Acta pathologica japonica最新文献_第8页

Adenoendocrine cell carcinoma of the gallbladder: a histochemical and immunohistochemical study. 胆囊腺内分泌细胞癌的组织化学和免疫组织化学研究。

Acta pathologica japonica Pub Date : 1993-05-01 DOI: 10.1111/j.1440-1827.1993.tb01143.x

T Ohmori, K Furuya, K Okada, R Tabei, S Tao

引用次数: 8

Morphometric analysis of gastric adenoma and well-differentiated adenocarcinoma as a basis for microscopic discrimination. 胃腺瘤和高分化腺癌的形态计量学分析作为显微鉴别的基础。

Acta pathologica japonica Pub Date : 1993-05-01 DOI: 10.1111/j.1440-1827.1993.tb01140.x

T Sano, Y Kondo, K Isono

{"title":"Morphometric analysis of gastric adenoma and well-differentiated adenocarcinoma as a basis for microscopic discrimination.","authors":"T Sano, Y Kondo, K Isono","doi":"10.1111/j.1440-1827.1993.tb01140.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb01140.x","url":null,"abstract":"Morphometric analyses were performed on 11 cases of well-differentiated gastric adenocarcinoma and six cases of gastric adenoma. The values for the mean nuclear area (AN), the index for roundness of the nucleus (FX), and the nucleus/cytoplasm ratio (N/C) were larger in the carcinoma group than in the adenoma group (P < 0.01; t-test). The value of nuclear numerical density (NA) was larger in the adenoma group than in the carcinoma group (P < 0.01; t-test). There was an overlap between the N/C ratio in the carcinoma and adenoma groups. It was concluded that roundness and enlargement of the nucleus, and a low nuclear density are important prerequisites for distinguishing the common type of adenocarcinomas from adenomas. An additional morphometric analysis was performed on seven cases of mucosal carcinoma. A three-dimensional discriminant analysis using AN, FX and NA revealed that of these seven cases, three were consistent with the carcinoma group while one case was consistent with the adenoma group. The remaining three cases were judged as borderline.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 5","pages":"253-9"},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb01140.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19310461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Lipofibromatous hamartoma of nerve in the foot. 足部神经脂肪纤维瘤错构瘤。

Acta pathologica japonica Pub Date : 1993-05-01 DOI: 10.1111/j.1440-1827.1993.tb01142.x

E Hirakawa, H Miki, S Kobayashi, M Ohmori, N Arima

引用次数: 28

Immunophenotypic and molecular analysis of a case of lymphocytic interstitial pneumonia. 1例淋巴细胞间质性肺炎的免疫表型和分子分析。

Acta pathologica japonica Pub Date : 1993-05-01 DOI: 10.1111/j.1440-1827.1993.tb01141.x

B Kawabuchi, S Tsuchiya, K Nakagawa, Y Sasajima, S Mori, R Machinami, E Tsuchiya

{"title":"Immunophenotypic and molecular analysis of a case of lymphocytic interstitial pneumonia.","authors":"B Kawabuchi, S Tsuchiya, K Nakagawa, Y Sasajima, S Mori, R Machinami, E Tsuchiya","doi":"10.1111/j.1440-1827.1993.tb01141.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb01141.x","url":null,"abstract":"A case of lymphocytic interstitial pneumonia was studied immunophenotypically and with molecular methods in order to clarify its lymphocytic clonality. The patient, a 43 year old Japanese female, underwent lobectomy for a suspected malignant lymphoma as no clear diagnosis could be made from the biopsy specimen. An ill-demarcated, yellowish and elastic firm lesion measuring 60 x 35 x 20 mm in size was located in the peripheral part of the middle lobe of the right lung. Histologically, the alveolar, peribronchial-vascular and subpleural interstitia within the lesion were thickened markedly with severe cellular infiltration largely composed of small lymphocytes with germinal centers. Immunostaining revealed immunoglobulin (Ig) kappa and Ig lambda-bearing cells to be evenly distributed, suggestive of polyspecificity. Immunoglobulin gene analysis further demonstrated the unrearranged germ-line DNA but no rearranged band. These results strongly indicated a reactive process rather than a neoplastic nature for the lesion.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 5","pages":"260-4"},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb01141.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19310462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Histological difference between complete responders and non-responders to interferon therapy of the livers of patients with chronic hepatitis C. 慢性丙型肝炎患者肝脏干扰素治疗完全应答者与无应答者的组织学差异

Acta pathologica japonica Pub Date : 1993-05-01 DOI: 10.1111/j.1440-1827.1993.tb01137.x

