Annales d'immunologie最新文献_第5页

The significance of T-cell subsets defined by monoclonal antibodies in human diseases. 单克隆抗体定义的t细胞亚群在人类疾病中的意义。

Annales d'immunologie Pub Date : 1982-09-01

J F Bach, L Chatenoud

引用次数: 0

[HLA-DR antigens: cellular expression and molecular structure]. HLA-DR抗原:细胞表达和分子结构。

Annales d'immunologie Pub Date : 1982-09-01

D J Charron

{"title":"[HLA-DR antigens: cellular expression and molecular structure].","authors":"D J Charron","doi":"","DOIUrl":"","url":null,"abstract":"The HLA complex encodes several sets of membrane glycoproteins with extensive genetic, functional and structural polymorphism. The HLA-D region and its products, the HLA-DR antigens, are central in immune phenomena. They control the mixed lymphocyte reaction, the graft versus host reaction in vivo and cell/cell interactions involved in immune responses. Monoclonal anti HLA-DR antigens have been used to investigate the expression and synthesis of human Ia antigens on B and active T lymphocytes and macrophages. They were subsequently used in structural studies of HLA-DR antigens analysed by two-dimensional gel electrophoresis. The HLA-DR antigens are composed of a bimolecular complex of two non-covalently linked subunits: a 34,000 dalton alpha chain and a 29,000 dalton beta chain. Glycosylation steps and molecular maturation include the addition of oligosaccharides and sialic acid residues to the native polypeptide chain. The structural polymorphism which correlates with the serologically defined HLA-DR determinants is localized on the beta chain and is of polypeptidic origin. A third component of the HLA-DR antigen is described: the 31,000-dalton \"invariant\" chain. Its peptide composition, glycosylation pattern and expression are reported. Homologies of HLA-DR antigens with the mouse Ia antigens are discussed. Structural studies of the human Ia system are important in dissecting the functional role of the different epitopes of the HLA-DR molecules.","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133D 2","pages":"155-69"},"PeriodicalIF":0.0,"publicationDate":"1982-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17251663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The active T rosette: an early marker for T-cell activation. 激活T花环:T细胞激活的早期标志。

Annales d'immunologie Pub Date : 1982-09-01

J Wybran, E Dupont

{"title":"The active T rosette: an early marker for T-cell activation.","authors":"J Wybran, E Dupont","doi":"","DOIUrl":"","url":null,"abstract":"This review summarizes some of the recent observations regarding the active T-rosette assay. This test, performed under suboptimal technical conditions, identifies a subpopulation of T lymphocytes with high-avidity receptors for sheep red blood cells. They are Ia-positive but appear to lack an Fc receptor. They can be either OKT4-positive or OKT8-positive. Isolated active T-rosette populations are capable of recognizing and killing allogeneic cells and they also modulate B-cell immunoglobulin production. They are directly correlated in vivo with specific cutaneous reactivity to an antigen. More interestingly, the percentage of active rosettes specifically increases in vitro after one hour of incubation with soluble or cellular antigens. This test fully correlates with the lymphocyte stimulation test. In the case of human mixed lymphocyte culture, the increase in active T rosettes is due to antigenic differences in the HLA D-DR region. The neoformation of active T rosettes is due to the early release of a rosetting factor. Drugs which are able to modulate T-cell functions, such as thymosin, transfer factor, isoprinosine and NPT-15392, also increase the percentage of active T rosettes. Therefore, the newly formed active T rosettes appear to be an early marker for lymphocyte activation.","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133D 2","pages":"211-8"},"PeriodicalIF":0.0,"publicationDate":"1982-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17283260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of a functional T-cell population by the use of surface markers: present limitations and new strategies. 利用表面标记物鉴定功能性t细胞群:目前的限制和新的策略。

Annales d'immunologie Pub Date : 1982-09-01

M C Mingari, A Moretta, G Pantaleo, L Moretta

引用次数: 0

[T-lymphocyte subpopulations in mice: their respective role in the regulation of isotype expression]. [小鼠t淋巴细胞亚群:各自在同型表达调控中的作用]。

Annales d'immunologie Pub Date : 1982-09-01

J Thèze

引用次数: 0

Developmentally controlled transcription of HLA and beta 2-microglobulin genes in human teratocarcinoma lines. 人畸胎瘤细胞系中发育控制的HLA和β 2微球蛋白基因转录。

Annales d'immunologie Pub Date : 1982-09-01

D Morello, P Avner