{"title":"[合成多肽GT对诱导对GT +甲基化牛血清白蛋白的迟发型超敏反应的抑制作用[作者译]。","authors":"G Drach, E Barbu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Delayed-type hypersensitivity (DTH) to the random copolymers poly(Glu50Tyr50) (GT) or poly(Glu60Ala30Tyr10) (GAT) could be produced in BALB/c mice when the polymers were injected complexed to a methylated bovine serum albumin (mBSA). The pretreatment with GT or with mBSA 4 days before the immunisation with the complex GT-mBSA suppressed the induction of the DTH to both GT and mBSA moieties of the GT-mBSA complex. A similar pretreatment with GAT had no suppressor effect on the induction of DTH to GT-mBSA. Injection of cyclophosphamide 2 days before or 2 days after the pretreatment with GT eliminated the suppressor effect of GT on the induction of DTH with the complex GT-mBSA.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"131D 3","pages":"299-307"},"PeriodicalIF":0.0000,"publicationDate":"1980-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Suppressive effect of synthetic polypeptide GT on the induction of delayed-type hypersensitivity to a complex GT + methylated bovine serum albumin (author's transl)].\",\"authors\":\"G Drach, E Barbu\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Delayed-type hypersensitivity (DTH) to the random copolymers poly(Glu50Tyr50) (GT) or poly(Glu60Ala30Tyr10) (GAT) could be produced in BALB/c mice when the polymers were injected complexed to a methylated bovine serum albumin (mBSA). The pretreatment with GT or with mBSA 4 days before the immunisation with the complex GT-mBSA suppressed the induction of the DTH to both GT and mBSA moieties of the GT-mBSA complex. A similar pretreatment with GAT had no suppressor effect on the induction of DTH to GT-mBSA. Injection of cyclophosphamide 2 days before or 2 days after the pretreatment with GT eliminated the suppressor effect of GT on the induction of DTH with the complex GT-mBSA.</p>\",\"PeriodicalId\":75508,\"journal\":{\"name\":\"Annales d'immunologie\",\"volume\":\"131D 3\",\"pages\":\"299-307\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1980-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annales d'immunologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales d'immunologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Suppressive effect of synthetic polypeptide GT on the induction of delayed-type hypersensitivity to a complex GT + methylated bovine serum albumin (author's transl)].
Delayed-type hypersensitivity (DTH) to the random copolymers poly(Glu50Tyr50) (GT) or poly(Glu60Ala30Tyr10) (GAT) could be produced in BALB/c mice when the polymers were injected complexed to a methylated bovine serum albumin (mBSA). The pretreatment with GT or with mBSA 4 days before the immunisation with the complex GT-mBSA suppressed the induction of the DTH to both GT and mBSA moieties of the GT-mBSA complex. A similar pretreatment with GAT had no suppressor effect on the induction of DTH to GT-mBSA. Injection of cyclophosphamide 2 days before or 2 days after the pretreatment with GT eliminated the suppressor effect of GT on the induction of DTH with the complex GT-mBSA.
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