American Journal of Otolaryngology最新文献

{"title":"Association between vitamin D deficiency and residual dizziness in idiopathic BPPV: Focus on otolith dysfunction and regression insights","authors":"Xuanchen Zhou ,&nbsp;Tao Lin ,&nbsp;Qiang Zhang ,&nbsp;Changle Li ,&nbsp;Ling Ding","doi":"10.1016/j.amjoto.2025.104704","DOIUrl":"10.1016/j.amjoto.2025.104704","url":null,"abstract":"<div><h3>Background</h3><div>Residual dizziness (RD) following successful canalith repositioning maneuvers (CRMs) in idiopathic benign paroxysmal positional vertigo (BPPV) is multifactorial, with vitamin D (VD) deficiency hypothesized to influence otolith-mediated vestibular pathways.</div></div><div><h3>Objective</h3><div>To determine the impact of VD deficiency severity on RD incidence and vestibular dysfunction, and to evaluate the effects of VD supplementation on vestibular dysfunction.</div></div><div><h3>Methods</h3><div>A cross-sectional study enrolled 138 idiopathic BPPV patients with different VD level. Participants were stratified by deficiency severity: normal (&gt;20 ng/mL), insufficiency (10–20 ng/mL), and deficiency (&lt;10 ng/mL). RD risk factors (gender, age, times of CRMs, involved semicircular canals) were recorded. Otolith function was assessed via cervical/ocular vestibular-evoked myogenic potentials (cVEMP/oVEMP), and vestibular function via bithermal caloric testing. RD severity was measured using the Dizziness Handicap Inventory (DHI) at 1 week post-CRM. A subgroup (<em>n</em> = 30) with deficiency/insufficiency received 12-week VD3 supplementation (0.25 μg of oral calcitriol twice daily). Binary regression analysis was used to analyze predictors of RD.</div><div><em>Results:</em> A moderate positive correlation emerged between serum VD and DHI scores (<em>r</em> = 0.365, <em>P</em> &lt; 0.001). cVEMP abnormalities were the only otolith parameter associated with RD (χ² = 9.75, <em>P</em> = 0.002). The degree of VD deficiency, cVEMP, and age emerged as significant predictors of RD. There was a significant increase in VD levels before and after treatment (13.29 ± 2.99 vs. 23.24 ± 4.78, P = 0.00) in the treatment group. Both groups showed significant shortening of cVEMP N23 wave latency after three months (<em>P</em> = 0.01 and <em>P</em> = 0.02), but only the treatment group showed significant reduction in oVEMP N10 wave latency (P = 0.01), with DHI scores reduced by 48.2 % (<em>P</em> = 0.008).</div></div><div><h3>Conclusions</h3><div>We confirmed that VD enhances otolith function and neural integrity. CVEMP, age, and VD levels predict RD likelihood. This research is the first to show VD supplementation improves saccule function and transmission pathways.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104704"},"PeriodicalIF":1.8,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary external auditory canal cholesteatoma: Clinical characteristics and role of endoscopic ear surgery","authors":"Yuvatiya Plodpai,&nbsp;Pittayapon Pitathawatchai,&nbsp;Pattarawadee Prayuenyong","doi":"10.1016/j.amjoto.2025.104701","DOIUrl":"10.1016/j.amjoto.2025.104701","url":null,"abstract":"<div><h3>Purpose</h3><div>Primary external auditory canal cholesteatomas (PEACCs) are uncommon, and the role of endoscopy in managing the lesion has not yet been clarified. We aimed to investigate the clinical characteristics of PEACC and explore the feasibility of endoscopy for its treatment.</div></div><div><h3>Material and methods</h3><div>A retrospective study in patients who diagnosed with PEACC from January 2012 to January 2024 was conducted. The presenting features, disease extension according to Naim's classification, and treatment option used were assessed. The clinical characteristics were compared between the conservative successful group and the surgical group.