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Bone marrow culture and transduction of stem cells in a miniature swine model. 微型猪模型的骨髓培养和干细胞转导。
Blood cells Pub Date : 1994-01-01
D W Emery, T Sablinski, J S Arn, C LeGuern, D H Sachs
{"title":"Bone marrow culture and transduction of stem cells in a miniature swine model.","authors":"D W Emery,&nbsp;T Sablinski,&nbsp;J S Arn,&nbsp;C LeGuern,&nbsp;D H Sachs","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recombinant retroviral vectors, engineered to express the beta-chain gene of swine major histocompatibility complex class II DR, were developed for the genetic modification of swine hematopoietic stem cells (HSC). The expression of these vectors in swine bone marrow has been studied both in culture and after bone marrow transplantation. In addition, myeloid progenitor colony assays were performed on swine umbilical cord blood as part of a study to identify alternative sources of HSC for somatic gene transfer, revealing the presence of both granulocyte macrophage colony forming-units (CFU-GM) and CFU-Mix at frequencies comparable to those found in juvenile swine bone marrow.</p>","PeriodicalId":75604,"journal":{"name":"Blood cells","volume":"20 2-3","pages":"498-502; discussion 502-3"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary: results of umbilical cord transplantation. 评论:脐带移植的结果。
Blood cells Pub Date : 1994-01-01
P G Beatty
{"title":"Commentary: results of umbilical cord transplantation.","authors":"P G Beatty","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75604,"journal":{"name":"Blood cells","volume":"20 2-3","pages":"242-4"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18750391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ex vivo expansion of cord blood-derived stem cells and progenitors. 脐带血来源的干细胞和祖细胞的体外扩增。
Blood cells Pub Date : 1994-01-01
M A Moore, I Hoskins
{"title":"Ex vivo expansion of cord blood-derived stem cells and progenitors.","authors":"M A Moore,&nbsp;I Hoskins","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cord blood-derived CD34+ cells have proved superior to adult marrow or elicited peripheral blood in ex vivo cell and progenitor expansion. In addition, cord blood-derived cells with a phenotype and function of early stem cells (e.g., long-term culture-initiating cells) can be expanded in vitro in the presence of a combination of cytokines by 15- to 20-fold over 7-14 days. These observations suggest that ex vivo expansion of cord blood CD34+ cells will permit improved engraftment of adults and will prove effective in retroviral-mediated gene transfection of early stem cell populations.</p>","PeriodicalId":75604,"journal":{"name":"Blood cells","volume":"20 2-3","pages":"468-79; discussion 479-81"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18544576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cord blood transplantation in thalassemia. 脐带血移植治疗地中海贫血。
Blood cells Pub Date : 1994-01-01
S Issaragrisil
{"title":"Cord blood transplantation in thalassemia.","authors":"S Issaragrisil","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thalassemias and hemoglobinopathies are prevalent in Thailand. Bone marrow transplantation can cure thalassemia, but less than 30% of the patients have an HLA-identical sibling. Cord blood is an alternative source of stem cells for transplantation. By prenatal diagnosis, the fetus can be diagnosed as having thalassemic disease. DNA typing for HLA will be performed. Cord blood can be collected for transplantation if the fetus is not affected and is HLA-identical to the patient. We report a successful cord blood transplantation in a patient with beta-thalassemia/hemoglobin E disease.</p>","PeriodicalId":75604,"journal":{"name":"Blood cells","volume":"20 2-3","pages":"259-62; discussion 263"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18751660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary: cytokine support after cord blood transplantation. 评论:脐带血移植后的细胞因子支持。
Blood cells Pub Date : 1994-01-01
J J Nemunaitis
{"title":"Commentary: cytokine support after cord blood transplantation.","authors":"J J Nemunaitis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75604,"journal":{"name":"Blood cells","volume":"20 2-3","pages":"264-6"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18751661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Directed cell movement: a biophysical analysis. 定向细胞运动:生物物理分析。
Blood cells Pub Date : 1993-01-01
H Gruler
{"title":"Directed cell movement: a biophysical analysis.","authors":"H Gruler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The directed movement or directed growth of a cell in a polar guiding field (such as an electric field, a concentration gradient of chemotactic active molecules, a necrotactic gradient induced by a lysed cell, etc.) can be characterized by two independent variables: the speed, nu, of the cell and its migration angle, phi. Here it is shown that the direction of migration is controlled by a cellular automatic controller. The automatic controller can be regarded as the framework for the directed movement or growth and it can be applied even when the physicochemical signals to which the cell is responding are unknown.</p>","PeriodicalId":75604,"journal":{"name":"Blood cells","volume":"19 1","pages":"91-110; discussion 110-3"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19384658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term chemotaxis of neutrophils in stable gradients: preliminary evidence of periodic behavior. 中性粒细胞在稳定梯度下的长期趋化:周期性行为的初步证据。
Blood cells Pub Date : 1993-01-01
G A Dunn, D Zicha
