{"title":"Resistance Training Improves Cognitive Function and Depression Without Changing BDNF Levels in People Living with HIV: a Randomized Controlled Clinical Trial.","authors":"Dayane Cristina de Souza, Kauana Borges Marchini, Pollyana Mayara Nunhes, Wagner Jorge Rodrigues Domingues, Dennis Armando Bertolini, Vitor Oliveira, Oldemar Mazzardo, Ademar Avelar","doi":"10.1007/s10461-025-04824-6","DOIUrl":"https://doi.org/10.1007/s10461-025-04824-6","url":null,"abstract":"<p><p>The increased life expectancy provided by Antiretroviral Therapy(ART) has led to the incidence of different comorbidities in people living with the Human Immunodeficiency Virus (HIV), especially comorbidities related to aging and mental health. Among these, cognitive impairment and depression increased in this population. Therefore, non-pharmacological strategies, such as physical exercise, have been studied to improve these outcomes. This study aimed to investigate the effects of eight weeks of resistance training(RT) on cognitive function and depression status in people with HIV. The sample consisted of 20 subjects (12 men and eight women), randomized in two groups: Control Group (CG, n = 9) and Training Group (TG, n = 11). Cognitive function (Stroop Test), depression status (Beck Depression Inventory- BDI), and plasma levels of Brain-Derived Neurotrophic Factor (BDNF) were assessed before and after the resistance training intervention. The results indicated thatRT was able to promote significant improvements in the cognitive domains and reduce symptoms of depression (ΔCG: 1.56 ± 2.46; ΔTG -3.18 ± 1.66, P > 0.001). Regarding BDNF, no significant change was observed (P > 0.05). In conclusion, eight weeks ofRT improves cognitive function and depression status in people with HIV, without changing the circulating BDNF levels (NCT03879993).</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIDS and BehaviorPub Date : 2025-07-25DOI: 10.1007/s10461-025-04825-5
Trey V Dellucci, Leslie A Hulvershorn, Tamika C B Zapolski, Zachary W Adams, Tyrel J Starks
{"title":"Experiences in Healthcare Predicts Pre-Exposure Prophylaxis Awareness and Attitudes: A Brief Report on Adolescent Sexual Minority Males.","authors":"Trey V Dellucci, Leslie A Hulvershorn, Tamika C B Zapolski, Zachary W Adams, Tyrel J Starks","doi":"10.1007/s10461-025-04825-5","DOIUrl":"https://doi.org/10.1007/s10461-025-04825-5","url":null,"abstract":"<p><p>This study examines the association between healthcare experiences and LGBTQ + connectedness with beliefs about pre-exposure prophylaxis (PrEP) among adolescent sexual minority males in romantic relationships. Results revealed that connection to the LGBTQ + community and comfort discussing sexual health with a healthcare provider was positively associated with perceived confidence in taking PrEP daily, while experiences of discrimination by a healthcare provider was negatively associated with the perceived PrEP effectiveness to prevent HIV. Findings highlight the importance of fostering an affirming environment for learning about HIV prevention and for increasing confidence in taking care of one's sexual health.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIDS and BehaviorPub Date : 2025-07-24DOI: 10.1007/s10461-025-04823-7
Jiegang Huang, Shanyin Yang, Zhiman Xie, Baodong Guo, Yingji Lan, Yanjun Li, Yuan Jiang, Leah S Forman, Karsten Lunze, Bingyu Liang, Abu S Abdullah, Li Ye, Hao Liang, Lisa M Quintiliani
{"title":"WeChat-based Messaging and Behavioral Counseling for Smoking Cessation for People with HIV in China: a Randomized Controlled Pilot Trial.","authors":"Jiegang Huang, Shanyin Yang, Zhiman Xie, Baodong Guo, Yingji Lan, Yanjun Li, Yuan Jiang, Leah S Forman, Karsten Lunze, Bingyu Liang, Abu S Abdullah, Li Ye, Hao Liang, Lisa M Quintiliani","doi":"10.1007/s10461-025-04823-7","DOIUrl":"https://doi.org/10.1007/s10461-025-04823-7","url":null,"abstract":"<p><p>Cigarette smoking among people with HIV is a leading preventable cause of morbidity and mortality, particularly in China given its immense burden of smoking. This pilot study aimed to evaluate the feasibility, acceptability, and efficacy on smoking cessation of a community-informed WeChat-based messaging and behavioral counseling intervention for people with HIV who smoke called Quit for Life. The study design was a 2-group randomized clinical trial. Data collection occurred between February 2022 and August 2023 within a tertiary infectious disease hospital in Nanning city, Guangxi, China. Participants included adults