American Journal of Otolaryngology最新文献

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The influence of tinnitus frequency on patients experiencing subjective tinnitus and the efficacy and prognosis of acoustic therapy 耳鸣频率对主观性耳鸣患者的影响以及声学疗法的疗效和预后
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2024-08-14 DOI: 10.1016/j.amjoto.2024.104498
{"title":"The influence of tinnitus frequency on patients experiencing subjective tinnitus and the efficacy and prognosis of acoustic therapy","authors":"","doi":"10.1016/j.amjoto.2024.104498","DOIUrl":"10.1016/j.amjoto.2024.104498","url":null,"abstract":"<div><h3>Objective</h3><p>This study examines the therapeutic impact and prognosis of acoustic therapy in patients with chronic subjective tinnitus across different tinnitus frequencies.</p></div><div><h3>Methods</h3><p>A total of 135 patients with subjective tinnitus were selected and categorized based on their primary tone frequency into three groups: high frequency (43 patients, 4–8 kHz), mid frequency (40 patients, 1–3 kHz), and low frequency (42 patients, &lt; 1 kHz). All patients received acoustic therapy customized to their specific frequency and loudness levels, along with tinnitus cognitive behavioral therapy. Changes in tinnitus loudness and efficacy rates before and after treatment in the different groups, as well as before and after tinnitus cognitive behavioral therapy were evaluated and assessed.</p></div><div><h3>Results</h3><p>The low frequency group showed a statistical improvement in tinnitus loudness compared to the mid and high frequency groups (<em>P</em> &lt; 0.05). The efficacy rate was 93.55 % in the low frequency group, 82.88 % in the mid frequency group, and 58.82 % in the high frequency group. The efficacy rate in the low frequency group was significantly higher than in the high frequency group, but there was no statistical difference when compared to the mid frequency group.</p></div><div><h3>Conclusion</h3><p>The frequency of tinnitus in patients with chronic subjective tinnitus might be a key factor affecting treatment effectiveness and could account for the differences in treatment outcomes among patients.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142040271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Individualized sublingual immunotherapy with dynamic maintenance dose ascending for house dust mite-induced allergic rhinitis 针对屋尘螨诱发的过敏性鼻炎,采用动态维持剂量递增的个性化舌下免疫疗法。
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2024-08-13 DOI: 10.1016/j.amjoto.2024.104476
{"title":"Individualized sublingual immunotherapy with dynamic maintenance dose ascending for house dust mite-induced allergic rhinitis","authors":"","doi":"10.1016/j.amjoto.2024.104476","DOIUrl":"10.1016/j.amjoto.2024.104476","url":null,"abstract":"<div><h3>Background</h3><p>Precision dosing in sublingual immunotherapy (SLIT) has become a hotspot gradually, yet no standardized dose adjustment pattern for house dust mite (HDM)-SLIT. This study aims to investigate the clinical feasibility of the dynamic maintenance dose ascending regimen for individualized SLIT.</p></div><div><h3>Methods</h3><p>A total of 258 allergic rhinitis (AR) patients treated with HDM-SLIT were included in this retrospective study. Patients were divided into the regular dose (RD) group (<em>n</em> = 101) and the high dose (HD) group (<em>n</em> = 157) according to different maintenance dosages of SLIT. In the RD group, patients received the fixed dose recommended by the manufacturer. In the HD group, patients received a maximum tolerance dose determined by dynamic dose ascending. The clinical efficacy was evaluated by combined symptom and medication score (CSMS) and visual analogue scale score (VAS) at the baseline, 0.5-year, 1-year, and 2-year. The safety was evaluated by adverse events (AEs).</p></div><div><h3>Results</h3><p>Significant reductions of CSMS and VAS at 0.5-year, 1-year, and 2-year were observed in both the RD group and the HD group compared to the baseline (<em>P</em> &lt; 0.05). In addition, greater improvements in these clinical parameters from 0.5- to 2-year were found in the HD group compared to the RD group (<em>P</em> &lt; 0.05). For subgroup analysis in the HD group, no significant differences in CSMS and VAS were observed among subgroups of patients &lt;14 years old and patients ≥14 years old (<em>P</em> &gt; 0.05). No serious AEs in the two groups and no significant differences were observed between the AE incidence rate of the RD group and HD group during the incremental and maintenance phases.</p></div><div><h3>Conclusions</h3><p>The 2-year HDM-SLIT with dynamic maintenance dose ascending regimen offers an “optimal” treatment for AR patients while maintaining safety. This study introduced a pattern for individualized dose adjustment in clinical practice, offering potential benefits for AR patients.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between blood transfusion and outcomes of free flap head and neck cancer surgery 输血与游离头颈癌皮瓣手术疗效之间的关系
