AIDS and Behavior最新文献_第9页

High Rates of Drug Use and Chemsex Among PrEP Users and People with HIV in Milan Highlight Need for Targeted Interventions. 米兰PrEP使用者和艾滋病毒感染者的高药物使用率和化学性行为突出了有针对性干预的必要性。

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2025-06-09 DOI: 10.1007/s10461-025-04778-9

Chiara Fusetti, Enrico Caruso, Andrea Giacomelli, Daniele Calzavara, Maria Vittoria Cossu, Nicoletta Frattini, Francesco Caruso, Pietro Vinti, Chiara Atzori, Francesco Petri, Spinello Antinori, Andrea Gori, Massimo Cernuschi, Davide Moschese

{"title":"High Rates of Drug Use and Chemsex Among PrEP Users and People with HIV in Milan Highlight Need for Targeted Interventions.","authors":"Chiara Fusetti, Enrico Caruso, Andrea Giacomelli, Daniele Calzavara, Maria Vittoria Cossu, Nicoletta Frattini, Francesco Caruso, Pietro Vinti, Chiara Atzori, Francesco Petri, Spinello Antinori, Andrea Gori, Massimo Cernuschi, Davide Moschese","doi":"10.1007/s10461-025-04778-9","DOIUrl":"https://doi.org/10.1007/s10461-025-04778-9","url":null,"abstract":"Chemsex, the use of psychostimulant substances during sexual activity particularly among men who have sex with men (MSM), is a growing public health concern. This study aimed to assess drug use, engagement in chemsex, and related knowledge among pre-exposure prophylaxis (PrEP) users and people with HIV (PWH) attending two sexually transmitted infection (STI) services in Milan, Italy. An anonymous online survey was conducted between January and March 2024 at a hospital-based clinic and a community-based center. The questionnaire explored demographics, HIV/PrEP status, drug use, chemsex, its disclosure to healthcare providers, and perceptions of drug use trends. Among 420 respondents, of whom 365 (84%) PrEP-users and 55 (13%) PWH, 167 (40%) reported current drug use and 68 (16%) engaging in chemsex. Polydrug use was also common (96/167, 57%). Commonly used substances included cocaine (50/167, 30%), mephedrone (45/167, 27%), 3,4-methylenedioxymethamphetamine (36/167, 22%), gamma-hydroxybutyrate/gamma-butyrolactone (33/167, 20%) and ketamine (29/167, 17%). The use of methylenedioxypyrovalerone (25/167, 15%) and crystal methamphetamine (10/167, 6%) was also consistent. Of the drug users, 62 (37%) did not disclose their substance use to healthcare providers, frequently citing lack of inquiry by clinicians or the perception that disclosure was not relevant. A total of 223/420 (53%) respondents knew people who used substances, and of these, 90.6% (202) perceived an increase in substance use within their community. In conclusion, the study revealed high rates of drug use and chemsex in Milan underscoring the need for increased healthcare provider awareness, and stigma-free environments to support risk reduction for chemsex users.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV Prevention and Treatment Information from Four Artificial Intelligence Platforms: A Thematic Analysis. 四个人工智能平台的艾滋病防治信息专题分析

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2025-06-07 DOI: 10.1007/s10461-025-04786-9

Stephen Beegle, Luis A Gomez, Jason T Blackard, Bingfang Yan, Jaime Robertson, Kevin T Fedders, Shaina Horner, Ramsey Miller, Chavez R Rodriguez, Abby Atreya, Jennifer L Brown

