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Study of the relation between the clinical pulmonary condition of children with cystic fibrosis and the lymphoblastic response to the antigen Pseudomonas aeruginosa. 囊性纤维化患儿临床肺部状况与淋巴细胞对抗原铜绿假单胞菌反应关系的研究。
Annales d'immunologie Pub Date : 1982-11-01
R Van Geffel, E Hubert, M Josse
{"title":"Study of the relation between the clinical pulmonary condition of children with cystic fibrosis and the lymphoblastic response to the antigen Pseudomonas aeruginosa.","authors":"R Van Geffel,&nbsp;E Hubert,&nbsp;M Josse","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study was performed on four sibling pairs affected by cystic fibrosis. Of each sibling pair, one was more affected than the other. The results show that the lymphoblastic response to the antigen Pseudomonas aeruginosa of the most affected patient was strongly reduced in comparison to the response of the less affected one. The plasma from the most affected patient contains an inhibitory factor which reduces the lymphoblastic response of the less affected one. On the other hand, plasma from the less affected patient improves the lymphoblastic response of the most affected one (although not significantly). One notes a better lymphoblastic response when the most affected patient's lymphocytes are put in the presence of the less affected one's antigens and plasma. These findings suggest a phenomenon of lymphocyte tolerance in the most affected patient towards P. aeruginosa.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133D 3","pages":"293-303"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18181560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antigen-specific human T-cell factors: T-cell helper and suppressor factors, immunochemical aspects. 抗原特异性人t细胞因子:t细胞辅助因子和抑制因子，免疫化学方面。
Annales d'immunologie Pub Date : 1982-11-01
C J Heijnen, F UytdeHaag, K H Pot, Z Bentwich, R E Ballieux
{"title":"Antigen-specific human T-cell factors: T-cell helper and suppressor factors, immunochemical aspects.","authors":"C J Heijnen,&nbsp;F UytdeHaag,&nbsp;K H Pot,&nbsp;Z Bentwich,&nbsp;R E Ballieux","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Some immunochemical characteristics of a T-cell-derived ovalbumin (OA) antigen-specific helper (ThF120-OA) and a corresponding OA-specific suppressor effector factor (TsF120-OA) are described. These immunoregulatory molecules are retained by columns containing either the insolubilized antigen OA or the lectin ConA, or antibodies specific for the VH-region of immunoglobulins, for the beta 2-microglobulin or for Ia-framework determinants. Neither the helper factor nor the suppressor factor showed affinity for antisera specific for immunoglobulin isotypes. In search of a constant-region-like structure in factor molecules, antisera were raised in rabbits using ThF120-OA and TsF120-OA. The results show that antisera raised against ThF120-OA recognize one or more determinants of different antigenic specificities common to human ThF. This common structure is not species-specific since it is also recognized by rabbit antisera to mouse helper factor. It is absent, however, on human TsF120-OA. In the same way, human TsF120-OA was shown to interact with rabbit antisera to human (or murine) suppressor factors of different antigenic specificities, but not with anti-ThF.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133D 3","pages":"221-34"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17251665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The idiotypic network: the murine MOPC315 anti-DNP system. 独特型网络:小鼠MOPC315抗dnp系统。
Annales d'immunologie Pub Date : 1982-11-01
M Amor, B Mariamé, D Voegtlé, P A Cazenave
{"title":"The idiotypic network: the murine MOPC315 anti-DNP system.","authors":"M Amor,&nbsp;B Mariamé,&nbsp;D Voegtlé,&nbsp;P A Cazenave","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>BALB/c mice were immunized against a monoclonal antiidiotypic antibody (Id 315.1.4) directed against the myeloma DNP-binding protein MOPC315 (IgA-lambda 2). This antibody is specific for an MOPC315 \"private\" idiotope, and the expression of this idiotope requires the interaction between MOPC315 heavy and lambda chains. Two categories of antibodies, able to combine with Id 315.1.4, were characterized in the sera of anti-Id 315.1.4 mice: (1) antibodies with a kappa light chain and without detectable anti-DNP function, and (2) antibodies with a lambda light chain and able to combine with DNP antigen. This observation suggests that the idiotypic network is not close-ended for a given idiotypic system but must be connected with other systems.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133D 3","pages":"255-62"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18032908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural and reinforced immunity against hapten-modified cells in vivo: importance of serum-borne and cellular factors. 体内对半抗原修饰细胞的自然和增强免疫:血清和细胞因子的重要性。
Annales d'immunologie Pub Date : 1982-11-01
P Bischoff, M Maugras, F Ferry, D Oth
