American Journal of Ophthalmology最新文献

{"title":"Comment on: Dropped Lens Fragments Retrieval Using Endoscopy-Assisted Pars Plana Vitrectomy in Patients With Corneal Opacity.","authors":"Fikret Ucar","doi":"10.1016/j.ajo.2025.03.048","DOIUrl":"10.1016/j.ajo.2025.03.048","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two novel extended depth-of-focus intraocular lenses targeted for mini-monovision: A prospective randomized controlled trial","authors":"Joukje C. Wanten,&nbsp;Noël J.C. Bauer,&nbsp;Tos T.J.M. Berendschot,&nbsp;Frank J.H.M. van den Biggelaar,&nbsp;Rudy M.M.A. Nuijts","doi":"10.1016/j.ajo.2025.04.024","DOIUrl":"10.1016/j.ajo.2025.04.024","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare the visual outcomes of two extended depth-of-focus (EDOF) intraocular lenses (IOLs).</div></div><div><h3>Design</h3><div>Single-center prospective randomized controlled trial.</div></div><div><h3>Methods</h3><div>Patients undergoing bilateral cataract surgery were randomly assigned to receive either the Acunex Vario IOL (Teleon Surgical B.V., Spankeren, The Netherlands) or the AcrySof IQ Vivity IOL (Alcon Laboratories Inc., Fort Worth, United States of America); both Vario-group and Vivity-group were targeted for mini-monovision. The primary outcome was the uncorrected intermediate visual acuity (UIVA, measured at 66cm). Secondary outcome parameters were uncorrected distance visual acuity (UDVA), uncorrected near visual acuity (UNVA), defocus curves, reading speed, contrast sensitivity, spectacle independence and quality of vision.</div></div><div><h3>Setting</h3><div>University Eye Clinic, Maastricht University Medical Center+, the Netherlands.</div></div><div><h3>Results</h3><div>A total of 31 subjects (62 eyes) were included, 16 patients were enrolled into the Vario-group and 15 patients into the Vivity-group. At three months postoperatively, no statistically significant differences were found for the binocular visual acuities between the groups after adjustment for covariates. The mean and standard deviation for the binocular UIVA was 0.04±0.11 and 0.15±0.11 logMAR (adjusted-P=0.264) for the Vario-group and Vivity-group, respectively. The binocular UDVA was 0.00±0.14 and 0.08±0.10 logMAR (adjusted-P=0.753), and UNVA was 0.22±0.17 and 0.31±0.14 logMAR (adjusted-P=0.235), for both groups, respectively. While the Vario-group had a larger range of defocus, no significant differences were found for patient satisfaction and spectacle independence. Contrast sensitivity and reading speed were comparable, and there were no statistically significant differences in optical side effects between the groups.</div></div><div><h3>Conclusion</h3><div>Bilateral implantation of the Acunex Vario IOL and the AcrySof IQ Vivity IOL targeted for mini-monovision had comparable results for binocular visual acuity outcomes, contrast sensitivity, optical side effects, and reading speed. The Vario-group showed a larger continuous range of defocus.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"276 ","pages":"Pages 286-296"},"PeriodicalIF":4.1,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pegcetacoplan Treatment for Geographic Atrophy in Age-Related Macular Degeneration Over 36 Months: Data From OAKS, DERBY, and GALE","authors":"Charles C. Wykoff ,&nbsp;Frank G. Holz ,&nbsp;Allen Chiang ,&nbsp;David Boyer ,&nbsp;Dilsher S. Dhoot ,&nbsp;Anat Loewenstein ,&nbsp;Jordi Mones ,&nbsp;Jeffrey Heier ,&nbsp;Ashkan M. Abbey ,&nbsp;Lawrence J. Singerman ,&nbsp;Lejla Vajzovic ,&nbsp;Jason Lin ,&nbsp;Chao Li ,&nbsp;Abhi Vilupuru ,&nbsp;Caroline R. Baumal ,&nbsp;OAKS, DERBY, and GALE Investigators","doi":"10.1016/j.ajo.2025.04.016","DOIUrl":"10.1016/j.ajo.2025.04.016","url":null,"abstract":"<div><h3>PURPOSE</h3><div>To report 12-month results from the GALE open-label extension study (NCT04770545), evaluating up to 36 months of intravitreal pegcetacoplan treatment for geographic atrophy (GA) in age-related macular degeneration (AMD).