{"title":"[Medical ethics and politics - one aspect of the history of medical ethics].","authors":"E Fischer-Homberger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Medical ethics became a medical topic of its own in the 16th and 17th centuries as a part of what could be called \"public medicine\". They served the interests of University-trained doctors by strenghthening their autonomy and by submitting their rivals to medical control. The patients' interests are considered more or less identical with the doctor's. Towards the 19th century an ideologization of medical ethics is observable which has partly been responsible for the inhumane ethical concepts of certain of the 20th century collectivists as well as for certain inhumanities within individualistic ethics of our times and regions. When these ideologies became problematic the question of the relation between patient's and doctor's interests arose. For this and other reasons medical ethics have been rethought in the 60s of the present century. Increased attention has been paid to the realm of non-standardizable ethical behaviour. Thus \"situation ethics\" were conceived - and, more recently, \"communication ethics\" which arises from social interchange. Where his own interests are concerned, these ethical concepts require the doctor, not to pursue or deny them but simply to be aware of and to discuss them openly. The practical equivalent of communication ethics is the doctor's dialogue with a patient who personally looks after his own interests, as well as ethical commissions and interdisciplinary symposia on medical ethics. Thus medical ethics are again part of a \"public medicine\". This development is congruent with the interests of the medical profession insofar as this profession and its concepts have been severely criticized in the last twenty years - an open discussion of medical ethics might contribute to medicine's equilibrium.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"36 4-6","pages":"395-410"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18055873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The dignity of the patient].","authors":"P Vogelsanger","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"36 4-6","pages":"249-58"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18481514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The dignity of the patient and medical progress from the Catholic point of view].","authors":"A Ziegler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"36 4-6","pages":"259-321"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18481516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Cellular and vascular aging of the brain].","authors":"G Lazorthes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The author first discusses the difficulties in making the distinctions between physiological and pathological cerebral aging. The initial question to be solved is whether or not the physiologic aging of the brain is the result of general vascular pathology or neuronal degeneration. Morphological modifications are then discussed: general and brain weight, lipofuscine deposits, aspect and number of cortical arteries, degenerative arterial lesions. Physiological modifications, i.e. alterations in neurotransmission, cerebral blood flow and metabolism are discussed in the second part of the presentation which is followed by a review of the current literature. The various conclusions drawn concern the available means to retard cerebral, neuronal and vascular aging.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"36 1-3","pages":"57-70"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17174668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Axonal transport from the nerve ending to the nerve cell body: a pathway for trophic signals and neurotoxins].","authors":"M E Schwab","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nerve cells with their very long axons and dendrites have an effective system of anterograde and retrograde transport. In the retrograde direction there is, in addition to endogeneous cell constituents, a substantial transport of exogenous material like e.g. trophic factors like NGF. We have found that molecules which bind with high affinity to receptors in the nerve teminal surface membranes (e.g. NGF, tetanus and cholera toxin, lectins) are selectively internalized and transported retrogrdely to the cell body. Although most of them are incorporated into lysosomes in the cell body, they can nevertheless exert specific signal functions in the cell (NGF). Tetanus toxin, however, is released by the dendrites and transferred trans-synaptically to higher order neurons. We suggest that this retrograde and trans-synaptic transport represents an important pathway for \"trophic\" signal molekules, which convey information from the target cells to the innervating neurons. The same pathways can be used by neurotoxins *tetanus toxin) and neurotrophic viruses for entering the nervous system.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"36 1-3","pages":"7-19"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17224734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Local cerebral energy metabolism: its relationship to local functional activity and blood flow.","authors":"L Sokoloff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of studies with the (14C)deoxyglucose technique unequivocally establish that local energy metabolism in cerebral tissues is, as in other tissues, closely coupled to local functional activity. Stimulation of local functional activity increases the local rate of glucose utilization; reduced functional activity depresses it. Local cerebral blood flow is normally distributed among the cerebral structures in almost exact proportion to their rates of glucose utilization and changes together with local glucose consumption in response to altered local functional activity. These results demonstrate that the level of functional activity in the structural and functional components of the central nervous syetem regulates the local rate of energy metabolism, and local blood flow is adjusted to the local metabolic demand.