Alternative therapies in health and medicine最新文献

筛选
英文 中文
Study on the Prevention of Fall Risk in Elderly Stroke Patients Based on an Intelligent Model of Rehabilitation Care. 基于智能康复护理模式的老年脑卒中患者跌倒风险预防研究。
IF 1.9 4区 医学
Xiaohui Li, Mengmeng Liu, Chunyan Wang
{"title":"Study on the Prevention of Fall Risk in Elderly Stroke Patients Based on an Intelligent Model of Rehabilitation Care.","authors":"Xiaohui Li, Mengmeng Liu, Chunyan Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Fall is a public health problem that cannot be ignored by elderly stroke patients, and rehabilitation care plays an important role in the rehabilitation process of elderly stroke patients.</p><p><strong>Objective: </strong>To investigate the prevention effect of fall risk in elderly stroke patients under the intelligent model of rehabilitation care.</p><p><strong>Methods: </strong>The general data of elderly patients who were diagnosed as stroke and admitted to our hospital between June 2021 and June 2022 were retrospectively analyzed, with exclusion like unclear clinical data or combined with other severe organ insufficiency. A total of 150 of them were selected for the study, and the patients were divided into a fall group and a non-fall group according to whether they had a fall or not. The factors associated with falls in stroke patients were analyzed univariately, and the rehabilitation care intelligence model of the predictive model of falls in stroke patients was established using multiple covariance ridge regression analysis to observe the predictive value of patients' risk of falling in the rehabilitation care intelligence model.</p><p><strong>Results: </strong>Results of multiple covariance ridge regression analysis to build the model showed age (P < .001), low MNA-SF score (P < .001), hypertension (P = .035), anaemia(P = .048), gout (P < .001), assistive devices (P = .002), visual impairment (P = .033), elevated ALB (P < .001), and elevated HGB (P < .001) as risk factors for falls in stroke patients. The diagnostic threshold for screening elderly stroke patients for falls based on risk factors was 0.272, with a sensitivity of 90.7%, specificity of 98.1% and an area under the ROC curve of 0.976 (P < .05), which was superior to other single indicators in terms of diagnostic value. The calibration of the prediction model, based on the Hosmer and Lemeshow test of goodness of fit, showed P = 1.14, indicating a high calibration of the prediction model.</p><p><strong>Conclusion: </strong>There are many risk factors for falls in stroke elderly patients, such as low MNA-SF score, gout, elevated ALB, and elevated HGB. Building a rehabilitation nursing intelligent model based on the above inducement factors can reduce the risk of patients falling to a certain extent, and the prediction model has a high degree of calibration. Therefore, a simple and standardized intelligent rehabilitation nursing model for stroke patients in the early stage can effectively prevent the occurrence of falls.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":"107-113"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141173761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Laparoscopic Right-lower Quadrant Approach for the Treatment of Right-sided Colon Cancer Offers Advantages Such as Shorter Surgical Time and Less Blood Loss. 腹腔镜右下象限方法治疗右侧结肠癌具有手术时间短、失血少等优势。
IF 1.9 4区 医学
Xu Zhang, Chuanxin Zhang, Xin Zheng, Anqi Xu, Peng Chen
{"title":"The Laparoscopic Right-lower Quadrant Approach for the Treatment of Right-sided Colon Cancer Offers Advantages Such as Shorter Surgical Time and Less Blood Loss.","authors":"Xu Zhang, Chuanxin Zhang, Xin Zheng, Anqi Xu, Peng Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to compare the therapeutic efficacy of laparoscopic right-lower quadrant and midline approaches for the treatment of right-sided colon cancer and evaluate the analgesic effect of parecoxib sodium.</p><p><strong>Methods: </strong>Sixty patients with right-sided colon cancer admitted to Hospital of Lin 'an District between January 2019 and November 2022 were selected. They were divided into the study group A (n=30) with a right-lower quadrant approach and the study group B (n=30) with a midline approach. All patients received parecoxib sodium. Surgical time, blood loss, postoperative complications, and other relevant indicators were recorded and compared between the two groups. Additionally, a control group of 60 right-sided colon cancer patients who underwent conventional non-exclusive analgesic laparoscopic surgery during the same period was included to compare the analgesic effects between the study and control groups.