{"title":"Age dependent phagocytosis of red cell membranes by the reticulohistiocytary system of the isolated perfused rat liver.","authors":"T Vömel, D Platt, N Müller, B Schnorr","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Isolated rat livers were perfused with a medium free of immune globulines, protein and hemoglobin to investigate age-dependent differences in the phagocytosis of erythrocyte membranes. Membranes of young erythrocytes were phagocytised in a significantly higher rate than those of old ones. The control parameters of the liver function were also significantly higher during the increased phagocytosis of the young cells than that of old cells and cells of the control group.</p>","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 6","pages":"229-32"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17207316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The correlation between serum lipid levels and the percentage of human peripheral blood lymphocytes bearing some surface markers.","authors":"J Witkowski, W Skassa, J Mysliwska, A Mysliwski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The correlations between serum HDL, total cholesterol, triglycerides or free fatty acids levels and the percentage of human peripheral blood lymphocytes bearing receptors for SRBC, MRBC, Con A or sIgG were sought in the aged people. The persons examined showed a marked heterogeneity in their serum lipid levels as well as in the results of lymphocyte surface receptor analysis. However, the only correlation found was that between the percentage of MRBC-rosette forming cells and the level of serum free fatty acids. The total cholesterol level, known as the modulator of some physical parameters of lymphocyte membrane, had, in our examination, no correlation with the changes of surface properties of lymphocytes. The possible physiological role of the phenomena observed is discussed.</p>","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 6","pages":"233-5"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17206368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Iatrogenic and environmentally induced diseases of the liver in old age: viral hepatitis in old age].","authors":"W Horak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Elderly people rarely develop hepatitis A, because of their acquired immunity, but they are more exposed to hepatitis-B and -nonAnonB infections. The course of viral hepatitis is usually more severe and more prolonged, the mortality of fulminant hepatitis is higher, and the risk of developing chronic hepatitis B is increased. There exists an association between chronic hepatitis B virus infection, old age, and the incidence of hepatoma. Exposed elderly persons should be vaccinated against hepatitis B but it might be necessary to give them additional booster doses in order to achieve sufficient antibody production.</p>","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 6","pages":"214-6"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17207311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Cell culture as an experimental system for studying aging processes].","authors":"M Steinhardt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The investigation of cellular aging has mainly been limited by experimental and descriptive work on two separate cell culture systems. On one hand studies were performed on in vitro aging, comparing fibroblasts in early and late passage. On the other hand, fibroblasts derived from donors of different age were compared (in vivo aging). Recently, results have been achieved, stating that some of the investigated parameters change similarly in both systems. Therefore it is of great importance to find criteria for cellular aging, not only to precise the results in both cell culture systems, but also to be able to draw conclusions concerning aging of the organism in vivo.</p>","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 6","pages":"223-5"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17207314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Psychosomatic relations between the date of death and birth].","authors":"K D Stumpfe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the life of old people the birthday has a special importance because at this day the entire family comes together and celebrates the anniversary. By means of 2000 advertisements of a daily newspaper the problem was investigated wether the birthday has a life-lengthening consequence in the meaning of that the old man or woman wants to be alive till this day and then he will die in peace. The results show fluctuations about the average monthly death-rate without statistical significance. Such a psychosomatic influence on the time of death commonly does not exist, although it may occur in an individual case.</p>","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 6","pages":"244-7"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17206371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Spatial orientation capability in the elderly].","authors":"R Winkler, E Opgenoorth, O Presslich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A labyrinth-learning experiment was conducted with 83 elderly subjects (median 53 years), which was validated against the architectural \"reality\" of the clinic in which the test was conducted. The orientation capability of psychologically normal subjects was compared with the performance of patients with a depressive syndrome and/or with an organic mental syndrome. Factor Analysis revealed the independent influence of component functions, the most important being spatial imaging, memory, goal-seeking orientation, labyrinth learning and right-left coordination. Orientation in reality is not accurately predicted by performance on the labyrinth test model. Contrary to our expectation, the presence of OMS alone did not decrease performance; however the presence of a depressive syndrome, both alone as well as in conjunction with OMS did. Diagnostic and therapeutic implications are discussed.