American Journal of Otolaryngology最新文献

{"title":"Anatomical distribution and demographic features of head and neck non-melanoma skin cancers","authors":"Pasquale Di Maio ,&nbsp;Marco Giudice ,&nbsp;Antonio Cavallero ,&nbsp;Claudio Carnevale ,&nbsp;Pedro Luis Sarría-Echegaray ,&nbsp;Guillermo Til-Pérez ,&nbsp;Alessandro Nobile ,&nbsp;Lorenzo Salvatore Solimeno ,&nbsp;Oreste Iocca","doi":"10.1016/j.amjoto.2026.104800","DOIUrl":"10.1016/j.amjoto.2026.104800","url":null,"abstract":"<div><h3>Purpose</h3><div>Non-melanoma skin cancer (NMSC) is the most commonly diagnosed cancer worldwide. NMSC predominantly affects the head and neck, with over 80% of cases arising in this region. This study aimed to investigate the differences in anatomical distribution, epidemiological and histological characteristics of NMSC in a Caucasian population.</div></div><div><h3>Materials and methods</h3><div>A retrospective analysis was conducted of 556 primary head and neck NMSC treated at a referral centre between January 2016 and December 2021. Relative tumour density (RTD), BCC/SCC ratio, and Chi-square test were used for skin tumour analysis.</div></div><div><h3>Results</h3><div>The RTD was highest on the nose (RTD 11.24, 95% CI 9.6–12.8) for basal cell carcinoma (BCC), on the ear and periauricular area (RTD 4.79, 95% CI 3.56–6.02) for squamous cell carcinoma (SCC), and on the cheek/cheekbone area (RTD 10, 95% CI 5.52–15.51) for SCC in situ. The total ratio BCC/SCC ratio was 2.69/1 (95% CI 2.5–2.87). The highest BCC/SCC ratio was found on the nose (6.35/1, 95% CI 5.81–6.88), while the lowest ratio on the scalp (0.4/1, 95% CI 0–3.81). Chi-square analysis revealed significant associations (p &lt; 0.05) between histologic type with primary anatomic site, age distribution, sex, and depth of invasion (DOI). At the time of diagnosis, SCC tumours were significantly larger than BCC, with mean diameters of 13.45 mm and 9.38 mm, respectively.</div></div><div><h3>Conclusions</h3><div>The analysis showed statistically significant differences in clinical presentation between BCC, SCC and SCC in situ in the head and neck region. These findings may guide clinical suspicion and therapeutic decisions during patient evaluation.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 2","pages":"Article 104800"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported quality-of-life outcomes following parotidectomy for benign parotid disease","authors":"Amy S. Wong ,&nbsp;Dean P. McKenzie ,&nbsp;Benjamin J. Dixon","doi":"10.1016/j.amjoto.2025.104770","DOIUrl":"10.1016/j.amjoto.2025.104770","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate quality-of-life (QoL) in patients undergoing extracapsular dissection or partial superficial parotidectomy for benign parotid disease.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted in 155 patients who underwent limited parotidectomy, via an extracapsular dissection or partial superficial parotidectomy approach, between July 2015 and June 2020. Patients with malignancy and revision surgery where the primary operation was performed at another institution were excluded. QoL assessment was prospectively evaluated via telephone interviews. General QoL, health-related QoL and patient satisfaction were assessed with validated patient-reported outcome instruments.</div></div><div><h3>Results</h3><div>62 patients which fit the inclusion criteria were included for postoperative evaluation. General QoL assessment for overall health and QoL demonstrated minimal impacts after parotid surgery. Sensory impairment was the most common patient-reported symptom. In particular, numbness was the most common and severe adverse effect and correlated with greater auricular nerve sacrifice (<em>p</em> = 0.038). Aesthetic outcomes and patient satisfaction were high amongst the patient group. Tingling, itching, discomfort and scar tenderness correlated negatively with overall health but not overall QoL. Post operative complications were not associated with reduced overall health, overall QoL or patient satisfaction.</div></div><div><h3>Conclusion</h3><div>Extracapsular dissection and partial superficial parotidectomy for benign parotid disease can result in high patient satisfaction, aesthetic outcomes and QoL. Evaluation of outcomes should incorporate assessment tools with a broader perspective on patient satisfaction including cosmetic results.