Acta pathologica japonica最新文献_第7页

Re-evaluation of a case of progressive multifocal leukoencephalopathy previously diagnosed as simian virus 40 (SV40) etiology. 先前诊断为猿猴病毒40 (SV40)病因的进行性多灶性白质脑病1例的重新评估。

Acta pathologica japonica Pub Date : 1993-06-01 DOI: 10.1111/j.1440-1827.1993.tb02575.x

Y Eizuru, K Sakihama, Y Minamishima, T Hayashi, A Sumiyoshi

{"title":"Re-evaluation of a case of progressive multifocal leukoencephalopathy previously diagnosed as simian virus 40 (SV40) etiology.","authors":"Y Eizuru, K Sakihama, Y Minamishima, T Hayashi, A Sumiyoshi","doi":"10.1111/j.1440-1827.1993.tb02575.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb02575.x","url":null,"abstract":"A case of progressive multifocal leukoencephalopathy (PML) reported previously to be of simian virus (SV40) etiology was re-evaluated. The supernatant from a 10% homogenate of brain material was inoculated into African green monkey kidney cells and BSC-1 cells which are permissive for SV40. However no cytopathic effect (CPE) developed and no virus was isolated. The brain supernatant agglutinated human group O erythrocytes and contained 5120 units/mL. The Hirt supernatant from the brain contained three DNA bands corresponding to forms I, II and III of circular double-stranded viral DNA. Restriction endonuclease cleavage analysis revealed that this viral DNA was different from SV40 DNA, but similar to JC virus DNA. After cloning of this viral DNA into pBR322 at the BamHI site, DNA homology of this virus and of SV40 was investigated. Cloned DNA from the brain hybridized with all the HpaI/EcoRI fragments of the SV40 genome at the effective temperature of Tm -50 degrees C [corrected]. At Tm -28 degrees C, however, the cloned DNA hybridized with only HpaI/EcoRI fragment B of the SV40 genome. In contrast to this, JC virus DNA hybridized with all five EcoRI/BamHI/HindIII fragments of cloned DNA even at Tm -28 degrees C. Therefore, the causative agent of this PML case was not SV40 but JC virus.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 6","pages":"327-32"},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb02575.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19378811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Immunohistochemical and ultrastructural characterization of autoimmune sialoadenitis in aging BDF1 mice. 衰老BDF1小鼠自身免疫性涎腺炎的免疫组织化学和超微结构表征。

Acta pathologica japonica Pub Date : 1993-06-01 DOI: 10.1111/j.1440-1827.1993.tb02571.x

K Fujiwara, A Larsson, T Watanabe

引用次数: 1

Protein-losing enteropathy due to secondary amyloidosis of the gastrointestinal tract. 继发性胃肠道淀粉样变引起的蛋白质丢失性肠病。

Acta pathologica japonica Pub Date : 1993-06-01 DOI: 10.1111/j.1440-1827.1993.tb02576.x

M Kawaguchi, F Koizumi, M Shimao, S Hirose

{"title":"Protein-losing enteropathy due to secondary amyloidosis of the gastrointestinal tract.","authors":"M Kawaguchi, F Koizumi, M Shimao, S Hirose","doi":"10.1111/j.1440-1827.1993.tb02576.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb02576.x","url":null,"abstract":"A case of a 71 year old woman who experienced weight loss, diarrhea and edema due to protein-losing enteropathy caused by amyloidosis secondary to rheumatoid arthritis is described. Amyloid deposits were found in the systemic organs, specifically in the bowel. The arterioles were massively involved within the laminae propriae and many were narrowed considerably due to amyloid deposits. Ulcerative lesions, which were accompanied with the ruptured arterioles, were also found. Lymphangiectasia was present in the submucosa, subserosa and mesenterium. The mesenteric lymphatic vessels were deposited markedly with amyloid. The principal cause of the protein loss might be related to the increased capillary permeability to plasma proteins and the exudation through an inflamed mucosa. Functional disruption of the lymphatic flow in the bowel and mesenterium might also participate in the mechanisms of the protein loss. Evidence in this study supports the theory that lymphatic disorders in some patients with gastrointestinal amyloidosis are one of the important factors in the pathogenesis of protein-losing enteropathy.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 6","pages":"333-9"},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb02576.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19333018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Myxoma of the breast: report of a case with unique histological and immunohistochemical appearances. 乳腺黏液瘤:报告一例独特的组织学和免疫组织化学表现。

