Alternative therapies in health and medicine最新文献

{"title":"Understanding Depression, Its Impact, and Management Strategies in the Light of Unani Medicine.","authors":"Arfa Bano, Mohammad Hashir, Mariyam Jameel, Sabba Saltanat, Fauzia Shahabuddin, Hifzur Rahman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Depression is a prevalent mental health disorder affecting millions globally, leading to significant personal and societal burdens. Characterized by persistent sadness, hopelessness, and various cognitive and physical symptoms, it remains a major clinical challenge. Current treatment methods primarily rely on antidepressants and psychotherapy; however, many patients experience limited relief or adverse side effects, necessitating alternative approaches. Unani medicine offers a holistic strategy, focusing on humoral balance through natural remedies, dietary adjustments, and lifestyle modifications.</p><p><strong>Objectives: </strong>This review aims to examine depression from both modern and traditional perspectives.</p><p><strong>Methodology: </strong>A comprehensive review was conducted by analyzing classical Unani manuscripts and contemporary scientific databases. Foundational texts such as Al-Qanoon Fit Tib, Kamil-us-Sana'a, Zakhira Khwarzam Shahi, Al Aqseer, and Moulijat Buqratiya were assessed for insights. Modern databases, including PubMed, Scopus, and Google Scholar, were systematically searched with terms like \"Malikhuliya\", \"Unani medicine\", \"depression\", \"black bile\", and \"mental disorders\". Articles addressing both theoretical frameworks and clinical perspectives on depression were included in the study.</p><p><strong>Results and discussion: </strong>Comparing modern and traditional treatments provides key insights into depression management. Conventional pharmacotherapy, including Selective Serotonin Reuptake inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake inhibitors (SNRIs), effectively alleviates symptoms but has drawbacks such as delayed efficacy, side effects, and relapse risks. Studies suggest that integrating Unani principles with modern therapies may enhance treatment outcomes by improving adherence, reducing side effects, and promoting holistic well-being.</p><p><strong>Conclusion: </strong>Unani medicine provides complementary strategies that emphasize overall well-being. Integrating both systems may enhance treatment effectiveness, ensuring a balanced and personalized approach. Clinical trials assessing Unani herbal formulations alongside conventional medications could optimize depression management, paving the way for improved mental health care globally.</p><p><strong>Keywords: </strong>depression, psychotherapy, melancholy, Unani Medicine, Malikhuliya.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Yoga on Risk of Fall, Gait Speed, and Quality of Life in Young Old Population: A Clinical Trial.","authors":"Anil R Muragod, Gawas Rutuja","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Ageing leads to changes in the musculoskeletal, vascular, and nervous systems, diminishing strength, balance, and coordination, which increases the risk of fall (RoF), and may result in injuries, fear, and social isolation. Yoga effectively reduces RoF in older adults by improving flexibility, strength, and balance, enhancing stability, confidence, and overall well-being.</p><p><strong>Objective: </strong>To evaluate the effect of a four-week yoga intervention on the RoF, gait speed, and quality of life (QoL) in the young-old population.</p><p><strong>Setting: </strong>The study was conducted in a single geographical area (Belagavi city, Karnataka, India) from October 2024 to February 2025.</p><p><strong>Participants: </strong>23 participants (11 men and 12 women) with mild to moderate balance impairment. Participants are aged 65 to 74 years old. The group had an average BMI of 25.38, was capable of walking 3 meters, and had no serious comorbid conditions. One person was lost to follow-up, and no adverse effects were reported.</p><p><strong>Intervention: </strong>Participants underwent a week-wise structured yoga intervention: a 30-minute session, thrice a week, for four weeks. Each session included 5 minutes of pre-workout, 20 minutes of yoga asanas, and 5 minutes of cool-down. Asanas progressed weekly in complexity and balance challenge.</p><p><strong>Primary outcome measures: </strong>RoF using the Berg Balance Scale (BBS), Gait speed using the Timed Up and Go test (TUG), and QoL using the Older People's Quality of Life (OPQOL)-Brief questionnaire.</p><p><strong>Results: </strong>Yoga intervention showed significant improvements (P < .05) over time in BBS, TUG, and OPQOL-Brief scores.</p><p><strong>Conclusion: </strong>Yoga intervention led to notable improvements in reducing the RoF, improving gait speed, and QoL from baseline to week 4 among the young-old population.</p><p><strong>Keywords: </strong>elderly, yoga, risk of fall, gait speed, berg balance scale, quality of life.