AIDS and Behavior最新文献_第5页

Barriers to and Facilitators of Heterosexual Men's Engagement with the PrEP Care Continuum in Sub-Saharan Africa: A Scoping Review. 撒哈拉以南非洲异性恋男性参与PrEP连续护理的障碍和促进因素：范围审查。

IF 2.4 2区医学

AIDS and Behavior Pub Date : 2025-08-14 DOI: 10.1007/s10461-025-04847-z

Connor Bondarchuk, Alex Cronin, Sonwabile Kwetana, Priya Kumar, Corinne Auger, Abigail Batchelder, Kenneth H Mayer

{"title":"Barriers to and Facilitators of Heterosexual Men's Engagement with the PrEP Care Continuum in Sub-Saharan Africa: A Scoping Review.","authors":"Connor Bondarchuk, Alex Cronin, Sonwabile Kwetana, Priya Kumar, Corinne Auger, Abigail Batchelder, Kenneth H Mayer","doi":"10.1007/s10461-025-04847-z","DOIUrl":"10.1007/s10461-025-04847-z","url":null,"abstract":"The HIV epidemic in sub-Saharan Africa (SSA) continues to spread primarily through heterosexual contact, and in many countries, heterosexual men continue to exhibit a high HIV incidence with resultant morbidity and mortality. While there is a growing recognition of the importance of engaging men in the pre-exposure prophylaxis (PrEP) care continuum, there remains a significant gap in our understanding of the multilevel influences that modulate heterosexual's men ability to utilize PrEP. We conducted a scoping review to explore emerging research examining the individual-, interpersonal-dyadic, and social-structural barriers and facilitators to PrEP awareness/willingness, uptake, adherence, and persistence in this population. Sixty-two articles were selected for inclusion in this review. We identified several multilevel influences on PrEP engagement for heterosexual men that were similar to those affecting other key populations, including doubts about PrEP safety and efficacy, difficulties communicating with partners, peers, and family members, as well as PrEP-related stigma, and costs associated with accessing PrEP. In addition, we found that heterosexual men's engagement with the PrEP care continuum was influenced by the interaction of individual-level characteristics and beliefs about PrEP and a distinct set of masculine norms governing men's personal, sexual, and economic lives. Results from this review can help guide future research and interventional approaches seeking to improve PrEP engagement among heterosexual men in the SSA context.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Everyday Discrimination and Vulnerability to HIV Transmission Among Sexual and Gender Minorities of Color in Raleigh-Durham, North Carolina. 在北卡罗来纳州罗利-达勒姆的有色人种中，日常歧视和艾滋病毒传播的脆弱性。

IF 2.4 2区医学

AIDS and Behavior Pub Date : 2025-08-14 DOI: 10.1007/s10461-025-04839-z

Dalton M Craven, Ann M Dennis, Justin Quimbo, Kham S K Piang, Britt Skaathun

{"title":"Everyday Discrimination and Vulnerability to HIV Transmission Among Sexual and Gender Minorities of Color in Raleigh-Durham, North Carolina.","authors":"Dalton M Craven, Ann M Dennis, Justin Quimbo, Kham S K Piang, Britt Skaathun","doi":"10.1007/s10461-025-04839-z","DOIUrl":"10.1007/s10461-025-04839-z","url":null,"abstract":"Sexual and gender minority (SGM) individuals of color face disproportionate HIV burdens in the United States, partly due to the effects of discrimination. Discrimination may drive behaviors linked to HIV risk, including increased sexual activity and substance use, but these relationships remain underexplored in the Southern U.S. We conducted a cross-sectional analysis using data from a social network survey of adult persons of color assigned male sex at birth (AMAB) who have sex with other AMAB individuals in Raleigh-Durham, North Carolina. Everyday discrimination was measured using the five-item Everyday Discrimination Scale (EDS), summed by the number of situations reported. Participants were categorized by sexual activity level-high (≥ 3 partners in the past 6 months) or low (0-2 partners). Multivariable logistic regression was used to assess associations between EDS scores, substance use, and sexual activity. Among 100 participants (median age 32), 79% identified as Black/African American, 22% as Latinx, 55% were living with HIV, and 10% identified as gender diverse. Most (87%) reported experiencing at least one type of everyday discrimination in the past year. EDS scores were significantly higher among those with high sexual activity (median 4 vs. 3, p = 0.007). In adjusted models, both EDS (OR 1.76; 95% CI 1.25-2.61) and recreational drug use (OR 4.69; 95% CI 1.59-15.5) were associated with high sexual activity. Discrimination and substance use are significantly associated with elevated sexual activity among SGM of color. Multilevel interventions addressing these factors are needed to improve HIV prevention outcomes in this population.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of an Economic Empowerment Intervention on Economic Security among AIDS-Orphaned Adolescents in Southern Uganda: the Moderating Role of Depression. 经济赋权干预对乌干达南部艾滋病孤儿青少年经济安全的影响：抑郁的调节作用。

