American Journal of Otolaryngology最新文献

{"title":"Health-related quality of life perspectives of cochlear implanted children, their hearing peers, and their parents: a prospective case-control study","authors":"Debora d.P. Jiménez Montesdeoca ,&nbsp;Juan C. Falcón González ,&nbsp;Silvia A. Borkoski Barreiro ,&nbsp;Angel M. Ramos Macías","doi":"10.1016/j.amjoto.2025.104652","DOIUrl":"10.1016/j.amjoto.2025.104652","url":null,"abstract":"<div><h3>Background</h3><div>Hearing loss is one of the most common sensory alterations in humans. Cochlear implants in children provide significant benefits from a clinical point of view. However, the benefits in the health-related quality of life have been seldom studied.</div></div><div><h3>Objective</h3><div>To assess whether the health-related quality of life of 5-18 old children with cochlear implants, as measured with the PedsQL pediatric quality of life questionnaire version 4.0, is comparable with the perception of their parents/caregivers.</div></div><div><h3>Design</h3><div>Prospective, observational, cross-sectional and analytical study.</div></div><div><h3>Setting(s)</h3><div>Hearing loss Unit of the Hospital Universitario Insular Materno-Infantil (Mother and Child University Hospital), León y Castillo Infant and Primary Education Center and La Minilla Secondary Education Institute.</div></div><div><h3>Participants</h3><div>140 pediatric subjects (108 with cochlear implants, 32 hearing) plus one of their parents or guardians.</div></div><div><h3>Methods</h3><div>The original and Spanish-validated PedsQL™ pediatric quality of life questionnaires version 4.0 were used.</div></div><div><h3>Results</h3><div>Cochlear implantation yielded statistically significant results in terms of physical functioning and psychosocial health in children of 5-18 years of age.</div></div><div><h3>Conclusions</h3><div>The health-related quality of life of cochlear implanted pediatric patients (5-18 years old) evaluated with the PedsQL™ pediatric quality of life questionnaire version 4.0, is comparable to the perception of their parents/caregivers.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 4","pages":"Article 104652"},"PeriodicalIF":1.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing loss among otolaryngologist and healthcare workers: Case control study","authors":"Dana A. Obeid ,&nbsp;Hassan Assiri ,&nbsp;Jawaher AlShalawi ,&nbsp;Abdullah AlKhaldi ,&nbsp;Farid AlZhrani","doi":"10.1016/j.amjoto.2025.104635","DOIUrl":"10.1016/j.amjoto.2025.104635","url":null,"abstract":"<div><h3>Background</h3><div>Noise-induced hearing loss is a prevalent occupational hazard characterized by gradual, sensorineural hearing impairment, primarily affecting higher frequencies (3–6 kHz) due to prolonged exposure to excessive noise. The severity of hearing impairment is directly linked to sound pressure intensity, frequency, exposure duration, and pattern. Otolaryngologists, among other healthcare specialists, frequently use instruments that surpass safety limits, rendering them more susceptible to noise-induced hearing loss. This condition detrimentally impacts communication, performance, healthcare personnel well-being, and patient safety.</div></div><div><h3>Objectives</h3><div>This study aims to assess whether otolaryngologists and other operating room staff face a higher risk of hearing loss compared to their peers in non-surgical fields, particularly considering advances in surgical instrumentation.</div></div><div><h3>Methods</h3><div>A case-control study conducted at King Saud University Medical City in Riyadh, Saudi Arabia, in collaboration with the Otolaryngology and Audiology departments from June 2021 to December 2023. Comprehensive medical histories, physical measurements, and various audiological tests, including tympanometry, standard pure-tone audiometry, extended high-frequency pure-tone audiometry, and distortion-product otoacoustic emission (DPOM), were administered to ensure precise results. The study included 20 otolaryngologists of varying ages and experience levels (<em>n</em> = 20) and a comparison group of 20 apparently healthy non-otolaryngologist medical professionals. Both groups were drawn from the same population and matched for age, socioeconomic factors, and environments. All subjects underwent extensive audiological testing for result accuracy.