Aktuelle Gerontologie最新文献_第6页

[Giant cell arteritis: multiform disease of the elderly human]. 巨细胞动脉炎:老年人的多形性疾病。

Aktuelle Gerontologie Pub Date : 1983-01-01

J Slany

引用次数: 0

[Insertion tendopathy of the elbow joint as geriatric disease picture]. [肘关节插入性肌腱病作为老年病图]。

Aktuelle Gerontologie Pub Date : 1983-01-01

F Horváth, L Kéry, P Sillar, G Bender, E Lengyel

引用次数: 0

[Carpal tunnel syndrome as an unrecognized disease in the aged]. [腕管综合征是一种未被认识的老年人疾病]。

Aktuelle Gerontologie Pub Date : 1983-01-01

H E Diemath, J Strohecker, H Kollmann

引用次数: 0

Effects of prolonged aminoglutethimid and dehydroepiandrosterone treatment on rat bones. 氨基乙硫胺和脱氢表雄酮长期治疗对大鼠骨骼的影响。

Aktuelle Gerontologie Pub Date : 1983-01-01

M Boross, E Morava, I Gergely, I Holló

{"title":"Effects of prolonged aminoglutethimid and dehydroepiandrosterone treatment on rat bones.","authors":"M Boross, E Morava, I Gergely, I Holló","doi":"","DOIUrl":"","url":null,"abstract":"Authors studied the effect of prolonged sex hormone deficiency on some parameters of bone metabolism in calcitonin sensitive young male rats. 30 rats were given aminoglutethimid (AG) for 36 days. Part of these animals received plus dehydroepiandrosterone (DEA) treatment. Corticoid deficiency was substituted by cortisone. In addition 22 rats were administered only cortisone, 11 animals cortisone and DEA, and 10 rats only DEA for 36 days. On day 37 the different parameters of treated rats were compared to findings in 31 control animals. It has been found that body weight, calcitonin hypocalcaemia, serum alkaline phosphatase, as well as bone ash weight pro unit body weight was significantly lower in AG treated rats as compared to controls and rats receiving DEA in addition to AG. Values of latter group did not differ from controls. It has also been established that neither cortisone substitution nor isolated DEA treatment did involve significant differences in the studied parameters of bone metabolism as compared to controls. The findings support the opinion that sex hormone deficiency, directly or indirectly results osteoporosis. The experimental model seems to be suitable for the study of androgen deficient osteopenia.","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 1","pages":"15-8"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17198512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age dependence of mechanical properties of rat tail tendons (hysteresis experiments). 大鼠尾肌腱力学性能的年龄依赖性(迟滞实验)。

Aktuelle Gerontologie Pub Date : 1983-01-01

H G Vogel

{"title":"Age dependence of mechanical properties of rat tail tendons (hysteresis experiments).","authors":"H G Vogel","doi":"","DOIUrl":"","url":null,"abstract":"Mechanical parameters of tail tendons have been studied depending on maturation and age using male Sprague Dawley rats at an age of 1, 2, 4, 12 and 24 months. Ultimate values, such as ultimate strain, ultimate load, tensile strength, and ultimate modulus of elasticity, were the highest at an age of 12 months. In old rats these values were slightly lower. Using tail tendons with the same diameter from the same rats hysteresis experiments have been performed at extension degrees of 2, 4, 6 and 8% respectively. Stress at the end of the loading phase was the highest at 4 months for 2 and 4% extension and at 12 months for 6 and 8% extension. Between 12 and 24 months no significant difference was found. Modulus of elasticity at the end of the loading phase showed a sharp increase due to maturation reaching the maximum at 4 months at 2 and 4% extension and at 12 month at 6 and 8% extension. Thereafter a decrease was noted as it was for ultimate modulus of elasticity. Energy input during the loading phase increased during maturation. This increase was less pronounced for energy dissipation indicated by the unloading phase. As a consequence, the ratio between energy dissipation and energy input decreases significantly during maturation, however, during aging merely a slight decrease is noted. Residual extension at the end of the unloading phase is considerably decreased during maturation. Between 12 and 24 months only minor changes of this parameter were noted. In conclusion the parameters describing the hysteresis phenomenon in rat tail tendons are considerably influenced by maturation but only to a minor degree by aging. In this phenomenon indicating plasticity no reversal in the direction of age dependent changes has been observed. The comparison of the results of the hysteresis experiments in rat tail tendons with similar experiments performed previously in rat skin shows similarities as well as significant differences between both tissues.","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 1","pages":"22-7"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17198514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Human calcitonin in the treatment of symptomatic Paget's disease]. 人降钙素治疗症状性佩吉特病

Aktuelle Gerontologie Pub Date : 1983-01-01

R Mathä, J Kovarik, W Woloszczuk, H Plenk, R Willvonseder, N Böhler, G Seidl, R Höfer

引用次数: 0

[Degree and interest in information on in nutritional problems of the elderly]. [对老年人营养问题信息的程度和兴趣]。

Aktuelle Gerontologie Pub Date : 1983-01-01

W Wirths, R I Strauch, C Niedermeyer

引用次数: 0

Changes in cell cultures of bovine corneal endothelium cells as related to donor age and number of passages in vitro. 牛角膜内皮细胞的细胞培养变化与供体年龄和体外传代次数有关。