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104770"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic transnasal repair of choanal atresia: clinical characteristics and outcomes from a main tertiary hospital in Syria","authors":"Diab Alkhouri ,&nbsp;Dima Alhomsi ,&nbsp;Mhd Nabil Dandachli","doi":"10.1016/j.amjoto.2025.104757","DOIUrl":"10.1016/j.amjoto.2025.104757","url":null,"abstract":"<div><h3>Introduction</h3><div>Congenital choanal atresia (CA) is a rare malformation that can present as a neonatal emergency or with delayed symptoms in older children. Despite advances in endoscopic transnasal repair, recurrence and restenosis remain major challenges, and evidence from resource-limited countries is scarce. This study reports a 12-year experience managing CA in Syria, highlighting clinical characteristics, surgical outcomes, and prognostic factors for recurrence.</div></div><div><h3>Methods</h3><div>This retrospective cohort study included 33 pediatric patients with choanal atresia who underwent endoscopic transnasal repair between 2012 and 2024. Patients were categorized by laterality (unilateral vs. bilateral) and by recurrence status (recurrence vs. non-recurrence) to identify prognostic factors. Demographics, clinical features, surgical details, and outcomes were extracted from medical records.</div></div><div><h3>Results</h3><div>Of 33 patients, 21 (63.6 %) had bilateral CA and 12 (36.4 %) unilateral. Mean age at diagnosis was 34.5 months, with bilateral cases diagnosed significantly earlier (0.8 months vs. 93.4 months, <em>p</em> &lt; 0.001). Mixed-type atresia predominated (93.9 %). Associated anomalies were present in 27.3 %, with cardiovascular anomalies being the most frequent. Recurrence was observed in 25 % of patients, while postoperative complications occurred in 14.3 %, mainly synechiae. Recurrence was not significantly associated with age, sex, laterality, or adjunctive measures (stents, topical steroids, mitomycin C, or laser).</div></div><div><h3>Conclusion</h3><div>Endoscopic transnasal repair of CA was shown to be safe and effective in a resource-limited setting, with recurrence and complication rates comparable to international reports. Routine use of stents, steroids, mitomycin C, or laser showed no clear benefit, supporting selective rather than standard application. These findings contribute regional data to the global literature and underscore the need for larger multicenter studies to refine prognostic factors and optimize long-term outcomes.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104757"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Septoplasty opioid prescription trends following the publication of opioid prescribing clinical practice guidelines","authors":"Robert E. Africa ,&nbsp;Shahrukh R. Ali ,&nbsp;Delaney Clark ,&nbsp;Brian J. McKinnon ,&nbsp;Charles A. Hughes ,&nbsp;Tyler A. Janz ,&nbsp;Farrah Siddiqui ,&nbsp;Scott A. Hardison","doi":"10.1016/j.amjoto.2025.104755","DOIUrl":"10.1016/j.amjoto.2025.104755","url":null,"abstract":"<div><h3>Background</h3><div>To address rising opioid prescriptions, more institutions have implemented prescribing guidelines emphasizing non-opioid and other multimodal pain control. In April 2021, the AAO-HNS released guidelines for common otolaryngologic procedures to improve patient safety, reduce unnecessary opioid use, and lower the risk of postsurgical opioid dependence. The goal of this study is to evaluate the trends in opioid and non-opioid prescribing for septoplasty in relation to the publication of a major clinical practice guideline by the AAO-HNS in April 2021.</div></div><div><h3>Methods</h3><div>This multicenter retrospective study analyzes de-identified patient data from the TriNetX database, focusing on individuals prescribed either opioid or non-opioid analgesics within 1–5 days following septoplasty from January 1, 2013 to December 31, 2023. Interrupted time series analysis in Statistical Analysis System (SAS) 9.4 was performed with significant set at <em>p</em> &lt; 0.05 to evaluate the changes in prescribing trends.