Mubin Mustafa Kiyani, Sarah Sadiq, Maria Sarfraz, Maisra Azhar Butt, Hamza Rehman, Hassan Burair Abbas, Mir Arif Hussain Talpur, Syed Ali Imran Bokhari
{"title":"肉桂醛纳米颗粒作为抗高尿酸血症、抗炎和抗氧化剂治疗BALB/c小鼠痛风性关节炎的潜力","authors":"Mubin Mustafa Kiyani, Sarah Sadiq, Maria Sarfraz, Maisra Azhar Butt, Hamza Rehman, Hassan Burair Abbas, Mir Arif Hussain Talpur, Syed Ali Imran Bokhari","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gout is a metabolic disorder characterized by the accumulation of urate crystals in joints due to a high concentration of uric acid in the blood. This leads to inflammation and joint swelling. Gout is traditionally treated with drugs that lower the uric acid level and reduce inflammation, but these treatments can have adverse effects. Phytopharmaceuticals, such as cinnamaldehyde nanoparticles (CANPs), have gained popularity as gout treatments. The study aimed to explore the anti-gout and antioxidant activities of CANPs in gouty mice.</p><p><strong>Methodology: </strong>Cinnamon bark was used to synthesize CANPs, which were then characterized. The in vivo study was conducted using BALB/c mice, randomly divided into six groups (n = 6 per group). The control group received a normal diet, while the MSU group was injected with monosodium urate (MSU) crystals into the ankle joint to induce a disease model. The allopurinol group was treated with the standard drug allopurinol, serving as a positive control. Three treatment groups were administered different doses of CANPs; the experimental drug at concentrations of 5 ppm, 10 ppm, and 20 ppm, respectively. CANPs were subsequently administered orally to the mice. CANPs were studied for their impact on liver function, renal function, lipid profile, total protein, antioxidant activity, and blood parameters.</p><p><strong>Results: </strong>CANP administration had a favorable effect on gouty mice, according to the findings. CANPs dramatically lowered uric acid, urea, and creatinine concentrations, demonstrating their potential for treating hyperuricemia and gout. CANPs improved liver function, lipid profile, antioxidant activity, and blood parameters.</p><p><strong>Conclusion: </strong>The study suggests that CANPs derived from cinnamon exhibit anti-gout and antioxidant properties in gouty mice. These findings support the potential use of CANPs as a natural and alternative treatment for gout. Further research is needed to explore the therapeutic applications of CANPs in treating gout in humans.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":"34-41"},"PeriodicalIF":1.9000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Therapeutic Potential of Cinnamaldehyde Nanoparticles as an Antihyperuricemic, Anti-Inflammatory, and Antioxidant Agent Against Monosodium Urate Crystals-Mediated Gouty Arthritis in BALB/c Mice.\",\"authors\":\"Mubin Mustafa Kiyani, Sarah Sadiq, Maria Sarfraz, Maisra Azhar Butt, Hamza Rehman, Hassan Burair Abbas, Mir Arif Hussain Talpur, Syed Ali Imran Bokhari\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Gout is a metabolic disorder characterized by the accumulation of urate crystals in joints due to a high concentration of uric acid in the blood. This leads to inflammation and joint swelling. Gout is traditionally treated with drugs that lower the uric acid level and reduce inflammation, but these treatments can have adverse effects. Phytopharmaceuticals, such as cinnamaldehyde nanoparticles (CANPs), have gained popularity as gout treatments. The study aimed to explore the anti-gout and antioxidant activities of CANPs in gouty mice.</p><p><strong>Methodology: </strong>Cinnamon bark was used to synthesize CANPs, which were then characterized. The in vivo study was conducted using BALB/c mice, randomly divided into six groups (n = 6 per group). The control group received a normal diet, while the MSU group was injected with monosodium urate (MSU) crystals into the ankle joint to induce a disease model. The allopurinol group was treated with the standard drug allopurinol, serving as a positive control. Three treatment groups were administered different doses of CANPs; the experimental drug at concentrations of 5 ppm, 10 ppm, and 20 ppm, respectively. CANPs were subsequently administered orally to the mice. CANPs were studied for their impact on liver function, renal function, lipid profile, total protein, antioxidant activity, and blood parameters.</p><p><strong>Results: </strong>CANP administration had a favorable effect on gouty mice, according to the findings. CANPs dramatically lowered uric acid, urea, and creatinine concentrations, demonstrating their potential for treating hyperuricemia and gout. CANPs improved liver function, lipid profile, antioxidant activity, and blood parameters.</p><p><strong>Conclusion: </strong>The study suggests that CANPs derived from cinnamon exhibit anti-gout and antioxidant properties in gouty mice. These findings support the potential use of CANPs as a natural and alternative treatment for gout. Further research is needed to explore the therapeutic applications of CANPs in treating gout in humans.</p>\",\"PeriodicalId\":7571,\"journal\":{\"name\":\"Alternative therapies in health and medicine\",\"volume\":\" \",\"pages\":\"34-41\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alternative therapies in health and medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alternative therapies in health and medicine","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
Therapeutic Potential of Cinnamaldehyde Nanoparticles as an Antihyperuricemic, Anti-Inflammatory, and Antioxidant Agent Against Monosodium Urate Crystals-Mediated Gouty Arthritis in BALB/c Mice.
Background: Gout is a metabolic disorder characterized by the accumulation of urate crystals in joints due to a high concentration of uric acid in the blood. This leads to inflammation and joint swelling. Gout is traditionally treated with drugs that lower the uric acid level and reduce inflammation, but these treatments can have adverse effects. Phytopharmaceuticals, such as cinnamaldehyde nanoparticles (CANPs), have gained popularity as gout treatments. The study aimed to explore the anti-gout and antioxidant activities of CANPs in gouty mice.
Methodology: Cinnamon bark was used to synthesize CANPs, which were then characterized. The in vivo study was conducted using BALB/c mice, randomly divided into six groups (n = 6 per group). The control group received a normal diet, while the MSU group was injected with monosodium urate (MSU) crystals into the ankle joint to induce a disease model. The allopurinol group was treated with the standard drug allopurinol, serving as a positive control. Three treatment groups were administered different doses of CANPs; the experimental drug at concentrations of 5 ppm, 10 ppm, and 20 ppm, respectively. CANPs were subsequently administered orally to the mice. CANPs were studied for their impact on liver function, renal function, lipid profile, total protein, antioxidant activity, and blood parameters.
Results: CANP administration had a favorable effect on gouty mice, according to the findings. CANPs dramatically lowered uric acid, urea, and creatinine concentrations, demonstrating their potential for treating hyperuricemia and gout. CANPs improved liver function, lipid profile, antioxidant activity, and blood parameters.
Conclusion: The study suggests that CANPs derived from cinnamon exhibit anti-gout and antioxidant properties in gouty mice. These findings support the potential use of CANPs as a natural and alternative treatment for gout. Further research is needed to explore the therapeutic applications of CANPs in treating gout in humans.
期刊介绍：
Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field.
Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