</div></div><div><h3>Results</h3><div>A total of 72 patients who completed the treatment protocols were enrolled. Per the classification by Naim et al., PEACC was categorized as stage II, III, and IV in 7, 42, and 23 cases, respectively. Successful nonoperative treatment using the transcanal endoscopic approach was achieved in 46 patients without tympanic perforation (<em>p</em> <em>=</em> <em>0.035</em>), scutum erosion (<em>p</em> <em>&lt;</em> <em>0.001</em>), ossicular involvement (<em>p</em> <em>=</em> <em>0.02</em>), erosion of the vertical segment of the facial canal (<em>p</em> <em>=</em> <em>0.018</em>), or mastoid involvement (<em>p</em> <em>=</em> <em>0.046</em>), with maintenance of dry ear for 2 months (<em>p</em> <em>&lt;</em> <em>0.001</em>). Endoscopy-assisted and exclusive endoscopic surgery were performed in nine and ten patients, respectively. Canal wall-down mastoidectomy with obliteration was performed in seven patients with advanced stage IV disease. Complications were not reported in either group.</div></div><div><h3>Conclusion</h3><div>Endoscopy is useful for PEACC management even in advanced stages. However, the approach varies according to the lesion extent. Successful nonoperative management feasible in patients without tympanic membrane perforation, scutum erosion, facial canal erosion, ossicular or mastoid involvement and in those with ear drainage for &lt;2 months.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104701"},"PeriodicalIF":1.8,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of auricular vagus nerve stimulation for globus pharyngeus: A prospective pilot study","authors":"Chao Hang ,&nbsp;Xiangming Meng","doi":"10.1016/j.amjoto.2025.104714","DOIUrl":"10.1016/j.amjoto.2025.104714","url":null,"abstract":"<div><h3>Purpose</h3><div>Globus pharyngeus (persistent “lump in the throat” sensation) is a common, often benign condition with unclear etiology and limited treatment options. This study aimed to evaluate the efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) in reducing globus symptoms in affected patients.</div></div><div><h3>Methods</h3><div>We conducted a prospective single-arm trial at a tertiary care center. Adult patients with GP received taVNS therapy once daily for 30 min over a two-week period. Stimulation was delivered via an electrode placed on the auricular branch of the vagus nerve. Symptom severity was assessed using the Laryngopharyngeal Measure of Perceived Sensation (LUMP) questionnaire. Anxiety and depression were assessed using the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS). Pre- and post-treatment scores were compared using paired nonparametric or <em>t</em>-tests, as appropriate. Subgroup analyses were conducted in patients with baseline anxiety or depression, defined as a SAS or SDS score ≥ 50.</div></div><div><h3>Results</h3><div>A total of 35 patients completed the trial (mean age 51.4 ± 10.9 years), of whom 28 (80 %) were female. All patients tolerated the taVNS protocol well, and no serious adverse effects were reported. There was a significant reduction in globus symptom severity following treatment: the median LUMP score decreased from 10 (IQR 7.5–15) at baseline to 5 (IQR 3–9) post-treatment (<em>p</em> &lt; 0.001). Mean anxiety and depression scores also decreased (SAS: 46.0 ± 8.4 to 43.0 ± 7.7, <em>p</em> = 0.002; SDS: 49.5 ± 11.7 to 44.7 ± 9.4, <em>p</em> = 0.005). Subgroup analyses indicated that mood-related improvements were confined to participants with baseline anxiety (−5.6 points; <em>p</em> = 0.008) or depression (−9.3 points; <em>p</em> = 0.001), while no significant changes were observed in those without baseline emotional symptoms.</div></div><div><h3>Conclusion</h3><div>taVNS significantly reduced globus pharyngeus symptoms and improved anxiety and depression scores, especially in patients with baseline emotional distress. These findings support the potential of taVNS as a well-tolerated neuromodulation approach for managing globus and warrant further validation in controlled trials.