Allergy, Asthma & Immunology Research最新文献

{"title":"Annual Change in Fungal Concentrations and Allergic Sensitization Rates to <i>Alternaria</i> and <i>Cladosporium</i> in Korea During the Period 1998-2022.","authors":"Young-Jin Choi, Kyung-Suk Lee, Jin Hyeok Jeong, Kyunghoon Kim, Seung Yang, Jae Yoon Na, Jae Kyoon Hwang, Yunsoo Choe, Kyu Rang Kim, Mae-Ja Han, Yung-Seop Lee, Jae-Won Oh","doi":"10.4168/aair.2023.15.6.825","DOIUrl":"10.4168/aair.2023.15.6.825","url":null,"abstract":"<p><strong>Purpose: </strong>Atmospheric fungi are associated with respiratory allergies in humans, and some fungal spores can cause allergic diseases. Environmental and biological factors influence the concentrations of atmospheric spores. In this study, we evaluated the climate change-induced annual variations in fungal spore concentrations and allergic sensitization rates in the Seoul Metropolitan Area over a period of 25 years.</p><p><strong>Methods: </strong>Fungal spores and pollen were obtained from Hanyang University Seoul and Guri Hospitals; they were identified and counted for 25 years (1998-2022). The study participants included patients who underwent tests for allergic diseases in both hospitals. Their allergenic sensitization rates were determined via allergic skin prick and serum tests, after which their sensitization rates to allergenic fungi and pollens were calculated. The daily climatic variables were obtained from the Korea Meteorological Administration.</p><p><strong>Results: </strong>The total annual atmospheric fungal concentrations decreased in both areas during the period. Simultaneously, we recruited 21,394 patients with allergies (asthma, 1,550; allergic rhinitis, 5,983; and atopic dermatitis, 5,422) from Seoul and Guri Hospitals for allergenic fungal sensitization evaluations over the period. The allergenic fungal sensitization rates decreased annually in both areas over that time `+(<i>Alternaria</i> [3.5%] and <i>Cladosporium</i> [4.4%] in 1998; <i>Alternaria</i> [0.2%] and <i>Cladosporium</i> [0.2%] in 2022). In contrast, the annual pollen concentrations increased with the sensitization rates to pollen in children.</p><p><strong>Conclusions: </strong>The atmospheric fungal concentrations decreased annually, with allergic sensitization rate decreasing over the period of 25 years. Allergenic fungal sporulation could decrease with climate changes, such as desertification and drought. Extended monitoring periods and further large-scale studies are required to confirm the causality and to evaluate the impact of climate change.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"825-836"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Standardization of Hum j 6 is Crucial to the Diagnosis of Pollinosis Due to Japanese Hop.","authors":"Young-Jin Choi, Jae-Won Oh","doi":"10.4168/aair.2023.15.6.702","DOIUrl":"10.4168/aair.2023.15.6.702","url":null,"abstract":"","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"702-704"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RDW-SD and PCT Are Potential Prognostic Factors for In-hospital Death in Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.","authors":"Lixia Zhang, Yunping Lan, Bo Qi, Ping Shuai, Qinchuan Hou, Wei Liu, Qian Wang","doi":"10.4168/aair.2023.15.6.812","DOIUrl":"10.4168/aair.2023.15.6.812","url":null,"abstract":"<p><strong>Purpose: </strong>Our study aimed to explore potential prognostic factors in Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) patients from easily accessible laboratory data and to investigate whether the combination of these indicators with a score for toxic epidermal necrolysis (SCORTEN) can improve the predictive value.</p><p><strong>Methods: </strong>Data from 85 SJS/TEN patients hospitalized from 2010 to 2021 were retrospectively analyzed. The primary outcome was in-hospital mortality. Univariate analysis was used to screen for laboratory indexes associated with death. Logistic regression was used to analyze significant risk factors for death. The differentiation and calibration of SCORTEN and modified score were assessed using receiver operating characteristic (ROC) curves and Hosmer-Lemeshow goodness-of-fit test. Net reclassification improvement (NRI) and integrated discrimination improvement (IDI) were used to evaluate the incremental prognostic value.