</div></div><div><h3>Results</h3><div>Immediately, the opioid prescribing increased for septoplasty by 1.41 %, but it was not statistically significant (<em>p</em> = 0.08). After the initial change, there was an overall statistically significant decrease in opioid prescribing by 0.24 % every 3 months (<em>p</em> &lt; 0.0001). For non-opioid prescriptions, a significant decrease occurred immediately by −0.53 % (<em>p</em> &lt; 0.0001), but a long-term significant slow increase in prescribing by 0.03 % was identified every 3 months (p &lt; 0.0001). The rate of opioid prescribing did not differ before and after guideline publication (<em>p</em> = 0.58), while non-opioid prescribing rate was significantly higher afterward (<em>p</em> = 0.03).</div></div><div><h3>Conclusions</h3><div>There was an associated decrease in opioid prescribing for septoplasty post-publication. However, this decrease was not observed immediately after the guideline publication, and rate of change before and after the publication was similar. Non-opioid prescription did not have an immediate increase, but the trend gradually increased in the post-publication period. This was a significant change from the pre-publication period.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104755"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Characteristics and prognosis of intractable otomastoiditis caused by nontuberculous mycobacteria” [American Journal of Otolaryngology Volume 46, Issue 6, November–December 2025, 104728]","authors":"Bang-Yan Zhang ,&nbsp;Chen-Chi Wu ,&nbsp;Tien-Chen Liu ,&nbsp;Ting-Hua Yang","doi":"10.1016/j.amjoto.2025.104751","DOIUrl":"10.1016/j.amjoto.2025.104751","url":null,"abstract":"","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104751"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145621989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the comment on “Clinicopathological features and prognostic value of CD276 expression in head and neck cancer: A meta-analysis”","authors":"Ziyu Chen ,&nbsp;Hang Su ,&nbsp;Juanjuan Hao ,&nbsp;Fenghua Zhang","doi":"10.1016/j.amjoto.2025.104783","DOIUrl":"10.1016/j.amjoto.2025.104783","url":null,"abstract":"","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104783"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of hypoacusis after radiochemotherapy for head and neck squamous cell carcinoma","authors":"Romina Mastronicola ,&nbsp;Maëlys Bresson ,&nbsp;Elise Kayser ,&nbsp;Agathe Barrat ,&nbsp;Alexandre Aubertin ,&nbsp;Pauline Le Roux ,&nbsp;Illyasse El Bouziani ,&nbsp;Hélèna Villard ,&nbsp;Sophie Cortese ,&nbsp;Emilie Beulque ,&nbsp;Giacomo Gravante ,&nbsp;Gilles Dolivet","doi":"10.1016/j.amjoto.2025.104772","DOIUrl":"10.1016/j.amjoto.2025.104772","url":null,"abstract":"<div><h3>Objective</h3><div>Treatment of head and neck cancers is based on many schemes, and in the case of radiochemotherapy, the main side effect impacting a patient's quality of life is hypoacusis. Its prevention and analysis are consequently essential.</div></div><div><h3>Methods</h3><div>A total of 118 patients who underwent chemotherapy and/or radiotherapy received follow-up care with audiometric tests. Corticosteroid therapy began during the treatment.</div></div><div><h3>Results</h3><div>At the end of the radiochemotherapy cycles and after corticosteroid therapy, 58 % of patients recovered 40 dB on average, and 42 % achieved total resolution of hypoacusis.</div></div><div><h3>Conclusion</h3><div>Prevention of the side effects of anticancer therapies is a major issue, and our study revealed the potential ability of corticosteroids to act as otoprotective drugs.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104772"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated facial pain as the sole presentation of a type I branchial cleft cyst in an adult male","authors":"Darien B. Reed ,&nbsp;Robert J. Macielak ,&nbsp;Oliver F. Adunka ,&nbsp;Yufan Lin ,&nbsp;Nolan B. Seim","doi":"10.1016/j.amjoto.2025.104762","DOIUrl":"10.1016/j.amjoto.2025.104762","url":null,"abstract":"<div><div>First branchial cleft cysts (FBCCs) are rare developmental anomalies that typically present in childhood. We report a unique case of a Type I FBCC in a 43-year-old male whose only symptom was isolated facial pain without infection or mass. Imaging and biopsies were inconclusive, prompting surgical excision for definitive diagnosis and symptomatic relief. Histopathology confirmed a branchial cleft anomaly. This case highlights the importance of including congenital anomalies in the differential diagnosis for atypical facial pain even in the adult population and underscores the value of a thorough and multi-disciplinary diagnostic workup.