</p>","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 6","pages":"236-40"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17206369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Relations of the ultrasonic image of the inferior vena cava and central venous pressure].","authors":"C Adler, W Büttner, R Veh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a prospective study of 50 patients a good correlation was found between the central venous pressure and the sonographic appearance of the inferior caval vein (ICV) behind the liver in right paramedian scanning. Dependent on central venous pressure (CVP) there were typical variations in the configuration, width and respiratory movements. These changes allowed a reliable estimation of the CVP. Decrease of the width in anteroposterior diameter in connection with a reduction of respiration-dependent caval movement indicated a deficiency of circulating blood volume. These alterations were always positive in cases of dehydration. Elongation of the vessel together with a widening over 2 cm and the lack of the normal end-inspiratory collapse were signs of an increased CVP. This non-invasive method is without risks or inconvenience for the patient. It is easily and quickly applied and very reliable for analyzing ICV haemodynamics. ICV ultrasonography can be recommended as a diagnostic aid for dehydration and hyperhydration as well as right heart failure, especially unrecognized, that means cardiac insufficiency without peripheral edema, constrictive pericarditis, tricuspid valve disease and for the assessment of the course of right cardiac failure.</p>","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 6","pages":"209-13"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17207310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Institutional care at the age of 79 in an urban population--an analysis from a longitudinal population study.","authors":"D Mellström, A Rundgren","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The need of institutional care is strongly correlated to age. In the population, that is between 70 and 79 years of age the proportion of patients in long-term medical care units increases twenty-fold. The present investigation is a part of the longitudinal population study of 70-year-olds who have been followed to 79 years of age in Göteborg. A representative sample of 79-year-old men and women has been investigated. At this age 8.7 per cent of the men and 8.3 per cent of the women were living in medical and social institutions. Institutionalization was defined as constant care outside the patient's home for at least three successive months at the time of the investigation. The percentage of men living in somatic long-term medical care facilities was 4.3, while for women it was 2.4. The corresponding figures for psychiatric long-term care were 1.9 per cent for men and 1.8 per cent for women. 1.9 per cent of the men and 3.7 per cent of the women had moved to old people's homes where the subjects are expected to manage their own daily activities. Among the institutionalized probands only 7 per cent of the women were married, while this was the case for 43 per cent of the men. The subjects in psychiatric long-term care had the longest nursing time, i.e. about 20 years, while in the other types of institutions this time was about 3 years. The longitudinal strategy makes it possible to describe age-related changes in the background factors behind institutionalization.</p>","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 6","pages":"241-3"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17206370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Hyperthyroidism in the aged].","authors":"C Lucke, G A Kleff, D Weiss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clinical symptoms in elderly patients with hyperthyroidism are atypical and uncharacteristic. In 13 patients with overt hyperthyroidism a goiter was found in only half the patients, eye signs in just three of them. Tachycardias, sometimes even paroxysmal tachycardias, predominate. In old people the diagnosis of hyperthyroidism is frequently missed, in 11 of 13 patients the disease was diagnosed following transfer to the rehabilitation center. About 50% of patients were iodine contaminated and this may have contributed to the disease. Data are presented to demonstrate that hyperthyroidism in old age may be a life threatening disease.</p>","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 6","pages":"217-20"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17207312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship of mitochondrial damage in human lymphocytes and age.","authors":"E Beregi, O Regius","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Authors examined the peripheral lymphocytes of 366 healthy individuals electron microscopically. They described age related degenerative changes in the mitochondria. The lamellar structure, electron-dense and electron-opaque material shown in the mitochondria of the lymphocyte proved to be similar to lipofuscin. The relationship of mitochondrial damage in lymphocytes and age was analysed, too. They stated that the number of patients with mitochondrial changes in the lymphocytes increased from 50 years of age until 80 years, but after 80 years decreased.</p>","PeriodicalId":75459,"journal":{"name":"Aktuelle Gerontologie","volume":"13 6","pages":"226-8"},"PeriodicalIF":0.0,"publicationDate":"1983-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17207315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}