AIDS and Behavior最新文献_第4页

Social Engagement and Neurocognition in Latino and Non-Latino White Older Persons with HIV. 感染艾滋病毒的拉丁裔和非拉丁裔白人老年人的社会参与和神经认知。

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2024-12-30 DOI: 10.1007/s10461-024-04586-7

Crystal X Wang, Mariam A Hussain, Lize Tibiriçá, Valarie Castellanos-Ponce, Mariana Cherner, Barton W Palmer, Lily Kamalyan, David Yassai-Gonzalez, Anya Umlauf, Lisa L Barnes, Robert K Heaton, Ronald J Ellis, María J Marquine

{"title":"Social Engagement and Neurocognition in Latino and Non-Latino White Older Persons with HIV.","authors":"Crystal X Wang, Mariam A Hussain, Lize Tibiriçá, Valarie Castellanos-Ponce, Mariana Cherner, Barton W Palmer, Lily Kamalyan, David Yassai-Gonzalez, Anya Umlauf, Lisa L Barnes, Robert K Heaton, Ronald J Ellis, María J Marquine","doi":"10.1007/s10461-024-04586-7","DOIUrl":"https://doi.org/10.1007/s10461-024-04586-7","url":null,"abstract":"The present study investigated differences in the quantity and quality of social engagement, and their associations with neurocognition among older Latino and non-Latino White persons with HIV (PWH). Participants were age 50 + community-dwelling PWH living in southern California (n = 116; 50% Latino [53% Spanish-speaking], 50% non-Latino White; Age: M = 58.03; Education: M = 13.29; 82% male; 58% AIDS; 95% on antiretroviral therapy). Neurocognition was assessed with a battery of 10 tests on which demographically-adjusted T-scores were derived. Social engagement was measured via self-report of frequency of participation in social activities over the past year (quantitative) and feelings and perceptions of loneliness (qualitative). There were few ethnic differences in degree of participation in social activities, but Latino PWH reported lower loneliness. Social activity and loneliness were significantly associated with processing speed in the overall sample, and with global neurocognition only in White PWH. Latino PWH reported better quality of social engagement than non-Latino White PWH despite small ethnic differences in quantity of social engagement. Social engagement was associated with better neurocognition primarily in older White PWH. Given documented HIV disparities in neurocognition, future studies should investigate HIV-related comorbidities and structural determinants of health as potential determinants of neurocognition among older Latino PWH.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attitudes, Beliefs, and Predictors of Gestational Weight Gain and Postpartum Weight Retention in South Africa: A Mixed Methods Analysis. 态度，信念，和预测因素妊娠期体重增加和产后体重保持在南非：混合方法分析。

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2024-12-30 DOI: 10.1007/s10461-024-04577-8

Chelsie Cintron, Hlengiwe Madlala, Ameerah Battle, Tishara Reid, Jennifer Pellowski, Lucia Knight, Landon Myer, Angela M Bengtson

{"title":"Attitudes, Beliefs, and Predictors of Gestational Weight Gain and Postpartum Weight Retention in South Africa: A Mixed Methods Analysis.","authors":"Chelsie Cintron, Hlengiwe Madlala, Ameerah Battle, Tishara Reid, Jennifer Pellowski, Lucia Knight, Landon Myer, Angela M Bengtson","doi":"10.1007/s10461-024-04577-8","DOIUrl":"https://doi.org/10.1007/s10461-024-04577-8","url":null,"abstract":"Suboptimal gestational weight gain (GWG) is associated with pregnancy complications and postpartum weight retention (PPWR). Little data exists about GWG and PPWR attitudes and beliefs in low-and-middle-income countries (LMICs) to inform interventions. We examined GWG and PPWR attitudes, beliefs, and intentions among pregnant people, with and without HIV, in Cape Town, South Africa. Pregnant persons were enrolled between 2019 and 2022 (N = 400). Study visits were conducted at 24-28 weeks' and 33-38 weeks' gestation. Rate of GWG (kg/week) between the second and third trimesters was estimated and reported as below, above, or within the 2009 Institute of Medicine guidelines. Multivariable-multinomial regression estimated predictors of GWG. In-depth interviews among pregnant participants, community leaders and healthcare providers informed GWG attitudes, beliefs, and perceptions. Over 90% of participants experienced suboptimal rates of GWG (35% below and 47% above guidelines) during pregnancy. Living with HIV [OR 0.50, 95% CI (0.26-0.95)] was protective against GWG rate above guidelines compared to those without HIV. Being 25-29 years old was associated with GWG rate below guidelines [OR 0.28 95% CI (0.08-0.95)]. Little concordance occurred between intended and true GWG. Despite GWG category, two-thirds of participants felt it was 'very important' to monitor GWG while 44% viewed losing weight gained during pregnancy as \"not important\". Barriers to meeting GWG goals included lack of access to healthy foods, exercise opportunities, and education. Given rising obesity in women of reproductive age in LMIC, locally-adapted interventions are needed during pregnancy and postpartum to aide in healthy GWG and improve maternal-child health outcomes.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Individual and Network Factors in HIV Care Continuum Outcomes among PLWH: An Egocentric Network Study in Yunnan, China. 个体因素和网络因素在艾滋病护理连续性结果中的作用：云南省自我中心网络研究