</p><p><strong>Results: </strong>The surgical time (RR = 0.608, 95%CI 0.51, 1.53, P = .042), blood loss (RR = 0.798, 95%CI 0.52, 1.02, P < .001), time for bowel function recovery (RR = 0.808, 95%CI 0.50, 1.77, P = .007), and length of hospital stay (RR = 0.766, 95%CI 0.56, 1.72, P =.052) were significantly lower in group A than in group B, while the number of lymph node dissections was higher in group A (RR = 0.803, 95%CI 0.62, 1.52, P = .047). The postoperative levels of tumor-specific growth factor (TSGF) (RR = 0.710, 95%CI 0.50, 1.55, P < .001) and carcinoembryonic antigen (CEA) (RR = 0.803, 95%CI 0.62, 1.52, P < .001) were significantly decreased in both groups A and B, with no significant difference between the groups (P > .05). The incidence of complications in group A was significantly lower than in group B (RR = 0.167, 95%CI 0.17, 0.63, P = .044). The VAS scores of the study group at 2/4/6/8 hours postoperatively were significantly lower than those of the control group (RR = 0.702, 95%CI 0.52, 1.62, P < .001). The SF-36 scores of the study group were significantly higher than those of the control group (RR = 0.753, 95%CI 0.56, 1.82, P < .001).</p><p><strong>Conclusions: </strong>The Laparoscopic right-lower quadrant approach for the treatment of right-sided colon cancer offers advantages such as shorter surgical time and less blood loss. It demonstrates significant clinical efficacy and reduces the incidence of postoperative complications. Parecoxib sodium enhances postoperative analgesic effect, effectively alleviating patient pain, promoting recovery, and improving quality of life. It is worth promoting in clinical practice.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":"86-91"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating Network Pharmacology and In Vitro Experiments for Assessing the Anti-Tumor Effects of Phyllanthus Urinaria L Anti-neoplastic Decoction in Hepatocellular Carcinoma. 结合网络药理学和体外实验评估乌药煎剂对肝细胞癌的抗肿瘤作用
IF 1.9 4区 医学
Chunshan Wei, Zhulin Wu, Xiaoya Yang, Xiaoyan Jiang, Lianan Wang, Jinsong He, Guangdong Tong
{"title":"Integrating Network Pharmacology and In Vitro Experiments for Assessing the Anti-Tumor Effects of Phyllanthus Urinaria L Anti-neoplastic Decoction in Hepatocellular Carcinoma.","authors":"Chunshan Wei, Zhulin Wu, Xiaoya Yang, Xiaoyan Jiang, Lianan Wang, Jinsong He, Guangdong Tong","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>In China, traditional Chinese medicine (TCM) is an important part of the comprehensive treatment of hepatocellular carcinoma (HCC), and Chinese herb formulas with the effect of \"yiqi jianpi jiedu huayu\" (replenishing qi, strengthening spleen, and removing toxicity and blood stasis) are the common and efficient treatments for HCC. However, the mechanism of these formulas in treating HCC remain unclear.</p><p><strong>Objective: </strong>In this paper, our goal is to explore the potential mechanism of Phyllanthus urinaria L anti-neoplastic decoction (PAD), the representative formula of \"yiqi jianpi jiedu huayu\", in treating HCC.</p><p><strong>Design: </strong>The research team performed the network pharmacology and in vitro experiment (preparation of PAD aqueous extract, cell cultures and MTT assay, cell apoptosis assay, wound healing assay, transwell assays, western blot).</p><p><strong>Setting: </strong>The study took place in the Department of Hepatology, the Fourth Clinical Medical College of Guangzhou University of Chinese Medicine (Shenzhen Traditional Chinese Medicine Hospital), China.</p><p><strong>Outcome measures: </strong>The active components and targets of PAD and HCC targets were screened by five Chinese herbs and two disease databases respectively. The network pharmacology was utilized to construct the relationship network between PAD and HCC, and the mechanism was predicted by pathway enrichment analysis. The experiment was performed to verify the intervention effect of PAD on HCC and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway.