Alternative therapies in health and medicine最新文献

{"title":"Effects of Spermidine-Rich Rice Germ Extract Supplement on Biomarkers of Healthy Aging and Autophagy-Proof-of-Concept Pilot Study.","authors":"Gene Bruno, Michael La Monica, Tim N Ziegenfuss","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Although epidemiological and preclinical research suggests that the polyamine spermidine improves the efficiency of autophagy, human clinical research demonstrating a specific dose of any source of spermidine capable of increasing biomarkers of autophagy is lacking.</p><p><strong>Primary study objective: </strong>The study aimed to examine the effects of spermidine from Miricell™ rice germ extract (Nutraland USA) on biomarkers/indices of autophagy, neuroprotection, and cardiometabolic health, as well as safety and adverse events.</p><p><strong>Methods/design: </strong>This 56-day study was conducted as a single-blinded, interventional, parallel-group, pilot trial. Vitals, diet records, and protocol compliance were recorded at weeks 0 and 8. Blood draws for cardiometabolic markers and adverse event monitoring took place at screening and weeks 0 and 8.</p><p><strong>Setting: </strong>Conducted at a clinical research laboratory in Ohio.</p><p><strong>Participants: </strong>Twelve (N=12) healthy men and women (age: 54.5 ± 7.9 years).</p><p><strong>Intervention: </strong>Random assignment to 1.5 mg or 3.3 mg of spermidine daily from Miricell™ rice germ extract (Nutraland USA).</p><p><strong>Primary outcome measures: </strong>Biomarkers of autophagy [Beclin-1 and Unc-51-like kinase 1(ULK1)], and biomarkers/indices of neuroprotection, including brain-derived neurotrophic factor (BDNF), homocysteine, and cardiometabolic health (high sensitivity C-reactive protein (hs-CRP), lipid panel).</p><p><strong>Results: </strong>Compared to baseline, only the 3.3 mg dose of spermidine from Miricell® increased Beclin-1 by 7.3%, ULK-1 by 13.4%, and BDNF by 12.1%. Compared to baseline, the same dose resulted in a 20.8% decrease in hs-CRP, a 20.1% decrease in VLDL, and a 26.9% decrease in triglycerides. Secondary outcomes, including clinical chemistry panel, CBC, vital signs, and adverse events, reflect a good safety profile for the use of 3.3 mg/day of spermidine from Miricell®.</p><p><strong>Conclusion: </strong>This pilot study found that 3.3 mg/day of spermidine from Miricell® rice germ extract tends to improve biomarkers of autophagy, neuroprotection, and cardiometabolic health. Appropriate follow-up studies are warranted to confirm these findings.</p><p><strong>Keywords: </strong>spermidine, autophagy, beclin-1, ULK1, rice germ extract, neuroprotection, BDNF, homocysteine, cardiometabolic, CRP, C-reactive protein, VLDL, triglycerides, aging.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric Analysis of India's Ayush Systems of Medicine Using Ayush Research Portal Data from 1954-2020: Current Status, Challenges, and the Way Forward for Future Research.","authors":"Sendhilkumar Muthappan, Natarajan Shanmugasundaram, Sainath Podugu, Anbarasi Chandrasekaran, Keerthiga Govindarajan, Shruthi Ramesh, Saketh Ram Thrigulla, Manickam Ponnaiah","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Research quality in Ayush systems of medicine is vital for evidence synthesis and decision-making. As Ayush gains global recognition, analyzing its trends and challenges is important for improving clinical outcomes. However, a comprehensive analysis of research publications is lacking.</p><p><strong>Primary study objective: </strong>We conducted a bibliometric analysis using data from the Ayush research portal to highlight key trends and challenges in this field.</p><p><strong>Methods: </strong>We extracted data from the Ayush Research Portal (ARP) database for the years 1954 to 2020, excluding books, workshops, conference papers, and incomplete entries. Our analysis evaluated the types of Ayush systems, authors' countries, publication years, author contributions, and the predatory status of journals. We used Epi Info (version 7.2) and Quantum GIS software for data analysis and map creation.</p><p><strong>Results: </strong>We included 24 037 articles for analysis. Our findings indicate a gradual increase in publications starting from 2000, followed by exponential growth from 2009, and a peak in 2011. Most articles focused on preclinical research (n=10 677; 44.0%). India leads in the quantity of publications (n=20 675; 86.0%), followed by the US (n=649; 2.7%). Within India, Tamil Nadu accounted for the highest number of publications (n=3517; 17.0%). Furthermore, approximately 10% of the journals and one-third of the articles (7268; 30%) were classified as predatory.</p><p><strong>Conclusion: </strong>This bibliometric review highlights a rise in publications across all systems, but raises concerns about quality, with one-third appearing in predatory journals. Thus, the Ayush systems of medicine should focus more on publication quality.</p><p><strong>Keywords: </strong>complementary therapies, Ayurveda, traditional medicine, Ayush research portal.