal ,&nbsp;Ariel Harsinay ,&nbsp;Joshua D. Rosenberg ,&nbsp;Mingyang L. Gray","doi":"10.1016/j.amjoto.2024.104547","DOIUrl":"10.1016/j.amjoto.2024.104547","url":null,"abstract":"<div><h3>Objective</h3><div>Limited research exists on mental health disorders (MHDs) in Bell's palsy patients. This study investigates risk factors associated with the development of MHDs in these patients.</div></div><div><h3>Methods</h3><div>MarketScan commercial and Medicare outpatient and prescription drug claims data were utilized to conduct this study on adults with Bell's palsy. Patients were identified using International Classification of Diseases, Ninth or Tenth Revision, Clinical Modification diagnosis codes from 2014 to 2020 data. A one-year washout period was applied where patients did not have any diagnosis of MHD before Bell's palsy diagnosis. Patients were included if they were continuously enrolled for at least two years. The primary outcome was new-onset of any MHDs within one year of diagnosis of Bell's palsy. Descriptive statistics and logistic regression model explored risk factors associated with the development of any MHDs.</div></div><div><h3>Results</h3><div>Out of 37,166 Bell's palsy patients (mean age 49; 50.4 % female), 8.27 % experienced new-onset MHDs, with anxiety being the most prevalent (3.88 %). Female sex [Adjusted odds ratio (AOR) 1.40, 95 % CI 1.30–1.51, <em>p</em> &lt; 0.0001], increasing Charlson comorbidity index (AOR 1.11, 95 % CI 1.04–1.176, <em>p</em> = 0.001), and symptoms like headache (AOR 1.16, 95 % CI 1.34–1.81, <em>p</em> &lt; 0.0001) and facial pain (AOR 1.71, 95 % CI 1.15–2.52, <em>p</em> = 0.007) were associated with increased odds of new-onset of MHDs.</div></div><div><h3>Conclusion</h3><div>Bell's palsy patients can develop MHDs within first year of diagnosis, although the incidence of MHDs in this cohort is lower than that of the general population. Several factors are associated with the development of MHDs. These findings underscore the significance of addressing mental health in Bell's palsy patients, offering valuable considerations for clinical care and future research.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104547"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The real prognostic role of laryngeal dysplasia in patients affected by invasive cancer","authors":"Francesco Chu ,&nbsp;Francesco Bandi ,&nbsp;Giacomo Pietrobon ,&nbsp;Marta Tagliabue ,&nbsp;Stefano Zorzi ,&nbsp;Rita De Berardinis ,&nbsp;Pietro Benzi ,&nbsp;Mohssen Ansarin","doi":"10.1016/j.amjoto.2024.104535","DOIUrl":"10.1016/j.amjoto.2024.104535","url":null,"abstract":"<div><h3>Purpose</h3><div>Transoral laser microsurgery is the mainstay in treating early-stage laryngeal squamous cell carcinoma. However, consensus is lacking in non-radical surgery for infiltrating cancer, and even doubts are cast for patients with laryngeal dysplasia at the resection margins. In this study we aim to assess the prognostic significance of laryngeal dysplasia at the surgical margins in patients radically treated for infiltrating cancer.</div></div><div><h3>Materials and methods</h3><div>Patients treated between 2000 and 2020 for infiltrating cancer were included. We selected patients whose final histopathological report confirmed radical excision for infiltrating cancer. The cohort was further divided into two subgroups according to the presence or the absence of dysplastic resection margins. All patients underwent follow up to assess oncological outcomes, and the results from the two subgroups were compared to assess the prognostic relevance of laryngeal dysplasia.</div></div><div><h3>Results</h3><div>A cohort of 281 patients was evaluated. From the statistical analysis, the supraglottic extension of infiltrating cancer and deep muscle infiltration were associated worse oncological outcomes. Conversely, the presence of critical dysplastic margins, dysplastic severity and the number of positive margins were not linked to worse outcomes.</div></div><div><h3>Conclusion</h3><div>In our experience, the presence of dysplasia at the resection margins does not affect patient survival. Thus, revision surgery for critical dysplastic margins, following radical excision of infiltrating carcinoma should not be performed. Instead, patients may undergo endoscopic monitoring, thereby avoiding unnecessary overtreatment and potential negative effects on voice outcomes.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104535"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How reliable is artificial intelligence in the diagnosis of cholesteatoma on CT images?","authors":"Avallone Emilio ,&nbsp;Pietro De Luca ,&nbsp;Timm Max ,&nbsp;Siani Agnese ,&nbsp;Viola Pasquale ,&nbsp;Ralli Massimo ,&nbsp;Chiarella Giuseppe ,&nbsp;Ricciardiello Filippo ,&nbsp;Salzano Francesco Antonio ,&nbsp;Scarpa Alfonso","doi":"10.1016/j.amjoto.2024.104519","DOIUrl":"10.1016/j.amjoto.2024.104519","url":null,"abstract":"<div><h3>Purpose</h3><div>This study analysed the main artificial intelligence (AI) models for the diagnosis of cholesteatoma on computed tomography (CT), evaluating their performance and comparing them with each other. The increasing application of AI in radiology requires a systematic comparison of available methodologies.