</p><p><strong>Results: </strong>The relationship network between PAD and HCC suggested that PAD mainly regulated the potential therapeutic targets of HCC by key active components such as quercetin, luteolin, calycosin, wogonin, and pinocembrin. Pathway analysis demonstrated PAD could play an anti-HCC effect via multiple pathways (e.g., PI3K/Akt). Results of the experiment showed that PAD could effectively inhibit the proliferation and migration of HCC cells, and promote HCC cells apoptosis in a concentration-dependent behavior. Additionally, PAD could decrease the protein expression of phosphorylated PI3K/Akt.</p><p><strong>Conclusion: </strong>PAD mainly exerts an anti-HCC effect through multiple active components represented by quercetin and multiple pathways represented by the PI3K/Akt pathway. This study provided an experimental basis for the clinical application of PAD.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":"114-121"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140954992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Matrix Rhythm Therapy (MARHYTHE©) on Diabetic Foot Ulcer. 基质节律疗法(MARHYTHE©)治疗糖尿病足溃疡的疗效。
IF 1.9 4区 医学
Varun Naik, Pushkar Naik Burye, Vaishnavi Naik Desai, Deepasvi Naik Gaonkar, Kapildev Hannurkar, Saumya Kine
{"title":"Effect of Matrix Rhythm Therapy (MARHYTHE©) on Diabetic Foot Ulcer.","authors":"Varun Naik, Pushkar Naik Burye, Vaishnavi Naik Desai, Deepasvi Naik Gaonkar, Kapildev Hannurkar, Saumya Kine","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcers are a serious complication accounting for about 4.54% of ulcers in people with diabetes. Matrix Rhythm Therapy (MRT) is an emerging modality focused on restoring cellular rhythm. This study explores its effect on diabetic foot ulcers (DFUs), a major complication of diabetes. By enhancing microcirculation and tissue regeneration, MRT offers a promising, non-invasive approach to wound healing and improving patient outcomes.</p><p><strong>Primary study objective: </strong>This study aimed to determine the effect of MRT on DFUs on wound characteristics, ulcer tissue healing, and ulcer grading score.</p><p><strong>Methods/design: </strong>It was a pilot study with a sample size of 9 participants.</p><p><strong>Setting: </strong>Recruitment of participants was monocentric, conducted at the General Surgery Department of Dr. Prabhakar Kore Hospital & Medical Research Centre.</p><p><strong>Participants: </strong>23 patients were screened and 14 were excluded since they did not meet the inclusion criteria. A total of 9 participants aged between 45 - 75 years with HbA1c < 7.5% and diagnosed DFU were recruited.</p><p><strong>Intervention: </strong>Each patient received 2 sessions of MRT for 45 minutes, with 3 days interval in between both sessions.</p><p><strong>Primary outcome measures: </strong>Participants were evaluated in terms of wound characteristics (imitoMeasure- Measure Wound App), ulcer tissue healing score (Bates-Jensen Wound Assessment Tool), and ulcer grade (Wagner Ulcer Grade Classification System).</p><p><strong>Results: </strong>The experimental group participants showed differences in pretest and posttest outcome scores of wound characteristics [(Area P = .0022) (Length P = .0032) (Width P = .0010), and (Circumference P = .0020)], ulcer tissue healing score P = .0001, and ulcer grading score P = .0431.</p><p><strong>Conclusion: </strong>The MaRhyThe© treatment, a recent 21st-century innovation, has demonstrated significant efficacy in treating non-healing DFUs, as evidenced by marked improvements in wound characteristics, ulcer tissue healing scores, and ulcer grading scores.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":"15-19"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Implementation and Effectiveness of Progressive Rehabilitation Nursing on Quality of Life, Self-Care Ability, and Psychological Status in Patients with Breast Cancer after Modified Radical Mastectomy. 渐进式康复护理对乳腺癌改良根治性乳房切除术后患者生活质量、自理能力和心理状态的影响及效果
IF 1.9 4区 医学
Minxia Wei, Liqun Zhang, Juan Xu, Yuanfei Chen