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104714"},"PeriodicalIF":1.7,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment effects of combined transcranial direct current stimulation and counseling for the treatment of chronic tinnitus","authors":"Zoo Young Lee ,&nbsp;Seung-Ho Shin ,&nbsp;Sung Wan Byun ,&nbsp;Soo Hee Oh ,&nbsp;Ho Yun Lee","doi":"10.1016/j.amjoto.2025.104699","DOIUrl":"10.1016/j.amjoto.2025.104699","url":null,"abstract":"<div><h3>Aims</h3><div>We aimed to evaluate the comparative efficacy of three treatment modalities for chronic tinnitus: TRT-based directive counseling, transcranial direct current stimulation (tDCS), and their combination. Primary endpoints were changes in tinnitus severity and psychological distress; secondary endpoints included treatment response rates and anxiety reduction.</div></div><div><h3>Methods</h3><div>Forty-one patients with chronic tinnitus lasting 3 months or more of duration were enrolled who were treated at a tertiary hospital between November 2021 and December 2023. Patients were allocated to counseling (<em>n</em> = 11), tDCS (<em>n</em> = 19), or combined therapy (n = 11) based on informed preference. Treatment outcomes were assessed using the Tinnitus Handicap Inventory (THI), Visual Analog Scale (VAS), Beck's Depression Inventory (BDI), and Hospital Anxiety-Depression Scale (HADS). Statistical analysis included Wilcoxon Signed-Rank tests for within-group comparisons and Kruskal-Wallis tests for between-group analyses.</div></div><div><h3>Results</h3><div>Clinically significant improvement (THI reduction ≥7 points) was achieved in 70.7 % of patients overall: 63.6 % in counseling, 73.7 % in tDCS, and 72.7 % in combined therapy groups. Mean THI scores decreased significantly from 54.3 ± 22.8 to 37.7 ± 19.7 (<em>p</em> &lt; 0.01). The combined therapy group showed superior anxiety reduction (HAD-A, <em>p</em> = 0.034) compared to single modalities. Both tDCS and combined therapy demonstrated greater improvements in multiple psychological measures compared to counseling alone.</div></div><div><h3>Conclusion</h3><div>Combined tDCS and counseling therapy shows enhanced efficacy in managing chronic tinnitus, particularly for patients with concurrent anxiety symptoms. This multimodal approach may provide a more comprehensive treatment strategy than single modalities alone. Future randomized controlled trials are needed to confirm these findings and establish optimal treatment protocols.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104699"},"PeriodicalIF":1.8,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144696702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of adverse reaction characteristics of four biologics for the treatment of chronic sinusitis with nasal polyps: A descriptive analysis from WHO-VigiAccess","authors":"Xiaobi Fang ,&nbsp;Tingfeng Zhou ,&nbsp;Fan Ye","doi":"10.1016/j.amjoto.2025.104705","DOIUrl":"10.1016/j.amjoto.2025.104705","url":null,"abstract":"<div><h3>Background</h3><div>Chronic rhinosinusitis with nasal polyps (CRSwNP) imposes a significant global disease burden. However, systematic comparisons of adverse drug reaction (ADR) profiles among these agents remain scarce, necessitating large-scale pharmacovigilance evaluation.</div></div><div><h3>Methods</h3><div>Utilizing the WHO VigiAccess database, we analyzed 402,778 ADR reports for four biologics—omalizumab, dupilumab, mepolizumab, and tezepelumab. Descriptive statistics and disproportionality analyses (reporting odds ratio [ROR], proportional reporting ratio [PRR]) were performed to identify safety signals across 27 system organ classes (SOCs). Severity stratification included fatal, hospitalization-requiring, and major adverse events.</div></div><div><h3>Results</h3><div>Females accounted for 56.08 %–65.80 % of reports, with geographic disparities (Americas: 70.91 %–91.98 %). Temporal trends revealed surging reports for newer agents (dupilumab: 26.62 % in 2024) versus declining rates for older therapies (omalizumab: 44.71 % pre-2019). Distinct SOC patterns emerged: dupilumab dominated cutaneous (24.40 %) and ocular ADRs (ROR = 6.51), while omalizumab showed elevated pregnancy-related risks (ROR = 12.15). Mepolizumab exhibited a 4.6-fold higher severe event incidence (1.81 %) versus dupilumab (0.39 %). Tezepelumab demonstrated unique musculoskeletal ADRs (10.02 %) and cardiac risks (ROR = 3.21).