IF 2.4 2区医学

AIDS and Behavior Pub Date : 2025-08-14 DOI: 10.1007/s10461-025-04862-0

Josephine Nabayinda, Samuel Kizito, Proscovia Nabunya, Olive Imelda Namuyaba, Vicent Ssentumbwe, Ozge Sensoy Bahar, Neilands Torstein, Mary McKay, Fred M Ssewamala

{"title":"The Impact of an Economic Empowerment Intervention on Economic Security among AIDS-Orphaned Adolescents in Southern Uganda: the Moderating Role of Depression.","authors":"Josephine Nabayinda, Samuel Kizito, Proscovia Nabunya, Olive Imelda Namuyaba, Vicent Ssentumbwe, Ozge Sensoy Bahar, Neilands Torstein, Mary McKay, Fred M Ssewamala","doi":"10.1007/s10461-025-04862-0","DOIUrl":"https://doi.org/10.1007/s10461-025-04862-0","url":null,"abstract":"Sub-Saharan Africa (SSA) bears a disproportionate HIV/AIDS burden, with adolescents heavily affected. Parental loss to AIDS has orphaned millions, exacerbating economic and psychosocial challenges. Economic empowerment interventions (EEIs) promote asset accumulation and financial stability, but the role of depression in moderating their effectiveness remains underexplored. This study examines the impact of an EEI on economic security among HIV/AIDS-orphaned adolescents in Southern Uganda, exploring depression as a moderator. Data from 1383 HIV-orphaned adolescents (10-16 years) were collected from 48 primary schools in Masaka, Uganda (2011-2016), under the Bridges to the Future study. Mixed-effects regression models assessed EEI impact on economic security, measured through physical assets (20-item index) and financial assets (savings yes/no). Depression (Child Depression Inventory) was included as a moderator. Participants' mean age was 12.68 years. The intervention significantly increased financial (χ²(8) = 32.79, p < 0.001) and physical assets (χ²(8) = 23.18, p = 0.003). Depression moderated both physical (χ²(12) = 52.89, p < 0.001) and financial asset accumulation (χ²(8) = 23.60, p = 0.023). Gender differences were also observed: the intervention positively impacted physical assets for females (χ²(8) = 38.41, p < 0.001) but not males (χ²(8) = 3.41, p = 0.906), while financial assets improved significantly for males (χ²(8) = 18.89, p = 0.015) but not females (χ²(8) = 13.33, p = 0.101). The EEI enhanced economic security among HIV/AIDS-orphaned adolescents, with gender-specific effects. Additionally, depression moderated asset accumulation, highlighting the need to integrate mental health support and adopt gender-sensitive approaches in EEIs to promote sustainable economic security. Trial Registration. ClinicalTrials.gov registration no. NCT01447615.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding Perceived Pill Burden in Older Adults with HIV: Exploring Clinical and Demographic Determinants. 了解老年艾滋病毒感染者的药丸负担：探索临床和人口统计学决定因素。

IF 2.4 2区医学

AIDS and Behavior Pub Date : 2025-08-14 DOI: 10.1007/s10461-025-04864-y

Chukwuemeka N Okafor, Deanna Ware, Liddy Kasraian, Deborah Gustafson, Valentina Stosor, Steven Meanley, Steve Shoptaw, Sabina Haberlen, Mackey Friedman, Michael Plankey

