视网膜光成像的纵向变化提供了早期和敏感的外视网膜疾病的生物标志物。

IF 4.2 1区医学 Q1 OPHTHALMOLOGY

American Journal of Ophthalmology Pub Date : 2025-05-28 DOI:10.1016/j.ajo.2025.05.032

Teng Liu , Benjamin J. Wendel , Jennifer Huey , Vimal Prabhu Pandiyan , Debarshi Mustafi , Jennifer R. Chao , Ramkumar Sabesan

{"title":"视网膜光成像的纵向变化提供了早期和敏感的外视网膜疾病的生物标志物。","authors":"Teng Liu , Benjamin J. Wendel , Jennifer Huey , Vimal Prabhu Pandiyan , Debarshi Mustafi , Jennifer R. Chao , Ramkumar Sabesan","doi":"10.1016/j.ajo.2025.05.032","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To examine whether optoretinography (ORG) can provide greater sensitivity for assessing the time-course of disease progression in Retinitis Pigmentosa (RP) compared to standard clinical imaging in a longitudinal study.</div></div><div><h3>Design</h3><div>Cohort study.</div></div><div><h3>Participants</h3><div>Five non-syndromic RP patients and 8 control subjects participated in the study.</div></div><div><h3>Methods</h3><div>Clinical examination, imaging sessions and data analysis were all conducted at the University of Washington. Five eyes of 5 patients diagnosed with RP, comparing standard clinical imaging to ORG, were collected over a 21-month span between August 2022 and May 2024.</div></div><div><h3>Main outcome and measures</h3><div>ORG response to visual stimuli, ellipsoid zone (EZ) width and outer segment length (OS length) were evaluated for longitudinal changes as markers of disease progression.</div></div><div><h3>Results</h3><div>The reduction in cone function with ORG over time exceeds that observed in standard clinical markers of photoreceptor structure - EZ width and OS length. EZ width and OSL decreased by 4.5% ± 5.9% and 6.5% ± 1.4%, respectively, approximately 9.9 and 6.9 times less than the reduction noted in ORG, respectively. The most notable degradation was noted at the borders of the transition zone, where ORG showed progressive and sub-clinical losses in photoreceptor function whereas standard OCT showed currently intact outer retinal structure.</div></div><div><h3>Conclusions</h3><div>Optoretinography detects sub-clinical disease and reliably identifies longitudinal markers of progression with greater sensitivity compared to standard clinical imaging. The ability to detect functional changes in the outer retina prior to standard clinical measures underscores its potential as a sensitive, accelerated and clinically-relevant outcome measure to guide patient selection and their therapeutic response in future clinical trials.</div></div>","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"277 ","pages":"Pages 375-386"},"PeriodicalIF":4.2000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Longitudinal Changes in Optoretinography Provide an Early and Sensitive Biomarker of Outer Retinal Disease\",\"authors\":\"Teng Liu , Benjamin J. Wendel , Jennifer Huey , Vimal Prabhu Pandiyan , Debarshi Mustafi , Jennifer R. Chao , Ramkumar Sabesan\",\"doi\":\"10.1016/j.ajo.2025.05.032\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To examine whether optoretinography (ORG) can provide greater sensitivity for assessing the time-course of disease progression in Retinitis Pigmentosa (RP) compared to standard clinical imaging in a longitudinal study.</div></div><div><h3>Design</h3><div>Cohort study.</div></div><div><h3>Participants</h3><div>Five non-syndromic RP patients and 8 control subjects participated in the study.</div></div><div><h3>Methods</h3><div>Clinical examination, imaging sessions and data analysis were all conducted at the University of Washington. Five eyes of 5 patients diagnosed with RP, comparing standard clinical imaging to ORG, were collected over a 21-month span between August 2022 and May 2024.</div></div><div><h3>Main outcome and measures</h3><div>ORG response to visual stimuli, ellipsoid zone (EZ) width and outer segment length (OS length) were evaluated for longitudinal changes as markers of disease progression.</div></div><div><h3>Results</h3><div>The reduction in cone function with ORG over time exceeds that observed in standard clinical markers of photoreceptor structure - EZ width and OS length. EZ width and OSL decreased by 4.5% ± 5.9% and 6.5% ± 1.4%, respectively, approximately 9.9 and 6.9 times less than the reduction noted in ORG, respectively. The most notable degradation was noted at the borders of the transition zone, where ORG showed progressive and sub-clinical losses in photoreceptor function whereas standard OCT showed currently intact outer retinal structure.</div></div><div><h3>Conclusions</h3><div>Optoretinography detects sub-clinical disease and reliably identifies longitudinal markers of progression with greater sensitivity compared to standard clinical imaging. The ability to detect functional changes in the outer retina prior to standard clinical measures underscores its potential as a sensitive, accelerated and clinically-relevant outcome measure to guide patient selection and their therapeutic response in future clinical trials.</div></div>\",\"PeriodicalId\":7568,\"journal\":{\"name\":\"American Journal of Ophthalmology\",\"volume\":\"277 \",\"pages\":\"Pages 375-386\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0002939425002697\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0002939425002697","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的在一项纵向研究中，探讨视网膜造影（ORG）在评估色素性视网膜炎（RP）疾病进展时是否比标准临床影像学更敏感。DesignCohort研究。5例非综合征性RP患者和8例对照受试者参加了研究。方法临床检查、影像学检查和数据分析均在华盛顿大学进行。在2022年8月至2024年5月的21个月期间，收集了5名被诊断为RP的患者的5只眼睛，将标准临床成像与ORG进行比较。主要结局和测量指标：org对视觉刺激的反应、椭球区（EZ）宽度和外段长度（OS长度）的纵向变化作为疾病进展的标志进行评估。结果随着时间的推移，ORG对视锥细胞功能的影响超过了光感受器结构的标准临床指标- EZ宽度和OS长度。EZ宽度和OSL分别减少4.5%±5.9%和6.5%±1.4%，分别比ORG减少约9.9和6.9倍。最显著的退化是在过渡区边界，在那里ORG显示了进行性和亚临床的光感受器功能丧失，而标准OCT显示目前完整的视网膜外结构。结论与标准临床影像相比，视网膜造影检测亚临床疾病，可靠地识别进展的纵向标记物，灵敏度更高。在标准临床措施之前检测外视网膜功能变化的能力强调了其作为一种敏感，快速和临床相关的结果测量的潜力，以指导患者选择及其在未来临床试验中的治疗反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Longitudinal Changes in Optoretinography Provide an Early and Sensitive Biomarker of Outer Retinal Disease

