AIDS and Behavior最新文献

{"title":"Expanding PrEP Access by Embedding Unannounced SNAPS Navigators in High STI Testing Clinical Sites.","authors":"Robert A Pitts, Mateo Rufo, Francois Ban, R Scott Braithwaite, Farzana Kapadia","doi":"10.1007/s10461-025-04868-8","DOIUrl":"https://doi.org/10.1007/s10461-025-04868-8","url":null,"abstract":"<p><p>We developed and implemented a PrEP navigation program (\"SNAPS\") in a NYC safety-net hospital with the objectives to co-locate navigation, clinical PrEP services, and payment assistance. Adherence and retention to PrEP-related care were assessed by mean medication possession ratios (MPRs) and number of appointments over 12 months. Compared to the pre-SNAPS cohort, the post-SNAPS cohort was less likely to be cisgender male (64.8% vs. 84.2%), White (6.5% vs. 23%) and to speak English (33.3% vs. 80.6%) (all p < 0.001). Mean MPR was lower for post-SNAPS (0.68, SD = 0.33) compared to pre-SNAPS (0.89, SD = 0.22) (p = 0.001). Among post-SNAPS patients, cisgender men and MSM were more likely to be retained in PrEP care compared to cisgender women (p < 0.05). Although SNAPS linked diverse patients to PrEP-care, mean MPR was lower post-SNAPS compared to the pre-SNAPS. Continued investments to strengthen later stages of the PrEP cascade model for all populations vulnerable to HIV are needed.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV Knowledge, Information Sources, and Perceived Risk among Reproductive-Aged Individuals in Kisumu, Kenya: A Latent Profile Analysis.","authors":"Talia A Loeb, K Willis, M A E Roach, V Sing'oei, J Otieno, R Oyugi, J Opany, C S Polyak, T A Crowell, J Owuoth, S Baral, K Rucinski","doi":"10.1007/s10461-025-04866-w","DOIUrl":"10.1007/s10461-025-04866-w","url":null,"abstract":"<p><p>Information, education, and communication programs to improve HIV knowledge and communication skills are critical to HIV responses. It is unclear if improved HIV knowledge translates to decreased HIV acquisition risks. We identified typologies of HIV knowledge to assess the relationship with HIV risk perceptions and prevention behaviors using data from reproductive-aged adults without previously diagnosed HIV at screening for entry into the RV393 HIV incidence cohort in Kisumu County, Kenya. Staff-administered questionnaires on sociodemographic characteristics, HIV knowledge, information sources (e.g., radio, television, community, school, etc.), and prevention/risk behaviors. HIV knowledge and information source typologies were identified using latent profile analysis (LPA). Mixture modeling was used to assess the relationship between typologies and perceived risk. Prevention/risk behaviors were compared and stratified by typology and risk perception (high or low/no risk). Of 926 participants in the analyses, 46.8% were female and 58.1% had at least a secondary education. LPA fit statistics suggested a three-class model (BIC = 7738; entropy = 0.793). Differences in latent profiles were characterized by engagement in community-sourced information. Across all classes, participants with high risk perception reported significantly greater numbers of sex partners and were more likely to exchange sex compared to those reporting low/no risk. HIV testing practices and consistent condom use were similar irrespective of typology. There was alignment between risk perception and risk/prevention behaviors, but knowledge and information typologies were not significantly associated with risk perception. Building knowledge alone may not be sufficient to improve outcomes, thus necessitating structural interventions that facilitate enabling environments for prevention services.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Depression, Suicidality, Alcohol Use Disorder and Associated Factors Among Adults on Antiretroviral Therapy in Namibia.","authors":"Ndeshiteelela K Conteh, Ozayr Mahomed","doi":"10.1007/s10461-025-04855-z","DOIUrl":"10.1007/s10461-025-04855-z","url":null,"abstract":"<p><p>The increased risk associated with HIV infection and suicidality, depression, and alcohol use disorder underscores the need to treat mental illness in people living with HIV by integrating mental health services into routine HIV care. This study, conducted at nine health facilities providing antiretroviral treatment in Namibia from August and September 2022, aimed to determine the prevalence and factors associated with depression, suicidality, and alcohol use disorder among adults living with HIV/AIDS in Namibia. Amongst the 400 participants, the prevalence of depression, suicidality, and alcohol use disorder was 8%, 21%, and 24%, respectively. The prevalence of depression and