{"title":"Understanding Perceived Pill Burden in Older Adults with HIV: Exploring Clinical and Demographic Determinants.","authors":"Chukwuemeka N Okafor, Deanna Ware, Liddy Kasraian, Deborah Gustafson, Valentina Stosor, Steven Meanley, Steve Shoptaw, Sabina Haberlen, Mackey Friedman, Michael Plankey","doi":"10.1007/s10461-025-04864-y","DOIUrl":"https://doi.org/10.1007/s10461-025-04864-y","url":null,"abstract":"Older persons with HIV (PWH) with comorbidities may experience increased perceived pill burden - a subjective experience of the demands associated with taking medications to sustain their health. The objective of this analysis was to examine the demographic, psychosocial, and HIV-related clinical factors associated with perceived pill burden in a sample of middle-aged and older PWH. Data came from men with HIV (MWH) aged ≥ 40 years from the Multicenter AIDS Cohort Study. Dependent variables were: [1] Pill frequency burden (\"The number of times each day I am supposed to take my pills is too often\") and [2] pill quantity burden (\"The total number of pills I am supposed to take is too much\") were assessed and dichotomized as \"Agree\" (indicating burden) versus a combined category of \"Neither Agree/Disagree\" and \"Disagree\" (indicating no burden). Participants (n = 586) had a median age of 59 years (IQR: 54-65), with 56.8% identifying as White non-Hispanic. In adjusted logistic regression model, significant depressive symptoms - defined as CES-D scores ≥ 16 - were significantly associated with increased odds of perceived pill frequency burden (aOR: 2.79; 95% CI: 1.14-6.84) and perceived pill quantity burden (aOR: 2.08; 95% CI: 1.09-3.95). Higher counts of HIV and non-HIV medications were also positively associated with greater odds of pill burden. These findings suggest the need for regular screening for perceived pill burden and depression for older MWH managing HIV and multiple chronic conditions. Additional research employing longitudinal designs is essential to examine the long-term history of perceived pill burden.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV Prevention Continuum Outcomes Following Implementation of a Municipal HIV Self-Testing Program. 实施市HIV自检项目后的HIV预防连续结果。

IF 2.4 2区医学

AIDS and Behavior Pub Date : 2025-08-14 DOI: 10.1007/s10461-025-04842-4

Cedric H Bien-Gund, Knashawn Morales, Javontae Williams, Brian Hernandez, Brandon Ptak, Kathleen Brady, Robert Gross

{"title":"HIV Prevention Continuum Outcomes Following Implementation of a Municipal HIV Self-Testing Program.","authors":"Cedric H Bien-Gund, Knashawn Morales, Javontae Williams, Brian Hernandez, Brandon Ptak, Kathleen Brady, Robert Gross","doi":"10.1007/s10461-025-04842-4","DOIUrl":"https://doi.org/10.1007/s10461-025-04842-4","url":null,"abstract":"HIV self-testing (HIVST) must lead to engagement in the HIV status neutral continuum to maximize its benefits. The objective of this research was to determine the reach of a public health HIVST program, characterize the HIV prevention continuum following self-testing, and identify correlates associated with obtaining post-test care and discussing PrEP. We prospectively recruited individuals who obtained an HIVST through a municipal program in Philadelphia, a metropolitan area with high burden of HIV. We examined factors associated with seeing a provider after self-testing, and among those who saw a provider, factors associated with discussing PrEP. Between October 2022 and March 2024, 282 people met inclusion criteria. Men who have sex with men (MSM) comprised 28% of the study sample, 22% identified as Black cis-gender women, and 22% reported no prior HIV test. At one-month follow-up, 53% of respondents with HIV-negative/unknown status saw a provider, but less than a quarter of those discussed PrEP. Black individuals were more than twice as likely to see a provider compared with White individuals. Among those who saw a provider, MSM and Latinx/e individuals were more likely to discuss PrEP, while those assigned female at birth were less likely to discuss PrEP. Implementation of a municipal HIVST program can advance health equity by reaching priority populations, including previously untested persons. Although over half of participants saw a provider after self-testing, very few discussed or initiated PrEP. Interventions to promote linkage to care and PrEP uptake are needed to maximize the impact of HIVST.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PrEP Care Continuum at an Urban Safety-Net Healthcare Program in Atlanta During its First Three Years of Implementation. 亚特兰大城市安全网医疗保健计划实施前三年的PrEP连续护理。

IF 2.4 2区医学

AIDS and Behavior Pub Date : 2025-08-11 DOI: 10.1007/s10461-025-04830-8

Valeria D Cantos, Kate Ferencsik, Anandi N Sheth, Jessica M Sales, Isabella Batina, Elizabeth Chang, Robert Krafty, Amalia Aldredge, Dylan Baker, Kelly Reyna, Ana Paula Duarte, Grant Roth, Meredith Lora

引用次数: 0

Maladaptive Coping Strategies Mediate the Relationship Between Depression and Anxiety and Moderate-to-Heavy Alcohol Use in Young South Africans with HIV. 适应不良的应对策略介导抑郁、焦虑和南非青年艾滋病毒感染者中度至重度酒精使用之间的关系。