</div></div><div><h3>DESIGN</h3><div>GALE is a prospective open-label extension study following the 24-month, sham-controlled, phase 3 OAKS (NCT03525613) and DERBY (NCT03525600) studies of pegcetacoplan.</div></div><div><h3>PARTICIPANTS</h3><div>Patients with nonsubfoveal or subfoveal GA who completed OAKS, DERBY, or phase 1b APL2-103 (NCT03777332) studies.</div></div><div><h3>METHODS</h3><div>Pegcetacoplan was administered monthly (PM) or every other month (PEOM) to all study eyes in GALE. Eyes receiving pegcetacoplan in OAKS and DERBY continued the same regimen (PM-PM and PEOM-PEOM), while eyes observed with sham in OAKS and DERBY crossed over to receive pegcetacoplan at the same dosing interval in GALE (SM-PM and SEOM-PEOM). Safety and efficacy through the first 12 months of GALE were assessed, reflecting up to 36 months of continuous pegcetacoplan treatment.</div></div><div><h3>MAIN OUTCOME MEASURE</h3><div>Mean rate of change in GA area, total number of microperimetry scotomatous points, and adverse events.</div></div><div><h3>RESULTS</h3><div>Through the first 12 months of GALE, 92.0% (727/790) patient retention was observed. Across all eyes, including eyes with nonsubfoveal and subfoveal GA, pegcetacoplan reduced the mean rate of change in GA area up to 32% versus projected sham. Year after year, the reductions in the mean rate of change in GA area increased, with up to a 42% reduction observed in eyes with nonsubfoveal GA in the PM-PM group compared with projected sham in the first year of GALE. An 18% reduction in new scotomatous points (<em>P</em> = .0156) was observed with PM-PM at 36 months, highlighting a significant impact in a prespecified microperimetry analysis. Adverse events included 33 (4.5%) eyes with exudative AMD, 15 (1.9%) intraocular inflammation (classified as mild or moderate in severity), 1 (0.1%) ischemic optic neuropathy, and 1 (0.1%) infectious endophthalmitis. No events of vasculitis were reported.</div></div><div><h3>CONCLUSION</h3><div>Over 36 months, pegcetacoplan continued to reduce GA growth with increasing efficacy over time and reduced formation of new scotomatous points. The safety profile of pegcetacoplan in the first 12 months of GALE was consistent with the prior 24-month OAKS and DERBY studies.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"276 ","pages":"Pages 350-364"},"PeriodicalIF":4.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suprachoroidal drug delivery for VEGF suppression in wet AMD and other diseases with choroidal neovascularization.","authors":"Bryce Chiang,Yooree Grace Chung,Mark R Prausnitz","doi":"10.1016/j.ajo.2025.04.020","DOIUrl":"https://doi.org/10.1016/j.ajo.2025.04.020","url":null,"abstract":"PURPOSEChoroidal neovascularization caused by age-related macular degeneration, among other diseases, causes significant visual impairment. Intravitreal therapeutics inhibiting vascular endothelial growth factor (VEGF) signaling have shown excellent safety and efficacy in regressing choroidal neovascularization and improving vision. Current FDA-approved treatments deliver these drugs into the vitreous cavity, even though choroidal neovascularization originates from aberrant signaling in the choroid.DESIGNSystematic review METHODS: A literature search was conducted across PubMed and Google Scholar from inception up to December 31, 2024, focusing on studies investigating suprachoroidal delivery of anti-VEGF therapy. Randomized controlled trials, cohort studies, and case-control studies were included, while case reports and review articles were excluded.RESULTSFifteen peer-reviewed articles, 3 press releases, 6 conference abstracts and presentations, and 8 clinical trials were identified that relevant to the topic of suprachoroidal delivery of anti-VEGF therapy.CONCLUSIONThe suprachoroidal space is a potential space between the sclera and the choroid, which has recently become a route of delivery in an FDA-approved treatment. Notably, suprachoroidal delivery results in higher choroidal drug concentrations than intravitreal delivery. Promising results thus far have been seen with suprachoroidal delivery of VEGF-targeting therapies in clinical and pre-clinical studies; future work is needed to more-fully demonstrate safety and efficacy.