High Preference for Injectable Pre-exposure Prophylaxis among Young Women in Kenya.

IF 2.7 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Kidist Zewdie, John Kinuthia, Daniel Matemo, Cynthia Wandera, Valarie Kemunto, Irene Cherotich, Tecy Oyambra, Mercy Bi, Esther Achieng, Steven Odhiambo, Beatrice Oduor, Daniel Sajita, Cole Grabow, Jennifer Morton, Renee Heffron, Kenneth K Mugwanya
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引用次数: 0

Abstract

Longer acting HIV pre-exposure prophylaxis (PrEP) products are effective options for HIV prevention that require less user-dependence. As programs are preparing to launch delivery of these longer acting products, it is important to understand users' needs and preferences. We conducted a cross-sectional study among women seeking services at 12 family planning clinics in Kisumu, Kenya. Participants were sexually active HIV-negative women ≥15 years, with at least one characteristic that is more common among women who acquire HIV. We assessed PrEP product preferences among PrEP-experienced and inexperienced women. We used descriptive statistics to summarize participants' characteristics, product preferences, and willingness to use different PrEP modalities. We used univariate and multivariate models to assess factors related to preferences for injectable PrEP. A total of 457 participants were enrolled, including 341 with no oral PrEP experience and 116 with recent oral PrEP experience. The median age was 26 [IQR:23-30], 83% were married or cohabiting and 31% reported using injectable contraceptives. Among participants without prior PrEP experience, 74% preferred injectable PrEP, 19% preferred oral PrEP, and 4% preferred the vaginal ring. Among previous oral PrEP users, 82% preferred injectable PrEP, 16% preferred oral PrEP, and only 2% preferred the dapivirine vaginal ring. Only perceived PrEP stigma was significantly associated with injectable PrEP preference (PR: 1.21, 95% CI 1.09, 1.37, P=0.001). Reproductive-age women in Kenya have a strong interest in long-acting injectable PrEP. Product rollout and implementation needs to consider women's preference and devise best approaches to deliver injectable PrEP.

肯尼亚年轻妇女对接触前注射预防的高度偏好。
长效艾滋病毒暴露前预防产品是预防艾滋病毒的有效选择,对使用者的依赖性较低。随着项目准备推出这些长效产品,了解用户的需求和偏好非常重要。我们对在肯尼亚基苏木的12家计划生育诊所寻求服务的妇女进行了横断面研究。参与者为性活跃的艾滋病毒阴性妇女≥15年,至少有一个特征在感染艾滋病毒的妇女中更为常见。我们评估了有PrEP经验和没有PrEP经验的妇女对PrEP产品的偏好。我们使用描述性统计来总结参与者的特征、产品偏好和使用不同PrEP方式的意愿。我们使用单变量和多变量模型来评估与注射PrEP偏好相关的因素。共有457名参与者入组,其中341名没有口服PrEP经验,116名最近有口服PrEP经验。年龄中位数为26岁[IQR:23-30], 83%已婚或同居,31%报告使用注射避孕药。在没有PrEP经验的参与者中,74%的人更喜欢注射PrEP, 19%的人更喜欢口服PrEP, 4%的人更喜欢阴道环。在以前口服PrEP使用者中,82%的人更喜欢注射PrEP, 16%的人更喜欢口服PrEP,只有2%的人更喜欢达匹维林阴道环。只有感知到的PrEP耻感与注射PrEP偏好显著相关(PR: 1.21, 95% CI 1.09, 1.37, P=0.001)。肯尼亚育龄妇女对长效可注射PrEP有浓厚兴趣。产品的推出和实施需要考虑妇女的偏好,并设计提供可注射PrEP的最佳方法。
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来源期刊
AIDS and Behavior
AIDS and Behavior Multiple-
CiteScore
6.60
自引率
13.60%
发文量
382
期刊介绍: AIDS and Behavior provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews. provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews.5 Year Impact Factor: 2.965 (2008) Section ''SOCIAL SCIENCES, BIOMEDICAL'': Rank 5 of 29 Section ''PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH'': Rank 9 of 76
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