T Uchida, M Taira, T Shikata, M Moriyama, N Tanaka, H Okubo, Y Arakawa

{"title":"Histological difference between complete responders and non-responders to interferon therapy of the livers of patients with chronic hepatitis C.","authors":"T Uchida, M Taira, T Shikata, M Moriyama, N Tanaka, H Okubo, Y Arakawa","doi":"10.1111/j.1440-1827.1993.tb01137.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb01137.x","url":null,"abstract":"Liver histology was compared in patients with chronic hepatitis C to note the differences between responders and non-responders to interferon treatment. Fifty-eight patients were administered interferon in varying doses and over various periods, and were then followed up for 1 year. According to the improvement status of serum alanine aminotransferase (ALT) levels during this period, the patients were classified into complete responders who showed complete normalization of ALT; partial responders who exhibited a significant decrease, but not complete normalization of ALT; and non-responders who did not reveal any significant decrease of ALT. Before application of the interferon treatment, liver biopsies were analyzed in four parameters and given scores from 0 to 5 for three groups in cord with no prior knowledge of the efficacy. The parameters included necroinflammation, fibrosis/lobular distortion, portal lymphocytic reaction and portal (or fibrous septal) outline destruction. Results indicated that there were no significant differences in the score of necroinflammation and portal lymphocytic reaction between the complete responder group and the non-responder group. In contrast, the complete responder group exhibited weaker fibrosis/lobular distortion and less portal outline destruction than the non-responder group. The partial responder group was more akin to the former group in these parameters. Thus, it is safe to conclude that liver histology may predict the efficacy of interferon treatment.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 5","pages":"230-6"},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb01137.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18690072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Spontaneous amyloidosis in senile NSY mice. 老年NSY小鼠自发性淀粉样变的研究。

Acta pathologica japonica Pub Date : 1993-05-01 DOI: 10.1111/j.1440-1827.1993.tb01135.x

K Shimizu, H Morita, T Niwa, K Maeda, M Shibata, K Higuchi, T Takeda

{"title":"Spontaneous amyloidosis in senile NSY mice.","authors":"K Shimizu, H Morita, T Niwa, K Maeda, M Shibata, K Higuchi, T Takeda","doi":"10.1111/j.1440-1827.1993.tb01135.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb01135.x","url":null,"abstract":"Senile Nagoya, Shibata, Yasuda (NSY) mice developed amyloidosis and died from renal failure as a result of amyloidosis. NSY mice were first reported as experimental congenital diabetic mice by Shibata et al. in 1980. This study questioned whether NSY mice died from diabetic nephropathy. The authors of the present study investigated the life span and cause of death in these mice. The life span of NSY mice was found to be 618.7 +/- 72.5 days. NSY mice that lived for more than 400 days showed rising blood urea nitrogen and large amounts of amyloid deposits in the glomerulus of the kidneys. NSY mice died of renal amyloidosis. Immunological methods revealed that AApoAII was evident in the amyloid deposits of NSY mice. Apart from the kidneys, amyloid deposition was also found in the tongue, esophagus, stomach, small intestine, large intestine, rectum, lung, heart and adrenal glands. Amyloid deposits were found to a slight degree in the liver and the spleen. The most dominant amyloid deposition in NSY mice was seen in the glomerulus of the kidneys. From the point of view of amyloid depositional distribution, NSY mice were unique compared with other spontaneous amyloid mice.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 5","pages":"215-21"},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb01135.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19308361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Collagen synthesis of human arterial smooth muscle cells: effects of platelet-derived growth factor, transforming growth factor-beta 1 and interleukin-1. 人动脉平滑肌细胞的胶原合成:血小板源性生长因子、转化生长因子- β 1和白细胞介素-1的作用

Acta pathologica japonica Pub Date : 1993-04-01 DOI: 10.1111/j.1440-1827.1993.tb01127.x

Y Okada, S Katsuda, H Watanabe, I Nakanishi

{"title":"Collagen synthesis of human arterial smooth muscle cells: effects of platelet-derived growth factor, transforming growth factor-beta 1 and interleukin-1.","authors":"Y Okada, S Katsuda, H Watanabe, I Nakanishi","doi":"10.1111/j.1440-1827.1993.tb01127.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb01127.x","url":null,"abstract":"The effects of platelet‐derived growth factor (PDGF), transforming growth factor‐β1 (TGF‐β1) and interleukin‐1 (IL‐1) on collagen synthesis of cultured human arterial smooth muscle cells in a confluent state were investigated. Synthetic activity of collagenous protein was determined with [3H]‐proline uptake, and subsequent analysis of collagen types by sodium dodecylsulfte‐polyacrylmide gel electrophoresis (SDS‐PAGE) followed by fluorography. Although PDGF (0.5 U/mL and 5.0 U/mL) enhanced total collagen synthesis per dish, it suppressed total collagen synthesis per DNA (DNA content in a dish). TGF‐β1 (10 pmol/L and 100 pmol/L) enhanced total collagen synthesis both per dish and per DNA. IL‐1 (0.1 U/mL and 1.0 U/mL) suppressed total collagen synthesis both per dish and per DNA. A fluorogram revealed that human arterial smooth muscle cells synthesize types I, III, IV and V collagen. Densitometric analysis showed PDGF suppressed the proportion of type V collagen. TGF‐β1 increased the proportions of types IV and V collagen. IL‐1 elicited un‐remarkable change in the proportion of collagen types. These results suggest that, in the event of human atherosclerosis, TGS‐β1 is most effective in enhancing collagen synthesis, and PDGF modulates collagen metabolism by stimulating a cell division of smooth muscle cells with a resultant increase of collagenous protein, especially of type V collagen.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 4","pages":"160-7"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb01127.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19476393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Comparison of immunoreactivity between two different monoclonal antibodies recognizing peptide and polysialic acid chain epitopes on the neural cell adhesion molecule in normal tissues and lung tumors. 正常组织和肺肿瘤细胞粘附分子多肽和聚唾液酸链表位单克隆抗体免疫反应性比较