with HIV who smoked, were willing to set a quit date, and received HIV care at the hospital. Participants were randomized to the 8-week Quit for Life intervention group (nicotine replacement therapy gum, self-help quitting smoking guide, behavioral counseling, and WeChat-based messaging), or the control group (nicotine replacement therapy gum and self-help guide only). Complete case analysis was performed. Of 219 people assessed for eligibility, 109 participants were randomized (mean [SD] age, 45.3 [15.1] years; men [96.3%]) and 98 completed the 12-week assessment (89.9% retention rate). At 12-week follow-up, the biochemically verified smoking cessation rate (primary outcome) was significantly higher in the intervention group compared to the control group (59.1% abstinence vs. 25.6%, adjusted odds ratio 5.3 [1.5,19.2]. Implementation and feasibility metrics indicated most participants receiving the intervention as intended gave high ratings of the usefulness of counseling sessions and WeChat-based messaging. Given these findings, subsequent studies should investigate implementation and scale-up of this intervention for people with HIV in China.Clinical trial registration details: Trial registration number: ClinicalTrials.gov Identifier: NCT05020899. Date of trial registration: 8-19-2021.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIDS and BehaviorPub Date : 2025-07-21DOI: 10.1007/s10461-025-04829-1
Norman Chong, Iskandar Azwa, Asfarina Amir Hassan, Mohammad Mousavi, Pui Li Wong, Rong Xiang Ng, Rumana Saifi, Sazali Basri, Sharifah Faridah Syed Omar, Suzan M Walters, Zachary K Collier, Marwan S Haddad, Frederick L Altice, Adeeba Kamarulzaman, Valerie A Earnshaw
{"title":"Strengthening HIV Activism Among Clinicians in Malaysia: A Randomised Controlled Trial.","authors":"Norman Chong, Iskandar Azwa, Asfarina Amir Hassan, Mohammad Mousavi, Pui Li Wong, Rong Xiang Ng, Rumana Saifi, Sazali Basri, Sharifah Faridah Syed Omar, Suzan M Walters, Zachary K Collier, Marwan S Haddad, Frederick L Altice, Adeeba Kamarulzaman, Valerie A Earnshaw","doi":"10.1007/s10461-025-04829-1","DOIUrl":"https://doi.org/10.1007/s10461-025-04829-1","url":null,"abstract":"<p><p>HIV continues to disproportionately affect key populations in Malaysia, compared to the general population. Lessons learned from decades of research and programmatic experience suggest that HIV activism can be a driver for change. We pilot-tested a tele-training platform, Project ECHO<sup>®</sup> for Stigma Reduction (PE-SR), in a randomised controlled trial from July 2022 to March 2023, alongside two comparator groups, i.e., Project ECHO<sup>®</sup>-Standard (PE-S) and the conventional HIV training program for clinicians, HIV Connect (HC). We randomised 78 primary care physicians and general practitioners across Malaysia into the three study arms (n = 26 each). We evaluated changes in HIV activist identity and commitment, and orientation towards day-to-day HIV activism and structural HIV activism. Repeated measure analysis of covariance (ANCOVA), controlling for age, years of practice, and contact with key populations as covariates, compared changes in HIV activism constructs across time and groups. The randomised controlled trial yielded mixed results. We observed statistically significant changes in HIV activist identity and commitment, as well as changes in orientation towards structural activism in all groups. We also found statistically significant mean differences between PE-S and HC in terms of HIV activist identity and commitment, and between PE-SR and HC in terms of orientation towards structural activism. Results suggest that stigma reduction tools embedded in a tele-training platform had a preliminary impact on HIV activism and could be scaled up and tailored to train clinician-activists.Trial Registration NCT05597787.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIDS and BehaviorPub Date : 2025-07-21DOI: 10.1007/s10461-025-04820-w
Eamonn McGonigle, Megan Mueller Johnson, Heather Tucker, Michael Hudgens, Ronald Dallas, Keith J Horvath, Rachel Goolsby, Elizabeth Secord, Murli Purswani, Daniel Reirden, Mobeen Rathore, Lisa-Gaye Robinson, Aditya H Gaur, K Rivet Amico