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2024-12-30 DOI: 10.1007/s10461-024-04602-w

Wenjun Yan, Di Xu, Qiongli Duan, Nengmei Huang, Jing Han, Yuhua Shi, Jian Li, Hongjie Liu

{"title":"Role of Individual and Network Factors in HIV Care Continuum Outcomes among PLWH: An Egocentric Network Study in Yunnan, China.","authors":"Wenjun Yan, Di Xu, Qiongli Duan, Nengmei Huang, Jing Han, Yuhua Shi, Jian Li, Hongjie Liu","doi":"10.1007/s10461-024-04602-w","DOIUrl":"https://doi.org/10.1007/s10461-024-04602-w","url":null,"abstract":"Due to limited data on the determinants of HIV care continuum outcomes among people living with HIV (PLWH) in resource-limited settings, this study aimed to identify individual and social support network factors influencing these outcomes, thereby informing the development of intervention strategies to achieve the UNAIDS 95-95-95 targets. PLWH in Yunnan, China, were recruited using convenience sampling at three stages of the HIV care continuum: linkage to care, antiretroviral therapy (ART) initiation, and viral suppression. An egocentric network design combined with multilevel logit modeling was employed to investigate factors associated with ART initiation and viral suppression. A total of 410 eligible participants were recruited into the study. Of these, 145 (35.4%) were linked to care but did not initiate ART, 265 (64.6%) initiated ART, and 131 (49.4%) achieved viral suppression. Higher trust in alters, larger network density, stronger social support, and longer ego-alter relationship were positively associated with ART initiation and viral suppression. Participants who received social support from friends or family members had higher odds of initiating ART compared to those who received support from sexual partners. Factors associated with viral suppression were larger network size, having older alters and alters with higher education in an ego's social support network. The findings enhance our understanding of how social support network determinants influence HIV care continuum outcomes. Interventions for PLWH in China should consider these social support network characteristics to improve outcomes.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reported Suicide Attempts among Adolescents in Uganda: Differences by HIV Status. 乌干达青少年自杀未遂报告：艾滋病毒状况的差异。

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2024-12-30 DOI: 10.1007/s10461-024-04581-y

Angel Nanteza, Joy Gumikiriza-Onoria, Anthony F Santoro, Christine Karungi, Christopher M Ferraris, Daphne Tsapalas, Courtney Kirsch, Mina Nguyen, Nana Asiedu, Mei Tan, Jun Liu, Curtis Dolezal, Victor Musiime, Sahera Dirajlal-Fargo, Reuben N Robbins