</p><p><strong>Results: </strong>Among the 85 patients (37 males, 48 females) aged 14-88 years, the mortality rate was 11.8% (n = 10). SCORTEN had good discrimination and calibration to predict mortality in this cohort of patients (area under the ROC curve [AUC] of 0.874, 95% confidence interval [CI], 0.758-0.990; Hosmer-Lemeshow goodness-of-fit test <i>P</i> = 0.994). Red cell distribution width-standard deviation index (RDW-SD) > 47.9 fL and procalcitonin (PCT) > 0.67 ng/mL were significant risk factors for death. When adding the 2 factors to SCORTEN, AUC was 0.915 (95% CI, 0.833-0.997), but not statistically different compared to SCORTEN alone (<i>P</i> = 0.091). The NRI was 1.2 (95% CI, 0.672-1.728; <i>P</i> < 0.001) and the IDI was 0.09 (95% CI, 0.011-0.173; <i>P</i> = 0.026), still suggesting that the modified score had better discriminatory and predictive power than SCORTEN alone. The modified score also showed good calibration (Hosmer-Lemeshow goodness-of-fit test, <i>P</i> = 0.915).</p><p><strong>Conclusions: </strong>SCORTEN is a good predictor of mortality in SJS/TEN patients in southwest China. Combining RDW-SD > 47.9 fL and PCT > 0.67 ng/mL with SCORTEN may enhance the ability to predict prognosis.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"812-824"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TNS1 and NRXN1 Genes Interacting With Early-Life Smoking Exposure in Asthma-Plus-Eczema Susceptibility.","authors":"Patricia Margaritte-Jeannin, Raphaël Vernet, Ashley Budu-Aggrey, Markus Ege, Anne-Marie Madore, Christophe Linhard, Hamida Mohamdi, Erika von Mutius, Raquell Granell, Florence Demenais, Cathrine Laprise, Emmanuelle Bouzigon, Marie-Hélène Dizier","doi":"10.4168/aair.2023.15.6.779","DOIUrl":"10.4168/aair.2023.15.6.779","url":null,"abstract":"<p><strong>Purpose: </strong>Numerous genes have been associated with allergic diseases (asthma, allergic rhinitis, and eczema), but they explain only part of their heritability. This is partly because most previous studies ignored complex mechanisms such as gene-environment (G-E) interactions and complex phenotypes such as co-morbidity. However, it was recently evidenced that the co-morbidity of asthma-plus-eczema appears as a sub-entity depending on specific genetic factors. Besides, evidence also suggest that gene-by-early life environmental tobacco smoke (ETS) exposure interactions play a role in asthma, but were never investigated for asthma-plus-eczema. To identify genetic variants interacting with ETS exposure that influence asthma-plus-eczema susceptibility.</p><p><strong>Methods: </strong>To conduct a genome-wide interaction study (GWIS) of asthma-plus-eczema according to ETS exposure, we applied a 2-stage strategy with a first selection of single nucleotide polymorphisms (SNPs) from genome-wide association meta-analysis to be tested at a second stage by interaction meta-analysis. All meta-analyses were conducted across 4 studies including a total of 5,516 European-ancestry individuals, of whom 1,164 had both asthma and eczema.</p><p><strong>Results: </strong>Two SNPs showed significant interactions with ETS exposure. They were located in 2 genes, <i>NRXN1</i> (2p16) and <i>TNS1</i> (2q35), never reported associated and/or interacting with ETS exposure for asthma, eczema or more generally for allergic diseases. <i>TNS1</i> is a promising candidate gene because of its link to lung and skin diseases with possible interactive effect with tobacco smoke exposure.</p><p><strong>Conclusions: </strong>This first GWIS of asthma-plus-eczema with ETS exposure underlines the importance of studying sub-phenotypes such as co-morbidities as well as G-E interactions to detect new susceptibility genes.