{"title":"Natural and reinforced immunity against hapten-modified cells in vivo: importance of serum-borne and cellular factors.","authors":"P Bischoff,&nbsp;M Maugras,&nbsp;F Ferry,&nbsp;D Oth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chromium 51-labelled murine splenocytes were injected intravenously into syngeneic non-immune recipients. The percentages of radioactivity recovered in the spleens and the livers were determined, together with the liver/spleen (L/S) radioactivity ratios. It was found that using trinitrobenzene sulphonate (TNBS)-treated cells resulted in a diminution of splenic recovery, with a concomitant augmentation of the L/S ratio, which corresponded to figures found when non-treated xenogeneic lymphocytes were injected. When using splenocytes modified with trifluoromethyl-dinitrobenzene sulphonate (CF3-DNBS)--an analogue of TNBS--this sort of natural immunity was not observed. As cell modifications with TNBS and CF3-DNBS have previously been shown to cross-react in purely cellular immunity tests, the striking difference observed here was tentatively attributed to differential sensitivity to serum-borne factors which mediate this in vivo natural resistance. These factors are likely to be naturally occurring anti-trinitrophenyl antibodies. Contrastingly, if TNBS- and CF3-DNBS-modified splenocytes were injected into either anti-TNBS or anti-CF3-DNBS immunized mice, the modification of radioactivity recovery and L/S indexes (compared to those in non-immunized controls) was always greater in the case of the CF3-DNBS cells. It is concluded that, of these two cross-reacting cell surface modifying treatments, one (TNBS) is sensitive both to natural and reinforced immunity, whereas the second (CF3-DNBS) is sensitive only to reinforced immunity. As we have previously shown in vitro, that CF3-DNBS-modified cells do not seem to be sensitive to cytotoxic antibodies, we believe that the in vivo immune rejection observed is essentially a cell-mediated reaction, whereas the natural immunity is mainly a serum-dependent reaction.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133D 3","pages":"281-91"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18181558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Preparation of immunosorbents from lipopolysaccharides and polysaccharides extracted from various gram-negative and gram-positive bacteria]. [从各种革兰氏阴性菌和革兰氏阳性菌中提取的脂多糖和多糖制备免疫吸附剂]。
Annales d'immunologie Pub Date : 1982-11-01
J Goichot, M Duphot
{"title":"[Preparation of immunosorbents from lipopolysaccharides and polysaccharides extracted from various gram-negative and gram-positive bacteria].","authors":"J Goichot,&nbsp;M Duphot","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The method of binding of lipopolysaccharides (LPS) extracted from Salmonella typhimurium to aminohexyl-sepharose 4B by activation with benzoquinone was applied to three different LPS extracted from several enterobacteria species: S. seftenberg 1,3,19, S. cholerae suis 6(2),7 and Escherichia coli O141:H32. It was also used for two polysaccharides (PS) extracted from S. seftenberg 1,3,19 and Streptococcus agalactiae type II strain, respectively. Both PS were free from amino groups but exhibited the corresponding antigenic determinants of the cell wall. The use of these immunosorbents enabled us to obtain a monospecific antiserum. They may be a useful tool for serological identification of salmonella and group B streptococci. This method may be applied for other bacterial surface PS. The possible regeneration of such immunosorbents without appreciable loss of their antigen binding capacity makes possible their use for obtaining monospecific antibodies on a preparative scale.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133D 3","pages":"327-34"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17814555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A simple photometric microassay for the quantitative evaluation of macrophage-mediated cytotoxicity on adherent cancer cells. 一种简单的显微光度法定量评价巨噬细胞介导的对粘附癌细胞的细胞毒性。
Annales d'immunologie Pub Date : 1982-11-01
N O Olsson, A Leclerc, J F Jeannin, F Martin
{"title":"A simple photometric microassay for the quantitative evaluation of macrophage-mediated cytotoxicity on adherent cancer cells.","authors":"N O Olsson,&nbsp;A Leclerc,&nbsp;J F Jeannin,&nbsp;F Martin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new in vitro microassay was devised for the quantitation of macrophage-mediated cytotoxicity on cancer cells. After 72 h of culture with macrophages, the residual adherent target cells were stained with methylene blue. The cell-bound dye was then eluted and measured in a photometer. This assay is simple, quickly performed and gives reproducible results in good correlation with direct counting of the residual cells. It allows a quantitative evaluation of the whole toxic effect (cytostasis and cytolysis) of activated macrophages on adherent tumour cells.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133D 3","pages":"245-54"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18181557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corynebacterium parvum: antibodies measured with the enzyme-linked immunosorbent assay (ELISA) in normal human sera and sera from cancer patients undergoing treatment. 细小棒状杆菌:用酶联免疫吸附试验(ELISA)测定正常人血清和接受治疗的癌症患者血清中的抗体。
Annales d'immunologie Pub Date : 1982-11-01
E J Ruitenberg, J Buys, P S Ursem