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Somato® TOMATO Fruit Extract on Key Physiological and Psychological Domains Associated with Sleep Quality, Autonomic Function, and Health-Related Quality of Life: A Pilot Study.","authors":"Mackenzie De Jesus, Kyle Bergquist, Gene Bruno","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>This 28-day pilot study aimed to evaluate the effects of plant-based melatonin (phytomelatonin) derived from Somato® tomato fruit extract (Nutraland USA) on key physiological and psychological domains associated with sleep quality, autonomic function, and health-related quality of life (HRQoL).</p><p><strong>Methods: </strong>Thirty-five healthy men and women (mean age: 42 years) were enrolled in a decentralized, open-label, real-world evidence study. Participants consumed 2 mg of phytomelatonin daily from Somato® oral strips for 28 days. Objective biometric data were collected using Oura Ring wearable devices. Validated participant-reported outcomes (e.g., Pittsburgh Sleep Quality Index (PSQI) and Short Form 36 Health Survey (SF-36)) helped to explore perceived tolerability, early efficacy signals, and mechanistic trends in a healthy adult population.</p><p><strong>Results: </strong>Twenty-two participants completed the study and were included in the final analysis. Compared to baseline, supplementation with Somato® tomato fruit extract significantly improved percentage change of sleep latency (-33%, PSQI, P = .005; -11.55%, Oura ring, P = .016), time awake (Oura ring, -10.08%, P = .002), sleep efficiency (Oura ring, -1.21%, P = .011), and global PSQI score (-14.22%, P = .025). A significant improvement was also noted in emotional well-being (8.22%, P = .02) based on the SF-36 health-related quality of life questionnaire. Other SF-36 variables also showed improvements that did not reach statistical significance, including general health (3.22%), energy & fatigue (15.12%), limitations due to emotional problems (15.22%), pain (5.83%), social functioning (6.11%), and physical function (2.81%).</p><p><strong>Conclusion: </strong>Supplementation with 2 mg/day of phytomelatonin from Somato® tomato fruit extract improved both physiological and psychological measures associated with sleep quality, autonomic function, and health-related quality of life. These findings support the feasibility of phytomelatonin as a plant-based sleep aid and warrant further investigation in a larger, randomized controlled trial.</p><p><strong>Keywords: </strong>tomato, melatonin, phytomelatonin, sleep latency, sleep efficiency, Pittsburgh Sleep Quality Index, Short Form 36 Health Survey, Oura ring, emotional well-being, energy, fatigue, pain, social functioning, physical function.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-Based Clinical Effectiveness of Kundalini Yoga: Systematic Review of RCTs Across Multiple Health Conditions.","authors":"Sharmistha Roy, Ashis Kumar Biswas, Manoj Sharma","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Kundalini Yoga (KY) integrates breathwork, meditation, dynamic movement, and chanting, and has gained recognition as a therapeutic intervention. Despite promising results from individual randomized controlled trials (RCTs), to our knowledge, no systematic review has exclusively synthesized RCT evidence on KY across health domains.</p><p><strong>Objective: </strong>To critically assess the clinical effectiveness and safety of KY interventions across diverse cognitive, psychological, emotional, sleep-related, and physical health outcomes.</p><p><strong>Methods: </strong>PRISMA-guided systematic review of RCTs evaluating KY was conducted from January 2015 to December 2024. Databases included MEDLINE (PubMed), Scopus, CENTRAL (Cochrane Library), Embase, PsycINFO, and CINAHL. Risk of bias was independently assessed using the Joanna Briggs Institute Critical Appraisal Checklist.</p><p><strong>Setting: </strong>Studies were conducted worldwide, across multiple sites.</p><p><strong>Participants: </strong>Approximately 1370 participants ranging from healthy adults to those diagnosed with conditions such as Mild Cognitive Impairment (MCI), Generalized Anxiety Disorder (GAD), Obsessive-Compulsive Disorder (OCD), Post-Traumatic Stress Disorder (PTSD), insomnia, chronic pain, and post-treatment Lyme disease syndrome. No serious adverse events were reported.</p><p><strong>Intervention: </strong>KY protocols (pranayama, asana/kriya, meditation, chanting) delivered in person, online, or hybrid formats; duration 6 weeks-12 months (most 8-12 weeks) with practice from once weekly to daily.</p><p><strong>Outcome measures: </strong>Pre-specified validated measures assessed cognitive function, psychological symptoms (e.g., anxiety, depression), sleep quality, emotional regulation, and physical health outcomes (e.g., hippocampal metrics, absenteeism, blood pressure).</p><p><strong>Results: </strong>This systematic review included 15 studies, among which 13 demonstrated a low risk of bias. The findings suggest that KY significantly improves memory, executive functioning, and hippocampal structure, reduces symptoms of anxiety, PTSD, OCD, and depression, enhances sleep quality and emotional regulation, and modestly improves fatigue, blood pressure, and functional outcomes.