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Acta Universitatis Carolinae. Medica最新文献

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Studies on cultured fibroblasts from patients with cutaneous malignant melanoma. 皮肤恶性黑色素瘤患者培养成纤维细胞的研究。
Acta Universitatis Carolinae. Medica Pub Date : 1992-01-01
H W Rüdiger, E Breitbart, M Roser, M Weichenthal, S Frenzer, V Bielfeld, M Oldigs, A Boehm, E Seemanová
{"title":"Studies on cultured fibroblasts from patients with cutaneous malignant melanoma.","authors":"H W Rüdiger,&nbsp;E Breitbart,&nbsp;M Roser,&nbsp;M Weichenthal,&nbsp;S Frenzer,&nbsp;V Bielfeld,&nbsp;M Oldigs,&nbsp;A Boehm,&nbsp;E Seemanová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cultured fibroblasts from patients with cutaneous malignant melanoma (CMM) were tested for chromosomal instability by determination of micronuclei (MN) and sister chromatide exchange (SCE). The constitutive as well as the UV-induced level of MN was increased in CMM patients, being most pronounced in the familial cases. There was an increased UV sensitivity in CMM by using SCE, but no spontaneously enhanced SCE value. The enhanced UV sensitivity in CMM patients was in a comparable range as those of XP heterozygotes. We thus conclude that chromosomal instability is a concurrent feature of a genetic predisposition for CMM.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"38 1-4","pages":"67-74"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19869077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sulphasalazine and Delagil--a comparative study in patients with juvenile chronic arthritis. 磺胺氮嗪与德拉吉尔治疗青少年慢性关节炎的比较研究。
Acta Universitatis Carolinae. Medica Pub Date : 1991-01-01
J Hoza, T Kadlecová, D Nĕmcová, S Havelka
{"title":"Sulphasalazine and Delagil--a comparative study in patients with juvenile chronic arthritis.","authors":"J Hoza,&nbsp;T Kadlecová,&nbsp;D Nĕmcová,&nbsp;S Havelka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thirty nine consecutive patients with pauciarticular and polyarticular juvenile chronic arthritis were randomised to treatment with either sulphasalazine or Delagil (chlorochinum diphosphoricum) in a parallel 6 month clinical trial. We compared clinical and laboratory signs of activity before and after the treatment. Of 21 patients with Sulphasalazine 10 were improved, 7 unchanged and in 4 patients had the therapy to be withdrawn. Of 18 patients with Delagil 5 were improved, 12 without effect and withdrawal was necessary in 1.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"37 1-2","pages":"80-3"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12852890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperlipidemia, dyslipoproteinemia and apolipoproteinopathia--classification and risk of atherosclerosis. Part 3: Hypertriacylglycerolemia. 高脂血症、脂蛋白异常血症和载脂蛋白病——动脉粥样硬化的分类和风险第三部分:高甘油三酯血症。
Acta Universitatis Carolinae. Medica Pub Date : 1991-01-01
B Choluj, T Votruba
{"title":"Hyperlipidemia, dyslipoproteinemia and apolipoproteinopathia--classification and risk of atherosclerosis. Part 3: Hypertriacylglycerolemia.","authors":"B Choluj,&nbsp;T Votruba","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors classify hypertriacylglycerolemias according to their relationship with atherosclerosis as disorders with and without chylomicronemia, atherogenous disorders with an increased level of apolipoprotein B in the VLDL fraction, and relatively harmless (benign) cases. They single out the remarkable heterogeneity of hypertriacylglycerolemias and their epidemiological aspects. The analysis of the various disorders comes complete with their pathobiochemistry and the clinic-biochemical criteria of their classification. The paper also draws attention to a number of possible clinical complications accompanying hypertriacylglycerolemias and their frequency among the population.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"37 3-4","pages":"116-28"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperlipidemia, dyslipoproteinemia and apolipoproteinopathia--classification and risk of atherosclerosis. Part 4: Apolipoproteinopathia. 高脂血症、脂蛋白异常血症和载脂蛋白病——动脉粥样硬化的分类和风险第四部分:载脂蛋白病。