</div></div><div><h3>Results</h3><div>The mean age of otolaryngologists was 31 ± 11 years with a balanced gender distribution. In contrast, the mean age of the non-otolaryngologist group was 32 ± 10 years, with a male predominance. Otolaryngologists exhibited higher odds of low-frequency hearing loss. Additionally, most otolaryngologists displayed the absence of DPOM at 8 kHz, 9 kHz, and 10 kHz, whereas in non-otolaryngologists, DPOM was predominantly present.</div></div><div><h3>Conclusions</h3><div>This study provides objective evidence of varying hearing levels among otolaryngologists and their peers in different specialties. Preventive measures should be implemented to mitigate communication challenges and enhance patient safety.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 4","pages":"Article 104635"},"PeriodicalIF":1.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of computed tomography in idiopathic subglottic stenosis","authors":"Sarah Benyo ,&nbsp;Radhika Duggal ,&nbsp;Rebecca C. Nelson ,&nbsp;Paul C. Bryson ,&nbsp;Michael S. Benninger ,&nbsp;William S. Tierney","doi":"10.1016/j.amjoto.2025.104651","DOIUrl":"10.1016/j.amjoto.2025.104651","url":null,"abstract":"<div><h3>Objectives</h3><div>1) To develop a standardized and reproducible protocol for evaluating airway stenosis on CT imaging. 2) To compare idiopathic subglottic stenosis (iSGS) measurements on CT imaging to intraoperative findings and determine the practical value of CT imaging in evaluation of the stenotic airway.</div></div><div><h3>Methods</h3><div>We conducted a single institution retrospective chart review of patients 18 years of age and older with a diagnosis of iSGS who had surgical intervention for iSGS performed at our institution and CT neck/chest within 6-months of first surgical intervention. We developed a standardized protocol for measuring cross-sectional area of the stenosis and percent stenosis based on CT imaging. Operative reports were queried for percent stenosis for comparison. Accuracy of CT measurements were assessed by interclass correlation coefficients (area of greatest stenosis, <em>r</em> = 0.936; distance below the vocal folds, <em>r</em> = 0.766).</div></div><div><h3>Results</h3><div>A total of 37 patients were included. One hundred percent were female and 86 % were Caucasian. The average age at first operative intervention was 48 years. The most common imaging modality was CT neck with IV contrast (64 %). The average percent stenosis on imaging was 59 % versus 62 % intraoperatively (<em>p</em> = 0.03). The average difference between percent stenosis on imaging and intraoperatively for each individual patient was 11 %.</div></div><div><h3>Conclusion</h3><div>This study directly examines the correlation of stenosis measurements on CT to intraoperative airway dimensions in patients with iSGS. Our results demonstrate that imaging may tend to underestimate stenosis by an average of 11 %, and generally correlated with intraoperative findings in 90 % of cases.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 4","pages":"Article 104651"},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iranian females report more severe symptoms on the SNOT-22: A cross-sectional population-based study","authors":"Soheila Nikakhlagh ,&nbsp;Nader Saki ,&nbsp;Bahman Cheraghian ,&nbsp;Zahra Rahimi ,&nbsp;Sara Saki ,&nbsp;Seyed Mohammad Tabibzadeh","doi":"10.1016/j.amjoto.2025.104631","DOIUrl":"10.1016/j.amjoto.2025.104631","url":null,"abstract":"<div><h3>Purpose</h3><div>Rhinosinusitis encompasses a group of conditions characterized by inflammation of the nasal mucosa and paranasal sinuses, impacting the quality of life for those affected. This study was designed to assess the quality of life in the general population using the SNOT-22 questionnaire.</div><div>This study was designed to assess quality of life among the general population using the SNOT-22 questionnaire, which is a tool for measuring quality of life related to rhinological issues.</div></div><div><h3>Material and methods</h3><div>This population-based cross-sectional study was conducted as part of the baseline assessment for the Hoveyzeh cohort study, focusing on adults aged 35–70 in southwest Iran. Data related to socioeconomic factors, demographic characteristics, and anthropometric measurements were gathered. Subsequently, a random sample of 1324 individuals participated in the study, completing the Self-reported SNOT-22 questionnaire.