</p><p><strong>Conclusion: </strong>KY appears safe and shows benefits for a wide range of cognitive, psychological, and physical health conditions. However, larger, standardized RCTs with active comparators, biomarkers, and longer follow-up are needed.</p><p><strong>Keywords: </strong>Kundalini Yoga, randomized controlled trials, cognitive function, mental health, sleep, PTSD, hypertension, complementary therapy, mind-body intervention.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy of Traditional Unani Medicine Formulations Versus Apremilast for Chronic Plaque Psoriasis: A Randomized Controlled Trial.","authors":"Sabreena Bashir, Muzafar Din Ahmad Bhat, Mohd Arshad Jamal, Ruksar Ayesha","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis remains an incurable and recurrent condition despite modern treatment. Traditional Unani Medicine recommends numerous formulations for psoriasis, but with little supporting scientific evidence.</p><p><strong>Primary study objectives: </strong>The study aimed to evaluate the efficacy and safety of Majoon Mundi and Roghan Gul compared to apremilast and coconut oil in managing chronic plaque psoriasis (CPP).</p><p><strong>Methods/design: </strong>The study was a randomized, open-label, standard-controlled clinical trial, with 33 participants. 20 patients completed the 6-week treatment course in the test group, while 10 patients completed the 6-week treatment course in the control group.</p><p><strong>Setting: </strong>The study was conducted at the National Institute of Unani Medicine (NIUM), Bangalore, India, from June 2021 to December 2021.</p><p><strong>Participants: </strong>Participants aged 18-60 years, of either gender, diagnosed with CPP, and based on psoriasis area and severity index (PASI) score.</p><p><strong>Interventions: </strong>The participants in the test group received 10 g of Majoon Mundi orally twice daily after meals and Roghan Gul for topical use twice daily, while the participants in the active control group received apremilast orally in a titrated dose and coconut oil as a topical application twice daily.</p><p><strong>Outcome measures: </strong>The primary outcome of the study was a reduction in PASI score, and the secondary outcome was a reduction in dermatology life quality index (DLQI) score. Photographic assessments were conducted at the 14th, 28th, and 42nd day of the follow-up period.</p><p><strong>Results: </strong>Intragroup analyses revealed that the test and control groups experienced a statistically significant reduction in PASI and DLQI scores (P < .001). Intergroup analysis showed no statistically significant difference in the reduction of PASI and DLQI scores between groups (P = .772 and .775, respectively).</p><p><strong>Conclusion: </strong>This study found that together, Majoon Mundi and Roghan Gul are as effective as apremilast and coconut oil in decreasing PASI and DLQI scores for managing CPP.</p><p><strong>Keywords: </strong>apremilast, comparative study, herbal medicine, psoriasis, unani medicine.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Role of Yoga and Naturopathy as Complementary Therapies in Chronic Kidney Disease Management: A Case Study.","authors":"K Harshini, V R Abitone, Shivaprasad Shetty","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a progressive condition often associated with hypertension and diabetes, leading to impaired renal function and poor quality of life.</p><p><strong>Objective: </strong>This study employed alternative and holistic approaches to enhance kidney function in a 56-year-old male diagnosed with CKD in 2021, hypertension in January 2021, and diabetes mellitus type 2 in 2022, who presented with worsening renal function and back pain symptoms.</p><p><strong>Study design: </strong>Single-patient case study at a single centre.</p><p><strong>Intervention: </strong>A 12-day intervention based on an integrated naturopathy and yoga approach was provided, which included therapeutic yoga, diet, hydrotherapy, manipulative, and relaxation techniques.</p><p><strong>Setting: </strong>Sri Dharmasthala Manjunatheshwara Yoga and Nature Cure Hospital, Dharmasthala, India.</p><p><strong>Outcome measures: </strong>General parameters (weight and body mass index), blood pressure (systolic and diastolic), kidney profile (creatinine and urea), urine profile (protein and sugar), blood glucose (fasting blood sugar and postprandial blood sugar), and pain (using Visual Analog Scale).</p><p><strong>Results: </strong>Post-treatment evaluation showed a notable improvement in his fasting blood sugar (15%), postprandial blood sugar (32%), blood pressure (~10%), serum creatinine (32%), proteinuria, glycosuria, and pain score relief (60-80%).</p><p><strong>Conclusion: </strong>This suggests that an integrated yoga and naturopathy approach may be considered an alternative or adjunct treatment for managing CKD. However, additional research is needed to validate these findings.