Acta pathologica japonica Pub Date : 1993-06-01 DOI: 10.1111/j.1440-1827.1993.tb02577.x

K Arihiro, K Inai, K Kurihara, S Takeda, N Khatun, K Kuroi, H Kawami, T Toge

引用次数: 9

Function of proteoglycans in the extracellular matrix. 蛋白聚糖在细胞外基质中的作用。

Acta pathologica japonica Pub Date : 1993-06-01 DOI: 10.1111/j.1440-1827.1993.tb02569.x

M Yanagishita

{"title":"Function of proteoglycans in the extracellular matrix.","authors":"M Yanagishita","doi":"10.1111/j.1440-1827.1993.tb02569.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb02569.x","url":null,"abstract":"Proteoglycans are glycosylated proteins which have covalently attached highly anionic glycosaminoglycans. Many forms of proteoglycans are present in virtually all extracellular matrices of connective tissues. The major biological function of proteoglycans derives from the physicochemical characteristics of the glycosaminoglycan component of the molecule, which provides hydration and swelling pressure to the tissue enabling it to withstand compressional forces. This function is best illustrated by the most abundant proteoglycan in cartilage tissues, aggrecan. During the past decade, diverse species of proteoglycans have been identified in many connective tissues, on cell surfaces and in intracellular compartments. These proteoglycans have distinct biological functions apart from their hydrodynamic functions, and their involvement in many aspects of cell and tissue activities has been demonstrated. For example, decorin, which is widely distributed in many connective tissues, may have functions in regulating collagen fibril formation and in modifying the activity of transforming growth factor-beta; perlecan, the major heparan sulfate proteoglycan in the glomerular basement membrane, may play an important role as the major anionic site responsible for the charge selectivity in glomerular filtration. Specific interactions between proteoglycans (through both their glycosaminoglycan and core protein components) and macromolecules in the extracellular matrix are the key factors in the functions of proteoglycans. Exciting biological functions of proteoglycans are now gradually emerging.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 6","pages":"283-93"},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb02569.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19333008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 251

Cell-cycle analysis detecting endogenous nuclear antigens: comparison with BrdU-in vivo labeling and an application to lung tumors. 细胞周期分析检测内源性核抗原:与brdu体内标记的比较及其在肺肿瘤中的应用。

Acta pathologica japonica Pub Date : 1993-06-01 DOI: 10.1111/j.1440-1827.1993.tb02573.x

Y Hayashi, M Fukayama, M Koike, S Kaseda, T Ikeda, T Yokoyama

{"title":"Cell-cycle analysis detecting endogenous nuclear antigens: comparison with BrdU-in vivo labeling and an application to lung tumors.","authors":"Y Hayashi, M Fukayama, M Koike, S Kaseda, T Ikeda, T Yokoyama","doi":"10.1111/j.1440-1827.1993.tb02573.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb02573.x","url":null,"abstract":"The versatility of non-radioactive cell-cycle analysis in detecting endogenous nuclear antigens of the proliferating cells was evaluated. Optimal conditions for immunostaining varied in fixation and pretreatment procedures among antigens, bromodeoxyuridine (BrdU), Ki-67 epitope, DNA polymerase alpha and PCNA. A significant correlation between BrdU labeling index (LI) was observed in each positive ratio (PR, positive/total neoplastic cells) for nuclear antigens in tumor-sections which had been labeled in vivo with BrdU. The best correlation was observed in Ki-67 PR (y = 1.26x + 2.5; y = Ki-67 PR; x = BrdU LI; r = 0.97). To determine its prognostic value, Ki-67 analysis was applied to the surgically resected lung tumors. Ki-67 PR were different according to the histologic types of the tumors: 47.8 +/- 3.4% in small cell carcinoma; 29.5 +/- 3.5% in squamous cell carcinoma; 28.3 +/- 4.7% in large cell carcinoma; 15.2 +/- 1.8% in adenocarcinoma and 0.1 +/- 0.1% in mature carcinoid tumor. When the mean value was used to divide each type to a higher or lower proliferative activity (15% Ki-67 PR for adenocarcinoma and 30% for squamous cell carcinoma), the group with the lower Ki-67 PR showed a significantly more favorable prognosis than that of a higher ratio. Ki-67 PR was not correlated with other pathologic factors such as size, lymph node metastasis or pleural involvement. Non-radioactive cell-cycle analysis was feasible and useful for detecting endogenous nuclear antigens even in the lung tumors, particularly when the analysis was coupled with histologic typing.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 6","pages":"313-9"},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb02573.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19333016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Intra-abdominal desmoplastic small cell tumor in an adolescent suggesting a neurogenic origin. 青少年腹腔内结缔组织增生小细胞瘤，提示神经源性起源。