IF 2.4 2区医学

AIDS and Behavior Pub Date : 2025-08-11 DOI: 10.1007/s10461-025-04849-x

Connor P Bondarchuk, Jessica Magidson, Claude Mellins, Tiffany L Lemon, Elzette Rousseau, Siyaxolisa Sindelo, Andrew Medina-Marino, Nkosiypha Sibanda, Lisa M Butler, Linda-Gail Bekker, Valerie A Earnshaw, Ingrid T Katz

{"title":"Maladaptive Coping Strategies Mediate the Relationship Between Depression and Anxiety and Moderate-to-Heavy Alcohol Use in Young South Africans with HIV.","authors":"Connor P Bondarchuk, Jessica Magidson, Claude Mellins, Tiffany L Lemon, Elzette Rousseau, Siyaxolisa Sindelo, Andrew Medina-Marino, Nkosiypha Sibanda, Lisa M Butler, Linda-Gail Bekker, Valerie A Earnshaw, Ingrid T Katz","doi":"10.1007/s10461-025-04849-x","DOIUrl":"https://doi.org/10.1007/s10461-025-04849-x","url":null,"abstract":"Young South Africans living with HIV experience high rates of depression and anxiety, which may contribute to poor HIV clinical outcomes by leading to moderate-to-heavy alcohol use. This analysis sought to examine whether maladaptive coping strategies mediated the relationship between depression and anxiety and moderate-to-heavy alcohol use in this population. This secondary analysis compared baseline data from two cohorts of young South Africans ages 18-24 from the Cape Town and East London. We performed a series of mediation analyses to determine the relationship among depression and anxiety, maladaptive coping, and moderate-to-heavy alcohol use. We found that higher levels of depressive (OR: 1.140, 95% CI: 1.054-1.234, p = 0.001, d = 0.072), but not anxiety (OR: 1.079, 95% CI: 0.987-1.180, p = 0.096, d = 0.042) was associated with moderate-to-heavy alcohol use. Negative emotion-focused coping was not a mediator of the relationship between depression and alcohol use, but avoidant coping was a significant partial mediator of the relationship between depressive symptoms and alcohol use (Indirect effect = 0.038, 95% CI: 0.010, 0.089). Both negative emotion-focused coping (Indirect effect = 0.049, 95% CI: 0.007, 0.116) and avoidant coping (Indirect effect = 0.046; 95% CI: 0.012, 0.115) were significant partial mediators of the relationship between anxiety symptoms and alcohol use. Our findings that avoidant coping and both avoidant and emotion-focused coping may mediate the relationships between depression and alcohol use and anxiety and alcohol use, respectively, may lend support to future interventions seeking to alter coping strategies as a means of reducing alcohol use among young people living with HIV.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous Methamphetamine Use, HIV Status and PrEP Uptake Among a U.S. Sample of 29,880 Gender and Sexual Minorities, 2022-2023. 2022-2023年美国29,880名性别和性少数群体样本中静脉注射甲基苯丙胺使用，艾滋病毒状况和PrEP摄取

IF 2.4 2区医学

AIDS and Behavior Pub Date : 2025-08-11 DOI: 10.1007/s10461-025-04846-0

Tyler S Bartholomew, Marina Plesons, Drew A Westmoreland, Alexa B D'Angelo, Chloe A Mirzayi, Michelle Dearolf, Yan Guo, Elena Hoeppner, Nicole S Richards, Viraj V Patel, Denis Nash, Adam W Carrico, Christian Grov

{"title":"Intravenous Methamphetamine Use, HIV Status and PrEP Uptake Among a U.S. Sample of 29,880 Gender and Sexual Minorities, 2022-2023.","authors":"Tyler S Bartholomew, Marina Plesons, Drew A Westmoreland, Alexa B D'Angelo, Chloe A Mirzayi, Michelle Dearolf, Yan Guo, Elena Hoeppner, Nicole S Richards, Viraj V Patel, Denis Nash, Adam W Carrico, Christian Grov","doi":"10.1007/s10461-025-04846-0","DOIUrl":"10.1007/s10461-025-04846-0","url":null,"abstract":"Methamphetamine use is prevalent among sexual and gender minority (SGM) populations and is associated with increased risk for HIV acquisition. Studies are needed to examine the prevalence of intravenous methamphetamine use and explore its association with HIV status and PrEP uptake. Between August 2022-July 2023, 29,880 SGM people who have sex with men in the U.S. aged 16 and over completed a screening survey for a cohort study on methamphetamine use and HIV prevention. The survey captured socio-demographic characteristics, methamphetamine use (any and injection) and other substance use, and HIV-related measures (including current and previous PrEP use). The median age was 34 years and 49.7% were persons of color. Overall, 35.0% reported methamphetamine use; of whom 45.1% had injected it in the prior 12 months. Compared to people with non-injection methamphetamine use, respondents who injected methamphetamine were more likely to be older, white (vs. non-Hispanic Black or Hispanic), living with HIV or not know their status (vs. HIV-negative), to have injected cocaine, and to have had a sexual encounter without consent under the influence of alcohol/drugs. Among those who were HIV-negative, people who injected methamphetamine were less likely to currently take PrEP and more likely to have discontinued PrEP compared to those who reported non-injection methamphetamine use. Expanded efforts are needed to develop and implement targeted interventions, including PrEP and harm reduction approaches for SGM people who inject methamphetamine, to reduce risk of HIV and other infectious diseases, as well as other injection-related harms.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: A Randomized Comparison Trial Testing Two Culturally Adapted HIV Prevention Approaches for Native Americans Reducing Trauma Symptoms Versus Substance Misuse 更正：一项随机比较试验测试了两种文化适应的艾滋病预防方法，以减少美洲原住民的创伤症状和药物滥用。