</p><p><strong>Keywords: </strong>chronic kidney disease, yoga, naturopathy, diet, case study.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fasd (Venesection) as a Treatment Option for Sciatica (Irq al-Nasa): A Case Report.","authors":"X Saliha, Faizan Khan, Syed Faisal Ali, Mohammad Naseem Khan, Ehsan Ahmad","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Sciatica is a type of musculoskeletal pain experienced in the leg along the distribution of the sciatic nerve. It is occasionally accompanied by lower backache. According to the Unani system of medicine, Irq al-Nasa (Sciatica) is a form of Wajaul Mafasil (Arthritis), characterised by hip pain that travels from the back of the thigh to the ankle joint. Conventional treatments for Sciatica typically involve medication, surgery, or occasionally both. The use of corticosteroids and painkillers is associated with a higher risk of adverse events, and their effectiveness is also questionable. This warrants the need for an effective, complementary treatment option for Sciatica.</p><p><strong>Aim: </strong>This case report aims to evaluate the efficacy of Fasd (Venesection) in managing Irq al-Nasa.</p><p><strong>Case description: </strong>The patient was a 63-year-old non-hypertensive, non-diabetic, euthyroid male, complaining of persistent left-sided pain in the upper thigh, lower buttock region, with pain radiating to the left leg, calf, and toes, along with numbness and tingling sensations. Sciatica was diagnosed based on three objective criteria: Visual Analogue Scale (VAS) pain score, Oswestry Disability Index (ODI), and Straight Leg Raising Test (SLRT), as well as from magnetic resonance imaging (MRI) of the lumbo-sacral spine.</p><p><strong>Intervention: </strong>Fasd (Venesection) was performed on the left saphenous minor vein of the patient once a week for two weeks. The patients were assessed using VAS, ODI, and SLRT.</p><p><strong>Outcome: </strong>Before the intervention, the VAS score was 8, the ODI was 42%, and the SLR was 30%. Following the first Fasd procedure, the VAS score decreased to 4, the ODI reduced to 22%, and the SLR improved to 60%. After the second procedure, the VAS score reached 0, the ODI further dropped to 8%, and the SLR increased to 90%.</p><p><strong>Conclusion: </strong>This case report provides preliminary evidence supporting the use of Fasd in treating Sciatica.</p><p><strong>Keywords: </strong>Fasd, Venesection, Sciatica, Irq al-Nasa, pain management, case report.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Transcriptomic Analysis Reveals Shared Molecular Signatures Between Asthma and Chronic Obstructive Pulmonary Disease.","authors":"Arman Mokaram Doust Delkhah, Milad Sheervalilou, Shahram Parvin, Masoud Arabfard","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Asthma and chronic obstructive pulmonary disease (COPD) are prevalent respiratory conditions with overlapping pathogenic features such as chronic inflammation.</p><p><strong>Primary study objective: </strong>This study aimed to identify key contributors and pathways that are common to both of these disorders, potentially allowing for the detection of therapeutic targets, particularly for patients with asthma-COPD overlap syndrome.</p><p><strong>Methods: </strong>Using an integrated transcriptomics approach, eight datasets were analyzed, including two each for COPD and asthma, in both blood and airway epithelial cells. Thereafter, by identifying shared differentially expressed genes between COPD and asthma, protein-protein interaction and miRNA-mRNA regulatory networks were constructed for blood and epithelial cells, and hub genes were determined. Lastly, functional enrichment analysis was conducted to determine the biological functions of the discovered shared protein-protein interaction (PPI) networks.</p><p><strong>Results: </strong>The construction of shared PPI networks for these two respiratory disorders highlighted key hub genes, including ribosomal proteins and IL-1β in blood and CTNNB1 in airway epithelial cells. Two members of the miR-30 family, including miR-30a-3p and miR-30e-3p, were discerned as multi-target regulators of hub genes in both networks of blood and airway epithelial cells. Infection-related pathways were substantially enriched, as revealed by functional analysis of shared networks for both blood and airway epithelial cells.</p><p><strong>Conclusion: </strong>IL-1β signaling may serve as a potential link between asthma and COPD, since it was identified as a hub gene in the shared network of blood. Likewise, downregulated CTNNB1 was discerned as a key gene in the shared network of airway epithelial samples.</p><p><strong>Keywords: </strong>asthma, chronic obstructive pulmonary disease, transcriptome, gene expression profiling, systems biology.