Acta pathologica japonica Pub Date : 1993-05-01 DOI: 10.1111/j.1440-1827.1993.tb01144.x

T Asano, Y Fukuda, Y Fukunaga, M Yamamoto, M Yokoyama, N Yamanaka

{"title":"Intra-abdominal desmoplastic small cell tumor in an adolescent suggesting a neurogenic origin.","authors":"T Asano, Y Fukuda, Y Fukunaga, M Yamamoto, M Yokoyama, N Yamanaka","doi":"10.1111/j.1440-1827.1993.tb01144.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb01144.x","url":null,"abstract":"A case of a desmoplastic small cell tumor of the large omentum associated with gross ascites that occurred in a male adolescent is reported. Light microscopic studies revealed that the tumor cells were small and epithelioid in nature with eosinophilic hyaline material located in the perinuclear area. They were surrounded by rich desmoplastic and myxoidal stromal bands. Immunohistochemical staining revealed globoid perinuclear positivity for desmin. Vimentin, cytokeratin (AE3, CaM 5.2), epithelial membrane antigen, tissue polypeptide antigen, neuron-specific enolase, chromogranin A, endocrine granule constituent and synaptophysin were also positive in the cytoplasm. Electron microscopy revealed whorled intermediate filaments and some dense core granules in the cytoplasm. Bundles of microtubules in the cytoplasmic process and occasional cell junctions of zonulae adherentes in the tumor cells were also observed. DNA analysis of the tumor cells showed the three-fold amplification of the N-myc gene. Although desmoplastic small cell tumors showed a heterogeneous pattern with immunohistochemical studies, it is suggested that the tumor may originate from neurogenic cells.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 5","pages":"275-82"},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb01144.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19310464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

A human T cell line with an abnormal trisomy 2 karyotype established by coculture of peripheral lymphocytes with an HTLV-II-infected simian leukocyte cell line. 通过外周淋巴细胞与htlv - ii感染的猿猴白细胞系共培养，建立了具有异常2三体核型的人T细胞系。

Acta pathologica japonica Pub Date : 1993-05-01 DOI: 10.1111/j.1440-1827.1993.tb01138.x

N Ohara, K Hayashi, K Miyamoto, N Tomita, K Fujiwara, E Kondo, K Takahashi, Y Ohtsuki, T Akagi

{"title":"A human T cell line with an abnormal trisomy 2 karyotype established by coculture of peripheral lymphocytes with an HTLV-II-infected simian leukocyte cell line.","authors":"N Ohara, K Hayashi, K Miyamoto, N Tomita, K Fujiwara, E Kondo, K Takahashi, Y Ohtsuki, T Akagi","doi":"10.1111/j.1440-1827.1993.tb01138.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb01138.x","url":null,"abstract":"A new human T cell line with a chromosomal abnormality (47,XY,+2), designated AS-IIA, was established by coculturing peripheral blood leukocytes of a healthy adult male with a lethally irradiated human T lymphotropic virus type II (HTLV-II)-infected simian leukocyte cell line (Si-IIA). A polymerase chain reaction method showed that this interleukin-2 (IL-2)-dependent cell line possessed the HTLV-II provirus genome; the cells also reacted with HTLV-II-positive human sera, anti-HTLV-I/II p24, and anti-HTLV-II gp46 antibodies. AS-IIA cells expressed the suppressor/cytotoxic T cell markers CD3+, CD4-, CD8+, CD25+, and HLA-DR+, with later conversion to CD8-. These cells showed better proliferation than other human HTLV-II-infected cell lines with normal karyotypes, but were not transplantable into severe combined immunodeficiency mice. Virus production from AS-IIA was confirmed not only by electron microscopic examination, which revealed mature and immature type C virus particles, but also by the capacity of the line to immortalize human T cells. These results suggest that HTLV-II shows broad tropism for T cells including CD4+ or CD8+, and that not only Si-IIA, but also AS-IIA, are good sources of HTLV-II. The authors of the present study believe that AS-IIA may be a useful human T cell line for the investigation of HTLV-II in comparison with HTLV-I.","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 5","pages":"237-43"},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb01138.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19308363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Erythroblasts as an index of initial stage of 2,7-FAA, ENU and BNU-induced rat leukemia. 红细胞作为2,7- faa、ENU和bnu诱导的大鼠白血病初始阶段的指标。