suicidality was highest in females (9.7%) and (24.7%), respectively, while males had a prevalence of alcohol use disorder of 35.3%. Patients with depression showed an increased and significant risk of suicidality (aOR=8.280, 95% CI: 3.644-18.815, p=0.000). For alcohol use disorder, male patients (aOR= 2.995, 95% CI: 1.816-4.938, p=<0.000) were more likely to have alcohol use disorder. Male sex (aOR= 0.447, 95% CI: 0.240-0.832, p=<0.011), depression (aOR= 8.283, 95% CI: 3.644-18.828, p=<0.000), and alcohol abuse (aOR= 2.393, 95% CI: 1.337-4.285, p=0.003) had an increased and significant association with suicidality. Overall, the study's results show that alcohol use disorder and suicidality are more prevalent in PLHIV compared to depression, and gender is a significant risk factor. Screening PLHIV and early initiation of treatment or interventions for various mental health disorders are important to improve retention, viral suppression, and other outcomes of ART.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a Lottery Incentive on STI/HIV Incidence Among Female Sex Workers in Tanzania: Outcomes of Rewarding STI Prevention and Control in Tanzania (RESPECT-2).","authors":"Marianna Balampama, Damien de Walque, William H Dow, Rebecca Hémono","doi":"10.1007/s10461-025-04822-8","DOIUrl":"https://doi.org/10.1007/s10461-025-04822-8","url":null,"abstract":"<p><p>Female sex workers (FSW) are a key population who experience a disproportionately high burden of HIV and sexually transmitted infections (STIs). A growing body of evidence suggests that financial incentives can reduce risky sexual behavior and reduce HIV/STI incidence, however few studies have examined a lottery-based incentive mechanism or been conducted with FSW. We examined the effect of a lottery intervention on combined HIV/HSV2 incidence among FSW. The RESPECT II trial was an unmasked, two-arm, parallel group randomized controlled trial conducted in Dar es Salaam, Tanzania (AEA RCT registry: AEARCTR-0002677). Individuals who were ≥ 18 years of age, HIV-negative, not currently pregnant, exchanged sex for money in the past six months, and living in Dar es Salaam were eligible. Participants were randomized in a 1:1 ratio to the basic test group (control) which included testing and counseling for HIV and biweekly text messages with information on safe sex practices, or to the lottery group, which provided the basic test group intervention plus entry into a weekly lottery with a 100,000 TZS (~ $50 USD) reward offered to ten randomly selected participants, conditional on negative test results for syphilis and trichomonas. The primary outcome was combined HIV/HSV2 incidence after 36 months. Between August 2018-February 2019, 2,489 individuals screened for eligibility and 2,206 were enrolled in the trial and randomized. Participants were followed for up to 36 months; 1089 (49.4%) were lost to follow-up at endline and 1,117 were included in the primary intent to treat analysis (609 lottery, 508 control). At 36 months, there was no effect of the lottery intervention on the incidence of combined HIV/HSV2 (unadjusted RD: - 0.006, 95% CI - 0.05, 0.04; adjusted RD - 0.001, 95% CI - 0.05, 0.05). However, the results may have been affected by disruption from the COVID-19 pandemic, and unexpectedly high study attrition levels made it impossible to statistically rule out possible moderate-sized effects.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Impacts of High-Intensity Interval Training (HIIT) in People Living with HIV: A Scoping Review.","authors":"Euripedes Barsanulfo Gonçalves Gomide, Igor Massari Correia, Chimenny Auluã Lascas Cardoso Moraes, Jeferson Roberto Collevatti Dos Anjos, Jéssica Fernanda Correa Cordeiro, Juliana Pereira Borges, Francisco Javier Soto-Rodríguez, Vitor H F Oliveira, Allison R Webel, André Pereira Dos Santos","doi":"10.1007/s10461-025-04844-2","DOIUrl":"https://doi.org/10.1007/s10461-025-04844-2","url":null,"abstract":"<p><p>People with human immunodeficiency virus (PWH) face increased health risks beyond those directly linked to HIV infection, including reduced cardiorespiratory fitness (CRF), cardiovascular disease, and accelerated aging. Physical exercise, particularly high-intensity interval training (HIIT), may help mitigate these issues. This scoping review aimed to map the current evidence on the effects of HIIT in PWH. In February 2024, searches were conducted across six databases (PubMed, EMBASE, Scopus, Lilacs, Web of Science, and SPORTDiscus) and gray literature (medRxiv). Two reviewers independently screened titles, abstracts, and full texts, selecting studies that met the inclusion criteria. Three studies were included: a pre-experimental trial, a randomized crossover pilot study, and a non-randomized intervention. Participants had a mean age of 41.5 years. HIIT was associated with improvements in CD4 + T lymphocyte count, VO₂peak, and CRF. These findings suggest HIIT may be a beneficial exercise strategy for improving health markers in PWH.