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"36 1-3","pages":"71-91"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18436307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacological effects of some medicaments on the human brain.","authors":"J Marshall","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The methodological problems of measuring the effect of drugs on cerebral blood flow (CBF) are examined. In animals these include choice of species, technique of measurement, route of administration and whether the drug crosses the blood-brain barrier. Additional factors in man are age, short or long-term effects, tendency for repeated measurements to give lower readings and need to measure not only CBF but also clinical performance. Despite these difficulties drugs affecting the cerebral circulation are worth intensive study, especially now, when reliable non-invasive methods of mesuring CBF are available and positron emission tomography enables us to study also cerebral metabolism in vivo.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"36 1-3","pages":"177-81"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17828447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regional cerebral blod flow studied by xenon-133. Intra-arterial injection studies and inhalation studies using emission tomography.","authors":"N A Lassen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A survey of the Xenon-133 techniques for measurement of regional cerebral blood flow, rCBF, in man is presented. The intra-arterial Xe-133 injection method is very sensitive for detecting even small hyperemic areas, but cannot \"see\" smaller ischemic areas. The Xe-133 inhalation (or i.v. inj.) technique is insensitive both to hyperemia and ischemia yielding essentially only a mean flow value. A new rapidly moving single photon tomograph following D. Kuhl's principle is presented applicable to Xe-133. Preliminary clinical data show that this technique is able to detect ischemic areas both with Xe-133 intra-arterial injection and with Xe-133 inhalation. The practical and economic advantages of Xe-133 or Xe-127 tomography over positron tomography for rCBF are discussed.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"36 1-3","pages":"93-100"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18017806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Pharmacologic modification of the circulation in the brain].","authors":"W D Heiss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hemispheric and regional cerebral blood flow were measured in 448 patients before and after application of various drugs. Of the tested substances, only a few affected hCBF: ephedrine-xanthines decreased hCBF, and midodrine, proxazole, vincamine, hexobendine, extract of ginkgo biloba, dextran, dextran-sorbitol, carboanhydrase inhibitor, and ouabain incresaed hCBF. In the rCBF maps different reaction patterns of regional flow were observed which were statistically tested by regression analysis. Homogeneous responses were seen as diffuse increases or decreases of rCBF. Heterogeneous responses occurred when perfusion of pathologic and normal areas reacted differently. An increase in rCBF in well-perfused areas with a shunt of blood from poorly supplied areas (intracerebral steal) was observed only with central vasodilators during the first days after an attack. Inverse cerebral steal phenomena with improvement of perfusion in the focus and decrease of flow in the surrounding brain may be elicited by different mechanisms. The effectiveness of drugs on cerebral circulation can be tested by measuring rCBF, but their therapeutic value for the treatment of patients with cerebrovascular disease must be shown in controlled clinical trials.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"36 1-3","pages":"183-207"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17174667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Cerebrovascular Doppler ultrasound studies (cv-Doppler)].","authors":"H Keller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With the cv-Doppler examination, obstructions in the extracranial cerebral arteries can be detected with high reliability. The method can be used - if properly applied - to determine the further diagnostic and therapeutic procedure in cerebrovascular patients. Carotid artery Doppler is based on measurement of blood flow in the teminal branches of the ophthalmic artery and the common carotid atery with and without additional compression manoeuvers of the common carotid artery and branches of the external carotid artery. With direct measurements over the carotid artery, external and internal carotid artery can be differentiated, and stenoses as well as major ulcerated lesions can be localized by pathological flow patterns in the vicinity of these obstructions. In Vertebral-/Subclavian artery Doppler blood flow of the vertebral artery is picked up with the probe placed through the mouth on the locally anesthesized mucous membrane of the oropharynx. By compression of the common carotid artery at the site and opposite to the vessel under examination, the vertebral artery is differentiated from branches of the carotid artery. Blood flow in the central portion of the subclavian artery is picked up by placing the probe in the supraclavicular fossa over the target vessel. - The cv-Doppler examination was used in 3961 patients of whom 570 underwent cerebral angiography. The findings of the noninvasive and invasive method corresponded in more than 94% of the cases.</p>","PeriodicalId":75639,"journal":{"name":"Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften","volume":"36 1-3","pages":"129-42"},"PeriodicalIF":0.0,"publicationDate":"1980-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18436303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}