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Heat Application on Pain, Anxiety, and Comfort Levels of Patients Undergoing Cystoscopy: A Randomized Controlled Trial.","authors":"Emine Karakaya, Kıvan Çevik Kaya","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Cystoscopy causes pain, anxiety, and dissatisfaction in patients and leads to increased discomfort. Therefore, it is helpful to use pharmacological and evidence-based complementary alternative medicine methods together for pain, anxiety, and comfort management during the cystoscopy procedure.</p><p><strong>Objective: </strong>This randomized controlled experimental study was conducted to determine the effects of heat application on patients' pain, anxiety, and comfort levels during cystoscopy.</p><p><strong>Methods: </strong>This study was conducted as a two-parallel group randomized controlled trial, from November 2023 to June 2024.</p><p><strong>Setting: </strong>The study was conducted in the cystoscopy unit of a state hospital located in Western Turkey.</p><p><strong>Participants: </strong>The study sample consisted of 62 patients.</p><p><strong>Intervention: </strong>The patients were randomly assigned to two groups using a computer program (www.randomizer.org): Group 1 (control group) and Group 2 (intervention group). The patients in the intervention group underwent heat application in the cystoscopy room.</p><p><strong>Primary outcome measures: </strong>Data were collected using the 'Patient Information Form', 'Visual Analog Scale', 'Data Recording Form', 'State Anxiety Inventory', and 'Shortened General Comfort Scale'. While the data were analyzed, descriptive statistical methods, chi-square analysis, independent samples t test, dependent samples t test, and analysis of variance test were used.</p><p><strong>Results: </strong>There was a statistically significant difference between the intervention and control groups in terms of the mean scores obtained from the VAS during and after the intervention, but there was no statistically significant difference between the scores obtained from the overall State Anxiety Inventory and Shortened General Comfort Scale and their subscales before and after the intervention.</p><p><strong>Conclusion: </strong>The study findings indicate that the heat application to patients during cystoscopy is effective in reducing pain.</p><p><strong>Keywords: </strong>anxiety, comfort, cystoscopy, heat application, pain, complementary and alternative medicine.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Individualized Homeopathic Treatment in Uncomplicated Odontogenic Infections: A Randomized, Double-blind, Placebo-controlled Clinical Trial.","authors":"Sushanta Sasmal, Samit Dey, Shubhamoy Ghosh, Anjani Kumar Rai, Abhijit Dutta","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Odontogenic infections are among the most common problems encountered in usual dental practice. The role and efficacy of complementary treatments such as individualized homeopathy are not well characterized.</p><p><strong>Methods: </strong>A double-blind, randomized, placebo-controlled clinical trial enrolled 60 patients with uncomplicated odontogenic infections. Patients were randomly assigned to receive either Individualized Homeopathy (IH, n=30) or Placebo (PL, n=30), in addition to non-medicinal management. Co-primary outcome measures included Visual Analog Scales for Pain (VAS-P) and Swelling (VAS-S). Secondary outcome measures comprised the Oral Health Impact Profile-14 (OHIP-14) and time taken for complete symptom resolution (Ts). All outcomes were assessed at baseline, 3rd day, 7th day, and 14th day, except Ts, which was monitored daily until symptoms completely resolved within 14 days.</p><p><strong>Results: </strong>IH showed significant improvement over PL in VAS-P at day 7 (P = .005) and day 14 (P < .001), as well as in VAS-S at day 7 (P = .001) and day 14 (P < .001). OHIP-14 improvement post-treatment was notably higher in IH than PL (F=3.404, P < .05). Kaplan-Meier analysis revealed a significant difference in Ts (P = .015), with reduced hazard in the PL group (Hazard Ratio = 0.3024, 95% CI: 0.1087-0.8414). The most prescribed medicines in the IH group were Mercurius solubilis (16.6%) and Hypericum perfoliatum (13.3%), whereas in the PL group, the most indicated medicines were Mercurius solubilis (13.3%) and Staphysagria (13.3%).</p><p><strong>Conclusion: </strong>This study demonstrated a significant therapeutic effect of homeopathy over placebo in alleviating pain and swelling linked to odontogenic infections. Nevertheless, to firmly establish this finding, a large-scale replication trial employing a similar methodology is deemed necessary.</p><p><strong>Keywords: </strong>homeopathy, odontogenic infections, randomized controlled trial, placebo, dental infections.