</div></div><div><h3>Conclusions</h3><div>This study delineates agent-specific ADR profiles tied to mechanistic targets, advocating for tailored monitoring strategies. Findings underscore the imperative for risk-stratified biologic selection in CRSwNP management, supported by ongoing pharmacovigilance and mechanistic investigations.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104705"},"PeriodicalIF":1.7,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes after radiofrequency neurolysis of the posterior nasal nerve for treating Chinese adults with moderate to severe allergic rhinitis","authors":"Jibin Huang,&nbsp;Ming Xu,&nbsp;Jiayan Wang,&nbsp;Di Wu","doi":"10.1016/j.amjoto.2025.104708","DOIUrl":"10.1016/j.amjoto.2025.104708","url":null,"abstract":"<div><h3>Background</h3><div>Temperature-controlled radiofrequency ablation (TCRA) represents a minimally invasive alternative to surgical posterior nasal neurectomy for the management of allergic rhinitis (AR). However, to date, the impact of this minimally invasive operation on Chinese adult individuals suffering from AR remains unclear.</div></div><div><h3>Objectives</h3><div>To assess the safety and efficacy of TCRA for the treatment of perennial moderate and severe AR in Chinese adults.</div></div><div><h3>Methods</h3><div>This retrospective case-control study included 48 consecutive patients assigned to two groups: one received TCRA and the other received posterior nasal neurectomy (PNN). Follow-up assessments were conducted at 11–13 months post-surgery. The reflective total nasal symptom score (rTNSS), total non-nasal symptom score (rTNNSS), total rhinitis medication score (TRMS), and total nasal resistance were measured both preoperatively and postoperatively.</div></div><div><h3>Results</h3><div>At the tertiary endpoint, the TCRA group demonstrated an 73.1 % improvement in rTNSS compared to baseline, while the PNN group showed a 74.0 % improvement. However, the mean change in rTNNSS at the tertiary endpoint was 72.7 % for the TCRA group and 73.1 % for the PNN group. The mean change in TRMS from baseline to the tertiary endpoint was 68.8 % for the TCRA group and 70.9 % for the PNN group. TCRA yielded a striking 62.5 % reduction in total nasal resistance. Notably, a positive linear correlation was observed between the subjective and objective assessments of nasal resistance at baseline, the secondary and the tertiary endpoints.</div></div><div><h3>Conclusion</h3><div>The findings suggest that the minimally invasive TCRA technique, as a safe and effective surgical procedure, can provide a novel and superior alternative to PNN for Chinese adults with AR.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104708"},"PeriodicalIF":1.8,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence: Use of ChatGPT for patient education involving HPV-associated oropharyngeal cancer","authors":"Hinpetch Daungsupawong ,&nbsp;Viroj Wiwanitkit","doi":"10.1016/j.amjoto.2025.104697","DOIUrl":"10.1016/j.amjoto.2025.104697","url":null,"abstract":"","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104697"},"PeriodicalIF":1.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annotating risk stratification of thyroid nodules: Assessing the suitability of ChatGPT for text-based analysis in thyroidology","authors":"Ilker Sengul ,&nbsp;Demet Sengul","doi":"10.1016/j.amjoto.2025.104696","DOIUrl":"10.1016/j.amjoto.2025.104696","url":null,"abstract":"","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104696"},"PeriodicalIF":1.