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2024-08-13 DOI: 10.1016/j.amjoto.2024.104497
{"title":"Association between blood transfusion and outcomes of free flap head and neck cancer surgery","authors":"","doi":"10.1016/j.amjoto.2024.104497","DOIUrl":"10.1016/j.amjoto.2024.104497","url":null,"abstract":"<div><h3>Objective</h3><p>Investigate the impact of patient risk factors and blood transfusions in Head and Neck free flap surgeries.</p></div><div><h3>Study design</h3><p>Retrospective chart review.</p></div><div><h3>Setting</h3><p>Single tertiary referral center.</p></div><div><h3>Methods</h3><p>400 patients were included undergoing free flap reconstruction from 2014 to 2020. The primary outcome measures were red blood cell transfusion and volume transfused. Race, sex, flap location and tissue type, pathology, dependent functional status, length of stay, and cancer recurrence were evaluated for association with red blood cell transfusion intraoperatively and/or postoperatively. Transfusions were indicated on patients with Hemoglobin &lt;7–8 and/or symptomatic anemia. ANOVA and Chi<sup>2</sup> statistical analysis were performed. The significance was set at <em>p</em> ≤0.05.</p></div><div><h3>Results</h3><p>Of the 400 patients included, 58 required red blood cell transfusion. Of these 67.8 % were males, racial demographics included 9.00 % African American, 1.30 % Asian, 1.00 % Hispanic/Latino, 87.8 % White, 1.00 % other. African American patients received a higher volume of transfused red blood cells versus white patients (855.00 mL vs. 437.07 mL, <em>p</em> = 0.005). Length of stay was significantly associated with red blood cell transfusion (5.95 days vs. 7.22 days, <em>p</em> ≤0.001). Dependent functional status and need for red blood cell transfusion were associated (<em>p</em> = 0.002). Type of free flap was associated with need for red blood cell transfusion (<em>p</em> ≤0.001) with anterolateral thigh flaps being the most common resulting in transfusion (34/58).</p></div><div><h3>Conclusion</h3><p>Red blood cell transfusion was significantly associated with race, dependent functional status and length of stay. Certain free flaps have a higher risk of blood transfusion.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141992855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A lightweight intelligent laryngeal cancer detection system for rural areas 适用于农村地区的轻型智能喉癌检测系统
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2024-08-08 DOI: 10.1016/j.amjoto.2024.104474
{"title":"A lightweight intelligent laryngeal cancer detection system for rural areas","authors":"","doi":"10.1016/j.amjoto.2024.104474","DOIUrl":"10.1016/j.amjoto.2024.104474","url":null,"abstract":"<div><h3>Objective</h3><p>Early diagnosis of laryngeal cancer (LC) is crucial, particularly in rural areas. Despite existing studies on deep learning models for LC identification, challenges remain in selecting suitable models for rural areas with shortages of laryngologists and limited computer resources. We present the intelligent laryngeal cancer detection system (ILCDS), a deep learning-based solution tailored for effective LC screening in resource-constrained rural areas.</p></div><div><h3>Methods</h3><p>We compiled a dataset comprised of 2023 laryngoscopic images and applied data augmentation techniques for dataset expansion. Subsequently, we utilized eight deep learning models—AlexNet, VGG, ResNet, DenseNet, MobileNet, ShuffleNet, Vision Transformer, and Swin Transformer—for LC identification. A comprehensive evaluation of their performances and efficiencies was conducted, and the most suitable model was selected to assemble the ILCDS.</p></div><div><h3>Results</h3><p>Regarding performance, all models attained an average accuracy exceeding 90 % on the test set. Particularly noteworthy are VGG, DenseNet, and MobileNet, which exceeded an accuracy of 95 %, with scores of 95.32 %, 95.75 %, and 95.99 %, respectively. Regarding efficiency, MobileNet excels owing to its compact size and fast inference speed, making it an ideal model for integration into ILCDS.</p></div><div><h3>Conclusion</h3><p>The ILCDS demonstrated promising accuracy in LC detection while maintaining modest computational resource requirements, indicating its potential to enhance LC screening accuracy and alleviate the workload on otolaryngologists in rural areas.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141964555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of SENS-401 in sudden sensorineural hearing loss: The AUDIBLE-S randomized placebo-controlled phase IIb trial SENS-401 对突发性感音神经性听力损失的疗效和安全性:AUDIBLE-S 随机安慰剂对照 IIb 期试验