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine (Shaqīqa): A Review of Understanding and Managing the Disease in Unāni Medicine.","authors":"Khalid Rahim Wani, Suresh Kumar Saral, Fatima Khan, Abdul Nasir Ansari, Mohd Nayab","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>In the Unani system of medicine, migraine is described as Shaqīqa, a term derived from the Arabic word \"shiq\" meaning \"a side\" or \"a section\", referring to the characteristic unilateral nature of the headache. Migraine is a chronic neurological disorder affecting approximately 14% of the global population.</p><p><strong>Objective: </strong>This review aims to provide a comprehensive account of Shaqīqa (migraine) within the framework of Unani medicine, focusing on its pathophysiology, clinical presentation, diagnostic principles, and therapeutic strategies.</p><p><strong>Methods: </strong>A thorough review of classical Unani texts was undertaken to extract relevant insights on migraine. Additionally, contemporary literature was retrieved through systematic searches in electronic databases such as PubMed, ScienceDirect, and Google Scholar to contextualize Unani perspectives with current biomedical understanding.</p><p><strong>Findings: </strong>In Unani medicine, migraine is classified under Sudā' Māddī (headache due to morbid humoral matter). It is typically unilateral, recurrent, and chronic, and is not attributed to Sū'-i-Mizāj Sāda (simple morbid temperament). Primary causes include Rīh (internal wind), Bukhārāt (vapors), and Akhlāt-i-Ghalīzah (viscous humors). Pathogenesis involves the ascent of Bukhārāt-i-Raddiya (morbid vapors) from the gastrointestinal tract or other organs to the brain, leading to headache. Treatment approaches in Unani medicine are highly individualized, based on the patient's temperament (Mizāj), the dominant humor, organ involvement, and severity. A range of single and compound herbal formulations is employed to restore humoral balance and alleviate symptoms.</p><p><strong>Conclusion: </strong>The Unani medicine offers a detailed and holistic understanding of migraine, encompassing its etiology, clinical features, and treatment modalities. This review underscores the need for further interdisciplinary research to validate and potentially integrate Unani therapeutic approaches into contemporary migraine management.</p><p><strong>Keywords: </strong>Migraine, Shaqīqa, Unāni medicine, Headache, 'Tilā.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Phytoestrogens in Gynecological Disorders from the Lens of Unani System of Medicine-A Review.","authors":"Aniya Afaq Khan, Ismath Shameem, Umer Hamid Wani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Abstract: </strong>In recent years, there has been a surge of interest in alternative and natural techniques for preventing and treating gynecological disorders. Numerous studies have focused on exploring treatments that have less adverse impact than standard hormonal treatment. Although the etiopathogenetic processes of many gynecological illnesses, such as endometriosis and uterine fibroids, remain unclear, the significance of steroid hormones is undeniable. Endometriosis, uterine leiomyomas, ovarian cancer, and breast cancer all exhibit significant hormonal imbalances. The Unani system of medicine, referred to as Greco-Arabic medicine, is a popular form of traditional medicine widely practiced in many countries. This system utilizes herbs rich in phytoestrogens, which bear structural similarity to 17β-estradiol, and thus have the potential to mimic its estrogenic activity and produce responses. This makes phytoestrogens a suitable substitute for conventional hormonal replacement therapy (HRT) with fewer side effects. Therefore, a comprehensive search for studies on phytoestrogens was conducted using electronic databases such as Google Scholar, ResearchGate, Science Direct, EMBASE, and PubMed. All the relevant literature on gynecological disorders in Unani medicine has been evaluated, assessed, and analyzed based on classical texts. This narrative review summarizes the literature on the physiological role of estrogens and the several potential health benefits of phytoestrogens, with particular attention to the possible role of phytoestrogens in gynecological disorders.</p><p><strong>Keywords: </strong>Phytoestrogens, Gynecological Disorders, Unani Medicine, Hormonal Replacement Therapy, Estrogen, Selective Estrogen Receptor Modulator.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Analysis, Lc-Ms/Ms-Qtof Identification of Phytocompounds and in vitro Antioxidant Activity of Traditional Medicinal Plant Formulation.","authors":"Sana Nafees, Qazi Zaid Ahmad, Aziz Ur Rahman, Pawan Kumar, Jamal Akhtar, Ashok Kumar Jaiswal, Jasbir Kaur","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Medicinal plants are invaluable sources of novel medications worldwide, used for centuries due to their therapeutic properties and health benefits. Comprehensive quality evaluation and monitoring studies are available on single medicinal plant, however, there are limited data on plant-based formulations especially the formulations described in ancient texts.