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Doxy-PEP Right for Me? Piloting a Novel Patient Decision Aid in an Urban Ambulatory Clinic.","authors":"Joan Bosco, Paul D'Avanzo, Caroline Carnevale, Edward Perez, Jenny Li, Juan Diego Ramirez, Kathrine Meyers, Magdalena Sobieszczyk, Jason Zucker","doi":"10.1007/s10461-025-04831-7","DOIUrl":"https://doi.org/10.1007/s10461-025-04831-7","url":null,"abstract":"<p><p>We iteratively designed a novel patient decision aid (PDA) to improve patient-provider communication regarding the benefits, risks, and proper usage of doxycycline as post-exposure prophylaxis (Doxy-PEP). We tested the feasibility, acceptability, and appropriateness of counseling using this PDA among a pilot group in two academic, urban sexual health clinics. Using a pretest-posttest model we assessed the extent to which this intervention impacted participants' knowledge of and attitudes towards Doxy-PEP. Participants (N = 30) were all assigned male at birth and had at least one sexually transmitted infection in the past year; 30% were living with HIV. We found that counseling using this PDA increased participants' familiarity with, comfort with, and knowledge of Doxy-PEP. Participants found this intervention to be acceptable, appropriate, and feasible. This model of employing formally evaluated PDAs to enhance patient-provider communication may be adaptable for other public health interventions.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering Women's PrEP Choices: Qualitative Insights into Long-Acting PrEP Preferences and Decision-Making during Pregnancy and Breastfeeding in South Africa and Botswana.","authors":"Jenny Chen-Charles, Lindsey De Vos, Prisca Vundhla, Avuyonke Gebengu, Elzette Rousseau, Linda-Gail Bekker, Remco Peters, Aamirah Mussa, Chelsea Morroni, Elona Toska, Chibuzor M Babalola, Jeffrey D Klausner, Dvora Joseph Davey","doi":"10.1007/s10461-025-04856-y","DOIUrl":"10.1007/s10461-025-04856-y","url":null,"abstract":"<p><p>Pregnant and breastfeeding women (PBW) are at heightened risk of HIV acquisition. We aimed to explore PBW's preferences of various long-acting PrEP modalities. In-depth interviews were conducted with PBW at three sites: Cape Town, East London (South Africa), and Gaborone (Botswana). We conducted thematic analysis, guided by the Health Belief Model, to examine participants' HIV risk perception during pregnancy and breastfeeding, their perceived individual-level facilitators and barriers of each PrEP modality, and the support needed by participants for PrEP uptake and continuation. 40 participants were interviewed, aged 18-39 years (mean 27 years), including 13 adolescent girls and young women (AGYW; 18-24 years). Participants were either pregnant (n = 20) or breastfeeding (n = 20). Perceived HIV risk during pregnancy motivated PrEP use. Long-acting methods were preferred over daily pills for convenience and perceived reliability, with injectables most favoured due to familiarity with contraceptive injections. However, concerns about pain and side effects persisted. Monthly oral PrEP was seen as easier than daily pills but raised similar concerns about adherence. Implants were met with fear and mistrust, often rooted in negative contraceptive experiences, though some valued their long-term protection. The vaginal ring was least acceptable due to unfamiliarity and discomfort with insertion. Participants emphasised the importance of external support (e.g. reminders), privacy and discretion, and community transparency to support PrEP adherence and reduce stigma. Addressing barriers - especially concerns about the safety and effectiveness of new modalities and challenges around adherence - could help improve strategies to better assist PBW in utilising long-acting PrEP modalities.