</div></div><div><h3>Methods</h3><div>A systematic literature review was conducted, selecting relevant articles from the main databases. The included studies had to fulfil specific criteria regarding methodology, use of AI models for cholesteatoma diagnosis and results in terms of sensitivity and specificity.</div></div><div><h3>Results</h3><div>The meta-analysis included three studies evaluating the MobilenetV2, Densenet201 and Resnet50 AI models. All models demonstrated high levels of sensitivity and specificity in the diagnosis of cholesteatoma at CT. No statistically significant differences were found between the performance of the various models, suggesting a robust common diagnostic capability between the different neural network architectures.</div></div><div><h3>Conclusions</h3><div>AI is making rapid progress in imaging, with recent studies already showing remarkable performance in cholesteatoma diagnosis. The speed of technological development is promising. However, to ensure safe and effective implementation in clinical practice, further studies are needed to validate and standardise these AI models. Future research should focus not only on the diagnostic accuracy, but also on the robustness, reproducibility and clinical integration of these emerging technologies.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104519"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost effectiveness analysis of BRAFV600E testing for low-risk papillary thyroid microcarcinomas","authors":"Idit Tessler ,&nbsp;Moshe Leshno ,&nbsp;Eran E. Alon ,&nbsp;Gilad Feinmesser ,&nbsp;Galit Avior","doi":"10.1016/j.amjoto.2024.104559","DOIUrl":"10.1016/j.amjoto.2024.104559","url":null,"abstract":"<div><h3>Objective</h3><div>Given the good prognosis of low-risk papillary thyroid microcarcinomas (lrPTMCs), accurate risk stratification is valuable to optimize management: active surveillance (AS) vs. hemithyroidectomy (HT). <em>BRAF</em>^{<em>V600E</em>} positive lrPTMC is associated with increased recurrence risk; hence, AS was suggested for mutation-negative lrPTMC. This study aims to evaluate the cost-effectiveness of <em>BRAF</em>^{<em>V600E</em>} testing for lrPTMC.</div></div><div><h3>Study design &amp; setting</h3><div>Decision tree cost-effectiveness analytic model.</div></div><div><h3>Methods</h3><div>We performed a cost-effectiveness analysis of the management strategies for lrPTMCs: AS, HT, and <em>BRAF</em>^{<em>V600E</em>} genetic testing (GT), in which treatment pathways were determined by <em>BRAF</em>^{<em>V600E</em>} status. Data on probabilities and complications were derived from current literature. One- and two-way sensitivity analyses were conducted to ascertain model robustness.</div></div><div><h3>Results</h3><div>Our model found GT as the cost-effective strategy, providing an additional 0.35 QALYs and an additional cost of $902 with an Incremental Cost-effectiveness ratio of $2542 compared to AS. In contrast, surgical intervention showed a lower utility with an increased cost of $381, positioning GT as the preferred strategy. Sensitivity analysis identified age at diagnosis as the most influential factor for cost-effectiveness between AS and GT; younger patients exhibited a lower ICER, indicating greater cost savings per QALY, till up to age 48 years, where AS becomes favorable. GT consistently outperformed QALY gains across varying incidences of <em>BRAF</em>^{<em>V600E</em>} positivity tumors.</div></div><div><h3>Conclusions</h3><div>In conclusion, this study demonstrates the economic and clinical advantages of incorporating <em>BRAF</em>^{<em>V600E</em>} genetic testing in the management of lrPTMCs. Our model supports further real-life studies of <em>BRAF</em>^{<em>V600E</em>} testing for lrPTMCs.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104559"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in completing testing for SARS-CoV-2 prior to otolaryngology procedures","authors":"Amber D. Shaffer,&nbsp;Jennifer L. McCoy ,&nbsp;Joseph E. Dohar","doi":"10.1016/j.amjoto.2024.104543","DOIUrl":"10.1016/j.amjoto.2024.104543","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine what patient characteristics are associated with completing asymptomatic pre-operative testing for SARS-CoV-2.</div></div><div><h3>Methods</h3><div>Charts from consecutive patients undergoing ambulatory surgery in otolaryngology at a tertiary care children's hospital from May 4 until May 26, 2020, were reviewed. If two or more siblings were scheduled, only the first sibling was included. Demographics, surgical details, and results of asymptomatic pre-operative testing for SARS-CoV-2 were collected. Patients who completed pre-operative testing were compared with those who did not using logistic regression or Wilcoxon rank-sum tests, α = 0.05.</div></div><div><h3>Results</h3><div>216 patients were included. 56.5 % were male, and median age at surgery was 2 years (range 4 months–20 years). 88 patients (40.7 %) had pre-operative SARS-CoV-2 RT-PCR testing. 97.7 % of sampling occurred 2–3 days prior to the procedure, and 98.9 % of results were available within 2 days. The virus was not detected in any cases. In multiple logistic regression, undergoing surgery at the main hospital location rather than a satellite location (OR: 3.13, <em>p</em> = 0.003) and greater median household income for zip (OR: 1.18/$10,000, <em>p</em> = 0.042) were associated with completing pre-operative testing. However, race, insurance type, surgeon, patient age, previous no-show appointments, and household composition did not alter the odds of completing pre-operative testing.