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2024-08-08 DOI: 10.1016/j.amjoto.2024.104480
{"title":"Efficacy and safety of SENS-401 in sudden sensorineural hearing loss: The AUDIBLE-S randomized placebo-controlled phase IIb trial","authors":"","doi":"10.1016/j.amjoto.2024.104480","DOIUrl":"10.1016/j.amjoto.2024.104480","url":null,"abstract":"<div><h3>Purpose</h3><p>Safety and efficacy of SENS-401, a serotonin type 3 (5-HT<sub>3</sub>) receptor antagonist and calcineurin inhibitor, in patients with acute sudden sensorineural hearing loss (SSNHL).</p></div><div><h3>Methods</h3><p>Multicentre randomized, double blind, placebo-controlled trial enrolled adult subjects with sudden sensorineural hearing loss (SSNHL) or unilateral/bilateral acute acoustic trauma leading to SSNHL within 96 h of disease onset. Subjects were randomly assigned to one of the three oral dose groups: 29 mg, 43.5 mg or placebo given twice daily for 28 days. The primary endpoint was the change from baseline in Pure Tone Average (PTA) in the affected ear to the end of treatment visit (day 28). Subjects were further followed up 8 weeks after the end of the treatment period (day 84).</p></div><div><h3>Results</h3><p>A total of 115 subjects were randomized. SENS-401 was well tolerated. Although the primary efficacy endpoint was not met at day 28, post-hoc analyses revealed clinically significant and meaningful efficacy outcomes with SENS-401 when compared to placebo in a substantial group of participants diagnosed with idiopathic SSNHL and who had received corticosteroid treatment. Notable improvements were observed in the PTA change from baseline, the complete hearing recovery rate, and the Word Recognition Score (WRS), particularly at day 84. The responder rate consistently favored treated subjects over those who received the placebo.</p></div><div><h3>Conclusion</h3><p>While the primary endpoint was not achieved at the end of the treatment period, the study revealed consistently positive efficacy results of clinical relevance in patients with idiopathic SSNHL who received SENS-401, particularly in the 8-weeks follow-up phase after the completion of the treatment.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perioperative opioids in high-risk children undergoing tonsillectomy – A single institution experience 在接受扁桃体切除术的高风险儿童中使用围手术期阿片类药物 - 单个机构的经验
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2024-08-08 DOI: 10.1016/j.amjoto.2024.104453
{"title":"Perioperative opioids in high-risk children undergoing tonsillectomy – A single institution experience","authors":"","doi":"10.1016/j.amjoto.2024.104453","DOIUrl":"10.1016/j.amjoto.2024.104453","url":null,"abstract":"<div><h3>Background</h3><p>Patients undergoing tonsillectomy/ adenotonsillectomy (T/AT) can experience substantial postoperative pain. The aims of this study are to assess perioperative pain management in high-risk children (children with severe obstructive sleep apnea and other complex medical comorbidities or age younger than 2 years) undergoing T/AT, and the impact on oxygen levels and pain during extended Post-Anesthesia Care Unit (PACU) admission.</p></div><div><h3>Methods</h3><p>A retrospective case series study at a tertiary care children's hospital.</p></div><div><h3>Results</h3><p>There were 278 children enrolled in the study. The Apnea-Hypopnea index and mean oxygen nadir on preoperative polysomnography were 31.3 ± 25.76/h and 79.5 ± 9.5 % respectively. Overall, 246 (89 %) patients received intraoperative opioids alone (<em>n</em> = 35, 13 %) or in combination with non-opioid analgesia (<em>n</em> = 209, 75 %). While the median dose of opioid-free medications (acetaminophen, ibuprofen) ranged from 93 to 100 % of standard maximal dosing by weight and age, the median dose of opioids was significantly lower and ranged from 54 to 63 % of standard maximal dosing by weight and age, with 43 % of the patients receiving less than half the recommended maximum dose. Oxygen desaturation was charted in 21 patients (8 %) during their PACU admission. Patients who received opioid-free analgesia were as likely to develop oxygen desaturations (<em>n</em> = 17 (81 %) vs. <em>n</em> = 228 (89.4 %), <em>p</em> = 0.27) and to receive rescue pain medication during their PACU stay as patients who received opioids intraoperatively (<em>n</em> = 18 (56 %) vs. <em>n</em> = 167 (68 %), <em>p</em> = 0.23).