{"title":"脐带血移植治疗地中海贫血。","authors":"S Issaragrisil","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Thalassemias and hemoglobinopathies are prevalent in Thailand. Bone marrow transplantation can cure thalassemia, but less than 30% of the patients have an HLA-identical sibling. Cord blood is an alternative source of stem cells for transplantation. By prenatal diagnosis, the fetus can be diagnosed as having thalassemic disease. DNA typing for HLA will be performed. Cord blood can be collected for transplantation if the fetus is not affected and is HLA-identical to the patient. We report a successful cord blood transplantation in a patient with beta-thalassemia/hemoglobin E disease.</p>","PeriodicalId":75604,"journal":{"name":"Blood cells","volume":"20 2-3","pages":"259-62; discussion 263"},"PeriodicalIF":0.0000,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cord blood transplantation in thalassemia.\",\"authors\":\"S Issaragrisil\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Thalassemias and hemoglobinopathies are prevalent in Thailand. Bone marrow transplantation can cure thalassemia, but less than 30% of the patients have an HLA-identical sibling. Cord blood is an alternative source of stem cells for transplantation. By prenatal diagnosis, the fetus can be diagnosed as having thalassemic disease. DNA typing for HLA will be performed. Cord blood can be collected for transplantation if the fetus is not affected and is HLA-identical to the patient. We report a successful cord blood transplantation in a patient with beta-thalassemia/hemoglobin E disease.</p>\",\"PeriodicalId\":75604,\"journal\":{\"name\":\"Blood cells\",\"volume\":\"20 2-3\",\"pages\":\"259-62; discussion 263\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Blood cells\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Blood cells","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Thalassemias and hemoglobinopathies are prevalent in Thailand. Bone marrow transplantation can cure thalassemia, but less than 30% of the patients have an HLA-identical sibling. Cord blood is an alternative source of stem cells for transplantation. By prenatal diagnosis, the fetus can be diagnosed as having thalassemic disease. DNA typing for HLA will be performed. Cord blood can be collected for transplantation if the fetus is not affected and is HLA-identical to the patient. We report a successful cord blood transplantation in a patient with beta-thalassemia/hemoglobin E disease.
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