AIDS and Behavior最新文献

{"title":"Intravenous Methamphetamine Use, HIV Status and PrEP Uptake Among a U.S. Sample of 29,880 Gender and Sexual Minorities, 2022-2023.","authors":"Tyler S Bartholomew, Marina Plesons, Drew A Westmoreland, Alexa B D'Angelo, Chloe A Mirzayi, Michelle Dearolf, Yan Guo, Elena Hoeppner, Nicole S Richards, Viraj V Patel, Denis Nash, Adam W Carrico, Christian Grov","doi":"10.1007/s10461-025-04846-0","DOIUrl":"10.1007/s10461-025-04846-0","url":null,"abstract":"<p><p>Methamphetamine use is prevalent among sexual and gender minority (SGM) populations and is associated with increased risk for HIV acquisition. Studies are needed to examine the prevalence of intravenous methamphetamine use and explore its association with HIV status and PrEP uptake. Between August 2022-July 2023, 29,880 SGM people who have sex with men in the U.S. aged 16 and over completed a screening survey for a cohort study on methamphetamine use and HIV prevention. The survey captured socio-demographic characteristics, methamphetamine use (any and injection) and other substance use, and HIV-related measures (including current and previous PrEP use). The median age was 34 years and 49.7% were persons of color. Overall, 35.0% reported methamphetamine use; of whom 45.1% had injected it in the prior 12 months. Compared to people with non-injection methamphetamine use, respondents who injected methamphetamine were more likely to be older, white (vs. non-Hispanic Black or Hispanic), living with HIV or not know their status (vs. HIV-negative), to have injected cocaine, and to have had a sexual encounter without consent under the influence of alcohol/drugs. Among those who were HIV-negative, people who injected methamphetamine were less likely to currently take PrEP and more likely to have discontinued PrEP compared to those who reported non-injection methamphetamine use. Expanded efforts are needed to develop and implement targeted interventions, including PrEP and harm reduction approaches for SGM people who inject methamphetamine, to reduce risk of HIV and other infectious diseases, as well as other injection-related harms.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: A Randomized Comparison Trial Testing Two Culturally Adapted HIV Prevention Approaches for Native Americans Reducing Trauma Symptoms Versus Substance Misuse","authors":"C. R. Pearson,&nbsp;D. Huh,&nbsp;M. Bedard-Gilligan,&nbsp;D. Walker,&nbsp;R. A. Marín,&nbsp;K. Saluskin,&nbsp;D. Kaysen","doi":"10.1007/s10461-025-04843-3","DOIUrl":"10.1007/s10461-025-04843-3","url":null,"abstract":"","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":"29 10","pages":"3313 - 3314"},"PeriodicalIF":2.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Dyad-Based Intervention to Improve Adherence to Antiretroviral Therapy among People with HIV who Inject Drugs in Kazakhstan: Results of a Randomized Controlled Trial.","authors":"Alissa Davis, Elena Rozental, Niall Bolger, Valera Gulyayev, Pavel Gulyayev, Alfiya Denebayeva, Hao Wen, Jiawen Cui, Assel Terlikbayeva, Sholpan Primbetova, Jackelyn Samandas, Frederick L Altice, Robert H Remien, Gaukhar Mergenova","doi":"10.1007/s10461-025-04841-5","DOIUrl":"https://doi.org/10.1007/s10461-025-04841-5","url":null,"abstract":"<p><p>Kazakhstan has one of the fastest-growing HIV epidemics in the world, concentrated in people who inject drugs (PWID) with suboptimal antiretroviral therapy (ART) adherence. We compared the efficacy of a dyad-based social support intervention to standard of care on increasing ART adherence among PWID in Kazakhstan. PWID with HIV and on ART for ≥ 3 months ('index cases') were recruited from Kazakhstan's largest HIV clinic. PWID invited a treatment support partner (i.e., spouse, family member, or friend) to participate. Dyads were randomized 1:1 to a standard of care or intervention arm, the latter involving three intervention sessions in four weeks. Assessments were completed at baseline (pre-intervention), one-month (immediately post-intervention), and three-month and six-month follow-up. We used multilevel mixed models to examine changes in ART adherence among index cases over time between arms. Among the 66 index cases, those in the intervention arm who had a partner with HIV had a significantly higher adjusted mean change (AMC) in self-reported ART adherence immediately post-intervention (one-month follow-up) than index cases in the control arm with partners with HIV (AMC 16.55, 95% CI [2.77, 30.34], p = 0.038); this effect was maintained at the six-month follow-up (AMC 17.05, 95% CI [3.14, 30.95], p = 0.033). No significant differences between arms were found among index cases who had partners without HIV. No significant differences in electronic monitoring device-measured adherence or viral suppression were found between arms. The dyad-based intervention significantly increased self-reported ART adherence among PWID with partners with HIV, indicating the importance of considering dyad-level factors in interventions.Clinical Trial Registration: NCT03555396.