Objective

To examine whether optoretinography (ORG) can provide greater sensitivity for assessing the time-course of disease progression in Retinitis Pigmentosa (RP) compared to standard clinical imaging in a longitudinal study.

Design

Cohort study.

Participants

Five non-syndromic RP patients and 8 control subjects participated in the study.

Methods

Clinical examination, imaging sessions and data analysis were all conducted at the University of Washington. Five eyes of 5 patients diagnosed with RP, comparing standard clinical imaging to ORG, were collected over a 21-month span between August 2022 and May 2024.

Main outcome and measures

ORG response to visual stimuli, ellipsoid zone (EZ) width and outer segment length (OS length) were evaluated for longitudinal changes as markers of disease progression.

Results

The reduction in cone function with ORG over time exceeds that observed in standard clinical markers of photoreceptor structure - EZ width and OS length. EZ width and OSL decreased by 4.5% ± 5.9% and 6.5% ± 1.4%, respectively, approximately 9.9 and 6.9 times less than the reduction noted in ORG, respectively. The most notable degradation was noted at the borders of the transition zone, where ORG showed progressive and sub-clinical losses in photoreceptor function whereas standard OCT showed currently intact outer retinal structure.

Conclusions

Optoretinography detects sub-clinical disease and reliably identifies longitudinal markers of progression with greater sensitivity compared to standard clinical imaging. The ability to detect functional changes in the outer retina prior to standard clinical measures underscores its potential as a sensitive, accelerated and clinically-relevant outcome measure to guide patient selection and their therapeutic response in future clinical trials.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

American Journal of Ophthalmology 医学-眼科学

CiteScore

9.20

自引率

7.10%

发文量

406

审稿时长

36 days

期刊介绍： The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect. The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports. Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.