Chronobiologia最新文献_第3页

Different programs of gene expression are associated with different phases of the 24h and sleep-wake cycles. 不同的基因表达程序与24小时和睡眠-觉醒周期的不同阶段有关。

Chronobiologia Pub Date : 1994-01-01

G Grassi Zucconi, M Menegazzi, A Carcereri De Prati, S Vescia, G Ranucci, M Bentivoglio

{"title":"Different programs of gene expression are associated with different phases of the 24h and sleep-wake cycles.","authors":"G Grassi Zucconi, M Menegazzi, A Carcereri De Prati, S Vescia, G Ranucci, M Bentivoglio","doi":"","DOIUrl":"","url":null,"abstract":"The Fos and Jun proteins are encoded by proto-oncogenes acting as immediate early genes in that they are rapidly induced by different kinds of stimuli in the nervous system. These two proteins bind to DNA regulating gene transcription, and thus determining the specificity of the neuronal response to the applied stimulation. We investigated whether the expression of these genes undergoes a variation during 24h in the absence of exogenous stimulation. Male Wistar adult (200 gr. body weight) rats, kept under a 12h/12h light-dark cycle, were sacrificed every 4h starting at 0700. The expression of c-fos, c-jun and jun B mRNAs was studied in six different brain areas by means of Northern blot hybridization, c-fos expression was also studied with in situ hybridization and immunohistochemistry. In basal conditions c-fos expression displayed a highly significant spontaneous oscillation, with the highest level during the darkness hours and the lowest during the light hours. Parallel levels of jun B expression were found in the cortex and striatum, whereas c-jun mRNA remained constantly high throughout 24 h. The periodicity of c-fos and jun B oscillation persisted also when the animals were exposed for 6 days to constant (24h/24h) light or darkness. Such oscillation could instead be inverted by manipulating the rest-activity cycle, i.e. keeping the animals awake during the light hours and allowing them to sleep during the dark hours. We then verified whether the expression of fos and jun could be correlated with states of wakefulness (W) and sleep (S), monitored with EEG recording under behavioral control.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":75705,"journal":{"name":"Chronobiologia","volume":"21 1-2","pages":"93-7"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18920224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telehygiene system for preventive chronopharmacology in space and remote areas on earth. 空间和地球偏远地区预防性时间药理学远程卫生系统。

Chronobiologia Pub Date : 1994-01-01

F Halberg, G Cornélissen, Y Kumagai, C Bingham, J Saito, K Tamura, K Otsuka, T Breus, S Rapoport, F Komarov

{"title":"Telehygiene system for preventive chronopharmacology in space and remote areas on earth.","authors":"F Halberg, G Cornélissen, Y Kumagai, C Bingham, J Saito, K Tamura, K Otsuka, T Breus, S Rapoport, F Komarov","doi":"","DOIUrl":"","url":null,"abstract":"A chronobiologic computerized modular health care (telehygiene) system for humans in extraterrestrial space 1) monitors and analyzes physiologic blood pressure, heart rate and other variation, including that in tumor markers; 2) recognizes earliest risk elevation by dynamic changes in the 'usual value' range (trend and rhythm alteration); 3) prompts timely and timed treatment for cardiovascular and emotional disease and malignancy prevention, and 4) serves for health improvement; the information from the system can also help optimize shift-work schedules for peak performance and provides endpoints of interest in basic science. The system exploits the chronome, a genetically anchored, habitat-synchronized structure of multifrequency rhythms and trends which is now documented (by longitudinal data series) to respond to magnetic disturbance in the solar system, with consequences expressed in catastrophic illness that is best prevented. Such a system, rated by peers as being of highest priority, could complement classical tools such as the stethoscope, proposed by the U.S. Johnson Space Center representative for use on the moon.","PeriodicalId":75705,"journal":{"name":"Chronobiologia","volume":"21 1-2","pages":"33-43"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18920371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chrono-neuroendocrinological aspects of physiological aging and senile dementia. 生理衰老和老年性痴呆的时间神经内分泌方面。