{"title":"Long-term chemotaxis of neutrophils in stable gradients: preliminary evidence of periodic behavior.","authors":"G A Dunn,&nbsp;D Zicha","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We observed and recorded the behavior of human neutrophils in stable linear gradients of the chemotactic attractant f-Met-Leu-Phe in a recently developed, direct-viewing, chemotaxis chamber. The cells were kept cold for the first hour after setting up the chemotaxis chamber in order to establish a stable gradient before allowing the cells to spread and begin to move by warming them up to 37 degrees C. We found that the cells showed very significant chemotaxis at different times throughout the 2-hour period of observation but, unexpectedly, the activity occurred in periodic or quasi-periodic cycles during which the cells entered phases of undirected motility lasting for several minutes. We discuss whether the periodicity is a population or single cell-based phenomenon and briefly speculate on its possible analogy to the well-known periodic chemotaxis of slime mould amoebas.</p>","PeriodicalId":75604,"journal":{"name":"Blood cells","volume":"19 1","pages":"25-39; discussion 39-41"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19386042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CD23 and chronic lymphocytic leukemia. CD23与慢性淋巴细胞白血病。
Blood cells Pub Date : 1993-01-01
M Sarfati
{"title":"CD23 and chronic lymphocytic leukemia.","authors":"M Sarfati","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chronic lymphocytic leukemia (CLL) is classically defined by the proliferation and accumulation of monoclonal CD5 positive B cells \"arrested\" at an intermediate stage of differentiation. The CD23 antigen (the low affinity receptor for IgE (Fc epsilon RII) is a 45 kD membrane glycoprotein primarily expressed on surface IgM and IgD positive B cells. The aim of this paper is to establish the link between CD23 and CLL disease and to propose that the CD23 molecule is not simply a marker of CLL disease but may also be involved in the proliferation of the leukemic B cells.</p>","PeriodicalId":75604,"journal":{"name":"Blood cells","volume":"19 3","pages":"591-6; discussion 597-9"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19014750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokine activation of human macro- and microvessel-derived endothelial cells. 人大血管和微血管内皮细胞的细胞因子活化。
Blood cells Pub Date : 1993-01-01
M E Gerritsen, M J Niedbala, A Szczepanski, W W Carley
{"title":"Cytokine activation of human macro- and microvessel-derived endothelial cells.","authors":"M E Gerritsen,&nbsp;M J Niedbala,&nbsp;A Szczepanski,&nbsp;W W Carley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of the inflammatory cytokines, tumor necrosis factor (TNF alpha), interleukin-1 alpha (IL-1), and gamma interferon (IFN gamma) on macro- and microvessel-derived endothelial cell proteolytic, adhesion protein and prostaglandin synthetic activities were compared. TNF alpha treatment of human umbilical vein endothelial (HUVE) cells induced urokinase-type plasminogen (uPA) activity, increased HUVE uPA-dependent extracellular matrix (ECM) degradation, and accelerated matrix remodeling and endothelial differentiation into tubes or cord-like structures. All of the aforementioned effects of TNF alpha on HUVE uPA-dependent activities were abrogated by co- or pretreatment with IFN gamma. In contrast, endothelium derived from human lung (HLE) exhibited high constitutive uPA and uPA-dependent matrix degradation and rapid tube formation in Matrigel, activities all unaffected by TNF alpha or IFN gamma. Endothelium derived from human rheumatoid synovium (HSE) exhibited uPA-dependent activities intermediate between the HLE and HUVE. TNF alpha or IL-1 treatment of HUVE potently induced surface ICAM-1 expression, whereas these cytokines were relatively ineffective on HLE and HSE ICAM-1 expression. Co-incubation with IFN gamma synergistically elevated TNF alpha or IL-1 induced ICAM-1 expression in HUVE, HLE, and HSE. The major prostaglandin synthesized by HUVE was PGI2, in contrast to HLE and HSE which produced PGE2 as the major product. Although cytokine treatment increased prostanoid production in all three cell types, HLE were not responsive to IL-1, and HSE demonstrated the greatest increase in prostaglandin synthetic capacity. These studies underline important differences not only in the \"constitutive\" activities expressed by EC from different vascular beds, but also in the responsiveness to proinflammatory cytokines alone or in combination. These observations further emphasize the need to study the endothelial cell derived from the vascular bed of interest rather than extrapolate from results obtained with HUVE or other macrovessel-derived endothelium.</p>","PeriodicalId":75604,"journal":{"name":"Blood cells","volume":"19 2","pages":"325-39; discussion 340-2"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18903128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preconceived ideas in the classification of leukemia. 白血病分类的先入为主的观念。
Blood cells Pub Date : 1993-01-01
C Debru
{"title":"Preconceived ideas in the classification of leukemia.","authors":"C Debru","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>General biological classifications have theoretical aims regarding the natural order of things. Classification in pathology has basic pragmatic aims regarding diagnosis, prognosis and treatment. In history, leukemia classifications were mainly (but not exclusively) based on classification of normal cells. Clinical data were introduced mainly secondarily. For a long time, no treatment was available. Two questions are asked: might classification of leukemia help to understand the disease's mechanisms; might better classification eliminate unclassifiable leukemias?</p>","PeriodicalId":75604,"journal":{"name":"Blood cells","volume":"19 3","pages":"537-41; discussion 542-7"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19014746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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