{"title":"HIV Prevention and Treatment Information from Four Artificial Intelligence Platforms: A Thematic Analysis.","authors":"Stephen Beegle, Luis A Gomez, Jason T Blackard, Bingfang Yan, Jaime Robertson, Kevin T Fedders, Shaina Horner, Ramsey Miller, Chavez R Rodriguez, Abby Atreya, Jennifer L Brown","doi":"10.1007/s10461-025-04786-9","DOIUrl":"https://doi.org/10.1007/s10461-025-04786-9","url":null,"abstract":"Health information is highly accessible with the prominence of artificial intelligence (AI) platforms, such as Chat Generative Pre-Trained Transformer (ChatGPT). Within the context of human immunodeficiency virus (HIV), it is paramount to understand and evaluate the information being provided by AI platforms concerning the safety, side effects, and efficacy of medications to prevent and treat HIV. Prompts (n = 38) requesting information regarding HIV medication use for prevention and treatment were inputted into three AI-based Large Language Models (LLMs; ChatGPT 3.5, ChatGPT 4.0, Google Bard [now Gemini]) and one chatbot (HIV.gov Chatbot) on four consecutive weeks. Outputs (n = 608) were recorded verbatim, weekly by platform. Qualitative analyses using a conventional content analysis coding approach examined key themes in responses; response comprehensiveness was rated via the number of themes represented in a response. Core themes emerged across prompts. A recommendation to speak with a medical professional for further information was the most common theme across platforms. Organ/bone side effects were the most prevalent side effect. Responses pointed to medication efficacy to prevent and treat HIV. ChatGPT 4.0 provided the most comprehensive responses across platforms, while the HIV.gov Chatbot gave the least comprehensive information. Health information on HIV medication safety, side effects, and efficacy is widely available using AI platforms. Results indicate that AI responses typically included recommendations to consult a medical professional to personalize care. The efficacy of medications was never questioned across AI platforms. Future research directions for AI use within the context of HIV prevention and care are provided.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Impact of Digital Communication Tools on Oral PrEP Adherence: A Systematic Review and Meta-analysis. 评估数字通信工具对口服PrEP依从性的影响：系统回顾和荟萃分析。

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2025-06-05 DOI: 10.1007/s10461-025-04779-8

Julien Brisson, Dorothy Apedaile, Mariangela Castro-Arteaga, Amaya Perez-Brumer

{"title":"Assessing the Impact of Digital Communication Tools on Oral PrEP Adherence: A Systematic Review and Meta-analysis.","authors":"Julien Brisson, Dorothy Apedaile, Mariangela Castro-Arteaga, Amaya Perez-Brumer","doi":"10.1007/s10461-025-04779-8","DOIUrl":"https://doi.org/10.1007/s10461-025-04779-8","url":null,"abstract":"This systematic review and meta-analysis evaluated the effect of digital communication tools (e.g., text message reminders) on improving daily oral HIV pre-exposure prophylaxis (PrEP) adherence. Searching PubMed, Embase, Web of Science, and PsychInfo, alongside clinical trial registries, we identified randomized controlled trials from 2012 to 2024 that compared digital interventions with standard care. The primary outcome of interest was PrEP adherence. From 975 studies reviewed, ten met our criteria, encompassing interventions on text messaging (n = 3), mobile applications (n = 6) and mobile games (n = 1). One study exclusively included cisgender women in Kenya. Nine studies focused on gay, bisexual, and other men who have sex with men (GBM)-four of these included transgender women (TW)-based in the USA (n = 8) and Thailand (n = 1). Studies measured PrEP adherence using tenofovir-diphosphate (TFV-DP) blood levels (n = 8), self-report (n = 1), and electronic bottle pill monitoring (n = 1). Utilizing a random-effects meta-analysis, we estimated pooled risk ratios (RR) for adequate PrEP adherence (TFV-DP levels ≥700 fmol/punch) at 12- and 24-weeks post-intervention. Due to differences in outcome measurement and timing, eight studies were pooled for the 12-week RR and seven for the 24-week RR. Those studies involved GBM and TW. At 12 weeks (n = 977), results showed a modest improvement in adherence (RR = 1.08, 95% CI: 1.02-1.14). There were no effects at 24 weeks (n = 562) (RR = 1.10, 95% CI 0.92-1.32). These findings suggest that digital communication tools had a limited impact on improving PrEP adherence. Further research is needed to develop sustained and diverse intervention strategies to support PrEP adherence.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Untangling Discrimination: The Impact of Internalizing Oppression on HIV Treatment Engagement Among Young Black Sexual Minority Men in the Southern US. 解开歧视：内化压迫对美国南部年轻黑人性少数男性艾滋病治疗参与的影响。