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male Circumcision and HIV Risk Compensation Among Men Who Have Sex with Men: A Systematic Review and Meta-Analysis.","authors":"Xinsheng Wu, Zhongwen Wang, Yongjian Shi, Thomas Fitzpatrick, Weijie Zhang, Zixin Wang, Phoenix K H Mo, Luyao Xie, Yu Liu, Domingo Fernández Vecilla, Qianqian Luo, Aidi Zhang, Ana Claudia Ossa-Giraldo, Kate M Mitchell, Sten H Vermund, Huachun Zou","doi":"10.1007/s10461-025-04850-4","DOIUrl":"https://doi.org/10.1007/s10461-025-04850-4","url":null,"abstract":"<p><p>Male circumcision (MC) has been shown to reduce the risk of HIV infection among men who have sex with men (MSM) in a recent randomised controlled trial. A question that remains unanswered is whether MC in MSM implies HIV compensation, i.e. condomless sex and/or multiple sex partners. We searched PubMed, Embase, and the Cochrane Library for relevant studies published before November 5, 2024 and reviewed references of included studies. We included interventional and observational studies reporting original quantitative data on the association between MC and condom use or the number of sex partners among MSM. Odds ratios (ORs) and 95% confidence intervals (CIs) were extracted directly from the studies or calculated from available data when necessary. A Mantel-Haenszel random effects model was used to calculate pooled ORs and CIs. The final analysis included 41,694 MSM from 15 eligible studies. No statistically significant association was found between MC and condomless sex (OR 1.02, 95% CI 0.91-1.14; k = 13; I² = 18%) or multiple sex partners (OR 1.03, 95% CI 0.94-1.12; k = 10; I² = 12%) among MSM. The lack of association persisted in the great majority of subgroup analyses, encompassing country income, age, recruitment setting, time length, year of recruitment, circumcision assessment, proportion circumcised, or risk of bias. In conclusion, MC among MSM was not found to be associated with either condomless sex or multiple sex partners. Nonetheless, standard minimum service packages, as per WHO guidelines, should be integrated and consistently provided within MC programs to better protect MSM from HIV infection.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"The Simplest Way to Go\": An Exploration of Why Women Who Inject Drugs Chose Long-Acting Injectable Cabotegravir Instead of Daily Oral PrEP.","authors":"Alexis M Roth, Kathleen M Ward, Erin McDowell, Elana Forman, K Rivet Amico, Tyler S Bartholomew, Douglas Krakower, Daniel Vader, Silvana Mazzella, Adam W Carrico, Susan G Sherman, Allison Groves","doi":"10.1007/s10461-025-04833-5","DOIUrl":"https://doi.org/10.1007/s10461-025-04833-5","url":null,"abstract":"<p><p>Long-acting injectable PrEP was approved for use in the US in 2021 but roll out has been slow, with few studies exploring uptake among cisgender women who inject drugs (WWID). We purposively recruited 25 WWID within 30-days of receiving a PrEP prescription from a low-barrier clinic co-located with a syringe services program to complete semi-structured interviews about PrEP product choice. We used an intersectional lens to compare decision-making between women choosing injectable PrEP versus oral PrEP and continued enrolling new participants until we reached thematic saturation (12/2022 to 2/2024). Participants represent a diverse sample of WWID (12 women of color) with median age 43 years. Daily injection drug use (72%) and ≥ 1 sex partner (64%) were common. Salient themes from interviews include: (1) PrEP provides women with a valued safety net and initiation is a form of self-preservation. (2) Co-located care, small incentives, and provider respect for WWID's medical autonomy helped participants navigate a multi-visit PrEP intake process. (3) Longer lasting HIV protection with less frequent dosing is preferrable to a shorter acting daily oral medication. When selecting a product, WWID evaluated its attributes against their medical history and personal circumstances like homelessness (64%). Most chose CAB-LA (72%) because it provides longer lasting protection which was a highly valued product attribute. Together, our findings underscore the critical importance of offering multiple PrEP options when implementing HIV prevention strategies that are patient-centered and responsive to the unique needs of WWID.