Acta pathologica japonica Pub Date : 1993-04-01 DOI: 10.1111/j.1440-1827.1993.tb01128.x

Y Tome, S Hirohashi, M Noguchi, Y Matsuno, Y Shimosato

{"title":"Comparison of immunoreactivity between two different monoclonal antibodies recognizing peptide and polysialic acid chain epitopes on the neural cell adhesion molecule in normal tissues and lung tumors.","authors":"Y Tome, S Hirohashi, M Noguchi, Y Matsuno, Y Shimosato","doi":"10.1111/j.1440-1827.1993.tb01128.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb01128.x","url":null,"abstract":"A comparative immunohistochemical study of two different monoclonal antibodies against different epitopes on the neural cell adhesion molecule (N-CAM) was performed. Various normal tissues and lung tumors were examined for reactivity with NCC-LU-243, a monoclonal antibody which recognizes a peptide epitope on N-CAM, and monoclonal antibody 735 (MoAb 735), which reacts with a polysialic acid chain epitope on N-CAM. When acetone-fixed normal tissues were used, the immunoreactivities of MoAb 735 and NCC-LU-243 were not identical. In lung tumors, almost all small cell cancers (SCLC) and carcinoid tumors, and some non-SCLC were stained by both monoclonal antibodies. NCC-LU-243 stained the cell membrane only of almost all SCLC cells and clusters of non-SCLC cells. MoAb 735 stained the cell membrane of SCLC in a patchy manner and not only the cell membrane but also the cytoplasm of some non-SCLC. However cytoplasmic staining was evaluated as 'not positive'. The number of positive cases and the size of the positive tumor cell population determined by cell membrane staining with MoAb 735 were smaller than those determined with NCC-LU-243 in both SCLC and non-SCLC cases. In routinely formalin-fixed materials, the immunoreactivity of both monoclonal antibodies, especially of NCC-LU-243, decreased after prolonged fixation as in surgically resected and autopsy materials. However, both monoclonal antibodies were found to be useful when materials were fixed for a short period of time as in biopsy specimens.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 4","pages":"168-75"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb01128.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18687464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Primitive neuroectodermal tumors of bone and soft tissue: histological subclassification and clinicopathologic correlations. 骨和软组织的原始神经外胚层肿瘤:组织学亚分类和临床病理相关性。

Acta pathologica japonica Pub Date : 1993-04-01 DOI: 10.1111/j.1440-1827.1993.tb01129.x

A Shishikura, S Ushigome, T Shimoda

{"title":"Primitive neuroectodermal tumors of bone and soft tissue: histological subclassification and clinicopathologic correlations.","authors":"A Shishikura, S Ushigome, T Shimoda","doi":"10.1111/j.1440-1827.1993.tb01129.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb01129.x","url":null,"abstract":"Recent reports of Ewing's sarcoma (EW) and extraskeletal Ewing's sarcoma (EEW) support the hypothesis that these tumors are neuroectodermal in origin. Primitive neuroectodermal tumors (PNET) of bone (32 cases) and soft tissue (25 cases) including those previously categorized as EW in 27 cases and EEW in 15 cases were carefully studied histologically, immunocytochemically and morphometrically, focusing on tumor cell differentiation. This study attempts to subclassify these tumors on the basis of the size of tumor cells and nuclei, their variations (uniformity or diversity), arrangement of tumor cells (rosette or non-rosette), focal differentiation to larger ganglion-like cells, and staining intensity for neural markers. All tumors were histologically subclassified as small, medium or large cell types, three basic subtypes (rosette type, abortive rosette type, non-rosette type) and four complementary subtypes (fibrillary type, non-fibrillary type, angiomatoid type, ganglion cell type). Classic EW or EEW is consistent with small or medium, non-rosette, non-fibrillary type tumors, previously described large cell EW with large, non-rosette, fibrillary or non-fibrillary type tumors, and classic neuroectodermal tumor with small or medium, rosette, fibrillary type tumors, according to the present subclassification. Clinicopathologic correlations with the different subtypes are discussed. Long-term survival, more than 5 years, was seen in patients with small cell type, and those younger than 14 years of age.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 4","pages":"176-86"},"PeriodicalIF":0.0,"publicationDate":"1993-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb01129.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19373439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Organ distribution of mutant mitochondrial tRNA(leu(UUR)) gene in a MELAS patient. MELAS患者线粒体tRNA(leu(UUR))基因突变的器官分布。

Acta pathologica japonica Pub Date : 1993-04-01 DOI: 10.1111/j.1440-1827.1993.tb01130.x

S Hamazaki, M Koshiba, T Sugiyama

引用次数: 20