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2025-06-05 DOI: 10.1007/s10461-025-04774-z

Carrie L Nacht, Cody Lentz, Wilson Vincent, Daniel Siconolfi, Lance M Pollack, Susan M Kegeles, Chadwick K Campbell, Adedotun Ogunbajo, Erik D Storholm

{"title":"Untangling Discrimination: The Impact of Internalizing Oppression on HIV Treatment Engagement Among Young Black Sexual Minority Men in the Southern US.","authors":"Carrie L Nacht, Cody Lentz, Wilson Vincent, Daniel Siconolfi, Lance M Pollack, Susan M Kegeles, Chadwick K Campbell, Adedotun Ogunbajo, Erik D Storholm","doi":"10.1007/s10461-025-04774-z","DOIUrl":"https://doi.org/10.1007/s10461-025-04774-z","url":null,"abstract":"Black sexual minority men living with HIV (BSMM+) in the Southern United States encounter multiple forms of discrimination, which are associated with decreased HIV care engagement. We analyzed data from 166 BSMM + in the South to assess direct associations between experiences of racism, heterosexism, and HIV-related discrimination with HIV care engagement. We further investigated indirect associations through three mediators: internalized racism, internalized heterosexism, and internalized HIV stigma. Experienced heterosexism was indirectly associated with HIV care engagement through internalized HIV stigma (bindirect = -0.039, p = 0.098). HIV discrimination was associated with internalized heterosexism (bdirect = 0.577, p = 0.007) and internalized racism (bdirect = 0.253, p = 0.009). There were significant direct associations between internalized HIV stigma and HIV care engagement (bdirect = -0.040, p = 0.001) and experienced heterosexism and internalized HIV stigma (bdirect = 0.974, p = 0.050). These findings aim to understand the factors affecting HIV care engagement among this population to improve HIV care engagement.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medication Adherence and Beliefs about HIV Treatment in Jordan: A Cross-Sectional Analysis. 约旦HIV治疗的药物依从性和信念：一项横断面分析。

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2025-06-04 DOI: 10.1007/s10461-025-04785-w

Sara Al-Ajlouny, Tareq L Mukattash, Anan S Jarab, Walid Al-Qerem, Omar M Khalifeh, Yazid Alhamarneh, Rana K Abu-Farha

{"title":"Medication Adherence and Beliefs about HIV Treatment in Jordan: A Cross-Sectional Analysis.","authors":"Sara Al-Ajlouny, Tareq L Mukattash, Anan S Jarab, Walid Al-Qerem, Omar M Khalifeh, Yazid Alhamarneh, Rana K Abu-Farha","doi":"10.1007/s10461-025-04785-w","DOIUrl":"https://doi.org/10.1007/s10461-025-04785-w","url":null,"abstract":"This study aimed to examine Antiretroviral Therapy (ART) adherence and beliefs about medications among People Living with HIV (PLHIV) in Amman, Jordan. A cross-sectional study was conducted at the Almashora Health Center for AIDS patients from December 2022 to February 2023, with participants diagnosed with AIDS for at least six months recruited using convenience sampling. Medication adherence was assessed using the 4-Item Morisky Medication Adherence Scale, and beliefs about medications were evaluated with the Beliefs About Medication Questionnaire. A total of 180 PLHIV were recruited. Among them, 42.2% (n = 76) demonstrated low to moderate adherence, with an adherence score of ≤ 75%. The most frequent reason for non-adherence was being careless about medication timing (n = 60, 33.3%). Ordinal regression analysis revealed that higher educational levels (OR = 2.10, p = 0.03) and stronger perceptions of medication necessity (OR = 1.35, p < 0.01) were positively associated with better adherence. Conversely, increased concerns about medications (OR = 0.73, p < 0.01) were negatively associated with adherence. These findings indicate suboptimal ART adherence among PLHIV in Jordan. Higher concerns about medication side effects and lower educational levels were significantly associated with non-adherence. Targeted interventions that address patients' concerns about ART and enhance medication-related education may improve adherence and health outcomes in this population.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preferences for HIV Pre-exposure Prophylaxis among Gay, Bisexual, and Men Who Have Sex with Men in China: a Discrete Choice Experiment. 中国同性恋、双性恋和男男性行为者对HIV暴露前预防的偏好：一个离散选择实验。