{"title":"Electronic Dose Monitoring Feedback (EMF) with Youth Living with HIV: Qualitative Exploration of Reactions to Viewing Dosing Calendars.","authors":"Eamonn McGonigle, Megan Mueller Johnson, Heather Tucker, Michael Hudgens, Ronald Dallas, Keith J Horvath, Rachel Goolsby, Elizabeth Secord, Murli Purswani, Daniel Reirden, Mobeen Rathore, Lisa-Gaye Robinson, Aditya H Gaur, K Rivet Amico","doi":"10.1007/s10461-025-04820-w","DOIUrl":"https://doi.org/10.1007/s10461-025-04820-w","url":null,"abstract":"<p><p>Electronic dose monitoring with feedback (EMF) offers an opportunity to visualize daily dosing behaviors that can otherwise be difficult to appreciate. Visual displays, including early, on-time, late, or missed doses over time, can foster insights around patterns of dosing. Reactions to seeing these patterns among youth with HIV (YWH) who struggle with adherence are important to consider with EMF. YWH (ages 14-25) participating in the ATN152 TERA intervention were presented withsmart-bottle-generated 1-month EMF calendars as part of their sessions with a remote 'coach'. To characterize how youth reacted to these visualizations, transcripts from this portion of the coaching sessions were thematically analyzed. A total of 64 youth-coach discussions were characterized across 37 unique participants (22 years old on average, 81% Black/African American, 46% acquired HIV vertically). Six main reactions to EMF calendars were identified: feelings of pride/satisfaction, empowerment/motivation, positive surprise, negative surprise, shame/guilt, and/or neutral reactions. Although most reactions were positive, those with negative reactions tended to be in response to calendars showing low adherence. Over a quarter (28%) of youth ranked the EMF as one of the most beneficial/helpful aspects of the intervention when asked about experiences with intervention tools within the coaching session. A calendar EMF appeared to offer unique opportunities to explore adherence in the context of a supportive counseling session.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIDS and BehaviorPub Date : 2025-07-21DOI: 10.1007/s10461-025-04821-9
Sophia Ngugi, Elizabeth Echoka, Vincent Were, Jacob Kazungu, Kenneth Ngure
{"title":"Preferences for Long-Acting HIV Pre-Exposure Prophylaxis among Women of Reproductive Age in Low- and Middle-income Countries: A Systematic Review.","authors":"Sophia Ngugi, Elizabeth Echoka, Vincent Were, Jacob Kazungu, Kenneth Ngure","doi":"10.1007/s10461-025-04821-9","DOIUrl":"https://doi.org/10.1007/s10461-025-04821-9","url":null,"abstract":"<p><p>HIV remains a major public health problem in low- and middle-income countries (LMICs). While oral pre-exposure prophylaxis (PrEP) is documented as safe and effective for HIV prevention, adherence remains a challenge. Long-acting PrEP could address adherence challenges associated with oral PrEP and significantly reduce HIV acquisition among high-risk populations. However, evidence of preferences for long-acting products remains limited, especially in LMICs. Understanding the preferences is crucial for informing the design of interventions to enhance not only adherence but also uptake. We conducted a systematic review to investigate preferences for long-acting PrEP among women of reproductive age (WRA), 15-49 years in LMICs. We searched PubMed, CINAHL and EMBASE databases for empirical literature relevant to our study, published between January 2010 and April 2024. Additional articles were manually searched for in the reference lists of included articles. We identified 20 studies reporting preferences for long-acting PrEP alone or in comparison with short-acting PrEP, such as oral daily pills, vaginal gels or suppositories. We found that WRA preferred long-acting PrEP products comprising injectables, implants and vaginal rings over short-acting options. The preferences were associated with product attributes, including longer duration of action, less frequent dosing, effectiveness and fewer side effects. The findings suggest that, in addition to oral PrEP, long-acting PrEP products can be employed as a strategy to reduce the burden of HIV among WRA in LMIC settings. Further research should be conducted to evaluate preferences in specific population groups, such as pregnant and lactating women, especially in high HIV prevalence settings.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIDS and BehaviorPub Date : 2025-07-18DOI: 10.1007/s10461-025-04816-6
Cathy J Reback, Chunqing Lin, Michael J Li, Jesse B Fletcher, Raymond P Mata