IF 2.4 2区医学

AIDS and Behavior Pub Date : 2025-08-11 DOI: 10.1007/s10461-025-04843-3

C. R. Pearson, D. Huh, M. Bedard-Gilligan, D. Walker, R. A. Marín, K. Saluskin, D. Kaysen

引用次数: 0

A Dyad-Based Intervention to Improve Adherence to Antiretroviral Therapy among People with HIV who Inject Drugs in Kazakhstan: Results of a Randomized Controlled Trial. 在哈萨克斯坦，一项基于二元的干预措施提高了注射毒品的艾滋病毒感染者抗逆转录病毒治疗的依从性：一项随机对照试验的结果。

IF 2.4 2区医学

AIDS and Behavior Pub Date : 2025-08-07 DOI: 10.1007/s10461-025-04841-5

Alissa Davis, Elena Rozental, Niall Bolger, Valera Gulyayev, Pavel Gulyayev, Alfiya Denebayeva, Hao Wen, Jiawen Cui, Assel Terlikbayeva, Sholpan Primbetova, Jackelyn Samandas, Frederick L Altice, Robert H Remien, Gaukhar Mergenova

{"title":"A Dyad-Based Intervention to Improve Adherence to Antiretroviral Therapy among People with HIV who Inject Drugs in Kazakhstan: Results of a Randomized Controlled Trial.","authors":"Alissa Davis, Elena Rozental, Niall Bolger, Valera Gulyayev, Pavel Gulyayev, Alfiya Denebayeva, Hao Wen, Jiawen Cui, Assel Terlikbayeva, Sholpan Primbetova, Jackelyn Samandas, Frederick L Altice, Robert H Remien, Gaukhar Mergenova","doi":"10.1007/s10461-025-04841-5","DOIUrl":"https://doi.org/10.1007/s10461-025-04841-5","url":null,"abstract":"Kazakhstan has one of the fastest-growing HIV epidemics in the world, concentrated in people who inject drugs (PWID) with suboptimal antiretroviral therapy (ART) adherence. We compared the efficacy of a dyad-based social support intervention to standard of care on increasing ART adherence among PWID in Kazakhstan. PWID with HIV and on ART for ≥ 3 months ('index cases') were recruited from Kazakhstan's largest HIV clinic. PWID invited a treatment support partner (i.e., spouse, family member, or friend) to participate. Dyads were randomized 1:1 to a standard of care or intervention arm, the latter involving three intervention sessions in four weeks. Assessments were completed at baseline (pre-intervention), one-month (immediately post-intervention), and three-month and six-month follow-up. We used multilevel mixed models to examine changes in ART adherence among index cases over time between arms. Among the 66 index cases, those in the intervention arm who had a partner with HIV had a significantly higher adjusted mean change (AMC) in self-reported ART adherence immediately post-intervention (one-month follow-up) than index cases in the control arm with partners with HIV (AMC 16.55, 95% CI [2.77, 30.34], p = 0.038); this effect was maintained at the six-month follow-up (AMC 17.05, 95% CI [3.14, 30.95], p = 0.033). No significant differences between arms were found among index cases who had partners without HIV. No significant differences in electronic monitoring device-measured adherence or viral suppression were found between arms. The dyad-based intervention significantly increased self-reported ART adherence among PWID with partners with HIV, indicating the importance of considering dyad-level factors in interventions.Clinical Trial Registration: NCT03555396.","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0