Chronobiologia Pub Date : 1994-01-01

D Dori, G Casale, S B Solerte, M Fioravanti, G Migliorati, G Cuzzoni, E Ferrari

{"title":"Chrono-neuroendocrinological aspects of physiological aging and senile dementia.","authors":"D Dori, G Casale, S B Solerte, M Fioravanti, G Migliorati, G Cuzzoni, E Ferrari","doi":"","DOIUrl":"","url":null,"abstract":"The circadian pattern of melatonin and cortisol secretion was evaluated in two groups of elderly subjects (aged 66-90 years), one with Alzheimer's type of multiinfarct dementia (n = 27) and the other without cognitive impairment (n = 16); 13 clinically healthy women aged 20 to 30 years were chosen as controls. All demented patients had severe mental impairment, corresponding to stage 6 of the Global Deterioration Scale. All subjects, either young or aged, were studied as in-patients and were well synchronized with respect to meal timing, diurnal activity and nocturnal rest. At the population mean cosinor analysis (Halberg, 1969) both melatonin and cortisol circadian rhythms reached statistical significance in the three groups of subjects. However, the melatonin circadian profile was clearly flattened in the two groups of elderly subjects by comparison with young controls, due to the selective impairment of melatonin nocturnal secretion. In both elderly groups, but particularly in demented patients, plasma cortisol levels were significantly higher by comparison to young controls, particularly at evening and night time. A significant direct relationship linked the subjects' age and the nadir values of plasma cortisol. Furthermore, the sensitivity of the hypothalamo-pituitary-adrenal axis to dexamethasone (DXM) suppression test (1 mg orally at 2300) was significantly reduced in both elderly groups, and especially in old demented patients, by comparison with young controls. Finally, plasma cortisol response to pulse i.v. injection of a small dose of synthetic corticotropin (Synacthen 2,500 ng) was significantly higher and more prolonged in old demented patients than in mentally healthy old subjects and in young controls.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":75705,"journal":{"name":"Chronobiologia","volume":"21 1-2","pages":"121-6"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18921122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of gestational hypertension by cosinor analysis of second trimester blood pressure. 孕中期血压余弦分析预测妊娠期高血压。

Chronobiologia Pub Date : 1994-01-01

A L Tranquilli, C Conti, B Rezai, G G Garzetti, C Romanini

{"title":"Prediction of gestational hypertension by cosinor analysis of second trimester blood pressure.","authors":"A L Tranquilli, C Conti, B Rezai, G G Garzetti, C Romanini","doi":"","DOIUrl":"","url":null,"abstract":"Objective: We evaluated the efficacy of cosinor analysis of blood pressure (BP) at the second trimester in predicting the subsequent development of gestational hypertension.Study design: We performed the cosinor analysis of BP in 313 normotensive non-proteinuric nulliparous women at the second trimester. We followed the pregnancy up to delivery and recorded the subsequent occurrence of gestational hypertension (sGH). We compared data from this group of 33 patients with those from the 280 women with uncomplicated normotensive pregnancy. We used the ANOVA to compare the means, statistical significance was assessed at p < .05.Results: Diastolic MESOR of women with uncomplicated pregnancy was significantly lower than the GH patients, although both groups were definitely normotensive at the time of the recording. (Diastolic: Controls M = 62.2 +/- 1.5, A = 5.1 +/- 0.7, O = 14:07, p = .0001; sGH M = 73.5 +/- 6.2m, A = 5.9 +/- 1.1, O = 14:48, p = .003; Systolic: Controls M = 108.3 +/- 2.2, A = 5.2 +/- 0.7, O = 15:00, p = .0001; sGH M = 122.4 +/- 2.1, A = 4.1 +/- 0.8, O = 15:59, p = .01) We did not find any other significant difference among the population-mean cosinors. The most sensitive cutoff of diastolic blood pressure MESOR proved to be 68 mmHg.","PeriodicalId":75705,"journal":{"name":"Chronobiologia","volume":"21 1-2","pages":"117-20"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18921121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human chronome research at the service of veterinary medicine: a legacy of Erna Halberg. 为兽医服务的人类生物钟研究:Erna Halberg的遗产。

Chronobiologia Pub Date : 1994-01-01

A P Arteaga, F Halberg, E Haus, A Alvarez, J C Illera, M Illera, G Cornélissen

引用次数: 0

Circadian variations and coronary artery disease. 昼夜节律变化与冠状动脉疾病。

Chronobiologia Pub Date : 1994-01-01

G H Rao

引用次数: 0

High affinity melatonin receptors in the vertebrate brain: implications for the control of the endogenous oscillatory systems. 高亲和力褪黑激素受体在脊椎动物大脑:内源性振荡系统的控制意义。

Chronobiologia Pub Date : 1994-01-01

F Fraschini, B Stankov

{"title":"High affinity melatonin receptors in the vertebrate brain: implications for the control of the endogenous oscillatory systems.","authors":"F Fraschini, B Stankov","doi":"","DOIUrl":"","url":null,"abstract":"Currently, the melatonin receptor is depicted as a membrane-associated protein, linked to a guanine nucleotide-binding protein (G-protein), and thus the melatonin receptor represents a member of a receptor superfamily, acting through G-proteins in the first step of their signal-transduction pathways. Although on a number of occasions specific binding of radioactive melatonin has been demonstrated in a wide variety of tissues and organs, to date, high affinity G-protein-regulated melatonin binding sites, suggestive for a functional melatonin receptor, have been convincingly confirmed in the brain only. There is a significant species variation in the distribution of the melatonin receptor in the vertebrate brain. The limited number of studies prevents any definitive conclusion in terms of phylogeny, though generally speaking, the lower vertebrates' brains tend to express melatonin receptors with wider distribution. Two sites have been consistently found to express high density of melatonin receptors: the pars tuberalis of the adenohypophysis and the hypothalamic suprachiasmatic nuclei (SCN). It must be pointed out, however, that there are some exceptions. Binding in the human pars tuberalis has not been reported, and apparently, the sheep and the mustelids' suprachiasmatic nuclei do not express detectable binding. The function of melatonin in pars tuberalis is unclear, and the control of the synthesis (and release) of paracrine factors that act at site(s) distant from the melatonin target cells, have been suggested.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":75705,"journal":{"name":"Chronobiologia","volume":"21 1-2","pages":"89-92"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18920223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian and circannual characteristics of blood pressure self-measured for 25 years by a clinically-healthy man. 临床健康男性自我测量血压25年的昼夜和年际特征

