高亲和力褪黑激素受体在脊椎动物大脑:内源性振荡系统的控制意义。

Chronobiologia Pub Date : 1994-01-01
F Fraschini, B Stankov
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引用次数: 0

摘要

目前,褪黑激素受体被描述为一种膜相关蛋白,与鸟嘌呤核苷酸结合蛋白(g蛋白)相连,因此褪黑激素受体代表了受体超家族的成员,在其信号转导途径的第一步通过g蛋白起作用。尽管在许多情况下,放射性褪黑激素的特异性结合已经在多种组织和器官中得到证实,但迄今为止,高亲和力的g蛋白调节的褪黑激素结合位点(提示功能性褪黑激素受体)仅在大脑中得到令人信服的证实。在脊椎动物大脑中,褪黑素受体的分布有显著的物种差异。虽然一般来说,低等脊椎动物的大脑倾向于表达分布更广的褪黑激素受体,但由于研究数量有限,无法在系统发育方面得出明确的结论。有两个部位一直被发现表达高密度的褪黑激素受体:垂体腺结节部和下丘脑视交叉上核(SCN)。然而,必须指出,也有一些例外。人类结节部的结合尚未见报道,显然,绵羊和鼠的视交叉上核未表达可检测到的结合。褪黑素在结节部中的作用尚不清楚,有人建议对远离褪黑素靶细胞的旁分泌因子的合成(和释放)进行控制。(摘要删节250字)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High affinity melatonin receptors in the vertebrate brain: implications for the control of the endogenous oscillatory systems.

Currently, the melatonin receptor is depicted as a membrane-associated protein, linked to a guanine nucleotide-binding protein (G-protein), and thus the melatonin receptor represents a member of a receptor superfamily, acting through G-proteins in the first step of their signal-transduction pathways. Although on a number of occasions specific binding of radioactive melatonin has been demonstrated in a wide variety of tissues and organs, to date, high affinity G-protein-regulated melatonin binding sites, suggestive for a functional melatonin receptor, have been convincingly confirmed in the brain only. There is a significant species variation in the distribution of the melatonin receptor in the vertebrate brain. The limited number of studies prevents any definitive conclusion in terms of phylogeny, though generally speaking, the lower vertebrates' brains tend to express melatonin receptors with wider distribution. Two sites have been consistently found to express high density of melatonin receptors: the pars tuberalis of the adenohypophysis and the hypothalamic suprachiasmatic nuclei (SCN). It must be pointed out, however, that there are some exceptions. Binding in the human pars tuberalis has not been reported, and apparently, the sheep and the mustelids' suprachiasmatic nuclei do not express detectable binding. The function of melatonin in pars tuberalis is unclear, and the control of the synthesis (and release) of paracrine factors that act at site(s) distant from the melatonin target cells, have been suggested.(ABSTRACT TRUNCATED AT 250 WORDS)

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