{"title":"Reported Suicide Attempts among Adolescents in Uganda: Differences by HIV Status.","authors":"Angel Nanteza, Joy Gumikiriza-Onoria, Anthony F Santoro, Christine Karungi, Christopher M Ferraris, Daphne Tsapalas, Courtney Kirsch, Mina Nguyen, Nana Asiedu, Mei Tan, Jun Liu, Curtis Dolezal, Victor Musiime, Sahera Dirajlal-Fargo, Reuben N Robbins","doi":"10.1007/s10461-024-04581-y","DOIUrl":"https://doi.org/10.1007/s10461-024-04581-y","url":null,"abstract":"Suicide remains a global public health concern and is a leading cause of death among adolescents. Adolescents with perinatally-acquired HIV (PHIV) are particularly vulnerable to suicide and other challenges, including discrimination, stigma, educational difficulties, risk-taking behaviors, and medical complications. In Uganda, adolescents with PHIV experience a high burden of mental health problems, but there is scant information regarding suicide attempts. This study examined lifetime suicide attempts, depressive symptoms, and adverse experiences among adolescents with PHIV and demographically matched HIV-negative adolescents. One hundred Ugandan adolescents (12-20 years old), 50 with and 50 without PHIV, completed the Adverse Childhood Experiences (ACEs) questionnaire, Patient Health Questionnaire-A (PHQ-A), and the Adolescent Life Events Questionnaire (ALEQ), which included additional questions about suicide attempts. Independent t-test and chi-square analyses were used to compare scores between the two HIV status groups. There were no significant differences in sex across the HIV groups. The mean total scores of the full sample were ACEs M = 2.92 (SD = 2.49), ALEQ M = 10.61 (SD = 9.08) and PHQ-A M = 2.25 (SD = 3.55). The PHIV group had significantly higher PHQ-A (p < .001), ALEQ (p < .01), and ACEs (p < .001) scores than the HIV-negative group. Among adolescents with PHIV, 14% reported at least one previous suicide attempt, while none of the HIV-negative adolescents reported any attempt (X2 = 8.20, p = .02). Despite overall low depression scores, the PHIV group had significantly more depressive symptoms and were more likely to have suffered from psychosocial stressors.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of HIV Prevention Strategies and Services Reported by Black Women with a Risk for and with HIV in the United States. 美国有感染和感染艾滋病毒风险的黑人妇女报告的艾滋病毒预防策略和服务的使用情况

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2024-12-30 DOI: 10.1007/s10461-024-04578-7

Toria Reaves, Rashunda Lewis, Sharoda Dasgupta, Shacara Johnson Lyons, Yunfeng Tie, Priya Nair, Tamara Carree, Xiaohong Hu, Jerris L Raiford, Ruthanne Marcus

{"title":"The Use of HIV Prevention Strategies and Services Reported by Black Women with a Risk for and with HIV in the United States.","authors":"Toria Reaves, Rashunda Lewis, Sharoda Dasgupta, Shacara Johnson Lyons, Yunfeng Tie, Priya Nair, Tamara Carree, Xiaohong Hu, Jerris L Raiford, Ruthanne Marcus","doi":"10.1007/s10461-024-04578-7","DOIUrl":"https://doi.org/10.1007/s10461-024-04578-7","url":null,"abstract":"Black women are disproportionately affected by HIV. We analyzed data from two Centers for Disease Control and Prevention's HIV surveillance systems to better understand HIV prevention strategies used by Black women at risk for and with HIV to help inform efforts to end HIV. Among sexually active Black women, we analyzed 2019 National HIV Behavioral Surveillance data on women without HIV (n = 4,033) and 2018-2020 Medical Monitoring Project data on women with HIV (n = 967). We reported percentages of HIV prevention strategies and services used and assessed differences between groups using Rao-Scott chi-square tests. Among Black women without HIV, 39% were aware of pre-exposure prophylaxis (PrEP); of these, 7% discussed PrEP with a healthcare provider, and 1% used PrEP in the past 12 months. Approximately 16% used a condom with their last sex partner; 36% reported that their last sex partner did not have HIV. Among Black women with HIV, 58% had condom-protected sex, 56% reported having sex while having sustained viral suppression, 3% had condomless sex with a partner on PrEP, and 24% had sex with a partner with HIV; 12% engaged in sex without using any HIV prevention strategy. HIV prevention strategies and services differed by selected demographic characteristics and social determinants of health. Although many sexually active Black women reported using HIV prevention strategies, there is room for improvement among those at risk for or with HIV. Tailoring prevention efforts based on individual needs and circumstances is essential for ending the HIV epidemic.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Willingness to Use Oral and Long-Acting Injectable PrEP in Substance-Using Men who have Sex with Men (SU-MSM) in High HIV Incidence Southern U.S. Cities: A NIDA Clinical Trials Network Study. 在美国南部 HIV 高发城市中，与男性发生性关系的吸毒男性 (SU-MSM) 使用口服和长效注射 PrEP 的意愿：NIDA 临床试验网络研究。