</p></div><div><h3>Conclusions</h3><p>Intraoperative pain management varies across high-risk pediatric tonsillectomies. Opioid-free analgesia was not associated with an increased need for pain medications during PACU admission, or with a decreased likelihood of oxygen desaturations compared to intra-operative opioid analgesia use.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141991235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between amblyopia and the risks of hearing loss: A propensity matched analysis 弱视与听力损失风险之间的关系:倾向匹配分析
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2024-08-08 DOI: 10.1016/j.amjoto.2024.104495
{"title":"The association between amblyopia and the risks of hearing loss: A propensity matched analysis","authors":"","doi":"10.1016/j.amjoto.2024.104495","DOIUrl":"10.1016/j.amjoto.2024.104495","url":null,"abstract":"<div><h3>Introduction</h3><p>Amblyopia occurs due to an imbalance in the visual input between the eyes. This can induce structural changes in the central nervous system and, if left untreated, eventually lead to permanent blindness in the affected eye. As these changes may also impact the auditory system, which closely interacts with the visual system, this study aimed to investigate the risk of hearing loss in patients with amblyopia.</p></div><div><h3>Materials and methods</h3><p>This study was a retrospective review of the electronic medical records contained in a United States national database of medical records. Patients younger than 18 years old with and without amblyopia were matched and compared to evaluate the relative risk (RR) of having a hearing loss. Stratified analyses were further performed to explore whether the disease laterality and the amblyopia subtype influenced the risks.</p></div><div><h3>Results</h3><p>Compared to the controls, patients with amblyopia had a higher overall risk of having hearing loss (RR: 1.09, CI: 1.03–1.14), specifically sensorineural hearing loss (SNHL) (RR: 1.24, CI: 1.08–1.42). The stratified analysis further revealed that SNHL was associated with refractive amblyopia (RR: 1.84, CI: 1.50–2.26), but not strabismic amblyopia (RR: 1.23, CI: 1.10–1.38). The laterality of amblyopia did not influence the risk of hearing loss.</p></div><div><h3>Conclusions</h3><p>Children with amblyopia have a higher rate of SNHL than children without amblyopia. As vision and hearing are essential in the proper cognitive development, language acquisition, and social and emotional well-being of children, patients with amblyopia may benefit from more frequent audiologic screening.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0196070924002813/pdfft?md5=0b2cb934e5695fc29201c38f92d0ffc4&pid=1-s2.0-S0196070924002813-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orbital preservation in the treatment of acute invasive fungal sinusitis 保留眼眶治疗急性侵袭性真菌性鼻窦炎
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2024-08-07 DOI: 10.1016/j.amjoto.2024.104466
{"title":"Orbital preservation in the treatment of acute invasive fungal sinusitis","authors":"","doi":"10.1016/j.amjoto.2024.104466","DOIUrl":"10.1016/j.amjoto.2024.104466","url":null,"abstract":"<div><p>Acute invasive fungal sinusitis (AIFS) is an aggressive disease with significant mortality and morbidity. Surgical debridement is a mainstay of treatment. However, orbital involvement may limit its efficacy and is an independent risk factor for mortality. Traditionally, orbital exenteration has been utilized in cases with orbital invasion and ophthalmoplegia or vision loss. Retrobulbar liposomal amphotericin B injection may improve disease control and has the potential to spare the morbidity associated with exenteration. In this video article, we document the use of serial endonasal debridement with retrobulbar injections to salvage the eye in a patient with significant orbital involvement. A 28-year-old immunocompromised female patient presented with acute onset restricted right extraocular movement, progressive orbital pain, V2 trigeminal numbness, and 20/40 vision. The patient underwent recurrent debridement and retrobulbar injections of liposomal amphotericin B. Her serial exams, including changes in extraocular muscle appearance and gradual improvement in extraocular movement, were documented. The exam six months after initial presentation demonstrated 20/20 vision, minimal extraocular movement restriction, and proper healing of the orbit and ethmoid. The salvage of the patient's orbit suggests that liposomal amphotericin B injections with debridement may be a viable treatment alternative in patients with acute invasive fungal sinusitis and orbital involvement.</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141964556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in remote otology and rhinology service delivery: A scoping review 远程耳鼻喉科服务的进展:范围审查