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2025-06-04 DOI: 10.1007/s10461-025-04793-w

Zhengcheng Tu, Shiyi He, Rui Zhao, Warittha Tieosapjaroen, Ying Zhang, Min Zhao, Jason J Ong, Lei Zhang

{"title":"Preferences for HIV Pre-exposure Prophylaxis among Gay, Bisexual, and Men Who Have Sex with Men in China: a Discrete Choice Experiment.","authors":"Zhengcheng Tu, Shiyi He, Rui Zhao, Warittha Tieosapjaroen, Ying Zhang, Min Zhao, Jason J Ong, Lei Zhang","doi":"10.1007/s10461-025-04793-w","DOIUrl":"https://doi.org/10.1007/s10461-025-04793-w","url":null,"abstract":"Pre-exposure prophylaxis (PrEP) is highly effective in preventing HIV in gay, bisexual, and other men who have sex with men (GBMSM). This study investigates PrEP usage and preferences among Chinese GBMSM and how key attributes influence their choices using a discrete choice experiment (DCE). Six PrEP attributes were evaluated: dosing frequency, dispensing venue, side effects, effectiveness, follow-up frequency, and extra services. From January to November 2022, a face-to-face survey was conducted among 1186 GBMSM in Xi'an, China. Multi- and mixed-logit models assessed preferences and heterogeneity by demographics. Latent class analysis examined unobserved preference patterns, and scenario analysis explored how changes in attributes affect PrEP acceptance. Among 995 valid participants (mean age 34 ± 9 years), 20.5% had ever used PrEP. The most influential attribute was dosing frequency, followed by side effects and follow-up frequency. Participants preferred on-demand PrEP, private dispensing venues, minimal side effects, at least 60% effectiveness, follow-up every 3 months, and comprehensive STI testing. Preferences varied by age, education, and income. Latent class analysis indicated 57.04% of participants preferred on-demand PrEP, STD/social health clinics, very low-risk kidney complications, 80% effectiveness, 3-month follow-up, and no extra services. Scenario analysis showed on-demand PrEP and 80% effectiveness would increase acceptance by 73.6% and 43.2%, respectively, compared to daily oral PrEP and 30% effectiveness. Conversely, switching from daily oral pills to bi-monthly injections decreased acceptance by 48.2%. Dosing frequency is the most influential attribute for HIV PrEP among Chinese GBMSM. Preferences vary by demographics, and reduced dosing and improved effectiveness may substantially boost uptake.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-Exposure Prophylaxis Care Engagement Among Men Who Have Sex with Men in the United States During the COVID-19 Pandemic: A Scoping Review. 美国男男性行为者在COVID-19大流行期间的暴露前预防保健参与：范围审查

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2025-06-04 DOI: 10.1007/s10461-025-04791-y

Junye Ma, Dafna Paltin, Keegan D Buch, Michael Miller-Perusse, Jahn Jaramillo, Keith J Horvath