{"title":"Corynebacterium parvum: antibodies measured with the enzyme-linked immunosorbent assay (ELISA) in normal human sera and sera from cancer patients undergoing treatment.","authors":"E J Ruitenberg,&nbsp;J Buys,&nbsp;P S Ursem","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An enzyme-linked immunosorbent assay (ELISA) was developed to monitor the antibody response to Corynebacterium parvum during cancer immunotherapy. Firstly, in sera from 176 clinically healthy individuals not treated with C. parvum, elevated ELISA extinction values were observed from the age of 11 years onwards for both sexes; these high values were probably due to preexisting antibodies to C. parvum or related organisms. Consequently, in order to evaluate C. parvum antibody levels after treatment it was essential to compare post- with pre-treatment sera. Next, a series of sera from 20 male patients with inoperable squamous cell carcinoma of the bronchus were tested. They originated from three different groups. The first group received both chemotherapy (cyclophosphamide) and immunotherapy (C. parvum), the second group cyclophosphamide alone and the third group neither of these agents. Compared to pre-treatment values, an increase in extinction values was already observed as from day 12 of C. parvum treatment; cyclophosphamide did not influence the extinction values. Antibody production per se did not seem to be correlated with an anti-tumour effect. The sensitivity of ELISA was similar to a previously described latex agglutination test.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133D 3","pages":"305-11"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18181561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular pharmacokinetics of spiramycin in cultured macrophages. 螺旋霉素在培养巨噬细胞中的细胞药代动力学。
Annales d'immunologie Pub Date : 1982-11-01
A Zenebergh, A Trouet
{"title":"Cellular pharmacokinetics of spiramycin in cultured macrophages.","authors":"A Zenebergh,&nbsp;A Trouet","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To gain a better understanding of the antibacterial and antiprotozoal activity of spiramycin as well as the characteristic conditions of cellular defence, we studied its accumulation and intracellular localization in cultured macrophages. Within two hours spiramycin in its active form is accumulated intracellularly by macrophages to a concentration 10 to 20 times that found in the extracellular medium; it is released slowly by the cells when they are incubated in antibiotic-free medium. After differential or isopycnic centrifugation, a bimodal localization of spiramycin was found; one part could be associated with the soluble cytosolic fraction and another with organelles sedimenting at a density of 1.17 g/ml, which represent part of the lysosomal population and perhaps the phagosomes.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133D 3","pages":"235-44"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18181556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human alpha-1-antichymotrypsin enhances primary antibody response in the mouse. 人α -1抗凝乳胰蛋白酶增强小鼠一抗反应。
Annales d'immunologie Pub Date : 1982-11-01
M Matsumoto, M Yamamura, T Ohkubo, I Shimizu, T Shimamura, T Katsunuma
{"title":"Human alpha-1-antichymotrypsin enhances primary antibody response in the mouse.","authors":"M Matsumoto,&nbsp;M Yamamura,&nbsp;T Ohkubo,&nbsp;I Shimizu,&nbsp;T Shimamura,&nbsp;T Katsunuma","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of human alpha-1-antichymotrypsin (alpha-1-Achy) on antibody response was studied in mice. alpha-1-Achy increased the number of antisheep erythrocyte antibody-producing cells. The increase was dependent on the dose of alpha-1-Achy injected (from 0.25 to 1 mg par mouse). alpha-1-Achy was effective if injected 2 days before or simultaneously with sheep erythrocytes. Asialylated alpha-1-Achy also enhanced the antibody response in the same way as native alpha-1-Achy. When alpha-1-Achy was heated at 60 degrees C for 15 min, it appeared to maintain immunoenhancing activity. However, when treated at 70 degrees C for 15 min, an intermediate immunoenhancing activity was observed, and heating at 100 degrees C for 15 min resulted in loss of activity.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133D 3","pages":"269-80"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17814996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heterogeneity of lymphokine production by murine T-lymphocyte clones. 小鼠t淋巴细胞克隆产生淋巴因子的异质性。
Annales d'immunologie Pub Date : 1982-09-01
H R MacDonald, A L Glasebrook, A Kelso, R H Zubler
{"title":"Heterogeneity of lymphokine production by murine T-lymphocyte clones.","authors":"H R MacDonald,&nbsp;A L Glasebrook,&nbsp;A Kelso,&nbsp;R H Zubler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The production of lymphokines by alloreactive murine T-lymphocyte clones was investigated. Clones derived by limiting dilution or by micromanipulation were stimulated with T-cell-depleted irradiated allogeneic spleen cells, and the resulting supernatants were assayed for interleukin-2 (IL-2), interferon-gamma (gamma-IFN), macrophage-activating factor (MAF), B-cell helper factor (BHF) or granulocyte/macrophage colony-stimulating factor (GM-CSF). Lymphokine production was found to be heterogeneous at the clonal level, with both cytolytic and non-cytolytic clones being able to produce some (or all) of the factors tested. Comparison of a large number of independently derived clonal supernatants allowed the separation of IL-2, BHF and GM-CSF from each other and from MAF and gamma-IFN; however, no dissociation between the latter 2 lymphokines was observed.</p>","PeriodicalId":75508,"journal":{"name":"Annales d'immunologie","volume":"133D 2","pages":"171-8"},"PeriodicalIF":0.0,"publicationDate":"1982-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17872030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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