</p><p><strong>Objective: </strong>Qualitative and quantitative evaluation of the phytochemicals present and the identification of active phytocompounds of a traditional Unani plant-based formulation (Zingiber officinalis, Piper longum, Coptis teeta, Piper nigrum, and Foeniculum vulgare) described by distinguished Persian physician of 10th century, Abul-Mansoor ul Hasan Qamari (d.980 A.D.) in classical text 'Ghina-Muna' for ocular ailments.</p><p><strong>Methods: </strong>Phytochemical analyses were conducted according to the guidelines given by the World Health Organisation. Antioxidant activity was determined by radical scavenging activity of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide inhibition activity.</p><p><strong>Results: </strong>Liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (LC-MS/MS-QTOF) analysis revealed berberine, coptisine, 6-shogaol, 6-dehydroshogaol, 6-dehydrogingerdione, 6-gingerol, 10-gingerol, gingerenone-A, piperine, piperic acid, quercetin-3-o-galactoside, kaempferol-3-o-rutinoside, kaempferol-3-o-glucoside, rosmarinic acid, 3-caffeoylquinic acid, 4-caffeoylquinic acid, eriodictyol-7-rutinoside, and 1,5-dicaffeoylquinic acid as the active phytoconstituents. These phytocompounds have promising neuroprotective and antioxidant activity. Findings showed the presence of alkaloids, glycosides, phenols, flavonoids, tannins, and saponins in the formulation. Quantitative analysis of total flavonoid and total phenolics content were found to be 102.889 mgQE/g and 12.004 mgGAE/g of extract, respectively. The results obtained revealed remarkable antioxidant activity of studied formulation as evidenced by the low half-maximal inhibitory concentration (IC50) and half-maximal effective concentration (EC50) values.</p><p><strong>Conclusion: </strong>The parameters evaluated in this study are adequate for quality control of traditional medicinal plant-based formulations and can serve as a reference for standardizing this formulation. The formulation has potent neuroprotective and antioxidant phytochemicals, implying that it could be used as a leading pharmacological intervention for preventing/or slowing the progress of neurodegenerative diseases, including ocular conditions like glaucoma.</p><p><strong>Keywords: </strong>Unani medicine, phytochemical screening, active phytoconstituents, neuroprotection, antioxidant activity.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrative Review of Suddah (Obstruction) in Unani Medicine.","authors":"Sadique Ali, Ishrat Rasool, Khaleequr Rahman, Asmat Rashid","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Obstructive conditions represent a major challenge in global healthcare, contributing to significant morbidity and mortality. These include a spectrum of diseases such as vascular thrombosis, embolism, respiratory tract obstructions, hepatobiliary blockages, lymphatic stasis, and intestinal obstructions. While modern medicine classifies and treats these conditions based on anatomical and physiological disruptions, historical records indicate that traditional medical systems, like Unani Medicine, had already developed detailed theoretical frameworks to understand such pathologies. In Unani literature, these conditions are referred to as \"Suddah,\" a term meaning \"blockage\" or \"closure of a passage.\" Ancient Unani scholars, such as Ibn Sina (Avicenna), Razi, and others, addressed the concept of Suddah in considerable depth, linking it with deranged humoral balance, altered temperament (Mizaj), and disruptions in the normal flow of humors (Akhlat) and vital spirit (Ruh). Their observations underscore the systemic importance of maintaining unobstructed pathways for optimal health.</p><p><strong>Objectives: </strong>This study aims to gather, interpret, and present a comprehensive overview of the concept of Suddah as documented in classical Unani texts. It seeks to unify scattered references and explanations from key Unani physicians and scholars into a coherent academic resource. Additionally, it provides a brief outline of traditional treatment strategies for such conditions based on Unani principles.</p><p><strong>Results: </strong>The narrative review of classical texts revealed a nuanced and integrative understanding of the causes, types, and therapeutic approaches related to obstructive disorders under the term Suddah, reflecting both philosophical and clinical insight.</p><p><strong>Conclusion: </strong>This study consolidates classical Unani views on obstruction, providing a foundational platform for further clinical exploration and integrative healthcare approaches involving traditional wisdom and modern practice.</p><p><strong>Keywords: </strong>obstructive diseases, Suddah, Unani medicine, narrative review.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal Properties of Erysimum cheiri L. (Tudri surkh) - Insights from Traditional Unani Medicine and Modern Phytochemical Analyses: A Narrative Review.","authors":"Hayder Ali Shah, Sabiha Khan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Plants provide us with significant therapeutic ingredients that serve as raw materials for both traditional and modern medicine. One such medication is Tudri surkh (Erysimum cheiri L), which can be used either alone or in compound pharmacopeial formulations. Tudri surkh is a perennial plant of the family Brassicaceae, originally a native of Europe.