Chronobiologia Pub Date : 1994-01-01

R B Sothern

{"title":"Circadian and circannual characteristics of blood pressure self-measured for 25 years by a clinically-healthy man.","authors":"R B Sothern","doi":"","DOIUrl":"","url":null,"abstract":"A normotensive, clinically healthy, diurnally-active man, 20.5 years of age at start of study, used an aneroid sphygmomanometer to self-measure systolic (S) and diastolic (D) blood pressure (BP) in triplicate several times daily during waking-only for > 340 days/year for 25 years. The 39,321 mean values (from 117,963 readings) were analyzed by year after editing for time-zone changes and overt illness. A significant time-effect of day and year could be demonstrated by ANOVA at p < 0.001 during each year for both SBP and DBP. Notwithstanding the lack of data during sleep, a circadian rhythm was described by the least-squares fit of a 24h cosmic (Single Cosinor analysis) at p < 0.001 for each BP during each year. Acrophases for SBP and DBP remained remarkably stable, with the circadian acrophase of DBP consistently occurring at midday (13(44) h) and that of SBP consistently occurring in the early evening (19(32) h). A circannual rhythm could be demonstrated in 24 out of 25 years for both SBP and DBP, with acrophases generally occurring between late Fall and early Spring. No trend over the 25-year observation span was found in SBP (p = 0.61), but one of +0.16 mmHg/y was detectable in DBP (p = 0.02), much less than the average circadian (3 - 5 mmHg) and circannual amplitudes (0.9 - 1.3 mmHg). As a complement to automatic around-the-clock monitoring, long-term self-measurement of BP (and other physiologic variables) is feasible and can cost-effectively provide individualized reference values (ranges, MESOR, amplitude, acrophase) in conjunction with the assessment of 1) multiple rhythmic components, 2) age, and 3) trends, thereby providing a reasonable guide for prognosis and diagnosis.","PeriodicalId":75705,"journal":{"name":"Chronobiologia","volume":"21 1-2","pages":"7-20"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18920376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of blood pressure, heart rate and activity between normotensive and spontaneously-hypertensive rats. 正常和自发性高血压大鼠血压、心率和活动的比较。

Chronobiologia Pub Date : 1994-01-01

I Kohno, H Honma, T Nakamura, K Tamura

引用次数: 0

Altered circadian rhythms of natural killer (NK) cell activity in patients with autoimmune rheumatic diseases. 自身免疫性风湿病患者自然杀伤(NK)细胞活性的昼夜节律改变

Chronobiologia Pub Date : 1994-01-01

R G Masera, R Carignola, A H Staurenghi, M L Sartori, A Lazzero, G Griot, A Angeli

{"title":"Altered circadian rhythms of natural killer (NK) cell activity in patients with autoimmune rheumatic diseases.","authors":"R G Masera, R Carignola, A H Staurenghi, M L Sartori, A Lazzero, G Griot, A Angeli","doi":"","DOIUrl":"","url":null,"abstract":"Natural Killer (NK) cells are a lymphocyte subset actively involved in cytotoxicity against tumor-transformed and virus-infected cells; they are a reliable model for the study of neuroendocrine-immune interactions. In previous works we demonstrated that in healthy subjects NK activity of peripheral blood mononuclear cells (PBMC) and susceptibility to endogenous modifiers display statistically validated circadian rhythms. In rheumatoid arthritis (RA) and in other autoimmune rheumatic diseases abnormalities of the circadian rhythm of serum cortisol and altered levels of NK cell activity have been reported. We evaluated the circadian pattern of NK cell activity in 7 hospitalized patients with autoimmune rheumatic diseases (4 RA, 1 scleroderma, 2 mixed connective tissue disease). Temporal variations of in vitro responses to either positive recombinant (immune interferon, r IFN-gamma IFN-gamma: 650 IU/ml; recombinant interleukin-2, r IL-2 IL-2: 100 IU/ml) or negative (cortisol: 10(-6) M) modifiers were also studied. Blood was drawn at 4h intervals for 24 h, starting at 0800. PBMC preparations were immediately separated and incubated for 20h in the presence or absence of modifiers. NK activity was assessed with a direct non-radiometric 4h cytolytic assay, using K 562 cells as targets. Significant circadian variations of spontaneous NK activity were documented only in women with RA, with a peak in the evening hours and a minimum in the night or in the early morning (p < 0.05, PR 51.5%, phi 1829). Population-mean cosinor analysis did not yield detection of significant circadian variations of in vitro responsiveness to modifiers.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":75705,"journal":{"name":"Chronobiologia","volume":"21 1-2","pages":"127-32"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18920369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0