Annales d'immunologie最新文献_第10页

[Adoptive transfer of immunity against Treponema of Fribourg-Blanc (TFB) in the hamster: role of T lymphocytes (author's transl)]. [仓鼠对弗里堡-勃朗螺旋体(TFB)的过继性免疫转移:T淋巴细胞的作用[作者译]。

Annales d'immunologie Pub Date : 1980-11-01

F T Tissot Guerraz, M Sepetjan, J C Monier

引用次数: 0

[Suppressive effect of synthetic polypeptide GT on the induction of delayed-type hypersensitivity to a complex GT + methylated bovine serum albumin (author's transl)]. [合成多肽GT对诱导对GT +甲基化牛血清白蛋白的迟发型超敏反应的抑制作用[作者译]。

Annales d'immunologie Pub Date : 1980-11-01

G Drach, E Barbu

引用次数: 0

[Automatic sorting of cells by cytofluorography]. [通过细胞荧光法自动分选细胞]。

Annales d'immunologie Pub Date : 1980-11-01

M E Goldberg

引用次数: 0

The self-nonself discrimination and the nature and acquisition of the antibody repertoire. 抗体库的性质和获得的自我非自我区别。

Annales d'immunologie Pub Date : 1980-11-01

A Coutinho

{"title":"The self-nonself discrimination and the nature and acquisition of the antibody repertoire.","authors":"A Coutinho","doi":"","DOIUrl":"","url":null,"abstract":"Network ideas are confronted with current hypotheses for the origin of antibody diversity and self-nonself discrimination. The difficulties of reconciling the promethean evolution of the antibody system with \"germ line\" theories are discussed, as well as the problems of \"somatic\" hypotheses to explain the completeness of the antibody repertoire. The formal incompatibility of the network theory with ideas basing self-nonself discrimination on the elimination of self-reactive cells is demonstrated, as well as the difficulties of these and other environment-dependent hypotheses for lymphocyte activation, to encompass the internal activity in the immune system. It is argued, on the other hand, that the limitations of the network theory in providing a functional basis for the idiotypic network and in accounting for self-nonself discrimination, can be solved by finding in a complete repertoire of antibody-combining sites the complementary structures to growth receptors on B lymphocytes, and by using these as internal mitogens in the expansion of the precursor cell pools and in the maintenance of the mature steady states. Letting self-nonself discrimination be accounted for by such growth receptors, both the integrity of the antibody repertoire and the internal activity in the system can also be ensured. Moreover, by postulating a germ line origin for the antireceptor antibodies and by accepting idiotypic cross-reactivity between growth receptors and other germ line antibodies, the possibilities are set for a phylogenetically and ontogenically autonomous immune system embodied with the capabilities for self-expansion, diversification and selection of available repertoires. Its promethean characteristics are explained by its completeness, and this is achieved by idiotypic interactions between growth receptors and a limited number of complementary or cross-reactive germ line antibodies, naturally selected on the basis of their structural relationships with growth receptors.","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"131D 3","pages":"235-53"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18061773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[A distinctive scheme of amino acid replacement was evolved for the generation of diversity, among hypervariable positions (author's transl)]. [一种独特的氨基酸替代方案被进化为多样性的产生，在高变的位置(作者的翻译)]。

