Chronobiologia最新文献_第2页

Biomedical pattern discrimination of neonatal cardiovascular risk. 新生儿心血管风险的生物医学模式辨析。

Chronobiologia Pub Date : 1994-07-01

R C Hermida

{"title":"Biomedical pattern discrimination of neonatal cardiovascular risk.","authors":"R C Hermida","doi":"","DOIUrl":"","url":null,"abstract":"Genetic risk is a primary contributing factor to the predisposition of a newborn child to elevated blood pressure later in life. An index for this factor is needed to assess in the neonate the success or failure of preventive interventions instituted for the pregnant woman. This index could be based on characteristics describing the variability of blood pressure and heart rate during the first days after birth. In the search for such an index, the systolic and diastolic blood pressures and heart rates of 150 newborn babies were automatically monitored at about 30-minute intervals for 48h with a Nippon Colin device, starting early after birth. On the basis of questionnaires given to the parents, the neonates were assigned to a group of either a negative or positive family history of high blood pressure, according to the absence or presence of high blood pressure and/or related cardiovascular disease in two generations (those of the newborn's parents and grandparents). Circadian characteristics and descriptive statistics for the three circulatory variables were used for classification by a so-called \"monotest\", an all-subsets variable selection technique for biomedical discriminant analysis. For a particular combination of variables, the \"monotest\" performs as many steps of separate analyses as the total number of subjects, each subject's data being compared as a set with those of all others (\"leave-one-out\" approach). When the circadian amplitude of systolic blood pressure was used as classifier, the \"monotest\" yielded a 63% classification equivalent to prior criteria, the latter being based on a negative or a positive family history of high blood pressure. The \"monotest\" complements rhythmometric procedures and defines a set of individualized criteria for risk assessment. The combined use of automatic hardware for time-specified sampling with proper software for signal processing and discriminant analysis allows to recognize parameters of blood pressure circadian variability as a source of information for neonatal classification according to cardiovascular disease risk.","PeriodicalId":75705,"journal":{"name":"Chronobiologia","volume":"21 3-4","pages":"227-40"},"PeriodicalIF":0.0,"publicationDate":"1994-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18732307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian rhythmic hepatic biliary flow, constituents, concentrations and excretory rates in patients after cholecystectomy. 胆囊切除术后患者的昼夜节律性肝胆流量、成分、浓度和排泄率。

Chronobiologia Pub Date : 1994-07-01

K J Ho

{"title":"Circadian rhythmic hepatic biliary flow, constituents, concentrations and excretory rates in patients after cholecystectomy.","authors":"K J Ho","doi":"","DOIUrl":"","url":null,"abstract":"Twelve adult patients with indwelling common bile duct T-tube were selected for the study of circadian fluctuation of biliary excretion. From the 10th postoperative day on when the enterohepatic circulation was well reestablished a 5 ml bile sample was collected at the end of each 4-h interval for 3 to 4 days for determination of the concentrations of various biliary constituents. This was followed by measurement of bile flow rate by collecting the bile continuously through the T-tube at 4-h intervals for another 3 to 4 days. One quarter of the twelve patients showed no persistent daily fluctuation of all the variables studied. A circadian rhythm was demonstrated by single cosinor rhythmometry in the biliary concentrations of bile acid, cholesterol, phospholipid, bilirubin, alkaline phosphatase, and lactate dehydrogenase in the remaining nine patients. Among them six also showed a circadian fluctuation of hepatic bile flow. The lack of synchronization of the rhythm of the concentrations of various biliary constituents with the bile flow rate resulted in undetectability of a circadian rhythm for their excretory rate in the great majority of patients. Those few patients in whom a rhythm remained to be detectable had a much reduced amplitude but the same acrophase. We concluded that bile flow rate played a major role in the circadian rhythm of biliary excretion and might coordinate the fluctuation of the concentrations of various biliary constituents. However, a true circadian rhythm for their concentrations also existed at least in certain subjects.","PeriodicalId":75705,"journal":{"name":"Chronobiologia","volume":"21 3-4","pages":"283-92"},"PeriodicalIF":0.0,"publicationDate":"1994-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18730220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistical significance without biologic signification is not enough: illustrative example. 没有生物学意义的统计学意义是不够的:举例说明。