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficiency of Curcumin and Fish Oil During the Formation of Pressure Ulcers in Mice: Do Curcumin and Fish Oil Prevent and Heal Pressure Ulcers?","authors":"Sevil Tultak, Ebru Karakoc, Birgul Yelken, Emine Dundar","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Context: &lt;/strong&gt;PUs increase mortality in intensive care units and the cost of hospital stays by prolonging the actual treatment process.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The study, in a mouse model, aimed to investigate the efficacy of curcumin and fish oil in preventing and healing PUs by administiring them simultaneously intraperitoneally.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;The research team performed an animal study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;The study took place at Eskişehir Osmangazi University's Medical and Surgical, Experimental Animal Practice Center.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Animals: &lt;/strong&gt;The animals were 28 healthy, female Balb c mice, eight weeks of age weighing about 30 grams.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Intervention: &lt;/strong&gt;The research team induced PUs in all mice using neodymium magnets capable of forming approximately 1000 Gauss of magnetic force.The team randomly divided the mice into four groups,with seven animals in each group: (1) the control group,which received an injecition if dimethyl sulfoxide (DMSO) only; (2) the curcumin group,which received an injection of 200 mg/kg of curcumin in DMSO; (3) the fish oil group,which received an injection of fish oil; and (4) the curcumin+fish oil group,which received an injection of 200 mg/kg of curcumin in DMSO and fish oil.The mice received all injections intraperitoneally.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcome measures: &lt;/strong&gt;To determine a wound's severity, the healing process, and nonhealing tissue, the research team examined the tissues separately: (1) dor degree of ulceration, (2) inflammation, (3) reepithelization, (4) neovascularization, and (5) granulation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study found third-degree pressure ulcer in all groups. No significant differences existed between the groups in terms of inflammation, which occurred in the control group with a maximum rate of 41.2%. The formation of reepithelization showed a significant difference between groups. Complete reepithelization ratios was higher in the fish oil group with 50% than the curcumin group and curcumin + fish oil group with 25%. Partiel reepithelization was seen with 46.1% highest ratio in curcumin + fish oil group. For neovascularization, the highest rate occurred in the curcumin +fish oil group at 75% at &gt;10 vessels per high power field (HPF) variable, and second highest ratio with 25% was curcumin group. Also 6-10 vessels per HPF (100%) was seen 42.9% in curcumin group and 42.9% in curcumin and fish oil group. Thus, amount of vessels were more in curcumin and fish oil group and curcumin group than control group and fish oil group. For formation of 3th degree granulation, the highest rate occurred in the fish oil group at 46.2% and second highest ratio was seen in curcumin + fish oil group with 38%. 2nd degree granulation was seen 55.6% in curcumin group. Thus, giving treatment induces the granulation that seen the lowest granulation in control group with 100%.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The current res","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Botanical Oral Health Products in Reducing Pathogenic Bacterial Overgrowth and Improving Gingival Health: A Case Report.","authors":"Ariana Ebrahimian, Shawn Manske, Christopher R D'Adamo, Kristen Klos-Maki","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Abstract: </strong>This case report evaluates the effectiveness of botanical oral health products in managing bacterial overgrowth and enhancing gingival and periodontal health in a 34-year-old female patient with mild-to-moderate gingivitis. The patient presented with bleeding on probing and positive pathogenic bacterial culture testing. The treatment regimen included a botanical toothpaste and oral rinse (Dentalcidin® and Dentalcidin® LS), oral probiotic, and dysbiosis protocol (Bioclear® Microbiome Detox Program). Post-treatment assessments revealed significant reductions in bleeding on probing and a marked decline in bacterial colony counts, indicating improved microbial balance. The bleeding index was reduced from 21% to 4% after six months, and from 4% to 1% during the subsequent three months using a botanical toothpaste and oral rinse. Periodontal pathogens that were present pre-treatment at high-risk levels were reduced to low-risk levels. These findings suggest that botanical oral health products can reduce bacterial overgrowth and improve periodontal parameters, offering a viable alternative to conventional therapies.</p><p><strong>Keywords: </strong>case report, oral microbiome, biofilm, oral dysbiosis, Tannerella forsythia, Fusobacterium nucleatum, herbal (botanical) medicine.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145123896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}