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Session Interventions To Enhance HIV Outcomes among Adolescents and Young Adults: A Systematic Scoping Review and Implications for Integrating HIV and Mental Health Services.","authors":"Juan Pablo Zapata, Andy Rapoport, Annie Wescott, Shivranjani Gandhi, Tyra Cole Bergstrom, Andrés Alvarado Avila, Lisa M Kuhns, Robert Garofalo, Jessica Lee Schleider","doi":"10.1007/s10461-025-04834-4","DOIUrl":"https://doi.org/10.1007/s10461-025-04834-4","url":null,"abstract":"<p><p>Significant progress has been made in HIV prevention and treatment for adolescents and young adults (AYA), but integrating mental healthcare remains essential to address risks and improve treatment engagement. Single-session interventions (SSIs) offer a cost-effective, scalable way to improve access to HIV and mental health services. While evidence shows SSIs reduce sexual risk behaviors and enhance mental health, their combined impact on both areas has not yet been reviewed. This scoping review evaluates SSIs designed for AYA that target HIV treatment and prevention outcomes, while assessing whether these SSIs had any secondary effects on co-occurring mental health outcomes. A systematic search of databases through August 2024 identified 21 SSIs that included HIV-related outcomes, such as intentions to test, improvements in HIV knowledge, attitudes toward HIV, PrEP uptake, and treatment engagement, and any reported mental health outcomes. Of the 21 studies analyzed, 19 focused on HIV prevention, showing significant improvements in knowledge, reduced stigma, and better self-assessment of HIV risk. The remaining two studies examined treatment-related outcomes, with some interventions like video-based programs and motivational interviews improving treatment initiation and attitudes toward adherence among AYA. Notably, only two of the 21 studies explicitly integrated mental health-related outcomes, despite nearly all interventions targeting change mechanisms common to mental health-focused interventions. Findings from this review highlight the promise of SSIs for improving HIV-related outcomes among AYA. However, to maximize their impact, future research should incorporate mental health-related outcomes into these interventions.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: A Competing Risks Duration Model to Study PrEP Discontinuation Among MSM in France: The ERAS 2023 Study","authors":"Clément Boutet,&nbsp;Marion Di Ciaccio,&nbsp;Bruno Spire,&nbsp;Annie Velter,&nbsp;Luis Sagaon-Teyssier","doi":"10.1007/s10461-025-04836-2","DOIUrl":"10.1007/s10461-025-04836-2","url":null,"abstract":"","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":"29 9","pages":"2728 - 2728"},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Dialectical Behavior Therapy (DBT)-Informed mHealth Intervention to Enhance Coping Skills and Mental Health among Men Who Have Sex with Men Living with HIV in China: A Mixed-Methods Feasibility Pilot Study.","authors":"Liying Wang, Weichao Yuwen, Vibh Forsythe Cox, Lingxiao Chen, Huang Zheng, Zhen Ning, Jane Simoni","doi":"10.1007/s10461-025-04812-w","DOIUrl":"https://doi.org/10.1007/s10461-025-04812-w","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Men who have sex with men (MSM) bear a disproportionate burden of HIV and mental health problems in China, hindering HIV-related care engagement and medication adherence. We developed a culturally-tailored dialectical behavior therapy (DBT)-informed mHealth intervention composed of individual skills training through a mobile app, online skills group, and on-demand skills coaching. The primary objective of this feasibility study was to assess the intervention acceptability, feasibility, and app usability. The secondary aim is to explore preliminary intervention effects. Participants were recruited in collaboration with Shanghai China Sex Worker & Men Who Have Sex with Men Center (SCMC), a community-based organization that provides HIV-related services in Shanghai, China. Eligible participants were randomly assigned to a 4-week mHealth intervention or control arm (treatment as usual). The intervention included individual skills learning using an app, online skills group facilitated by trained SCMC staff, and on-demand skills coaching by trained SCMC staff. Both groups completed weekly surveys for 4 weeks. Quantitative data were analyzed using linear mixed-effects models to evaluate the intervention's impact on primary outcomes (depression, anxiety, quality of life, medication adherence) and intermediate outcomes (emotion regulation difficulties, HIV-related stigma, and coping self-efficacy). Quantitative and qualitative data on intervention feasibility, acceptability, and app usability were analyzed using