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the Role of Neighborhood Disadvantage in a Digital PrEP Intervention for Young Sexual and Gender Minority Men.","authors":"Michael P Williams, Justin Manjourides, Louisa H Smith, Crissi B Rainer, Lisa Hightow-Weidman, Danielle F Haley","doi":"10.1007/s10461-025-04860-2","DOIUrl":"https://doi.org/10.1007/s10461-025-04860-2","url":null,"abstract":"<p><p>While digital health interventions (DHIs) have become an increasingly common approach to address HIV vulnerability among young sexual and gender minority men who have sex with men (YSGMMSM), few studies consider the role of neighborhood disadvantage in DHI efficacy and engagement. The present study is a secondary data analysis of 212 YSGMMSM aged 16-24 that combined biological and clinical survey data from the primary efficacy randomized controlled trial (RCT) of P3, a PrEP adherence DHI, with a measure of neighborhood disadvantage to characterize P3 engagement and efficacy among high and low disadvantage neighborhoods. We found that participants residing in high disadvantage neighborhoods engaged with P3 a median of 63 days (IQR = 39-76), compared to 77 days (IQR = 51-82) in low disadvantage neighborhoods. Among those who received the P3 intervention, participants residing in high disadvantage neighborhoods had higher odds of PrEP non-adherence (OR = 3.6, CI = 1.2, 10.4). Further, we found that there was minimal difference in PrEP non-adherence rates among those residing high disadvantage neighborhoods between intervention and control groups (28% vs. 25%) compared to 9% in the intervention condition and 18% in the control condition among those residing in low disadvantage neighborhoods. Despite this, receiving the P3 intervention did not moderate the relationship between neighborhood disadvantage and PrEP non-adherence. These findings suggest that neighborhood disadvantage may play a role in PrEP adherence DHI efficacy and engagement among YSGMMSM. Further research is needed to quantify the role of neighborhood disadvantage in YSGMMSM using HIV DHIs.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV Testing in African American Churches: Results from the Taking It to the Pews Cluster-Randomized Trial.","authors":"Jannette Berkley-Patton, Carole Bowe Thompson, Alexandria G Bauer, Marcie Berman, Kelsey Christensen, Andrea Bradley-Ewing, Kathy Goggin, Delwyn Catley, Eric Williams, Cassandra Wainright, Kathryn P Derose, Alex Geyer, Frank Thompson, Lesha Dennis, Stephen Smith, Jenifer E Allsworth","doi":"10.1007/s10461-025-04852-2","DOIUrl":"https://doi.org/10.1007/s10461-025-04852-2","url":null,"abstract":"<p><p>To examine effects of a multilevel, religiously-tailored HIV testing intervention, Taking It to the Pews (TIPS), on receipt of HIV testing with African American church-affiliated populations, 14 African American churches (N = 1,491) were randomized to TIPS or a multilevel, non-tailored HIV education attention-control arm in a cluster-randomized trial (Kansas City urban area, 2013 to 2019). Receipt of an HIV test was examined using objective data and participant self-reports (last 12 months), including self-reported exposure to intervention components. Overall, 471 HIV tests were completed; TIPS intervention churches conducted significantly more tests than controls (339 versus 132, p = 0.003). Also, a larger proportion of intervention participants self-reported receipt of an HIV test than controls (38% versus 34%). Participants in intervention churches self-reported exposure to an average of 7 of 14 different intervention arm HIV-related activities; activities with the most exposures were printed information/posters (71%), resource tables (70%), sermons (63%), and health professional or HIV-positive speakers (60%). Odds of HIV testing increased 47% for each additional intervention exposure reported. African American faith communities delivering a multilevel, religiously-tailored HIV testing intervention can significantly impact receipt of HIV testing with African American church-affiliated populations.Trial registration number and date: NCT02529644 Aug 06 2015.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Electronic Patient Portal Enrollment and HIV Care Outcomes Among People Living with HIV at an Urban Academic Medical Center.","authors":"Jessica P Ridgway, Daniela Zimmer, Raj Shetty, Neda Laiteerapong","doi":"10.1007/s10461-025-04869-7","DOIUrl":"10.1007/s10461-025-04869-7","url":null,"abstract":"<p><p>Electronic patient portals are associated with improved health outcomes in primary care settings. We assessed the relationship between patient portal enrollment and retention in care and HIV viral suppression in an urban HIV care clinic. In multivariable models, people with HIV with an active portal account had higher odds of HIV viral suppression (Odds Ratio [OR]: 2.02, 95% CI [1.3-3.7]) and higher odds of retention in care (OR: 2.2 95% CI[1.4-3.4]) than those without an active portal account. Our findings suggest that portal enrollment is associated with improved HIV care outcomes among people with HIV.</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12443438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}