</div></div><div><h3>Conclusions</h3><div>Families were less likely to complete testing if surgery was being performed at a satellite location or if they lived in an area with lesser median household income. This work draws attention to the impact of socioeconomic factors on access to and compliance with pandemic mitigation measures, with important implications for future public health crises.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104543"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual task iTUG to investigate increased fall risk among older adults with bilateral hearing loss","authors":"Maura Cosetti ,&nbsp;Liraz Arie ,&nbsp;Jennifer Kelly ,&nbsp;Jennifer Ren ,&nbsp;Anat V. Lubetzky","doi":"10.1016/j.amjoto.2024.104536","DOIUrl":"10.1016/j.amjoto.2024.104536","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate fall risk among older adults with bilateral sensorineural hearing loss (BHL) by comparing single task (ST) and dual task (DT) performance on the instrumented “Timed Up &amp; Go” test (iTUG). The TUG is a well-validated clinical tool for fall risk; addition of wireless sensors increases the test's sensitivity and allows for subcomponent analysis.</div></div><div><h3>Methods</h3><div>Adults with audiometrically confirmed normal hearing or BHL were prospectively recruited and screened for visual, musculoskeletal, neurologic, or vestibular pathology and Dizziness Handicap Inventory (DHI) &lt; 10. Total and sub-component iTUG data in the ST and DT condition (serial subtraction) was collected.</div></div><div><h3>Results</h3><div>35 adults (50–78 years) were included: 20 (mean 69 years) with BHL and 15 controls (mean age 63 years). Total iTUG duration did not differ between groups in either the ST or DT condition. In sit-to-stand, BHL were significantly slower than controls (<em>p</em> &lt; 0.03) in both ST and DT conditions. In the final subcomponent (stand-to-sit), a significant interaction was observed such that the BHL group were significantly slower with DT compared to the control group.</div></div><div><h3>Conclusions</h3><div>BHL performed slower on sub-component analysis of the iTUG compared with age-matched normal hearing controls. Slower times on the final iTUG phase for BHL may suggest a lower threshold for attentional capacity that may be cumulative. Further investigation into the impact of treatment (including amplification and training) is warranted.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104536"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocturnal mouth-taping and social media: A scoping review of the evidence","authors":"Sarah K. Fangmeyer,&nbsp;Christopher D. Badger,&nbsp;Punam G. Thakkar","doi":"10.1016/j.amjoto.2024.104545","DOIUrl":"10.1016/j.amjoto.2024.104545","url":null,"abstract":"<div><h3>Objective</h3><div>Across social media, nocturnal mouth-taping has been credited with benefits from increased energy and immunity to improved dental health. This scoping review summarizes the literature on mouth-taping and prominent social media claims pertaining to this practice.</div><div>Data Sources.</div><div>PubMed and Embase were searched using terms related to nocturnal mouth-taping. A search of TikTok was performed using the term “mouth taping.”</div><div>Review Methods.</div><div>Studies yielded by this literature search were reviewed for relevance and excluded if they did not assess mouth-taping during sleep. Study characteristics were extracted for analysis. TikTok videos discussing mouth-taping during sleep were evaluated, and videos lacking spoken or written words were excluded. The first fifty videos meeting inclusion and exclusion criteria were reviewed for claims regarding mouth-taping and presenter type.</div></div><div><h3>Results</h3><div>One hundred and seventy-seven unique studies were identified; nine met inclusion and exclusion criteria. Two studies found significant improvements in obstructive sleep apnea (OSA) metrics, one with mouth-taping alone and one with mouth-taping plus a mandibular advancement device. A study of non-OSA patients reported improved snoring with mouth-taping combined with other measures. A study of mouth-taping in asthma found no benefit. However, one study found that mouth-taping effectively reduced mouth leak during bilevel ventilation. The most common proposed advantages of mouth-taping on TikTok were improved sleep and oral health.</div></div><div><h3>Conclusion</h3><div>This is the first comprehensive literature review on mouth-taping. The literature on this subject is markedly heterogeneous, and there is little consensus on mouth-taping's benefits. Few TikTok claims regarding the practice have been evaluated. However, some research indicates that mouth-taping may be advantageous in OSA, snoring, and bilevel ventilation. Additional high-quality research is necessary to elucidate the role and efficacy of this practice.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 1","pages":"Article 104545"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}