Acta Universitatis Carolinae. Medica Pub Date : 1991-01-01
B Choluj, T Votruba
{"title":"Hyperlipidemia, dyslipoproteinemia and apolipoproteinopathia--classification and risk of atherosclerosis. Part 4: Apolipoproteinopathia.","authors":"B Choluj,&nbsp;T Votruba","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The article defines apolipoprotein diseases as the structural defects of apolipoproteins or disorders in their synthesis or secretion. The survey covers a range of atherogenous defects, providing a detailed description of their clinical-biochemical and genetic aspects as well as diagnostic and differential diagnostic criteria. Attention is paid also to the significance of analytical isoelectric focusing.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"37 3-4","pages":"129-40"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yersinia pseudotuberculosis infection as a cause of arthritis in children. 假结核耶尔森菌感染是引起儿童关节炎的原因。
Acta Universitatis Carolinae. Medica Pub Date : 1991-01-01
A L Mäkelä, R Tertti, K Granfors, R Vuento, A Toivanen
{"title":"Yersinia pseudotuberculosis infection as a cause of arthritis in children.","authors":"A L Mäkelä,&nbsp;R Tertti,&nbsp;K Granfors,&nbsp;R Vuento,&nbsp;A Toivanen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"37 1-2","pages":"21-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multilocular pigmented villonodular synovitis in a child (case report). 儿童多房性色素绒毛结节性滑膜炎1例(附1例报告)。
Acta Universitatis Carolinae. Medica Pub Date : 1991-01-01
M Matĕjícek, P Dungl, V Trnka, S Havelka, J Hoza
{"title":"Multilocular pigmented villonodular synovitis in a child (case report).","authors":"M Matĕjícek,&nbsp;P Dungl,&nbsp;V Trnka,&nbsp;S Havelka,&nbsp;J Hoza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A case of multilocular pigmented villonodular synovitis in a child is described. It is an uncommon disorder, slowly progressive. Investigation, diagnosis and treatment are very difficult.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"37 1-2","pages":"31-6"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibodies to core lipid fractions of endotoxin in children with rheumatic disease. 风湿病患儿内毒素核心脂质部分抗体
Acta Universitatis Carolinae. Medica Pub Date : 1991-01-01
L C Olds, J J Miller
{"title":"Antibodies to core lipid fractions of endotoxin in children with rheumatic disease.","authors":"L C Olds,&nbsp;J J Miller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The titer of IgG and IgM antibodies to two fragments of endotoxin derived from Salmonella minnesota R 595, lipid A width a 2-keto-3-deoxyoctanate oliosaccharide (KDO lipid A), and monophosphoryl lipid A (mono-P lipid), were measured in normal children, children with cystic fibrosis, and children with SLE and all forms of chronic juvenile arthritis. Elevated titers of IgM anti mono-P lipid A were found in all of the rheumatic diseases, but not in cystic fibrosis. The elevated IgM titers were not correlated with concentration of activation fragments of C3 or C4, but IgG anti mono-P lipid A titers, even though not usually elevated, did correlate with C3a and C3d concentrations. The elevated IgM titers to mono-P lipid A may represent a genetically determined hyper-reactivity to normal gastrointestinal antigens, an increased antigenic stimulus from the intestinal tract, or polyspecificity of an antibody of undetermined primary reactivity.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"37 1-2","pages":"37-40"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technetium-99m nanocolloid scintigraphy in rheumatic inflammation in children. 锝-99m纳米胶体显像在儿童风湿性炎症中的应用。
Acta Universitatis Carolinae. Medica Pub Date : 1991-01-01
A L Mäkelä, I Soini, P Mäkelä