Chronobiologia Pub Date : 1994-07-01

G Cornélissen, R B Sothern, H W Wendt, B Tarquini, M Antuñano, J Siegelová, B Fiser, J Dusek, P Prikryl, F Halberg

引用次数: 0

Subjective time scaling: influence of age, gender, and Type A and Type B behavior. 主观时间尺度:年龄、性别、A型和B型行为的影响。

Chronobiologia Pub Date : 1994-07-01

A D Eisler, H Eisler

引用次数: 0

Cross-spectral coherence between geomagnetic disturbance and human cardiovascular variables at non-societal frequencies. 在非社会频率地磁干扰和人类心血管变量之间的交叉光谱相干性。

Chronobiologia Pub Date : 1994-07-01

Y Watanabe, D C Hillman, K Otsuka, C Bingham, T K Breus, G Cornélissen, F Halberg

引用次数: 0

A local renin-angiotensin system in the human adrenal gland: evaluation of in vitro secretion by a non-parametric combination of randomness permutation tests. 人肾上腺局部肾素-血管紧张素系统:通过随机排列试验的非参数组合评估体外分泌。

Chronobiologia Pub Date : 1994-07-01

P Belluardo, F Fallo

引用次数: 0

Broad scope of a newly developed actometer in chronobiology, particularly chronocardiology. 一种新开发的时间生物学，特别是时间心脏学的宽范围活络计。

Chronobiologia Pub Date : 1994-07-01

K Otsuka, G Cornélissen, F Halberg

{"title":"Broad scope of a newly developed actometer in chronobiology, particularly chronocardiology.","authors":"K Otsuka, G Cornélissen, F Halberg","doi":"","DOIUrl":"","url":null,"abstract":"The scope and the details of a newly developed actometer were introduced. We are able to select a desired threshold of gravity(g)-forces between 0.01g and 0.50g and to simultaneously monitor 3 kinds of activity along with an averaged g-force every minute. As a routine study, we monitored at settings of 0.01g, 0.05g and 0.20g and averaged on one channel. Part of the time, physical activity was monitored together with ambulatorily monitored blood pressure (BP) and the ECG, or at least heart rate (HR). Physical activity showed a circasemiseptan and circaseptan periodicity as well as the circadian component, especially in subjects with an irregular sleep-wakefulness life style. On the average, physical activity was greater on a working day than on a holiday. Everyday physical activity reflects in part the ability to exercise, and it is expected that this actometer can contribute or provide an objective individualized quality-of-life index. The effect of physical activity on circadian profiles of BP, HR and HR variability is also examined. We observed that BP started to increase several hours before getting up. This fact likely shows that there is an endogenous circadian rhythm in BP, independently of the sleep-wakefulness cycle. Lastly, we investigated the relationship between physical activity and HR in patients permanently paced; we confirmed that the DDDR pacing mode was more physiological than the VVI or VVIR mode. This newly developed actometer will bring about further progress in chronobiology.","PeriodicalId":75705,"journal":{"name":"Chronobiologia","volume":"21 3-4","pages":"251-64"},"PeriodicalIF":0.0,"publicationDate":"1994-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18732308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Agostino Carandente. 奥古斯丁·卡兰登特。

Chronobiologia Pub Date : 1994-07-01

F Halberg

引用次数: 0

Models for chronobiologic risk and prepathology detection. A tribute to Bill W. Kennedy. 时间生物学风险和病理前检测模型。向比尔·w·肯尼迪致敬。

Chronobiologia Pub Date : 1994-07-01

F Halberg, F Guillaume, G Cornélissen

引用次数: 0

Further data and analyses. 进一步的数据和分析。

Chronobiologia Pub Date : 1994-07-01

F Carandente, G Cornélissen, F Halberg

引用次数: 0