Circadian and circannual characteristics of blood pressure self-measured for 25 years by a clinically-healthy man.

Chronobiologia Pub Date : 1994-01-01
R B Sothern
{"title":"Circadian and circannual characteristics of blood pressure self-measured for 25 years by a clinically-healthy man.","authors":"R B Sothern","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>A normotensive, clinically healthy, diurnally-active man, 20.5 years of age at start of study, used an aneroid sphygmomanometer to self-measure systolic (S) and diastolic (D) blood pressure (BP) in triplicate several times daily during waking-only for > 340 days/year for 25 years. The 39,321 mean values (from 117,963 readings) were analyzed by year after editing for time-zone changes and overt illness. A significant time-effect of day and year could be demonstrated by ANOVA at p < 0.001 during each year for both SBP and DBP. Notwithstanding the lack of data during sleep, a circadian rhythm was described by the least-squares fit of a 24h cosmic (Single Cosinor analysis) at p < 0.001 for each BP during each year. Acrophases for SBP and DBP remained remarkably stable, with the circadian acrophase of DBP consistently occurring at midday (13(44) h) and that of SBP consistently occurring in the early evening (19(32) h). A circannual rhythm could be demonstrated in 24 out of 25 years for both SBP and DBP, with acrophases generally occurring between late Fall and early Spring. No trend over the 25-year observation span was found in SBP (p = 0.61), but one of +0.16 mmHg/y was detectable in DBP (p = 0.02), much less than the average circadian (3 - 5 mmHg) and circannual amplitudes (0.9 - 1.3 mmHg). As a complement to automatic around-the-clock monitoring, long-term self-measurement of BP (and other physiologic variables) is feasible and can cost-effectively provide individualized reference values (ranges, MESOR, amplitude, acrophase) in conjunction with the assessment of 1) multiple rhythmic components, 2) age, and 3) trends, thereby providing a reasonable guide for prognosis and diagnosis.</p>","PeriodicalId":75705,"journal":{"name":"Chronobiologia","volume":"21 1-2","pages":"7-20"},"PeriodicalIF":0.0000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chronobiologia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

A normotensive, clinically healthy, diurnally-active man, 20.5 years of age at start of study, used an aneroid sphygmomanometer to self-measure systolic (S) and diastolic (D) blood pressure (BP) in triplicate several times daily during waking-only for > 340 days/year for 25 years. The 39,321 mean values (from 117,963 readings) were analyzed by year after editing for time-zone changes and overt illness. A significant time-effect of day and year could be demonstrated by ANOVA at p < 0.001 during each year for both SBP and DBP. Notwithstanding the lack of data during sleep, a circadian rhythm was described by the least-squares fit of a 24h cosmic (Single Cosinor analysis) at p < 0.001 for each BP during each year. Acrophases for SBP and DBP remained remarkably stable, with the circadian acrophase of DBP consistently occurring at midday (13(44) h) and that of SBP consistently occurring in the early evening (19(32) h). A circannual rhythm could be demonstrated in 24 out of 25 years for both SBP and DBP, with acrophases generally occurring between late Fall and early Spring. No trend over the 25-year observation span was found in SBP (p = 0.61), but one of +0.16 mmHg/y was detectable in DBP (p = 0.02), much less than the average circadian (3 - 5 mmHg) and circannual amplitudes (0.9 - 1.3 mmHg). As a complement to automatic around-the-clock monitoring, long-term self-measurement of BP (and other physiologic variables) is feasible and can cost-effectively provide individualized reference values (ranges, MESOR, amplitude, acrophase) in conjunction with the assessment of 1) multiple rhythmic components, 2) age, and 3) trends, thereby providing a reasonable guide for prognosis and diagnosis.

临床健康男性自我测量血压25年的昼夜和年际特征
一名血压正常,临床健康,每日活动的男性,研究开始时20.5岁,使用无血管血压计自我测量收缩压(S)和舒张压(D) (BP),一式三次,每天数次,仅在清醒时进行,超过340天/年,持续25年。在对时区变化和显性疾病进行编辑后,对39,321个平均值(来自117,963个读数)进行了年分析。在每年的收缩压和舒张压的方差分析中,p < 0.001可以证明日期和年份的显著时间效应。尽管缺乏睡眠期间的数据,但通过24小时宇宙(单余弦分析)的最小二乘拟合来描述昼夜节律,每年的每个血压p < 0.001。收缩压和舒张压的顶相保持显著稳定,舒张压的昼夜节律顶相始终发生在正午(13(44)h),收缩压的昼夜节律顶相始终发生在傍晚(19(32)h)。收缩压和舒张压的昼夜节律在25年中有24年存在周期性,顶相通常发生在深秋和早春之间。在25年的观测范围内,收缩压没有变化趋势(p = 0.61),但舒张压有+0.16 mmHg/y的变化趋势(p = 0.02),远低于平均昼夜节律(3 - 5 mmHg)和年轮振幅(0.9 - 1.3 mmHg)。作为自动24小时监测的补充,长期自我测量血压(以及其他生理变量)是可行的,并且可以经济有效地提供个性化的参考值(范围、MESOR、振幅、肢相),同时评估1)多种节律成分,2)年龄,3)趋势,从而为预后和诊断提供合理的指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信