{"title":"The Implementation and Effectiveness of Progressive Rehabilitation Nursing on Quality of Life, Self-Care Ability, and Psychological Status in Patients with Breast Cancer after Modified Radical Mastectomy.","authors":"Minxia Wei, Liqun Zhang, Juan Xu, Yuanfei Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the implementation and effectiveness of progressive rehabilitation nursing in patients undergoing modified radical mastectomy for breast cancer.</p><p><strong>Methods: </strong>A total of 70 patients undergoing modified radical mastectomy for breast cancer in our hospital were selected as the research subjects, and they were randomly divided into a control group and an observation group, with 35 patients in each group. The control group received routine rehabilitation nursing intervention after surgery, while the observation group received progressive rehabilitation nursing intervention based on the control group's nursing. The quality of life, self-care ability, mental state, and incidence of complications were compared between the two groups.</p><p><strong>Results: </strong>Before the intervention, the two groups had no significant difference in the quality of life (P > .05). After the intervention, the quality of life in the observation group was significantly better than that in the control group (P < .05). Before the intervention, the two groups had no significant difference in the self-care ability (P > .05). After the intervention, the self-care ability in the observation group was significantly better than that in the control group (P < .05). Before the intervention, the two groups had no significant difference in the SAS and SDS scores (P > .05). After the intervention, the SAS and SDS scores in the observation group were significantly lower than those in the control group (P < .05). The incidence of complications in the control group was 22.86%, while that in the observation group was 5.71%. The incidence of complications in the observation group was significantly lower than in the control group (P < .05).</p><p><strong>Conclusion: </strong>Compared with routine nursing intervention, the implementation of progressive rehabilitation nursing intervention can further improve the quality of life, self-care ability, and mental state of patients undergoing modified radical mastectomy for breast cancer and reduce the risk of related complications, which helps promote the recovery process of patients and is worthy of clinical promotion and application.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":"65-71"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nocturnal Enuresis and Homeopathy: A Case Report. 夜间遗尿与顺势疗法:1例报告。
IF 1.9 4区 医学
Ragini Kulkarni
{"title":"Nocturnal Enuresis and Homeopathy: A Case Report.","authors":"Ragini Kulkarni","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Context: </strong>Bedwetting is a socially disruptive condition that can lower an individual's self-confidence. Bedwetting is quite common in school-going children and a close correlation has been observed between the mind and physical symptoms in many cases. Reassurance and relieving the anxiety in patients can help reduce the complaints. Nocturnal enuresis in a 9-year-old girl was treated with the constitutional approach to homeopathic medicine.</p><p><strong>Objective: </strong>This case was undertaken to assess the efficacy of individualized homeopathic medicine for managing nocturnal enuresis.</p><p><strong>Case summary: </strong>A 9-year-old girl came with complaints of bedwetting for the past 1 year. It was noticed that she had lost her sister who was 5 years old. The patient was thirsty and thermally chilly. No change in bowel habits was noted. Sleep was disturbed in the first half of night due to involuntary urination. The patient had a craving for sweets and a strong aversion to milk. After a detailed analysis of the case, the homeopathic medicine Ignatia amara 30C was prescribed for 15 days, and satisfactory results were observed.</p><p><strong>Result: </strong>This case was successfully treated with the selected homeopathic medicine, preventing further complications.</p><p><strong>Conclusion: </strong>Further studies can be undertaken to assess the effectiveness of homeopathy in the management of nocturnal enuresis.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":"62-64"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of Head of Bed Elevation Using Adjustable Bed and Its Effects on Sleep: A Pilot Randomized Trial. 使用可调节床抬高床头及其对睡眠的影响:试点随机试验。
IF 1.9 4区 医学
Sangeun Lee, Joo Hyun Park, Jin Youp Kim, Seok-Won Park, Hong-Bum Shin, Bo Hae Kim