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144656553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mastoid obliteration with bone dust mixed with concentrated growth factor","authors":"Sabri Baki Eren ,&nbsp;Alper Yenigun ,&nbsp;Erol Senturk ,&nbsp;Abdullah Ozdem ,&nbsp;Remzi Dogan ,&nbsp;Orhan Ozturan","doi":"10.1016/j.amjoto.2025.104695","DOIUrl":"10.1016/j.amjoto.2025.104695","url":null,"abstract":"<div><h3>Background</h3><div>Mastoid obliteration is a useful surgical step in the treatment of chronic ear operation. The technique of mastoid obliteration involves filling the cavity with self-tissue and/or osseocartilaginous graft material, following removing the mastoid air cell.</div></div><div><h3>Objective</h3><div>The aim of this study is to show the advantages of mastoid obliteration using a mixture of CGF and bone dust.</div></div><div><h3>Material and method</h3><div>Bone dust was collected with an apparatus from the healthy mastoid cortex. Collected bone dust was mixed with CGF to form a gel. Then, mastoid cavity and epitympanum obliteration were performed.</div></div><div><h3>Results</h3><div>Fifteen patients who underwent canal wall down mastoidectomy for cholesteatoma were included in the study. In all patients, the targeted external ear canal and hearing results were obtained after obliteration.</div></div><div><h3>Conclusion</h3><div>It is an effective surgical technique for creating a natural external ear path after mastoidectomy applied for mastoid obliteration, chronic ear infections and cholesteatoma treatment with CGF. Mastoid obliteration using bone dust mixed with CFG is an effective surgical technique to create a natural and healthy external ear canal.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104695"},"PeriodicalIF":1.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear implantation in cochlear nerve deficiency: A systematic review","authors":"Alexa N. Pearce,&nbsp;Peter Eckard,&nbsp;Andrew R. Mangan,&nbsp;Alaina Baggett,&nbsp;John Dornhoffer,&nbsp;Robert A. Saadi","doi":"10.1016/j.amjoto.2025.104694","DOIUrl":"10.1016/j.amjoto.2025.104694","url":null,"abstract":"<div><h3>Objectives</h3><div>Our goal was to review the current literature to better understand outcomes following cochlear implantation (CI) in patients with cochlear nerve deficiency (CND).</div></div><div><h3>Data sources</h3><div>PubMed, MED-LINE, and Google Scholar.</div></div><div><h3>Review methods</h3><div>Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol, PubMed, MED-LINE, and Google Scholar were queried for articles published from January 2000 to December 2023 describing cochlear implantation in patients with cochlear nerve agenesis or deficiency.</div></div><div><h3>Results</h3><div>Of 1820 articles initially identified, 28 articles met inclusion criteria, amounting to 514 patients and 513 cochlear implantations. Among the 24 studies that differentiated between cochlear nerve hypoplasia (CNH) and aplasia (CNA), there were 154 ears with hypoplasia and 364 ears with aplasia. The most common outcome measured was Categories of Auditory Performance; other outcomes used by multiple studies included hearing threshold, Meaningful Auditory Integration Scale, Meaningful Use of Speech Scale, and Speech Intelligibility Rating. The average pre-operative CAP was 0.5, and the average post-operative CAP was 3.6. The average pre-operative hearing threshold was 101.3 dB, and 85.5 % of participants had no response on pre-operative auditory brain response. The average post-operative aided hearing threshold was 42.5 dB, with 4.2 % of patients showing no response.</div></div><div><h3>Conclusions</h3><div>CI in children with CND offers the potential for significant improvement in hearing threshold and speech development, but outcomes are variable in those with more profound nerve hypoplasia or aplasia. Families should be counseled pre-operatively on the possibility of limited results and the potential benefit of alternative treatments like auditory brainstem implantation.</div></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":"46 5","pages":"Article 104694"},"PeriodicalIF":1.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}