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2024-12-30 DOI: 10.1007/s10461-024-04594-7

Susan Tross, Tanja C Laschober, Margaret Paschen-Wolff, Melissa Ertl, C Mindy Nelson, Lynette Wright, Chloe Lancaster, Daniel J Feaster, Mauda Monger, Phil Toal, Joshua P Fegley, David Meche, Colby Hankey, Christina Woodhouse, Anya Spector, Lauren Dresser, Landhing Moran, Eve Jelstrom, Louise Haynes, Steven Shoptaw, Mary A Hatch

{"title":"Willingness to Use Oral and Long-Acting Injectable PrEP in Substance-Using Men who have Sex with Men (SU-MSM) in High HIV Incidence Southern U.S. Cities: A NIDA Clinical Trials Network Study.","authors":"Susan Tross, Tanja C Laschober, Margaret Paschen-Wolff, Melissa Ertl, C Mindy Nelson, Lynette Wright, Chloe Lancaster, Daniel J Feaster, Mauda Monger, Phil Toal, Joshua P Fegley, David Meche, Colby Hankey, Christina Woodhouse, Anya Spector, Lauren Dresser, Landhing Moran, Eve Jelstrom, Louise Haynes, Steven Shoptaw, Mary A Hatch","doi":"10.1007/s10461-024-04594-7","DOIUrl":"https://doi.org/10.1007/s10461-024-04594-7","url":null,"abstract":"In Southern U.S. states with high HIV incidence and low HIV Pre-Exposure Prophylaxis (PrEP) uptake, enhanced efforts to increase interest in and willingness to use PrEP are needed. This implementation survey examined the associations of sociodemographic background, substance use, and sexual risk behaviors with willingness to use daily oral and long-acting injectable (LAI) PrEP among substance using men who have sex with men (SU-MSM). Participants were 225 SU-MSM recruited from sexually transmitted infection (STI) clinics, syringe services programs (SSPs), and substance use treatment programs (SUTPs) in eight Southern U.S. cities. Rates of willingness were high for both daily oral PrEP (78%) and LAI PrEP (66%). In multivariable analyses, distinct factors were associated with willingness towards each. For daily oral PrEP, greater willingness was associated with condomless anal sex, less frequent non-injection opioid use, prior PrEP awareness, and past use of PrEP. For LAI PrEP, greater willingness was associated with Black race, identifying as gay, being single, and higher injection drug use frequency. Lower willingness to use LAI PrEP was associated with higher non-injection opioid use frequency. Findings about willingness to use LAI PrEP, as a relatively newer modality, and greater willingness among Black SU-MSM as a disproportionately HIV-impacted population, are especially important. These findings argue for the necessity to enhance PrEP promotion efforts that distinguish between oral and LAI PrEP and that are specifically tailored to major SU-MSM subgroups in the Southern U.S.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychosocial and Behavioral Impacts of the Mpox Outbreak among People with and without HIV in the United States. Mpox在美国HIV感染者和非HIV感染者中爆发的社会心理和行为影响

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2024-12-30 DOI: 10.1007/s10461-024-04603-9

Hannah Yellin, Sydney Bornstein, Madhu Balachandran, Marc Siegel, Manya Magnus

引用次数: 0

The Informal, Non-Prescribed Use of Antiretroviral Medications for PrEP Among a National US-Based Sample of Gay, Bisexual, and Other Men Who Have Sex with Men: A Cross-Sectional Study. 在美国全国同性恋、双性恋和其他男男性行为者样本中，非正式、非处方地使用抗逆转录病毒药物进行PrEP：一项横断面研究。

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2024-12-30 DOI: 10.1007/s10461-024-04589-4

Mance E Buttram, Matthew S Ellis, Krishen D Samuel, Matthew Hayhurst

引用次数: 0

County-Level Factors Associated with Reversal of Insurer-Approved HIV Pre-Exposure Prophylaxis Prescriptions in the United States, 2018. 2018年美国县级因素与保险公司批准的HIV暴露前预防处方逆转相关

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2024-12-30 DOI: 10.1007/s10461-024-04585-8

Rahel Dawit, William C Goedel, Hsien-Yen Chang, Amy S Nunn, Philip A Chan, Jalpa A Doshi, Lorraine T Dean