{"title":"A Treatment Mobile App for Sexual Minority Men Who Use Methamphetamine Demonstrates Reductions in Methamphetamine Use and HIV Sexual Risk Behaviors: Getting Off.","authors":"Cathy J Reback, Chunqing Lin, Michael J Li, Jesse B Fletcher, Raymond P Mata","doi":"10.1007/s10461-025-04816-6","DOIUrl":"10.1007/s10461-025-04816-6","url":null,"abstract":"<p><p>Sexual minority men (SMM) have elevated rates of methamphetamine use, which is deeply integrated into their sexual identities, sexual behaviors, and cultural spaces. Smartphone applications (apps) are often used to procure drugs and sexual partners. This study was a randomized clinical trial that evaluated the efficacy of the adaptation of an evidence-based intervention (Getting Off) into a mobile app format. From May 2021 to May 2023, 226 SMM who self-reported methamphetamine use in the past year were randomized to immediate delivery (ID) of the Getting Off app (n = 113) or a 30-day delayed delivery (DD) of the Getting Off app (n = 113). The average DSM-5 score for MUD was in the severe range (8.9 out of a possible 11). Mixed-effects models showed that at 1-month assessment, participants in the ID condition had significantly fewer days of injection methamphetamine use (estimate = - 0.57; SE = 0.15; p < 0.001), lower likelihood to have condomless anal intercourse (CAI; estimate = - 1.14; SE = 0.47; p = 0.017), and CAI while high on methamphetamine (estimate = - 1.15; SE = 0.49; p = 0.021) in the past 30 days, compared to the DD condition. When comparing pre- to post-app delivery, the combined ID and DD sample showed significant reductions in all methamphetamine use and sexual risk outcomes, including days using and injecting methamphetamine, CAI, and CAI while high on methamphetamine (p < 0.05 for all post-app assessments, with some fluctuations at certain time points). Overall, the reductions in methamphetamine use and sexual risk behaviors demonstrated the efficacy of the Getting Off app, which is extremely promising for the future of app-based treatment options.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Longitudinal Patterns and Predictors of Racial Disparities of HIV Retention in Care: A Statewide Cohort Analysis.","authors":"Fanghui Shi, Chen Zhang, Jiajia Zhang, Bankole Olatosi, Sharon Weissman, Xiaoming Li, Xueying Yang","doi":"10.1007/s10461-025-04813-9","DOIUrl":"https://doi.org/10.1007/s10461-025-04813-9","url":null,"abstract":"<p><p>Racial disparities have historically existed regarding HIV care outcomes, including retention in care (RIC). However, data regarding the longitudinal patterns and predictors of such disparities among different racial groups and various geolocations are limited. This study aims to explore the contribution of contextual features (e.g., socioeconomic and structural environmental factors) to the changes in RIC outcome disparity at the county level. All adult people with HIV who received a HIV diagnosis in South Carolina (SC) between 2013 and 2020 were included in this study, and their de-identified CD4 counts and viral load information were derived from the SC statewide HIV registry system. All contextual factors were extracted from multiple publicly available datasets, such as the American Community Survey. To provide a comprehensive view, we used four indices to measure racial disparities in the county-level percentage of RIC, i.e., Black to White ratio (BWR), Index of Disparity (ID), Weighted Index of Disparity (Weighted ID), and Gini coefficient. Linear mixed-effect models were used to estimate the relationship between various contextual factors and these disparity indexes, except BWR. The temporal trend of the four indices suggested no significant increase or decrease in racial disparities in RIC across 46 counties in SC from 2013 to 2020. Counties with more primary care providers and higher social capital in collective efficacy showed lower racial disparities in RIC when ID and Gini coefficient were used as outcomes. For ID only, higher racial disparities in RIC were observed in counties with lower isolation index (β=-1.92, 95%CI: -3.31~-0.53). For weighted ID only, no county-level contextual features explored were significantly associated with racial disparities in RIC. Racial disparities in RIC persist without major changes in SC despite the national implementation of the \"Ending the HIV Epidemic\" initiative. Efforts to address racial disparities should continue; specifically, efforts that focus on social and structural factors should be developed and implemented for populations that have poor HIV outcomes in the US.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIDS and BehaviorPub Date : 2025-07-16DOI: 10.1007/s10461-025-04768-x
Kristin Tansil Roberts, Mary Mullins, Darrel H Higa, Linda J Koenig, Megan Mallett, Megan Wichser, Christa L Denard, Jayleen Gunn, Miriam A M Nji, Briana Nguyen, Janae Mitchell, Miya Pontes, Madison Underwood, Theresa Ann Sipe