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"67 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Penetrating Keratoplasty Versus Lamellar Endothelial Keratoplasty in Iridocorneal Endothelial Syndrome: A Systematic Review and Meta-Analysis","authors":"GÁBOR TÓTH ,&nbsp;SZILÁRD VÁNCSA ,&nbsp;TAMÁS KÓI ,&nbsp;KITTI KORMÁNYOS ,&nbsp;PÉTER HEGYI ,&nbsp;NÓRA SZENTMÁRY","doi":"10.1016/j.ajo.2025.04.017","DOIUrl":"10.1016/j.ajo.2025.04.017","url":null,"abstract":"<div><h3>Purpose</h3><div>To compare surgical outcomes following penetrating keratoplasty (PK), Descemet stripping endothelial keratoplasty (DSEK), and Descemet membrane endothelial keratoplasty (DMEK) in patients with iridocorneal endothelial (ICE) syndrome.</div></div><div><h3>Design</h3><div>Systematic review and meta-analysis on individual patient data (IPD).</div></div><div><h3>Methods</h3><div>Pre-registration was performed in the PROSPERO database (registration number: CRD42024539444). Eligible studies from Embase, MEDLINE (via PubMed), and the Cochrane Central Register of Controlled Trials (CENTRAL) were retrieved up to April 24, 2024. Studies were included those reporting clinical outcomes after PK, DSEK, or DMEK- graft survival, best spectacle-corrected visual acuity (BSCVA) and endothelial cell density (ECD) - in people with ICE syndrome. Cochrane Handbook was followed for data extraction/ synthesis, and the Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) and the Joanna Briggs Institute Critical Appraisal Checklists were used to assess risk of bias. Meta-analyses were conducted using a random-effects model. Heterogeneity between studies was assessed using Q-test and I² statistics.</div></div><div><h3>Results</h3><div>Nineteen of the 1963 screened studies were included in the meta-analysis. Multivariate pooled Kaplan-Meier curves with 95% confidence intervals, based on IPD from studies with at least 10 cases indicated that graft survival was better after PK compared to DSEK in patients with ICE syndrome. No significant difference (<em>P = .</em>92) was found in BSCVA improvement between PK [-0.77 (95% CI, -1.45 to -0.09)], DSEK [-0.87 (95% CI, -1.35 to -0.39)] and DMEK [-0.85 (95% CI, -1.07 to -0.62)]. No significant differences in ECD were observed between DSEK and DMEK 6 (<em>P = .</em>88) and 12 months (<em>P = .</em>33) postoperatively. IPD analysis revealed no significant difference in graft survival between patients with and without anytime glaucoma (-0.04 ± 0.50 SEM; <em>P = .</em>940) or cataract surgery (-0.45 ± 0.40 SEM; <em>P = .</em>265).</div></div><div><h3>Conclusions</h3><div>PK demonstrated better graft survival compared to DSEK in patients with ICE, however, further research and additional evidence are needed to draw more definitive conclusions. Improvements in BSCVA were comparable across PK, DSEK and DMEK. Glaucoma surgery, whether performed before or after keratoplasty, appear to have no significant impact on graft survival.