</p><p><strong>Objective: </strong>This review aims to explore the therapeutic uses and medicinal properties of Tudri surkh, based on research on phytochemicals and pharmacology as well as Unani medicine.</p><p><strong>Methods: </strong>A thorough review of the literature was conducted using several search engines, including Google Scholar, PubMed, Web of Science, and Scopus. To obtain as much information as possible about the Tudri surkh (Erysimum cheiri), other literary sources, such as Wikipedia, Unani literature, and ethnobotanical texts, were also examined.</p><p><strong>Results: </strong>Tudri surkh (Erysimum cheiri) has significant potential as a medicinal plant in the traditional health care system, particularly in treating inflammatory, infectious, and non-communicable diseases. Tudri surkh contains bioactive compounds, such as alkaloids, glucosides (e.g., Erysimoside, Cheiroside A), flavonoids (e.g., Quercetin), and phenols, which contribute to its pharmacological properties, including antioxidant, anti-inflammatory, antimicrobial, and chemopreventive effects. Studies demonstrate the ability of Tudri surkh seed extracts to scavenge free radicals, inhibit skin tumorigenesis, and reduce inflammation comparably to conventional drugs like diclofenac. Traditional uses include Muqawwi-e-Bah (aphrodisiac), Mu'alid-i-Sha'r (hair grower), Musakkin wa Mulattif (febrifuge and demulcent), Mukhrij wa Munaffith-i-Balgham (expectorant), Muqawwi-i-Mi'da (stomachic), Musammin-i-Badan (adipogenous), externally Muhallil (resolvent), Muqawwi-i-Dimagh (brain tonic). However, despite its historic applications, modern pharmacopoeias lack comprehensive monographs on Tudri Surkh (Erysimum cheiri).</p><p><strong>Conclusion: </strong>Tudri surkh (Erysimum cheiri) holds significant therapeutic value in Unani medicine for treating inflammatory conditions and as a source of natural antioxidants. However, further research is needed to validate its mechanisms and integrate traditional knowledge with scientific evidence.</p><p><strong>Keywords: </strong>Erysimum, Medicinal plants, Narrative review, Phytochemicals, Unani medicine.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Acute Effect of Suboccipital Release Technique on Trapezius Muscle Activation and Pain in Individuals with Anxiety.","authors":"Bahriye Baş, Sezen Tezcan, Tamer Çankaya","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Anxiety is an unpleasant emotional and observable response to stressful situations and can adversely affect many systems, including the musculoskeletal system. The study aims to determine the immediate effect of the suboccipital release technique on the trapezius muscle pain threshold, muscle activation, and anxiety level in individuals with anxiety.</p><p><strong>Methods: </strong>Thirty-six participants with symptoms of anxiety and depression were included in this single-blind, randomized sham-controlled study, with 18 assigned to the control group and 18 to the acute intervention group. Anxiety levels, bilateral upper trapezius muscle pain thresholds, and muscle activation were assessed. The experimental group received a single session of the suboccipital release technique, while the control group received a sham suboccipital release. Evaluations were conducted before and immediately after the intervention.</p><p><strong>Results: </strong>The mean age of the experimental group was 21.66 ± 2.40 years, and the mean age of the control group was 22.00 ± 2.08 years. There were no statistically significant differences in baseline demographics or most scores before acute intervention (P > .05), except for cranial rhythmic impulse (P = .000) and surface electromyography right eccentric % maximum voluntary contraction (P = .043). There were also no significant between-group differences in score changes for any outcome measures (all P > .05), except for post-acute intervention cranial rhythmic impulse values (P = .003), favoring the experimental group. Within-group analyses showed significant improvements in trapezius pain thresholds and surface electromyography right concentric % maximum voluntary contraction in both groups (P < .05).</p><p><strong>Conclusion: </strong>The findings suggest that suboccipital release technique can increase the upper trapezius muscle pain threshold and concentric muscle activation after acute intervention in individuals with anxiety. This technique may be considered a potential approach to reduce the pain of individuals who have pain problems in the upper part of the trapezius muscle due to anxiety.</p><p><strong>Keywords: </strong>Anxiety, Trapezius muscle, Muscle Activation, Pain, Surface Electromyography.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}