{"title":"Pre-Exposure Prophylaxis Care Engagement Among Men Who Have Sex with Men in the United States During the COVID-19 Pandemic: A Scoping Review.","authors":"Junye Ma, Dafna Paltin, Keegan D Buch, Michael Miller-Perusse, Jahn Jaramillo, Keith J Horvath","doi":"10.1007/s10461-025-04791-y","DOIUrl":"10.1007/s10461-025-04791-y","url":null,"abstract":"The COVID-19 pandemic substantially impacted the pre-exposure prophylaxis (PrEP) care continuum among men who have sex with men (MSM). While PrEP use during the pandemic has been studied, regional differences in PrEP regulations highlight the need for U.S.-specific reviews. This scoping review evaluates empirical literature on COVID-19's impact on PrEP engagement among U.S. MSM. A systematic search on August 29, 2024, identified articles from PubMed, PsycINFO, and Embase. Eligible studies (a) collected empirical data from U.S. MSM, (b) assessed COVID-19's impact on PrEP engagement, and (c) were peer-reviewed, English-language, full-text articles. Standardized forms were used to extract study information. Study quality was appraised using validated tools for qualitative and quantitative research. Findings were synthesized using descriptive statistics and narrative summaries, categorized by distinct pandemic phases. Of 438 records, 21 studies were included (15 quantitative, five qualitative, one mixed-method), mostly conducted during the lockdown phase. Results showed reduced PrEP use (5.9-35.6%), increased missed doses (8.3-14.2%), and higher discontinuation rates (9.0-33.3%) during COVID-19. Barriers included refill issues (9.0-20.0%), limited access to care (2.5-17.0%), disrupted lab testing (~ 25.5%), and changes in clinic procedures. College-aged youth reported confidentiality concerns after returning home. Qualitative evidence highlighted telehealth and injectable PrEP as promising alternatives. This review reveals significant disruptions to PrEP care for U.S. MSM during COVID-19, a lack of post-lockdown research, underrepresentation of MSM from Northeastern and Pacific regions, and limited use of objective PrEP adherence measures. These findings underscore the need for emergency-prepared PrEP services and expanded telehealth and home-delivery options for future crises.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factor Structure, Reliability, and Validity of the 10-Item HIV Stigma Scale for Adolescents and Youth Living with HIV in Rural, Southwestern Uganda. 乌干达西南部农村青少年艾滋病污名量表的因素结构、信度和效度

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2025-06-03 DOI: 10.1007/s10461-025-04781-0

Scholastic Ashaba, Alain Favina, Charles Baguma, Patricia Tushemereirwe, Denis Nansera, Alison Comfort, Jessica M Perkins, Maling Samuel, Brian C Zanoni, Alexander C Tsai

{"title":"Factor Structure, Reliability, and Validity of the 10-Item HIV Stigma Scale for Adolescents and Youth Living with HIV in Rural, Southwestern Uganda.","authors":"Scholastic Ashaba, Alain Favina, Charles Baguma, Patricia Tushemereirwe, Denis Nansera, Alison Comfort, Jessica M Perkins, Maling Samuel, Brian C Zanoni, Alexander C Tsai","doi":"10.1007/s10461-025-04781-0","DOIUrl":"https://doi.org/10.1007/s10461-025-04781-0","url":null,"abstract":"HIV stigma undermines HIV treatment outcomes for adolescents and young adults living with HIV. However, there are few stigma measures that are appropriate for this age and the Ugandan cultural context. Between October and December 2021, we administered the 10-item stigma scale for adolescents living with HIV (ALHIV-SS) to 300 adolescents and young adults (aged 15-24 years) with perinatally-acquired HIV in Mbarara, Uganda. Exploratory factor analysis of the ALHIV-SS revealed three factors corresponding to internalized, anticipated, and enacted forms of stigma. The ALHIV-SS was internally consistent overall (Cronbach's α = 0.78) and for each of the subscales: internalized stigma, 0.76; enacted stigma, 0.68; and anticipated stigma, 0.57. The ALHIV-SS was strongly correlated with depression (Spearman's ρ = 0.44; p < 0.001). Mean stigma scores were also higher among study participants who had thoughts of self-harm (6.5 vs. 3.0, t = 5.7, P < 0.001), those who reported sometimes forgetting to take their ART (4.0 vs. 2.8, t = 3.3, P = 0.001), and among those who reported any days in the past 2 weeks on which they took no ART (3.9 vs. 3.2, t = 1.59, P = 0.11). The findings suggest that the 10-item ALHIV-SS is a valid, reliable, and coherent measure of HIV stigma among adolescents and young adults living with perinatally acquired HIV in Uganda.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motivations for Starting and Stopping PrEP: Experiences of Adolescent Girls and Young Women in the HPTN 082 Trial. 开始和停止PrEP的动机：青少年女孩和年轻女性在HPTN 082试验中的经验。

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2025-06-03 DOI: 10.1007/s10461-025-04703-0

Lisa Mills, Makhosazane Nomhle Ndimande-Khoza, Jennifer Velloza, Millicent Atujuna, Miria Chitukuta, Sybil Hosek, Hlukelo Chauke, Petina Musara, Nomvuyo Mangxilana, Prisca Mutero, Lerato Michelle Makhale, Thelma Tauya, Connie Celum, Sinead Delany-Moretlwe