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"276 ","pages":"Pages 218-229"},"PeriodicalIF":4.1,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Birth of a Change Agent: The Founding of “Women in Ophthalmology”","authors":"Marjorie A. Mosier ,&nbsp;Penny A. Asbell ,&nbsp;Jaqueline Lustgarten ,&nbsp;Jane D. Kivlin ,&nbsp;Eve Higginbotham ,&nbsp;Bronwyn Bateman","doi":"10.1016/j.ajo.2025.04.008","DOIUrl":"10.1016/j.ajo.2025.04.008","url":null,"abstract":"","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"276 ","pages":"Pages 261-271"},"PeriodicalIF":4.1,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rate of Progression Among Different Age Groups in Glaucoma With High Myopia: A 10-Year Follow-Up Cohort Study","authors":"Jaekyoung Lee ,&nbsp;Young In Shin ,&nbsp;Min Gu Huh ,&nbsp;Yoon Jeong ,&nbsp;Young Kook Kim ,&nbsp;Jin Wook Jeoung ,&nbsp;Ki Ho Park","doi":"10.1016/j.ajo.2025.04.012","DOIUrl":"10.1016/j.ajo.2025.04.012","url":null,"abstract":"<div><h3>PURPOSE</h3><div>To investigate the rate of structural and functional progression in different age groups of highly myopic glaucoma patients and identify risk factors associated with rate of change in functional parameters.</div></div><div><h3>DESIGN</h3><div>Retrospective clinical cohort study.</div></div><div><h3>METHODS</h3><div>This study included open-angle, normal-tension glaucoma (NTG) patients with high myopia who had been followed-up for at least 8 years. Patients were divided into two age groups, “younger (under age 40)” and “older (age 40 or over),” according to their age at presentation, and progression rates for visual field index (VFI), mean deviation (MD) and peripapillary retinal nerve fiber layer (RNFL) thickness were evaluated. Intergroup comparison was performed, and associations between age and progression rates for structural and functional parameters were assessed by scatter plots with linear regression and locally weighted scatterplot smoothing. Cox proportional hazards modeling was performed to identify factors for progression rate of functional parameters.</div></div><div><h3>RESULTS</h3><div>A total of 320 eyes of 320 highly myopic NTG patients (mean age at presentation, 38.7 ± 10.4 years) were included in this study with a mean follow-up duration of 13.1 ± 6.2 years. The rate of VFI, MD, and RNFL thickness change showed a positive correlation with the age at presentation (<em>P</em> = .013, .002, and .003, respectively). The mean rate of MD change was −0.36 ± 0.39 dB/year in younger age group and −0.22 ± 0.27 dB/year in older age group (<em>P</em> &lt; .01). In the locally weighted scatterplot, the rate of change in VFI, MD, and RNFL thickness showed a fast-progressing pattern in those aged 19 to 29 years and 40 to 49 years, and a slow-progressing pattern in those aged 30 to 39 years and 50 years or older. Baseline IOP (β= −0.041; 95% CIs, −0.139-0.413; <em>P</em> = .047) and baseline VFI (β= 0.364; 95% CIs, 0.247-0.461; <em>P</em> &lt; .01) was significantly related to the VF MD change rate.</div></div><div><h3>CONCLUSIONS</h3><div>The glaucoma progression rate in highly myopic NTG showed a bimodal pattern based on the age at presentation, younger patients exhibiting faster progression compared to older patients. Baseline IOP and VFI were significantly related to functional progression rate. The findings of this study may assist in deciding the treatment strategy for highly myopic NTG patients.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"276 ","pages":"Pages 201-209"},"PeriodicalIF":4.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal Sensory Changes and Nerve Plexus Abnormalities in Chronic Neuropathic Ocular Pain and Dry Eye Postrefractive Surgery","authors":"Amanda Vázquez ,&nbsp;Marta Blanco-Vázquez ,&nbsp;Elena Martínez-Plaza ,&nbsp;Eva M. Sobas ,&nbsp;María J. González-García ,&nbsp;Alberto López-Miguel ,&nbsp;Enrique Ortega ,&nbsp;Amalia Enríquez-de-Salamanca ,&nbsp;Margarita Calonge","doi":"10.1016/j.ajo.2025.04.004","DOIUrl":"10.1016/j.ajo.2025.04.004","url":null,"abstract":"<div><h3>Purpose</h3><div>Chronic neuropathic ocular pain (NOP) can develop alongside chronic dry eye (DE) post–laser-assisted in-situ keratomileusis (LASIK), yet its specific characteristics remain poorly understood. This study aims to compare the clinical characteristics of patients who developed both DE and NOP after LASIK to those with only DE and to asymptomatic LASIK patients, to facilitate the diagnosis of NOP.