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"779-794"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Manifestations and Genotype of Primary Ciliary Dyskinesia Diagnosed in Korea: Multicenter Study.","authors":"Minji Kim, Mi-Hee Lee, Soo-Jong Hong, Jinho Yu, Joongbum Cho, Dong In Suh, Hyung Young Kim, Hye-Young Kim, Sungsu Jung, Eun Lee, Sooyoung Lee, Kyunguk Jeong, Jung Yeon Shim, Jeong Hee Kim, Hai Lee Chung, Yoon Young Jang, Ji-Won Kwon, Ju-Hee Seo, Ju Hee Kim, Ji Young Ahn, Kun-Baek Song, Kyu-Sang Song, So Yeon Kim, Seon Young Kim, Hong Ryang Kil, Eun Hee Chung","doi":"10.4168/aair.2023.15.6.757","DOIUrl":"10.4168/aair.2023.15.6.757","url":null,"abstract":"<p><strong>Purpose: </strong>Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder that leads to secondary ciliary dysfunction. PCD is a rare disease, and data on it are limited in Korea. This study systematically evaluated the clinical symptoms, diagnostic characteristics, and treatment modalities of pediatric PCD in Korea.</p><p><strong>Methods: </strong>This Korean nationwide, multicenter study, conducted between January 2000 and August 2022, reviewed the medical records of pediatric patients diagnosed with PCD. Prospective studies have been added to determine whether additional genetic testing is warranted in some patients.</p><p><strong>Results: </strong>Overall, 41 patients were diagnosed with PCD in 15 medical institutions. The mean age at diagnosis was 11.8 ± 5.4 years (range: 0.5 months-18.9 years). Most patients (40/41) were born full term, 15 (36.6%) had neonatal respiratory symptoms, and 12 (29.3%) had a history of admission to the neonatal intensive care unit. The most common complaint (58.5%) was chronic nasal symptoms. Thirty-three patients were diagnosed with transmission electron microscopy (TEM) and 12 patients by genetic studies. TEM mostly identified outer dynein arm defects (alone or combined with inner dynein arm defects, n = 17). The genes with the highest mutation rates were <i>DNAH5</i> (3 cases) and <i>DNAAF1</i> (3 cases). Rare genotypes (<i>RPGR</i>, <i>HYDIN</i>, <i>NME5</i>) were found as well. Chest computed tomography revealed bronchiectasis in 33 out of 41 patients. Among them, 15 patients had a PrImary CiliAry DyskinesiA Rule score of over 5 points.</p><p><strong>Conclusions: </strong>To our knowledge, this is the first multicenter study to report the clinical characteristics, diagnostic methods, and genotypes of PCD in Korea. These results can be used as basic data for further PCD research.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"757-766"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet Needs of Patients With Chronic Urticaria: A Survey in Korea.","authors":"Joonhong Min, Young Her, Ki Won Moon, Ji In Park, Sunmi Kim, Eun-Hee Cho, Kyu-Hyoung Lim, Jae-Woo Kwon","doi":"10.4168/aair.2023.15.6.837","DOIUrl":"10.4168/aair.2023.15.6.837","url":null,"abstract":"<p><p>Chronic urticaria (CU) is a common problem with a high disease burden that has a significant negative impact on quality of life. Many patients are undertreated, and awareness of management strategies is low among clinicians. The present study aimed to improve understanding of CU from the patients' perspective, including the disease burden and current healthcare system use. Adult patients who presented to our referral hospital for CU treatment completed self-report questionnaires about demographics, clinical characteristics of CU, the impact of CU on daily life, unmet needs, and the history of medical service usage. This self-report survey included 127 participants (females, 57.0%; mean age, 42.0 ± 13.6 years; mean CU duration, 1.8 ± 3.4 years); 51.6% reported frequent discomfort with CU in daily life, including 44.1% of those who reported a good response to medication. More than half of the respondents reported a depressed mood and anxiety. Although 46.4% of the respondents reported that urticaria completely disappeared while on medication, only 10% were satisfied with the CU management provided by primary care hospitals. The principal cause of dissatisfaction was that they did not know the cause of CU (68.4% of patients). In total, 55% of the patients visited 2 or more hospitals before presenting to our referral hospital and 6.3% had tried folk remedies. In conclusion, most patients report that CU is not adequately controlled. Therefore, in addition to appropriate medication, information on the cause of CU, long-term treatment plan, medication safety, and expected prognosis is required to meet patients' needs.