</div></div><div><h3>Result</h3><div>The mean age of 1324 participants was 49.92 ± 8.97 years, and about 60 % were women. The average SNOT-22 score was 7.84 ± 10.78. Approximately 34 % of the participants had an abnormal score on the SNOT-22 questionnaire. These participants were assessed for domains related to nasal, otologic, sleep and emotional symptoms. The most common issues reported were sneezing, dizziness or vertigo, waking up tired, and feelings of sadness, respectively. We observed that the odds of having an abnormal SNOT-22 scores were 62 % higher in women compared to men.</div></div><div><h3>Conclusion</h3><div>Our results revealed a relatively higher prevalence of abnormal SNOT-22 scores, especially among women. Therefore, designing and implementing therapeutic and educational interventions for these people seems necessary.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 4","pages":"Article 104631"},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathology of superior turbinate mucosal contact in migraine: Preliminary findings","authors":"Dean Clerico,&nbsp;Benjamin Keiser,&nbsp;Jordon Wagner","doi":"10.1016/j.amjoto.2025.104623","DOIUrl":"10.1016/j.amjoto.2025.104623","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the histopathology of migraine-inducing mucosal compression between the superior turbinate and septum.</div></div><div><h3>Study design</h3><div>Observational case control series.</div></div><div><h3>Setting</h3><div>Primary author's private practice.</div></div><div><h3>Methods</h3><div>Superior turbinates in contact with the nasal septum in four migraine patients were excised, variously stained, and examined histologically. Superior turbinates free of contact with septum from three patients without migraine served as controls.</div></div><div><h3>Results</h3><div>Compared to control turbinates, we found epithelial denudation, fibrosis, calcification, fewer glands, and nerve fiber hypertrophy in the mucosa of superior turbinates of migraine patients. All four of these patients improved substantially after superior turbinate resection.</div></div><div><h3>Conclusion</h3><div>Areas of mucosal contact/compression from superior turbinates of migraine patients show pathologic changes that are apparently responsible for migraine symptoms. This is the first study we know of that demonstrates pathologic changes in the turbinates of patients with mucosal contact headaches.</div><div>Level of Evidence: 4</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 4","pages":"Article 104623"},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioid prescribing after thyroid and parathyroid surgery: A survey of North American surgeons","authors":"Phillip Staibano ,&nbsp;Michael Xie ,&nbsp;Kelvin Zhou ,&nbsp;Han Zhang","doi":"10.1016/j.amjoto.2025.104640","DOIUrl":"10.1016/j.amjoto.2025.104640","url":null,"abstract":"<div><h3>Objectives</h3><div>Opioid overprescribing remains an issue following thyroid and parathyroid surgery (TPS). We performed a cross-sectional survey study to describe opioid prescribing trends of otolaryngology–head and neck surgeons across North America.</div></div><div><h3>Methods</h3><div>We performed a cross-sectional survey study of otolaryngology–head and neck surgeons who are members of the Canadian Society of Otolaryngology–Head and Neck Surgery (CSO) or the American Head and Neck Society (AHNS). The voluntary 20-item online survey addressed surgeon analgesia practices for TPS and was distributed from February 2023–July 2024. Statistical analysis included descriptive methods, multivariable logistic regression, and Chi-square testing.</div></div><div><h3>Results</h3><div>Overall, 153 surgeons completed the survey (response rate: 22.6 %) and of these surgeons, most were Canadian, fellowship-trained, and practicing for 0–10 years. Most surgeons (73 %) rated postoperative patient pain as 3–5/10. Over 75 % of surgeons prescribed opioids for inpatient thyroid surgery with early-career surgeons more likely to prescribe opioids and US surgeons were less likely to prescribe opioids. Oxycodone was commonly prescribed by US surgeons and Canadian surgeons preferred codeine. Canadian surgeons were likelier to prescribe opioids, especially ≥20 opioid tabs, when compared to US surgeons. Almost 50 % of surgeons prescribed 10–19 opioid tabs despite predicting that postoperative patients likely only use 0–10 opioid tabs.</div></div><div><h3>Conclusions</h3><div>Otolaryngology–head and neck surgeons routinely prescribe opioids for TPS despite identifying that patients only consume a fraction of their opioid prescription. Standardization of opioid prescribing and promotion of multimodal analgesia practices are needed to reduce opioid overprescription.