</div></div><div><h3>Methods</h3><div>Prospective, cross-sectional “case-control” comparison study<strong>.</strong> An 89-subject post-LASIK study comprised 3 groups: 34 patients developing NOP and DE (NOP-DE group), 25 patients developing only DE (DE group), and 30 asymptomatic subjects (control group). Assessments included clinical history and symptom questionnaires (OSDI, mSIDEQ, NRS, WFPRS), anxiety and depression evaluation (HADS), tear film stability (osmolarity and TBUT) and production (Schirmer), and ocular surface integrity. Corneal mechanical and thermal sensitivity thresholds were measured using Belmonte's noncontact esthesiometer, whereas tactile sensitivity threshold was assessed pre-/post-topical anesthesia using the Cochet-Bonnet esthesiometer. In vivo confocal microscopy (IVCM) was used to evaluate the sub-basal nerve plexus characteristics and dendritic cell density in the central cornea. Group comparisons and correlations were conducted.</div></div><div><h3>Results</h3><div>Compared with DE group, patients in the NOP-DE group exhibited significantly more DE symptoms with mSIDEQ (<em>P</em> = .019) higher level of pain with NRS and WFPRS, increased use of ocular lubrication (<em>P</em> = .003), greater frequency of patients with pathological results on anxiety and depression questionnaires (<em>P</em> &lt; .001), and a higher prevalence of central sensitization syndromes (<em>P</em> &lt; .001). Additionally, NOP-DE patients demonstrated higher tactile corneal sensitivity post-topical anesthesia (<em>P</em> = .002). IVCM revealed lower nerve density (<em>P</em> = .049) and higher microneuroma density (<em>P</em> = .008) in the sub-basal nerve plexus of NOP-DE patients compared to DE patients without NOP (<em>P</em> = .008). Most nerve metrics correlated moderately to strongly with clinical parameters.</div></div><div><h3>Conclusions</h3><div>Persistent high corneal tactile sensitivity postanesthesia, reduced nerve density, and increased microneuroma density in the central cornea may serve as diagnostic indicators for confirming NOP in patients experiencing chronic DE post-LASIK. These findings underscore the potential utility of incorporating these measures into clinical assessments to improve diagnostic accuracy and guide management strategies in this patient population.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"276 ","pages":"Pages 170-185"},"PeriodicalIF":4.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the SCREENROP Criteria for Retinopathy of Prematurity Screening: A Canadian Model for Consideration","authors":"Felicia Tai ,&nbsp;Yasmin Jindani ,&nbsp;Amit Mukerji ,&nbsp;Kourosh Sabri","doi":"10.1016/j.ajo.2025.04.010","DOIUrl":"10.1016/j.ajo.2025.04.010","url":null,"abstract":"<div><h3>Purpose</h3><div>Reducing unnecessary retinopathy of prematurity (ROP) screenings in neonates is important for minimizing morbidity associated with such examinations including pain for the child, anxiety in parents, and conserving healthcare resources. The Seminal Canadian Recommendations for Evidence-Based Examination of Neonates for Retinopathy of Prematurity (SCREEN-ROP) guidelines recommend only screening babies with birth weight (BW) &lt;1200 g or gestational age (GA) &lt;30 weeks to prevent unnecessary screenings. This study aims to retrospectively test the sensitivity of SCREEN-ROP in a large urban Canadian setting for capturing babies requiring treatment for ROP.</div></div><div><h3>Design</h3><div>Retrospective accuracy analysis of revised diagnostic testing criteria.</div></div><div><h3>Methods</h3><div>All babies born at McMaster Children Hospital from July 1, 2016 to May 31, 2024 who: 1) received at least one ROP eye exam, or 2) received ROP treatment, were included. Birth weight (BW) and gestational age (GA) at birth were collected from Canadian Neonatal Network (CNN) and BORN Ontario, which stores all information on babies admitted to level 3 and level 2 Neonatal Intensive Care Units (NICUs), respectively. SCREEN-ROP criteria were applied to the cohort. Institutional ethics approval was obtained from Hamilton Integrated Research Ethics Board (REB #13216-C) and CNN (REB #04-062).