content analysis and supplemented with quantitative data summarized with descriptive statistics. Of the 64 people who completed the screening survey, 31 enrolled and completed the study without dropping out. The intervention (n = 16) and control arm (n = 14) did not differ in demographic characteristics, primary outcomes, or intermediate outcomes at baseline. Most participants were 23-30 years old, college-educated, employed, and single. Overall, the intervention was perceived to be highly feasible and acceptable, with above-average app usability. Compared to the control group, time was significantly associated with a greater decrease in the following outcomes in the intervention group: depression (β = - 0.73, 95% CI [-1.37, - 0.10]), emotion regulation difficulties (β = - 1.56, 95% CI [-2.72, - 0.41]), specifically non-acceptance of emotions (β = - 0.48, 95% CI [- 0.88, - 0.09]), and impact of emotions on goals (β = - 0.37, 95% CI [- 0.72, - 0.03]). Participants in the intervention group also showed more improvement in HIV mastery (β = 0.37, 95% CI [0.01, 0.74]), life satisfaction (β = 0.85, 95% CI [0.11, 1.59], coping efficacy around emotions (β = 0.97, 95% CI [0.06, 1.88]), and seeking social support from family and friend (β = 0.82, 95% CI [0.08, 1.57], compared with the control group. The DBT-informed mHealth intervention is acceptable and feasible among MSM living with HIV in China. The intervention shows promise in reducing depression","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Is the Effect of Medicaid Expansions on Preexposure Prophylaxis for HIV Prevention Use among Women?","authors":"Dion C Allen, Silvia E Rabionet, Sannisha K Dale, Ioana Popovici","doi":"10.1007/s10461-025-04828-2","DOIUrl":"10.1007/s10461-025-04828-2","url":null,"abstract":"<p><p>Pre-exposure prophylaxis (PrEP) is a key biomedical tool for combatting HIV spread, but women account for only 5% of users. Between 2015 and 2019, men saw a 9% decrease in new HIV diagnoses, while rates among women remained constant. Using a difference-in-differences regression model and state level HIV surveillance data (utilizing sex assigned at birth) reported by AIDSVu from 2012 to 2021, we examined the impact of Medicaid expansions under the Affordable Care Act on PrEP outcomes. The study revealed that Medicaid expansions were associated with better PrEP outcomes overall, with increases of 18.9% in PrEP rate and 40.4% in PrEP-to-need ratio for every state that expanded Medicaid. Males experienced better outcomes with a 43% increase in PrEP-to-need ratio, while females saw a 15.6% increase that was not statistically significant. Medicaid expansion improves PrEP access for all, however more targeted strategies are needed to increase PrEP uptake among women vulnerable to HIV.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance Training Improves Cognitive Function and Depression Without Changing BDNF Levels in People Living with HIV: a Randomized Controlled Clinical Trial.","authors":"Dayane Cristina de Souza, Kauana Borges Marchini, Pollyana Mayara Nunhes, Wagner Jorge Rodrigues Domingues, Dennis Armando Bertolini, Vitor Oliveira, Oldemar Mazzardo, Ademar Avelar","doi":"10.1007/s10461-025-04824-6","DOIUrl":"https://doi.org/10.1007/s10461-025-04824-6","url":null,"abstract":"<p><p>The increased life expectancy provided by Antiretroviral Therapy(ART) has led to the incidence of different comorbidities in people living with the Human Immunodeficiency Virus (HIV), especially comorbidities related to aging and mental health. Among these, cognitive impairment and depression increased in this population. Therefore, non-pharmacological strategies, such as physical exercise, have been studied to improve these outcomes. This study aimed to investigate the effects of eight weeks of resistance training(RT) on cognitive function and depression status in people with HIV. The sample consisted of 20 subjects (12 men and eight women), randomized in two groups: Control Group (CG, n = 9) and Training Group (TG, n = 11). Cognitive function (Stroop Test), depression status (Beck Depression Inventory- BDI), and plasma levels of Brain-Derived Neurotrophic Factor (BDNF) were assessed before and after the resistance training intervention. The results indicated thatRT was able to promote significant improvements in the cognitive domains and reduce symptoms of depression (ΔCG: 1.56 ± 2.46; ΔTG -3.18 ± 1.66, P > 0.001). Regarding BDNF, no significant change was observed (P > 0.05). In conclusion, eight weeks ofRT improves cognitive function and depression status in people with HIV, without changing the circulating BDNF levels (NCT03879993).</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}