Aktuelle Gerontologie Pub Date : 1982-11-01

K Sames, J Lindner

{"title":"Changes in cell cultures of bovine corneal endothelium cells as related to donor age and number of passages in vitro.","authors":"K Sames, J Lindner","doi":"","DOIUrl":"","url":null,"abstract":"Aging changes of the acidic glycosaminoglycans (aGAG) were investigated in bovine corneal endothelium cells grown in vitro, using histochemical methods and the determination of hexosamine and uronic acid. The time interval between trypsination and confluency of the monolayer and the cell counts at different time intervals of the same passage number served as parameters for the proliferation capacity of the cultures. A cell line, derived from the eye of a 1,5 year old cattle showed a low proliferation capacity in the first 9 passages, which increased until the 15th passage, to decrease thereafter until the 29th passage. In cells from eyes aged 11 and 12 years respectively the initial proliferation capacity was very low to reach the same values as in cultures of the young eye at the 10th passage but remained constant thereafter. Chromosome counts showed an increased number of hyperploids in late passages of cells from the aging eye with counts around 4n-8n increased to 17% as compared to 5% in the cells derived from the young eye. The cell densities were increased in cultures of high passage numbers. Histochemically the aGAG were shown in the cell nucleus, and the cytoplasm as well as in the intercellular space. In the nuclei of cells from aging eyes and in late passage cells of the young eye they showed an increased resistance against resting hyaluronidase. The hexosamine and uronic acid values were high in early passages of cultures from the young eye and decreased in late passages of the young eye as well as in early passages of cells from the aging eyes. The changes in the aGAG as well as the changes in the cell proliferation are similar comparing early passage cells of aging eyes to late passage cells of the young eyes. But the aGAG changes are more pronounced in cells of eyes aged in vivo. In the eye the proliferation of the corneal endothelium cells is inhibited. As such these cells provide a useful model to comparing in vivo-aging changes of resting cells to changes of the same cells proliferating in vitro.","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"12 6","pages":"206-12"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17197436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Biological and gerontological significance of oxygen]. [氧气的生物学和老年学意义]。

Aktuelle Gerontologie Pub Date : 1982-11-01

H Nohl

{"title":"[Biological and gerontological significance of oxygen].","authors":"H Nohl","doi":"","DOIUrl":"","url":null,"abstract":"The phylogenetic \"discovery\" of oxygen as the terminal electron acceptor of respiration may be regarded as a prerequisite of the development to higher forms of life. The rationale for this assumption is based on the considerable higher energy gain associated with aerobic respiration which allowed to go new pathways in metabolism. However, oxygen constitutes both a benefit and a threat to living things because aerobic respiration involves the formation of dangerously reactive intermediates. These intermediates have been recognized to play a key role in many pathogenetic events and postulated to contribute to the biological process of aging. Organisms which have availed themselves of the benefit of aerobic respiration, developed a series of synergistic defenses against its danger. Perturbation of oxygen homeostasis occurs when formation of toxic oxygen intermediates exceeds the capacity of protective mechanisms. A sudden event which leads to such an imbalance may cause the manifestation of different types of maladies. Our own investigations on rat-heart mitochondria have indicated that aging is associated with a progressive loss in the capacity to balance the formation of toxic oxygen metabolites. Despite a clear induction, activities of protecting enzymes seem to be \"swamped\" by an age-dependent raise of steady state levels of dangerous oxygen intermediates. The resulting structural damage and functional impairment of mitochondria are discussed as the primary cause of cellular aging.","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"12 6","pages":"195-9"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17197434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pick's disease. A special type of pathological aging of the brain]. (选择的疾病。一种特殊类型的大脑病理性老化]。

Aktuelle Gerontologie Pub Date : 1982-11-01

F Seitelberger

{"title":"[Pick's disease. A special type of pathological aging of the brain].","authors":"F Seitelberger","doi":"","DOIUrl":"","url":null,"abstract":"Pick's disease (circumscribed lobar atrophy of the brain) in its typical form, is a so-called presenile type of dementia, i.e. a cerebral disease which begins in the sixth decade of life, and leads to a progressive loss of intellectual capacity traits. Neuropathologically, Pick's disease is characterised by severe focal atrophy of the cerebral cortex, mainly of basal parts of the temporal and frontal lobe. In the long run, all the nerve cells of the affected areas and their processes are destroyed. This also involves the subcortical white matter (loss of nerve fibres and cicatrisation). Concomitant atrophies of other parts of the brain are frequent. The article reports on the results of the clinico-neuropathological examination of 30 cases of Pick's disease basing on the author's own observations. Special emphasis is placed on \"neuronal atrophising dystrophy\" of cortical systems as a characteristic change caused by Pick's disease; this phenomenon is interpreted as an endogenous disturbance of the neuronal structural metabolism. This process is, as a matter of principle, identical with the physiological \"atrophising dystrophy\" which represents part of cerebral aging. There are also pathogenetical parallels to orthological neuronal reactions to damaging of the axis cylinder processes. Pick's disease is characterised by the pathological extent and type of manifestation of \"neuronal atrophising dystrophy\". This pathological distortion of physiological processes is probably due to a specifically genetic and sometimes hereditary constellation. Finally, the article discusses the functional neuropathology or neuropsychology of Pick's disease. The importance of the basal temporofrontal cortex for the quality and preservation of human personality is emphasised; the changes of the high-class performances of the human brain, as caused by Pick's disease, are interpreted. Referring to the peculiarities of Pick's disease compared with normal cerebral aging, particular attention is drawn to the concept of \"disease\" and the definition of senile cerebral aging.","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"12 6","pages":"200-5"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17197435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0