Annales d'immunologie Pub Date : 1980-11-01

J J Bourgarit

{"title":"[A distinctive scheme of amino acid replacement was evolved for the generation of diversity, among hypervariable positions (author's transl)].","authors":"J J Bourgarit","doi":"","DOIUrl":"","url":null,"abstract":"The diversity of amino acid residues, at a same position when comparing several aligned polypeptide sequences, may be translated as follows. The way along which a given amino acid, A, is replaced--in average--by another amino acid, B, is characterized by a coefficient linked with the pair A-B. Thus, one given amino acid is given a \"set\" of 19 coefficients, and the 20 different such sets may be analyzed. This method applies to the analysis of the diversity, among different sequences VH and VL of the variable regions of immunoglobulin heavy chains and light chains. From an observation of the alterations of those different sets, according to the sample of positions from which they were derived, it is possible to reach to the following conclusions. A) In the first approximation, all the amino acids present the same behaviour, whichever the sample. The frequency of replacement of an amino acid, A, by another amino acid B, is mainly a function of the proportion of B in the sample. B) In the second approximation, a more elaborate scheme of replacement is apparent, and is linked with an equivalent scheme in the genetic code; it is shown that hypervariable positions as well as random positions in VH and VL obey to this scheme. C) In the third approximation, a complementary structure is observed, which only pertains to the sample of hypervariable positions, and which might constitute a peculiar aspect of a selective process: this complementary structure is quite diverging from the genetic code. This analysis brings a strong argument against somatic theories, for the generation of diversity.","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"131D 3","pages":"267-87"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17838246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence on macrophage functions as a possible basis of immunomodification by polyanions. 对巨噬细胞功能的影响可能是聚阴离子免疫修饰的基础。

Annales d'immunologie Pub Date : 1980-11-01

N Bloksma, M J de Reuver, J M Willers

引用次数: 0

Response of the lymphoid organs of the mouse to the peptidoglycan of a gram-positive bacterium (Streptococcus pyogenes). 小鼠淋巴器官对革兰氏阳性细菌(化脓性链球菌)的肽聚糖的反应。

Annales d'immunologie Pub Date : 1980-11-01

R Caravano, H Mauss, J Oberti, J Roux

{"title":"Response of the lymphoid organs of the mouse to the peptidoglycan of a gram-positive bacterium (Streptococcus pyogenes).","authors":"R Caravano, H Mauss, J Oberti, J Roux","doi":"","DOIUrl":"","url":null,"abstract":"The response of the lymphoid organs of the mouse to the injection of a Gram-positive (Streptococcus pyogenes) bacterial peptidoglycan (PGL) has been investigated by several complementary techniques. Special cares were brought to: a) the extraction mode and the characterization of the bacterial fraction, b) the sanitary and microbiological status of the mice, and c) the lack of biologically active contaminants, even at a trace level. In these conditions, the local reaction at the site of inoculation was very moderate, transient and not very distinctive. No toxic reactions were observed, even with doses of several milligrams per mouse. Changes in lymphoid organs, as determined by changes in weight, incorporation of radioactive precursors and detailed histological study revealed that PGL did not induce the typical responses of ordinary antigens. Changes in the weight of organs were not significant and there was no dose-response relationship. In the lymph node, the response was confined to the paracortical area; the lymphocyte activation stood at an early stage and became characterized only after booster injection. There was no activation of antibody-producing cells. An important recruitment of active macrophages was observed; this could participate to the adjuvant activity of PGL, whose at least a part of the biological activity is therefore independent of the inflammatory and/or toxic response.","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"131D 3","pages":"309-35"},"PeriodicalIF":0.0,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18061775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flash detection of anti-H-2 antibodies using chemiluminescence, without complement. 闪光检测抗h -2抗体使用化学发光，无补体。

Annales d'immunologie Pub Date : 1980-11-01

B Descamps, A T Nguyen, M N Feuillet-Fieux

引用次数: 0

Immunity and tolerance induced by two antigens in individual B cells. 两种抗原在单个B细胞中诱导的免疫和耐受。

Annales d'immunologie Pub Date : 1980-09-01

C Bleux, C Desaymard, J Couderc, P Liacopoulos

引用次数: 0

Lymphotoxin and chemotactic factor produced in vitro by human lymphocytes during their proliferative response in the presence of phytohaemagglutinin and Nocardia water-soluble mitogen. 人淋巴细胞在植物血凝素和诺卡菌水溶性丝裂原存在下的增殖反应中产生的淋巴素和趋化因子。

Annales d'immunologie Pub Date : 1980-09-01

A M Prieur, T Pham Huu

引用次数: 0