{"title":"Implementation of Head of Bed Elevation Using Adjustable Bed and Its Effects on Sleep: A Pilot Randomized Trial.","authors":"Sangeun Lee, Joo Hyun Park, Jin Youp Kim, Seok-Won Park, Hong-Bum Shin, Bo Hae Kim","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Although mild head of bed elevation (HBE) is a proven method to reduce obstructive sleep apnea, there is no study to apply mild HBE in daily life using an adjustable bed.</p><p><strong>Objective: </strong>We aimed to explore the applicability of mild HBE using an adjustable bed in daily life by investigating adverse events and discomforts induced by mild HBE. This pilot randomized trial additionally investigated the objective effects of mild HBE on sleep using polysomnography (PSG).</p><p><strong>Methods: </strong>Pilot randomized controlled trial. With a two-tailed alpha of 0.05 and a power of 0.95, the minimum number of participants for each group; control group slept on flat bed and study group slept on bed with mild HBE on follow-up PSG; was calculated to be 12. Considering a 20% follow-up loss, we enrolled a total of 32 participants (16 participants for each group).</p><p><strong>Setting: </strong>Dongguk University, Ilsan hospital.</p><p><strong>Participants: </strong>A total of 37 individuals complained of subjective sleep disturbance in the Republic of Korea, 32 of whom met the inclusion criteria between September 2021 to July 2022. 23 participants completed the study and participants were randomly assigned into two groups.</p><p><strong>Intervention: </strong>A mild HBE of 7.5 degrees using an adjustable bed was implemented. PSG results and questionnaires were evaluated.</p><p><strong>Results: </strong>There was no difference in the proportion of adverse events between groups after post-intervention which was adjusting mild HBE on study group. Changes in sleep satisfaction from baseline to post-intervention showed no significant difference between groups either. However, changes in respiratory distress index (RDI) (F = 6.088, 95% CI, 17.0% to 26.4%; P = .023) and apnea-hypopnea index (AHI) (F = 5.542, 95% CI, 13.6% to 23.5%; P = .029) were significantly different.</p><p><strong>Conclusions: </strong>Mild HBE is an implementable method for changing sleep posture without definitely causing discomfort or worsening sleep satisfaction. Since an easily applicable way to implement mild HBE using an adjustable bed in daily life reduces RDI and AHI in both subjects complaining of sleep disturbance and obstructive sleep apnea, it can be an alternative treatment for obstructive sleep apnea.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":"122-128"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140954990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Potential of Cinnamaldehyde Nanoparticles as an Antihyperuricemic, Anti-Inflammatory, and Antioxidant Agent Against Monosodium Urate Crystals-Mediated Gouty Arthritis in BALB/c Mice. 肉桂醛纳米颗粒作为抗高尿酸血症、抗炎和抗氧化剂治疗BALB/c小鼠痛风性关节炎的潜力
IF 1.9 4区 医学
Mubin Mustafa Kiyani, Sarah Sadiq, Maria Sarfraz, Maisra Azhar Butt, Hamza Rehman, Hassan Burair Abbas, Mir Arif Hussain Talpur, Syed Ali Imran Bokhari
{"title":"Therapeutic Potential of Cinnamaldehyde Nanoparticles as an Antihyperuricemic, Anti-Inflammatory, and Antioxidant Agent Against Monosodium Urate Crystals-Mediated Gouty Arthritis in BALB/c Mice.","authors":"Mubin Mustafa Kiyani, Sarah Sadiq, Maria Sarfraz, Maisra Azhar Butt, Hamza Rehman, Hassan Burair Abbas, Mir Arif Hussain Talpur, Syed Ali Imran Bokhari","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Gout is a metabolic disorder characterized by the accumulation of urate crystals in joints due to a high concentration of uric acid in the blood. This leads to inflammation and joint swelling. Gout is traditionally treated with drugs that lower the uric acid level and reduce inflammation, but these treatments can have adverse effects. Phytopharmaceuticals, such as cinnamaldehyde nanoparticles (CANPs), have gained popularity as gout treatments. The study aimed to explore the anti-gout and antioxidant activities of CANPs in gouty mice.