{"title":"County-Level Factors Associated with Reversal of Insurer-Approved HIV Pre-Exposure Prophylaxis Prescriptions in the United States, 2018.","authors":"Rahel Dawit, William C Goedel, Hsien-Yen Chang, Amy S Nunn, Philip A Chan, Jalpa A Doshi, Lorraine T Dean","doi":"10.1007/s10461-024-04585-8","DOIUrl":"https://doi.org/10.1007/s10461-024-04585-8","url":null,"abstract":"Identifying county-level factors that influence pre-exposure prophylaxis (PrEP) adherence is critical for ending the HIV epidemic in the United States (US). PrEP primary reversal is a term used to describe patients who do not obtain their prescribed medication from the pharmacy. This study sought to identify factors associated with PrEP reversal at the county level in 2018. Data were collected from Symphony Health Analytics, AIDS Vu, the US Census Bureau, and the Centers for Disease Control and Prevention National Prevention Information Network. Bivariate Choropleth maps were created to identify counties with high and low levels of PrEP reversal and HIV incidence. This was followed by bivariate analysis to determine the association between predictor variables and percent PrEP reversal. Finally multivariable logistic regressions were used to assess the association between percent PrEP reversal and variables that were significant from the bivariate analysis. A total of 308 counties were included in this analysis, where the mean number of PrEP prescriptions for counties was 44, with a median of 14 (Interquartile range 7-34). In the multivariable analysis, counties with higher level of unemployment (aOR: 1.10, 95% CI: 1.05-1.16) and rural counties (1.10: 1.04-1.17) had higher odds of PrEP reversal; while counties with higher household crowding (0.97: 0.95-0.99) had lower odds of PrEP reversal. Findings show the need for expanding and implementing programs as well as policies to improve PrEP services that are tailored to local socioeconomic circumstances.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Factors of ART Follow-Up Loss in HIV Patients (2018-2022): A Retrospective Cohort Study. 2018-2022年HIV患者ART随访损失的预测因素：一项回顾性队列研究

IF 2.7 2区医学

AIDS and Behavior Pub Date : 2024-12-30 DOI: 10.1007/s10461-024-04595-6

Mengjie Li, Hang Chen, Ticheng Xiao, Ji Ma, Mingzhe Ding, Fuli Huang, Yanhua Chen, Run Chen, Ailing Li, Song Fan

{"title":"Predictive Factors of ART Follow-Up Loss in HIV Patients (2018-2022): A Retrospective Cohort Study.","authors":"Mengjie Li, Hang Chen, Ticheng Xiao, Ji Ma, Mingzhe Ding, Fuli Huang, Yanhua Chen, Run Chen, Ailing Li, Song Fan","doi":"10.1007/s10461-024-04595-6","DOIUrl":"https://doi.org/10.1007/s10461-024-04595-6","url":null,"abstract":"Loss to follow-up (LTFU) in antiretroviral therapy (ART) poses significant challenges in the management of HIV/AIDS. This study aims to identify socio-demographic and clinical factors influencing LTFU among patients undergoing ART in Luzhou, China, and to develop a predictive model for LTFU using Cox risk regression analysis. In this retrospective cohort study, data from 8,770 patients diagnosed with HIV infection between January 1, 2018 and December 31, 2022 who were enrolled in the national free ART program were analyzed. The primary outcome was the first occurrence of LTFU. Cox proportional risk regression analyses were conducted to identify predictors of LTFU. The study population had a median age of 64.25 years, and 73.2% were male. The overall LTFU rate was 4.14 per 100 person-years. Factors associated with a decreased likelihood of LTFU included female gender, homosexual transmission, absence of HIV-related diseases, negative HBV surface antigen, higher final CD4 count, and an increase in CD4 count from baseline. In contrast, older age, longer time from diagnosis to ART initiation, higher baseline viral load, missed medication doses, and the development of medication side-effects were associated with an increased risk of LTFU. Our prediction model identifying the risk of loss to follow-up demonstrated good predictive performance with a C-index of 0.721. The study highlights the importance of considering a range of socio-demographic and clinical factors in managing LTFU among people living with HIV (PLHIV) on ART. Our prediction model can be a valuable tool for healthcare providers to identify patients at high risk of LTFU, facilitating targeted interventions to improve treatment adherence and outcomes.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0