Salivary and tissue CD44 expression in laryngeal cancer

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

American Journal of Otolaryngology Pub Date : 2025-07-21 DOI:10.1016/j.amjoto.2025.104702

Maria Rita Bianco , Federico Occhiuzzi , Cosimo Galletti , Mario Lentini , Lidia Puzzo , Eugenia Allegra

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引用次数: 0

Abstract

The most common malignant tumor of head and neck cancer is laryngeal carcinoma, often diagnosed at advanced stages, underscoring the need for reliable diagnostic and prognostic biomarkers. This study investigates the correlation between CD44 expression in tumor tissues and its soluble fraction (CD44sol) in saliva, evaluating their potential as diagnostic and prognostic markers. The study was conducted on 74 patients with laryngeal carcinoma. CD44 expression in tumor tissues was assessed using immunohistochemical techniques, while salivary CD44sol levels were measured using Enzyme Linked ImmunoSorbent Assay (ELISA). A significant statistical correlation was found between CD44 tumor expression and salivary CD44sol levels. Furthermore, CD44 expression was identified as a prognostic biomarker for low-grade tumors, and metastatic lymphadenopathy at diagnosis. Similarly, positive salivary CD44sol levels were identified as predictive factors for low-grade tumors, tumor site, and lymph node metastasis at diagnosis. To the best of our knowledge, this study is the first to demonstrate a significant correlation between salivary levels and tumor tissue expression of CD44 in patients with laryngeal cancer.

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喉癌涎腺及组织CD44表达

头颈癌中最常见的恶性肿瘤是喉癌，通常在晚期诊断出来，强调需要可靠的诊断和预后生物标志物。本研究探讨了CD44在肿瘤组织中的表达与唾液中CD44可溶性组分（CD44sol）的相关性，评估了它们作为诊断和预后指标的潜力。研究对象为74例喉癌患者。使用免疫组织化学技术评估肿瘤组织中CD44的表达，而使用酶联免疫吸附试验（ELISA）测量唾液中CD44sol的水平。CD44肿瘤表达与唾液CD44sol水平有显著的统计学相关性。此外，CD44表达被确定为低级别肿瘤和转移性淋巴结病诊断时的预后生物标志物。同样，唾液CD44sol阳性水平被确定为诊断时低级别肿瘤、肿瘤部位和淋巴结转移的预测因素。据我们所知，本研究首次证明喉癌患者唾液水平与肿瘤组织CD44表达之间存在显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Otolaryngology 医学-耳鼻喉科学

CiteScore

4.40

自引率

4.00%

发文量

378

审稿时长

41 days

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