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2024-08-05 DOI: 10.1016/j.amjoto.2024.104399
{"title":"Advances in remote otology and rhinology service delivery: A scoping review","authors":"","doi":"10.1016/j.amjoto.2024.104399","DOIUrl":"10.1016/j.amjoto.2024.104399","url":null,"abstract":"","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0196070924001856/pdfft?md5=bd83dad610cdb0f4bd1afd105a440fb6&pid=1-s2.0-S0196070924001856-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141992856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative efficacy of different thermal ablation and conventional surgery for the treatment of Papillary Thyroid Microcarcinoma: Systematic review including traditional pooling and Bayesian network meta-analysis 不同热消融术和传统手术治疗甲状腺乳头状微癌的疗效比较:包括传统汇总和贝叶斯网络荟萃分析在内的系统综述。
IF 1.8 4区 医学
American Journal of Otolaryngology Pub Date : 2024-08-05 DOI: 10.1016/j.amjoto.2024.104479
{"title":"Comparative efficacy of different thermal ablation and conventional surgery for the treatment of Papillary Thyroid Microcarcinoma: Systematic review including traditional pooling and Bayesian network meta-analysis","authors":"","doi":"10.1016/j.amjoto.2024.104479","DOIUrl":"10.1016/j.amjoto.2024.104479","url":null,"abstract":"<div><h3>Purpose</h3><p>To compare the efficacy of different thermal ablation and conventional surgery for the treatment of Papillary Thyroid Microcarcinoma, using a systematic review including traditional pooling and Bayesian network meta-analysis.</p></div><div><h3>Materials and methods</h3><p>A comprehensive literature search in PubMed, EMBASE, and the Cochrane Library databases identified retrospective studies evaluating the tumor volume change after different thermal ablation or conventional surgery. Studies from the date of their inception to January 6, 2024, were included. A review of 4463 potential papers, including a full-text review of 23, identified 10 eligible papers covering a total of 2658 patients for meta-analysis. The tumor volume change over a 12-month follow-up was compared between different thermal ablations. Tumor diameter change, complications, recurrence, operation and hospitalization time were evaluated by network meta-analysis.</p></div><div><h3>Results</h3><p>Based on the traditional frequentist approach, the overall pooled estimates for the standardized mean difference (SMD) in tumor volume change of radiofrequency ablation (RFA), laser ablation (LA), and microwave ablation (MWA) were 1.38 (95 % credibility interval (CI), 0.62–2.13), 1.94 (95%CI, 0.78–3.10) and 1.38 (95%CI, 1.01–1.75), respectively. Based on the Bayesian network meta-analysis, in examining the surface under the cumulative ranking area (SUCRA) ranking, RFA (SUCRA, 76.6), MWA (SUCRA, 66.6), and LA (SUCRA, 39.8) were identified as the three interventions that were associated with the greatest reduction in risk for complications compared with conventional surgery (CS), with RFA (SUCRA, 76.6) being ranked as the highest in safety. MWA, SMD 4.43 [95%CI, 2.68–6.17], RFA SMD 4.24 [95 % CI, 1.66–6.82], and LA SMD 4.24 [95 % CI, 1.48–7.00] were associated with the shorter operation time compared with CS. LA SMD 4.61 [95 % CI, 1.79–7.44] and MWA SMD 3.07 [95 % CI, 1.32–4.83] were associated with the shorter hospitalization time compared with CS, with LA (SUCRA, 86.5) yielding the highest ranking. MWA was associated with a reduced risk for tumor recurrence RR 0.02 [95 % CI, −0.44-0.49], compared with CS.</p></div><div><h3>Conclusion</h3><p>We conducted a comprehensive review of the published literature on the effectiveness and safety of different thermal ablation techniques and conventional surgery for papillary thyroid microcarcinoma. Important research gaps persist due to a lack of long-term data and high-quality randomized controlled trials (RCTs).</p></div>","PeriodicalId":7591,"journal":{"name":"American Journal of Otolaryngology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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