</div></div><div><h3>Results</h3><div>Sensitivity and specificity of the model was calculated with 95% confidence intervals. Chi-squarede test was used to compare the babies captured with SCREEN-ROP criteria versus prior criteria (GA&lt;31 weeks or birth weight &lt;1251 g). 823 unique babies were screened from July 1, 2016 to May 31, 2024 of which 79 unique babies were treated for ROP. Applying the SCREEN-ROP criteria captured all 79 babies requiring ROP treatment while avoiding another 61 babies (7.41%) from being unnecessarily enrolled into ROP screening. Sensitivity of SCREEN-ROP criteria for capturing babies requiring ROP treatment was 100% (95% CI: 95.44% to 100%), and the specificity was 8.20% (95% CI: 6.33% to 10.41%).</div></div><div><h3>Conclusions</h3><div>By screening babies with BW &lt;1200 g or GA &lt;30 weeks, 7.41% of babies would have been saved from unnecessary ROP screenings, and all babies requiring ROP treatment would have been captured with 100% sensitivity. Further validation in other large centers and countries may allow for broader implementation of SCREEN-ROP guidelines.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"276 ","pages":"Pages 230-234"},"PeriodicalIF":4.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Restrictive Strabismus Associated With Anomalous Orbital Structures: MRI Findings and Clinical Characteristics","authors":"Dan Wang ,&nbsp;Yan-Yan Yang ,&nbsp;Qing-Lin Chang ,&nbsp;Qian Ma ,&nbsp;Yi-Di Wang ,&nbsp;Feng-Yuan Man ,&nbsp;Yong-Hong Jiao","doi":"10.1016/j.ajo.2025.04.013","DOIUrl":"10.1016/j.ajo.2025.04.013","url":null,"abstract":"<div><h3>PURPOSE</h3><div>To evaluate and classify the magnetic resonance imaging (MRI) features of anomalous orbital structures (AOS) and correlate these findings with clinical manifestations.</div></div><div><h3>DESIGN</h3><div>Retrospective, observational case series.</div></div><div><h3>METHODS</h3><div>The detailed clinical data from 35 patients diagnosed with congenital restrictive strabismus and AOS were retrospectively reviewed between July 2010 and October 2024. All patients underwent brain stem and intraorbital MRI.</div></div><div><h3>MAIN OUTCOME MEASURES</h3><div>The morphological features of AOS, extraocular muscles (EOMs), and ocular motor nerves were examined.</div></div><div><h3>RESULTS</h3><div>This retrospective study included 35 cases (21 males and 14 females). The mean ± SEM age was 6.9 ± 0.8 years (range: 2-22 years). Sixteen patients had right-eye involvement, and 19 had left-eye involvement. AOS were categorized into three types: Type 1, discrete anomalous bands extending from the rectus muscles to the posterior sclera (25.7%), with the inferior rectus (IR) being the most affected; Type 2 refers to anomalous connections observed between the extraocular muscles (EOMs) (65.7%), often occurring in the area between the superior rectus (SR) and medial rectus (MR); Type 3, abnormal connection between the posterior sclera and the surrounding optic nerve sheath and extending to the equatorial region of the globe (8.6%). Varying degrees of restricted eye movements and strabismus were observed in all patients. Most patients also exhibited amblyopia and eyelid malposition in the affected eye.</div></div><div><h3>CONCLUSIONS</h3><div>Discrete anomalous bands most commonly involve the IR, while abnormal EOM connections primarily occur between the SR and MR. Eyelid malposition could suggests the possible presence of AOS.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"276 ","pages":"Pages 195-200"},"PeriodicalIF":4.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}