Acta pathologica japonica Pub Date : 1993-05-01 DOI: 10.1111/j.1440-1827.1993.tb01136.x

S Takayama

引用次数: 1

Clinicopathologic, enzyme and histochemical studies of centrocytic (mantle cell) lymphoma: comparison with other types of low-grade B cell lymphoma based on the updated Kiel classification. 中心细胞(套细胞)淋巴瘤的临床病理、酶和组织化学研究:基于更新的Kiel分类与其他类型低级别B细胞淋巴瘤的比较

Acta pathologica japonica Pub Date : 1993-05-01 DOI: 10.1111/j.1440-1827.1993.tb01139.x

M Takeshita, Y Masuda, Y Sumiyoshi, K Ohshima, M Kikuchi, N Kimura, T Okamura, J Nishimura, M Kozuru

{"title":"Clinicopathologic, enzyme and histochemical studies of centrocytic (mantle cell) lymphoma: comparison with other types of low-grade B cell lymphoma based on the updated Kiel classification.","authors":"M Takeshita, Y Masuda, Y Sumiyoshi, K Ohshima, M Kikuchi, N Kimura, T Okamura, J Nishimura, M Kozuru","doi":"10.1111/j.1440-1827.1993.tb01139.x","DOIUrl":"https://doi.org/10.1111/j.1440-1827.1993.tb01139.x","url":null,"abstract":"Lymph nodes from 21 cases of malignant lymphoma of a centrocytic (mantle cell) type, (ML, cc (mc)) were examined. All the cases had monoclonal surface immunoglobulin (sig) M and/or D, but were negative for CD10 (CALLA), and CD11c (LeuM5). Lymphoma cells with CD25 (anti-Tac)+, CD5 (Leu1)+, and alkaline phosphatase (ALPase)- in eight cases showed bone marrow involvement (10-66% of the nucleated cells; mean 32 +/- 18%) but with no leukemic changes. These eight cases had a similar phenotype and were distributed by the lymphoma cells to the examined B-chronic lymphocytic leukemia. Seven cases showed an infiltration of CD25-, CD5+, and ALPase- lymphoma cells, in which only two cases showed focal bone marrow involvement. There was a close relationship between CD25 expression and bone marrow invasion by the lymphoma cells in ML, cc (mc). Three of the six CD25- and CD5- cases presented zonal proliferation of ALPase+ lymphoma cells with round nuclei and a high anti-proliferating cell nuclear antigen/cyclin (PCNA/c) rate in the mantle zone and paracortex, accompanied by a prominent interdigitating dendritic and histiocytic cell reaction. Examined CD25-, CD5- and ALPase+ lymphoma showed a neoplastic counterpart of so-called marginal zone lymphocytes, which was different from other cases of ML, cc (mc). Lymphoma cells in ML, cc (mc), except for those of the so-called marginal zone lymphoma, might be derived from slgM+, D+/-, CD25+/-, CD5+/-, ALPase-, CD10- and CD11c- lymphocytes present in the mantle zone and primary lymph follicles.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":75413,"journal":{"name":"Acta pathologica japonica","volume":"43 5","pages":"244-52"},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1440-1827.1993.tb01139.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19310460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10