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 4","pages":"Article 104640"},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing radiation-related laryngotracheal stenosis","authors":"Natalia Queenan ,&nbsp;Jay Trivedi ,&nbsp;Dylan Bertoni ,&nbsp;Sana H. Siddiqui ,&nbsp;Austin Yap ,&nbsp;Kathleen M. Tibbetts","doi":"10.1016/j.amjoto.2025.104643","DOIUrl":"10.1016/j.amjoto.2025.104643","url":null,"abstract":"<div><h3>Background</h3><div>Radiation-related laryngotracheal stenosis (RLTS) develops due to fibrosis of the airway after radiotherapy. We aim to characterize the presentation, management, and outcomes of patients with RLTS and compare these to patients with iatrogenic laryngotracheal stenosis (ILTS).</div></div><div><h3>Methods</h3><div>In a single-center retrospective cohort study, patients diagnosed with RLTS between 2017 and 2022 were identified. Demographic data, risk factors, cancer history and treatment, presentation of stenosis, primary stenosis intervention, and outcomes were extracted. Patients were compared to a cohort of patients with ILTS and no history of radiation therapy. Data were analyzed using Fisher's Exact Tests and paired <em>t</em>-tests.</div></div><div><h3>Results</h3><div>Seven patients with head and neck malignancies (six laryngeal, one thyroid) who developed RLTS after radiation therapy were included. One patient had supraglottic stenosis, three glottic, five subglottic, and two tracheal. Mean time to diagnosis of RLTS from initiation of radiation was 14.8 months (range: 2–46 months). Five patients were treated with laser ablation of stenosis. The patients with RLTS were compared to a cohort of 105 patients with ILTS. Patients with RLTS were less likely to have obesity (Odds Ratio (OR) = 0.06; 95 % Confidence Interval (CI) = 0.003–0.99) and more likely to have coronary vascular disease (OR = 5.5; 95 % CI = 1.04–29.6). No significant differences in interventions or outcomes were found.</div></div><div><h3>Conclusions</h3><div>Risk factors for RLTS and ILTS differ, but management strategies and treatment outcomes are comparable.</div><div>Level of evidence: IV</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 4","pages":"Article 104643"},"PeriodicalIF":1.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of vascularization patterns in juvenile Angiofibroma and the impact of preoperative embolization on surgical excision","authors":"Hon Minh Hao Nguyen ,&nbsp;Minh Tran Quang Le ,&nbsp;Hai Thanh Nguyen ,&nbsp;Hong Viet Tran ,&nbsp;Luan Viet Tran","doi":"10.1016/j.amjoto.2025.104632","DOIUrl":"10.1016/j.amjoto.2025.104632","url":null,"abstract":"<div><h3>Background</h3><div>Juvenile nasopharyngeal angiofibroma (JNA) is a rare, highly vascular tumor posing a significant challenge for endoscopic excision due to excessive intraoperative bleeding. Exploring feeding vessels and preoperative embolization could reduce intraoperative blood loss and improve surgical outcomes for JNA. This study investigates the vascularization patterns of JNA and the impact of preoperative embolization on surgical excision.</div></div><div><h3>Methods</h3><div>This was a descriptive cross-sectional study of 30 histopathologically confirmed JNA patients who underwent preoperative embolization followed by endoscopic surgical excision from January 2019 to May 2023 at Ear Nose Throat Hospital of Ho Chi Minh City. The distribution of vascular supply of tumors, as well as the role of preoperative embolization, were analyzed.</div></div><div><h3>Results</h3><div>Most tumors received exclusive blood supply from the internal maxillary artery (IMA) accounting for 50%, with 20% of cases being supplied by bilateral IMAs. A combined supply pattern involving the IMA and other external carotid artery branches was observed in 26.6%. Three complex cases (10%) received blood from the internal carotid artery (ICA). Embolization was performed at branches originating from the external carotid artery (ECA) but not from the ICA to avoid complications. All patients achieved complete endoscopic JNA excision. The average intraoperative blood loss was 608 mL (range: 100 mL - 3000 mL), and the average Boezaart score was 2.63. No major surgical complications occurred in the perioperative period. Significant differences in blood loss were observed among different UPMC tumor stages (<em>p</em> &lt; 0.001) and tumor sizes (<em>p</em> = 0.008). Advanced-stage tumors were more likely to have an ICA blood supply (<em>p</em> = 0.038).