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"837-845"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Ciliary Dyskinesia: A More Prevalent Disease Than Previously Believed?","authors":"Kyung Won Kim","doi":"10.4168/aair.2023.15.6.699","DOIUrl":"10.4168/aair.2023.15.6.699","url":null,"abstract":"","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"699-701"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Hum j 6, a Major Allergen From <i>Humulus japonicus</i> Pollen, the Primary Cause of Weed Pollinosis in East Asia.","authors":"Kyoung Yong Jeong, Minkyu Sang, Yong Seok Lee, Gabriele Gadermaier, Fatima Ferreira, Jung-Won Park","doi":"10.4168/aair.2023.15.6.767","DOIUrl":"10.4168/aair.2023.15.6.767","url":null,"abstract":"<p><strong>Purpose: </strong><i>Humulus japonicus</i> (<i>HJ</i>) is one of the most important causes of weed pollinosis in East Asia. The 10 kDa protein with pI 10 in 2-dimensional gel has been recognized as the representative major allergen of <i>HJ</i>, but its major allergens have not been characterized. This study aimed to characterize the major allergen of <i>HJ</i>.</p><p><strong>Methods: </strong>A major allergen in Japanese hop was detected by proteome analysis; it was purified to homogeneity and its sequence was obtained by transcriptome analysis. The recombinant proteins were produced in <i>Escherichia coli</i> and <i>Pichia</i> expression systems, and their immunoglobulin E (IgE) reactivities were compared to those of the natural counterpart. We also analyzed post-translational modifications such as glycosylation and phosphorylation.</p><p><strong>Results: </strong>Pectin methylesterase inhibitor, Hum j 6, was found to be the major allergen of <i>HJ</i>, and <i>in silico</i> signal peptide prediction corresponds to a 15.1 kDa protein with a theoretical pI of 8.28. Natural Hum j 6 was recognized by IgE antibodies from 86.4% (19/22) of <i>HJ</i> pollinosis patients, whereas the recombinant proteins did not show strong IgE reactivity. No glycosylation was detected, while at least 15 phosphorylated amino acids, possibly causing the pI and molecular weight shift, were detected by tandem mass spectrometry analysis.</p><p><strong>Conclusions: </strong>Hum j 6 was identified as the representative major allergen of <i>HJ</i> and seems to be modified significantly after translation. These findings are useful for the development of component-resolved diagnosis and immunotherapy.</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"767-778"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study.","authors":"Mengru Zhang, Alyn H Morice, Fengli Si, Li Zhang, Qiang Chen, Shengyuan Wang, Yiqing Zhu, Xianghuai Xu, Li Yu, Zhongmin Qiu","doi":"10.4168/aair.2023.15.6.795","DOIUrl":"10.4168/aair.2023.15.6.795","url":null,"abstract":"<p><strong>Purpose: </strong>Only limited studies have depicted the unique features and management of refractory chronic cough (RCC) and unexplained chronic cough (UCC). These led to the initiation of this study, which reported the demographic characteristics, manifestations, and long-term outcomes on a large series of consecutive RCC/UCC patients, providing a guideline-led real-world clinical experience.</p><p><strong>Methods: </strong>Retrospective baseline information was obtained from Clinical Research Database (January 2016 to May 2021). At least 6 months after the last clinic visit, included subjects were prospectively followed up.