{"title":"Technetium-99m nanocolloid scintigraphy in rheumatic inflammation in children.","authors":"A L Mäkelä,&nbsp;I Soini,&nbsp;P Mäkelä","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Technetium-99m HSA (human serum albumin) is a nanometer-sized albumin-based inert colloid, which has a specific ability to accumulate in inflamed soft tissue lesions. With a particle size smaller than 30 nm, Tc-99m HSA spills into the extravascular space in the sites of inflammation because of the changed capillary permeability. The conventional tracer in joint scintigraphy, technetium-99m methylene diphosphonate (Tc-99m-MDP) is a boneseeking compound, which strongly accumulates in the epiphyseal area of growing bones. This makes the estimation of the inflammatory process in the joints of growing children difficult. The nanocolloid compound has not this disturbing tendency. This fact makes the joint scans more specific and the detection of inflammatory lesions is easier especially in children. In our study Tc-99m HSA is used for the detection of rheumatic inflammation in children with juvenile rheumatoid arthritis. We examined 24 children with juvenile rheumatoid arthritis, age 3-19 years, 20 girls and 4 boys, who all had clinically active inflammation in the joints or in the tendon sheets. The uptake pattern of nanocolloid parallels the severity of the inflammatory process in periarticular tissues and tendon sheets. In suspicious cases, the comparison with the contralateral area helps in the detection of the lesion. Therefore, when investigating paired joints, the scintigraphy of symmetrical parts is necessary.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"37 1-2","pages":"61-7"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vasculitis and calcinosis in juvenile dermatomyositis. 青少年皮肌炎的血管炎和钙质沉着。
Acta Universitatis Carolinae. Medica Pub Date : 1991-01-01
H Truckenbrodt, R Häfner
{"title":"Vasculitis and calcinosis in juvenile dermatomyositis.","authors":"H Truckenbrodt,&nbsp;R Häfner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dermatomyositis of childhood onset is characterized by vasculitic lesions and often complicated by calcinosis. We describe 32 patients with juvenile dermatomyositis. All suffered from vasculitic skin changes like facial erythema often with edema, Gottron's sign, telangiectasias, erythematous eruptions, different rashes and necrotic ulcerations. Vasculitis appeared also in inner organs as gastrointestinal ulceration, neurologic and cardiac manifestation. 4 children complained of Raynaud's phenomenon. Calcinosis of soft tissues developed in 21 patients within 0.5 to 10 years after onset. In 6 of them we saw regression of calcium deposits after a progressive phase of 1 to 5 years. Functional outcome in juvenile dermatomyositis depends mainly on the degree of calcinosis together with shortening of diseased muscles.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"37 1-2","pages":"8-15"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperlipidemia, dyslipoproteinemia and apolipoproteinopathia--classification and risk of atheroslcerosis. Part I: Principles of classification and methods of dyslipoproteinemia determination. 高脂血症、脂蛋白异常血症和载脂蛋白病——动脉粥样硬化的分类和风险第一部分:异常脂蛋白血症的分类原则和检测方法。
Acta Universitatis Carolinae. Medica Pub Date : 1991-01-01
B Choluj, T Votruba, E Kormúth
{"title":"Hyperlipidemia, dyslipoproteinemia and apolipoproteinopathia--classification and risk of atheroslcerosis. Part I: Principles of classification and methods of dyslipoproteinemia determination.","authors":"B Choluj,&nbsp;T Votruba,&nbsp;E Kormúth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper sums up new findings in the field of pathogenetic relations between lipid and lipoprotein metabolical disorders on the one hand and the risk of early forms of atherosclerosis on the other hand. Detail classification of disorders proceeds from precise clinical and biochemical criteria, genetic considerations and therapeutical aspects. It provides definitions of hyperlipidemia, hyperlipoproteinemia, normolipidemic (latent) dyslipoproteinemia, secondary hyperlipidemia, apolipoproteinopathia and relatively harmless (benign) hyperlipidemia. The paper provides detail tables and systematic graphs.</p>","PeriodicalId":75422,"journal":{"name":"Acta Universitatis Carolinae. Medica","volume":"37 3-4","pages":"91-105"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13006395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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