</p><p><strong>Methodology: </strong>Cinnamon bark was used to synthesize CANPs, which were then characterized. The in vivo study was conducted using BALB/c mice, randomly divided into six groups (n = 6 per group). The control group received a normal diet, while the MSU group was injected with monosodium urate (MSU) crystals into the ankle joint to induce a disease model. The allopurinol group was treated with the standard drug allopurinol, serving as a positive control. Three treatment groups were administered different doses of CANPs; the experimental drug at concentrations of 5 ppm, 10 ppm, and 20 ppm, respectively. CANPs were subsequently administered orally to the mice. CANPs were studied for their impact on liver function, renal function, lipid profile, total protein, antioxidant activity, and blood parameters.</p><p><strong>Results: </strong>CANP administration had a favorable effect on gouty mice, according to the findings. CANPs dramatically lowered uric acid, urea, and creatinine concentrations, demonstrating their potential for treating hyperuricemia and gout. CANPs improved liver function, lipid profile, antioxidant activity, and blood parameters.</p><p><strong>Conclusion: </strong>The study suggests that CANPs derived from cinnamon exhibit anti-gout and antioxidant properties in gouty mice. These findings support the potential use of CANPs as a natural and alternative treatment for gout. Further research is needed to explore the therapeutic applications of CANPs in treating gout in humans.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":"34-41"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Herbal Interventions for Obesity: A Review of Unani Medicinal Herbs. 草药干预肥胖:Unani草药综述。
IF 1.9 4区 医学
Dr Saliha, Mohammad Naseem Khan, S M Abbas Zaidi, Ehsan Ahmad
{"title":"Herbal Interventions for Obesity: A Review of Unani Medicinal Herbs.","authors":"Dr Saliha, Mohammad Naseem Khan, S M Abbas Zaidi, Ehsan Ahmad","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>World Health Organization (WHO) defines obesity and overweight as excessive or aberrant fat accumulation that poses an increased health risk. Despite this oversimplified definition, obesity is a complex illness caused by a persistently positive energy balance, or when dietary energy intake surpasses energy expenditure. Extra energy is transformed into triglycerides, which are then stored in depots of adipose tissue that enlarge, resulting in weight gain and an increase in body fat. The escalating global prevalence of obesity, impacting more than two billion individuals, necessitates innovative and holistic approaches in public health. This review paper aims to evaluate the potential of medicinal herbs in obesity management by systematically examining their mechanisms of action, including enzyme inhibition, appetite suppression, and modulation of metabolic processes, to propose an integrative, safer, and holistic approach to enhance current strategies for obesity treatment. A comprehensive search of literature was conducted in PubMed, Google scholar, and Science Direct. Search was conducted using the terms - \"Unani herbs\", obesity management, Siman Mufrit. This review paper highlights critical evaluation of contemporary obesity management strategies, emphasizing need for safer and more sustainable alternatives. Insights from Unani medicine contribute to a holistic understanding of obesity, paving way for an exploration of medicinal herbs and their mechanisms of action. Enzyme inhibition, appetite suppression, and modulation of metabolic processes emerge as key factors in anti-obesity effects of medicinal herbs. In conclusion, this comprehensive review underscores potential of medicinal herbs as promising contributors to global obesity management drawing insights from epidemiological data and traditional Unani medicine. By combining traditional wisdom with modern research, a more holistic and individualized approach can be achieved. The proposed integrative strategy advocates for further research, collaboration, and shift towards natural and culturally sensitive healthcare practices to address obesity.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":"42-47"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Katie Emerson Discusses the Health Benefits of Cognizin® Citicoline. 凯蒂·艾默生讨论了Cognizin®胞胆碱的健康益处。
IF 1.9 4区 医学
Katie Emerson, Sheldon Baker
{"title":"Katie Emerson Discusses the Health Benefits of Cognizin® Citicoline.","authors":"Katie Emerson, Sheldon Baker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>No Abstract Available.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":"31 3","pages":"6-9"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信