</p><p><strong>Results: </strong>Three hundred and sixty-nine RCC and UCC patients (199 females, 53.9%) were analyzed. The median cough duration was 24.0 (12.0-72.0) months. Laryngeal symptoms were reported in 95.9% of the patients. The common triggers for coughing were talking (74.9%), pungent odors (47.3%), eating (45.5%), and cold air (42.8%). RCC was considered in 38.2%, and the remainder of 228 patients had UCC, with an equal sex distribution (<i>P</i> = 0.66). Among the 141 RCCs, 90.8% (128) had refractory reflux cough, which was more responsive to current treatments (<i>P</i> < 0.01). Although most features and test results between RCC and UCC were similar, UCC was more commonly inappropriately treated (<i>P</i> < 0.01). Nineteen (7.7-41.1) months after the final clinic visit, 31.2% still coughed persistently, while 68.8% reported cough improvement or remission. RCC reported more favorable treatment outcomes (including cough improvement, control, and spontaneous remission) than UCC (<i>P</i> < 0.01). Coughs with long duration before the initial cough clinic visit (<i>P</i> < 0.01), frequent urinary incontinence (<i>P</i> < 0.01), and being sensitive to \"talking\" (<i>P</i> < 0.01) or \"cold air\" (<i>P</i> < 0.01) were less likely to be solved.</p><p><strong>Conclusions: </strong>The current treatments only improve cough symptoms in two-thirds of patients. Clinical indicators for treatment failure were those coughing for long duration and being sensitive to \"talking\" or \"cold air.\"</p>","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"15 6","pages":"795-811"},"PeriodicalIF":4.4,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10643855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92152264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Sublingual Immunotherapy using a Combination of Dermatophagoides Pteronyssinus and Blomia Tropicalis Extracts in Patients with Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial","authors":"Macedo Priscilla Rios Cordeiro, Moraes Priscila, Arruda Luisa Karla, Castro Fábio Fernandes Morato, Kalil Jorge, Santos Galvão Clóvis Eduardo","doi":"10.29328/journal.aaai.1001033","DOIUrl":"https://doi.org/10.29328/journal.aaai.1001033","url":null,"abstract":"The aim of this study was to evaluate the safety and efficacy of sublingual immunotherapy (SLIT) with extracts of Dermatophagoides pteronyssinus and Blomia tropicalis in patients with moderate/severe persistent allergic rhinitis (AR). Methods: This was a double-blind, randomized, placebo-controlled trial of SLIT for the treatment of house dust mite-induced AR. A total of 65 patients, aged between 12 and 60 years, were treated for 12 months and randomized into two groups: SLIT and placebo. The SLIT group received a combination of extracts containing Dermatophagoides pteronyssinus and Blomia tropicalis allergens. All had their sensitization confirmed by skin prick test or serum-specific IgE. Total Nasal Symptom Score, RQLQ quality of life questionnaire, current treatment, and need for medication to control symptoms were recorded during the study. Total serum IgE, serum specific IgE, and IgG4 levels to Der p 1 and Blo t were assessed at baseline, 6 and 12 months after treatment. Results: There was no significant difference in the number of adverse events between groups. The SLIT group showed a significant reduction in the consumption of antihistamines to control symptoms (p < 0.0001) when compared to placebo. There was no significant change in serum total IgE, serum specific IgE, and IgG4 to both allergens when comparing the SLIT and placebo groups. Conclusion: After one year, SLIT using a dose of 1 mcg of Der p 1/day and 753 UBE of Blo t/day proved to be effective and safe in controlling AR exacerbations.","PeriodicalId":7547,"journal":{"name":"Allergy, Asthma & Immunology Research","volume":"158 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136238299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}