{"title":"Assessing the Effectiveness of Data-to-Care Strategies for Improving HIV Care Outcomes: A Systematic Review.","authors":"Kristin Tansil Roberts, Mary Mullins, Darrel H Higa, Linda J Koenig, Megan Mallett, Megan Wichser, Christa L Denard, Jayleen Gunn, Miriam A M Nji, Briana Nguyen, Janae Mitchell, Miya Pontes, Madison Underwood, Theresa Ann Sipe","doi":"10.1007/s10461-025-04768-x","DOIUrl":"https://doi.org/10.1007/s10461-025-04768-x","url":null,"abstract":"<p><p>Data-to-Care (D2C) is a strategy that uses HIV surveillance data or other data sources to identify out-of-care (OOC) persons with HIV (PWH) and link or re-engage them in care to improve viral suppression (VS). While some evidence suggests D2C is effective, no comprehensive systematic review has been published. This review aims to determine the effectiveness of D2C. A systematic search in five databases (i.e., MEDLINE, EMBASE, PsycINFO, CINAHL, sociological abstracts) identified 3868 U.S. studies published between January 2009 and January 2021 that described D2C interventions and measured HIV care outcomes. Two reviewers screened titles/abstracts, reviewed full reports for eligibility, and abstracted data. Risk of bias was assessed using the Mixed Methods Appraisal Tool, and included studies were synthesized quantitatively and qualitatively (Protocol registered on PROSPERO ID = CRD42020173095). Thirty-four studies with 30 unique interventions were identified. Two different meta-analyses, each with six interventions, found that D2C approached significance in improving engagement in care (Relative Risk (RR) 95% CI 1.18 [0.99 to 1.41]) and VS (RR 95% CI 1.44 [0.99 to 2.09]). Studies that could not be incorporated into the meta-analyses, also showed improvements in engagement in care (median percent [IQI]: 63% [45% to 81%], 18 interventions) and VS (median percent [IQI]: 39% [25% to 57%], 14 interventions). Overall, this systematic review suggests that D2C may enhance HIV care outcomes, emphasizing the need for effective strategies to identify and engage OOC persons in care.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIDS and BehaviorPub Date : 2025-07-16DOI: 10.1007/s10461-025-04803-x
Alanna J Bergman, Michael V Relf, Nomusa Mthinkhulu, Nkateko Ndlouvu, Kelly Lowensen, Jason E Farley
{"title":"Stigma and Time: A Longitudinal Qualitative Analysis of Co-occurring HIV and Tuberculosis Stigma in South Africa.","authors":"Alanna J Bergman, Michael V Relf, Nomusa Mthinkhulu, Nkateko Ndlouvu, Kelly Lowensen, Jason E Farley","doi":"10.1007/s10461-025-04803-x","DOIUrl":"https://doi.org/10.1007/s10461-025-04803-x","url":null,"abstract":"<p><p>For people with HIV and tuberculosis (TB), stigma may change over time. Identifying time points when individuals are most likely to experience HIV or TB related stigma, or when stigma begins to abate, may be useful in tailoring stigma-reduction interventions in resource-limited settings. This study used longitudinal qualitative data to explore if and how HIV and TB stigma change over the course of treatment. People living with HIV and rifampicin-resistant TB were purposively recruited at a district TB hospital in KwaZulu-Natal, South Africa. Participants consented to in-depth interviews throughout TB treatment. The team used reflexive thematic analysis to develop latent themes within the transcripts. This study was designed to identify longitudinal changes stigma over time from the perspective of someone living with HIV and TB. However, participants were more expansive in their conceptualization of evolving stigma. 30 individuals discussed changes in stigma from three distinct perspectives. First was a perspective of lived experience, where participants described changes in experienced, internalized, and anticipated stigma over time beginning with diagnosis. The second was from a shifted perspective, as participants described their diagnosis and movement from status neutral to status positive transitioning from a potential enactor of stigma to someone at risk for experiencing stigma. Finally, participants described changes in stigma from the community perspective whose attitudes towards HIV and TB disease were shaped by time. To strengthen care engagement, we must effectively intervene on disease-related stigma. Appropriate interventions must consider time and shifting social expectations that impact stigma.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}