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104762"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of intravenous drug use on neck abscess outcomes: 30-day readmission & 5-year survival rates","authors":"Elliott M. Sina ,&nbsp;Bryce Hambach ,&nbsp;Eric Mastrolonardo ,&nbsp;Sruti Tekumalla ,&nbsp;Meghan Crippen ,&nbsp;Richard Goldman","doi":"10.1016/j.amjoto.2025.104754","DOIUrl":"10.1016/j.amjoto.2025.104754","url":null,"abstract":"<div><h3>Objectives</h3><div>Injection drug use (IDU) is a known risk factor for neck abscesses, often requiring urgent surgical intervention by acute-care Otolaryngologists. However, data on the prevalence and long-term outcomes of IDU-related neck abscesses are limited. This study investigates differences in 30-day readmission rates and 5-year all-cause mortality between patients with and without a history of IDU hospitalized for neck abscesses.</div></div><div><h3>Methods</h3><div>This is a retrospective cohort study utilizing the TriNetX national clinical database. Patients hospitalized for neck abscesses (ICD-10: L02.11) were categorized into two cohorts: IDU (current/previous) and non-IDU. Demographics, 30-day readmission rates, and 5-year survival were analyzed. 1:1 Propensity score matching (PSM) was used to adjust for 15 covariates known to be associated with IDU-related neck abscesses, and a two-sample <em>t</em>-test was applied. Kaplan-Meier analysis was performed to assess 5-year survival.</div></div><div><h3>Results</h3><div>In a cohort of 32,655 patients (mean age: 54.7, 58.4 % female), PSM resulted in 2410 patients per cohort. IDU patients had higher 30-day readmission rates than controls (10.2 % vs 7.81 %; OR: 1.32; 95 % CI: 1.10–1.62; <em>p</em> = 0.0061) and lower 5-year survival (77.2 % vs 81.8 %; HR: 1.21).</div></div><div><h3>Conclusion</h3><div>Patients admitted for IDU-related neck abscesses have significantly higher 30-day readmission rates and decreased 5-year survival compared to non-IDU patients. These findings underscore the critical need for early detection and intervention by Otolaryngologists in this vulnerable population.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104754"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical strategy in submandibular sialolithiasis: Impact of stone location and size on approach selection and outcomes","authors":"Joo Hyun Kim","doi":"10.1016/j.amjoto.2025.104768","DOIUrl":"10.1016/j.amjoto.2025.104768","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate how stone location and size influence surgical approach selection in submandibular sialolithiasis, and to identify computed tomography (CT)-based imaging predictors to aid preoperative planning.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed 428 consecutive surgeries (March 2020–December 2024). Preoperative non-contrast CT classified stones as distal duct, mid-duct, hilum, or intraglandular. Surgical approaches were transoral ductal incision, sialendoscopy-assisted removal, and external submandibular gland excision. Group comparisons used standard parametric/non-parametric tests. Receiver operating characteristic (ROC) analysis assessed size thresholds associated with selection of an invasive approach.</div></div><div><h3>Results</h3><div>Distal duct stones were most often treated by transoral incision (83.7 %), mid-duct stones by sialendoscopy-assisted removal (58.1 %), and intraglandular stones by external excision (71.0 %). Stones in the hilum/intraglandular regions were significantly larger than those in distal or mid-duct locations (<em>p</em> &lt; 0.001). ROC analysis identified 5.5 mm as the optimal cutoff for predicting selection of an invasive approach (AUC = 0.83; sensitivity 74.2 %; specificity 78.9 %). Overall surgical success was 97.8 %. Complication rates varied by approach, lowest after sialendoscopy-assisted removal (4.4 %) and highest after external excision (15.2 %).</div></div><div><h3>Conclusions</h3><div>A simple CT-based framework incorporating stone location and size was associated with approach selection and outcomes in submandibular sialolithiasis. Using a 5.5 mm size threshold alongside anatomic zoning may help guide minimally invasive, gland-preserving strategies and reduce morbidity. Prospective validation is warranted.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"47 1","pages":"Article 104768"},"PeriodicalIF":1.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}