</div></div><div><h3>Conclusion</h3><div>Understanding the vascularization patterns of juvenile angiofibroma and the role of preoperative embolization can facilitate endoscopic excision of these tumors.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 3","pages":"Article 104632"},"PeriodicalIF":1.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extra-capsular nodal extension after surgical resection for HPV-positive oropharyngeal Cancer: Adjuvant radiation versus chemoradiation","authors":"Allen M. Chen ,&nbsp;Tjoson Tjoa ,&nbsp;William B. Armstrong","doi":"10.1016/j.amjoto.2025.104639","DOIUrl":"10.1016/j.amjoto.2025.104639","url":null,"abstract":"<div><h3>Purpose</h3><div>The prognostic significance of extra-capsular nodal extension (ECE) after surgical resection for human papillomavirus (HPV)-positive oropharyngeal cancer is controversial, and the optimal choice of adjuvant therapy is uncertain in this setting.</div></div><div><h3>Methods and materials</h3><div>A review of institutional databases identified a total of 63 patients with pathological evidence of ECE in at least 1 cervical lymph node after transoral robotic surgery and neck dissection for HPV-positive squamous cell carcinoma of the oropharynx. Clinical outcomes were compared based on whether patients received adjuvant radiation (20 patients) or chemoradiation (43 patients). The Kaplan Meier method was used to determine survival statistics with comparisons between groups conducted with the log-rank test.</div></div><div><h3>Results</h3><div>With a median follow-up of 50 months (range, 6 to 110 months), the 3-year overall survival for the entire population was 87 %. No significant difference was observed between patients treated by adjuvant radiation and chemoradiation with respect to 3-year overall survival (86 % versus 87 %, <em>p</em> = 0.45), local-regional control (91 % vs. 90 %, <em>p</em> = 0.71), and progression-free survival (83 % vs. 85 %, <em>p</em> = 0.57). Exploratory subset analysis of competing variables failed to identify any group in which the addition of chemotherapy to radiation improved outcome.</div></div><div><h3>Conclusions</h3><div>While the presence of ECE after surgical resection has historically been considered an indication for the use of concurrent chemoradiation in the adjuvant setting, these data suggest that this paradigm should be re-evaluated in the setting of HPV-positive oropharyngeal cancer.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 4","pages":"Article 104639"},"PeriodicalIF":1.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of anti-IGE treatment for allergic rhinitis","authors":"Rongrong Lv ,&nbsp;Jie Shan ,&nbsp;Anchi Sun ,&nbsp;Zhiwei Xing ,&nbsp;Qun Xu ,&nbsp;Qianqian Shao ,&nbsp;Hui Li","doi":"10.1016/j.amjoto.2025.104646","DOIUrl":"10.1016/j.amjoto.2025.104646","url":null,"abstract":"<div><h3>Background</h3><div>Allergic rhinitis (AR) is an inflammatory reaction of the nasal mainly mediated by Immunoglobulin E(IgE). It is one of the most common chronic diseases in the world. Patients with nasal discomfort, persistent nasal itching, sneezing, runny nose and so on as the main symptoms, it is a refractory allergic disease, will seriously reduce the quality of life of patients.</div></div><div><h3>Objective</h3><div>At present, the treatment of patients with allergic rhinitis is mainly to avoid contact with allergens, drug treatment and desensitization treatment. The serum IgE level of most patients is significantly increased. By introducing monoclonal antibodies into the gene-expression environment of IgE, the levels of free IgE can be effectively suppressed, resulting in a significant reduction in the incidence of AR. Therefore, this article will explore the mechanism and clinical application of this new anti-IgE drug, omalizumab.</div></div><div><h3>Conclusion</h3><div>Omalizumab can significantly relieve the condition of AR patients and reduce the dosage of corticosteroids and antihistamines, but its long-term efficacy and safety need further observation and analysis. Before use, the patient's status should be confirmed and the potential risks should be discussed with the patient in advance.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 3","pages":"Article 104646"},"PeriodicalIF":1.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}