{"title":"Motivations for Starting and Stopping PrEP: Experiences of Adolescent Girls and Young Women in the HPTN 082 Trial.","authors":"Lisa Mills, Makhosazane Nomhle Ndimande-Khoza, Jennifer Velloza, Millicent Atujuna, Miria Chitukuta, Sybil Hosek, Hlukelo Chauke, Petina Musara, Nomvuyo Mangxilana, Prisca Mutero, Lerato Michelle Makhale, Thelma Tauya, Connie Celum, Sinead Delany-Moretlwe","doi":"10.1007/s10461-025-04703-0","DOIUrl":"https://doi.org/10.1007/s10461-025-04703-0","url":null,"abstract":"Oral PrEP effectiveness depends on consistent use during periods of potential HIV exposure, but adolescent girls and young women (AGYW) find this challenging. Data on PrEP use decision-making and alignment with risk among AGYW are limited. From 2016 to 2018, we conducted in-depth interviews with participants in HPTN 082, an open-label PrEP study in South Africa and Zimbabwe, to explore reasons for PrEP starts, stops, and restarts. Of 60 PrEP acceptors, 12 delayed acceptance, 15 used PrEP intermittently, 18 paused and restarted PrEP, and 13 permanently discontinued PrEP during 12-month follow-up. Perceived HIV vulnerability motivated PrEP start, but there was little evidence that fluctuating risk perception motivated prevention-effective use. PrEP stops were motivated by stigma, misconceptions and side effects; PrEP restarts were prompted by support from family, peers and clinic staff. Decision-making was related to social, gendered and normative influences, highlighting opportunities for psycho-educational support and multimedia campaigns to normalise HIV prevention.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Closer Look at the Perceived Factors Contributing To Late HIV Diagnoses: A Qualitative Study among People with HIV. 近距离观察导致HIV晚期诊断的感知因素：一项HIV感染者的定性研究。

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2025-06-03 DOI: 10.1007/s10461-025-04792-x

Christina E Parisi, Abigail Gracy, Sashaun Ranger, Natalie Chichetto, Awewura Kwara, Zhigang Li, Robert L Cook, Shantrel S Canidate

{"title":"A Closer Look at the Perceived Factors Contributing To Late HIV Diagnoses: A Qualitative Study among People with HIV.","authors":"Christina E Parisi, Abigail Gracy, Sashaun Ranger, Natalie Chichetto, Awewura Kwara, Zhigang Li, Robert L Cook, Shantrel S Canidate","doi":"10.1007/s10461-025-04792-x","DOIUrl":"https://doi.org/10.1007/s10461-025-04792-x","url":null,"abstract":"Late HIV diagnosis is an obstacle to ending the HIV epidemic. This study aimed to identify perceived reasons for late HIV diagnoses through semi-structured interviews among people with HIV. Researchers used the social-ecological model (SEM) to examine how factors at the individual, relationship/interpersonal, and community levels affect timely HIV testing and diagnosis. Nineteen participants who had a CD4 count below 350 cells/µL at the time of their diagnosis (mean age 51.3 years, 5 [26%] cisgender female, 9 [47%] non-Hispanic Black, 7 [37%] non-Hispanic White) and who lived throughout Florida were recruited from the Southern HIV and Alcohol Research Consortium (SHARC) contact registry. Interviews were conducted between December 2023 and March 2024. Common individual-level reasons for late diagnosis included lack of HIV knowledge, denial, avoidance, substance use, and health issues that led to testing. At the relationship/interpersonal level, participants were exposed to HIV by trusted sexual partners, while others experienced stigma that prevented them from seeking testing. At the community level, limited access to healthcare and missed testing opportunities with healthcare providers were major factors contributing to late diagnosis. Our findings highlight the need for research and interventions that address multiple levels of the SEM, as well as targeting both community members and healthcare providers. These results can inform strategies to increase HIV testing, reduce late diagnoses, and support efforts to end the HIV epidemic.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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