Mahesh Sharma, Sourabh Deshmukh, Trupti Thakre, Rohit Waskar, Nitika Senger
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引用次数: 0
Abstract
Background: Huntington's Chorea is a progressive neurodegenerative disorder characterized by involuntary movements, cognitive decline, and psychiatric disturbances. It is caused by an autosomal dominant mutation in the HTT gene, leading to an abnormal expansion of CAG repeats. The disease typically manifests in mid-adulthood and gradually worsens over time. The progressive nature of the disease leads to motor, cognitive, and psychiatric impairments, significantly affecting the quality of life.
Aim: This study aims to highlight the progressive nature of Huntington's disease, its impact on motor and cognitive functions, and the role of symptomatic management in improving the patient's quality of life through Ayurveda.
Methods: A 40-year-old male presented with involuntary movement in the upper and lower extremities, difficulty in doing daily routine work, anxiety, difficulty in walking, and sleeplessness for a year. A thorough Huntington's disease mutation analysis was conducted to confirm the diagnosis. The patient was treated with Ayurvedic shodana (Bio-purification), Sarvanga Snehan with Prasarini Taila, followed by Shashtik Shali Pinda Swedan, Nasya with Shadbindu Taila, Shiropichu with Brahmi Taila, Sarvang Dhara with dashmoola kwath, Erandmooladi niruh basti, and shamana (palliative) chikitsa (treatment), Zandopa powder, Balasaireyakadi Kashaya, Kalyanak ghrit, and capsule palsineuron orally for 4 months.
Result: Ayurvedic management promoted substantial improvements in behavioral health, neuromotor function, and activities of daily living as assessed by the Universidade Federal de Minas Gerais (UFMG) Sydenham's Chorea Rating Scale (USCRS).
Discussion: The patient's clinical presentation and diagnostic findings were consistent with Huntington's Chorea.
Conclusion: Huntington's Chorea is a debilitating condition with no definitive cure. Early diagnosis and a multidisciplinary management approach can help alleviate symptoms and improve patient well-being. Genetic counseling plays a crucial role in managing the familial impact of the disease.
Keywords: HTT gene, Genetic Counseling, CAG Repeat Expansion, Huntington's Chorea, Motor Dysfunction, Ayurvedic Medicine, Case Report.
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Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field.
Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.
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