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Acta pathologica et microbiologica Scandinavica. Section C, Immunology最新文献

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Precipitating antibodies in dermatophytosis demonstrated by crossed immunoelectrophoresis. 交叉免疫电泳证实了皮肤癣的沉淀抗体。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-02-01
E Svejgaard, A H Christiansen
{"title":"Precipitating antibodies in dermatophytosis demonstrated by crossed immunoelectrophoresis.","authors":"E Svejgaard,&nbsp;A H Christiansen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A total of 289 serum specimens from 262 patients with dermatophytosis were studied, using crossed immunoelectrophoresis with an intermediate gel. Rabbit antidermatophyte antisera were used as reference, and the antigens were water soluble extracts of Trichophyton (T) rubrum, T. mentagrophytes, Microsporum (M.) canis or Epidermophyton (E.) floccosum. Each serum was tested against the dermatophyte antigen corresponding to the infectious agent of the patient in question. Antidermatophyte antibodies could be demonstrated in 25 (9.5%) of the patients, and these were particularly frequent in patients with highly inflammatory lesions and those with chronic dermatophytosis caused by T. rubrum. Antibodies were detected in all four patients with kerion Celsi. Nine patients, five with acute dermatophytosis and four with chronic disease, who had precipitating antibodies at the initial examination were studied several times during the course of the disease. While the antibodies disappeared in all the patients with acute disease, they persisted in those with chronic dermatophytosis. The human antibodies showed marked cross reactivity with T. rubrum, T. mentagrophytes, M. canis and E. floccosum.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 1","pages":"23-7"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11639652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of the Fc part of IgG with Lancefield extracts of hemolytic streptococci. Strain specificity and activity. IgG Fc部分与溶血性链球菌兰斯菲尔德提取物的相互作用。菌株的特异性和活性。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-02-01
P Christensen, L A Burova, A Grubb, R Grubb, G Samuelsson, C Schalén, M L Svensson
{"title":"Interaction of the Fc part of IgG with Lancefield extracts of hemolytic streptococci. Strain specificity and activity.","authors":"P Christensen,&nbsp;L A Burova,&nbsp;A Grubb,&nbsp;R Grubb,&nbsp;G Samuelsson,&nbsp;C Schalén,&nbsp;M L Svensson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lancefield extracts of 19 types of group A streptococci as well as one group C and one group G strain were examined for agglutination of human red cells coated with various anti-Rh antibodies. Fourteen extracts agglutinated one or more of the coated cell samples, while five did not. The agglutination was inhibited by Fc but not by Fab fragments of human IgG. After mouse passages, three of the non-agglutinating strains acquired agglutinating capacity. At least three different reactivities were distinguished by the action of the extracts on IgG1 and IgG3 coated cells, respectively. Two of the streptococcal extracts, agglutinating the same anti-Rh coated cells, could be further differentiated in hemagglutination inhibition (HAI) experiments using purified IgG3 myeloma proteins. Five selected agglutinating systems were inhibited by purified myeloma proteins of the IgG1, IgG2, and IgG4 subclasses. IgG3 proteins inhibited only two of the five HAI systems.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 1","pages":"73-7"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11581744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guinea pigs inbred for studies of respiratory anaphylaxis. 为研究呼吸道过敏反应而近亲繁殖的豚鼠。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-02-01
L Lundberg
{"title":"Guinea pigs inbred for studies of respiratory anaphylaxis.","authors":"L Lundberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A selective inbreeding of approximately 24 generations of albino guinea pigs by brother x sister mating has resulted in two strains, registered IMM/S and IMM/R, with high and low responsiveness, respectively, to ovalbumin-induced respiratory anaphylaxis. The two guinea pig strains differed in their ability to be immunized by the inhalation of antigen and produce antibodies, as well as to develop respiratory anaphylaxis. A correlation between the strength of the anaphylactic reactions and the amount of hemagglutinating antibodies produced was observed. When immunization was carried out by an intradermal injection of ovalbumin (OA), even in small doses incorporated in FCA, guinea pigs from both strains produced hemagglutinating antibodies in nearly the same amount. These antibodies do not influence the ability of the animals to react with a high respectively low anaphylactic response on subsequent challenge by inhalation of OA, neither in the actively sensitized animals nor in passively sensitized animals. However, with repeated inhalations of OA, desensitization occurred in the intradermally immunized high-responders, while the passively immunized high-responders could be provoked several times without any signs of desensitization. No systematical differences between the two strains with regard to sensitivity to inhalations of histamine were demonstrated. The low responders were found to be less resistant to infections than high-responders.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 1","pages":"55-66"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11774257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precipitation of streptococcal peptidoglycan by human sera: influence of anti-immunoglobulins. 人血清沉淀链球菌肽聚糖:抗免疫球蛋白的影响。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-02-01
C Schalén, P Christensen
{"title":"Precipitation of streptococcal peptidoglycan by human sera: influence of anti-immunoglobulins.","authors":"C Schalén,&nbsp;P Christensen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antibodies to streptococcal peptidoglycan (PG) were detected by gel-precipitation in 38% of sera from blood donors and in 71% of sera with a Waaler-Rose test titre of greater than or equal to 1:64. Twenty-six rheumatoid arthritis sera revealed patterns of interference with complete or partial fusion between PG and aggregated human IgG while none of the sera precipitating both these preparations showed non-interference. The reactions were interpreted as denoting interference between the PG-antibody complexes and aggregated IgG. Conversion of some non-precipitating blood donor sera to PG precipitation was obtained by addition of isolated rheumatoid factor, in itself not precipitating PG, to the sera. Thus, the high frequency of PG precipitation among rheumatoid arthritis sera could--at least in part--be attributed to the participation of anti-IgG in the reaction.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 1","pages":"37-40"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11328087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The timing of the immune response in relation to virus growth determines the outcome of the LCM infection. 与病毒生长有关的免疫反应的时间决定了LCM感染的结果。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-02-01
A R Thomsen, M Volkert, O Marker
{"title":"The timing of the immune response in relation to virus growth determines the outcome of the LCM infection.","authors":"A R Thomsen,&nbsp;M Volkert,&nbsp;O Marker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In the present study earlier observations of a dual role of the immune response against lymphocytic choriomeningitis (LCM) virus were confirmed and extended. At different times after intracerebral (i.c.) inoculation of the virus, groups of immunosuppressed recipients were transplanted with primary effector cells or memory cells, and the mortality was recorded. The brains and blood of untransplanted immunosuppressed recipients were titrated at intervals after the i.c. challenge, and so were the brains of mice receiving peak primary effector cells at various times relative to the i.c. challenge. The results showed a definite correlation between the brain virus titre at the time of the immune attack and the clinical outcome of the LCM infection. Furthermore, the results indicated that the extent of the extraneural infection is not unimportant but may affect the outcome of the infection through competition for the effector cells. The possible implications of these findings are discussed.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 1","pages":"47-54"},"PeriodicalIF":0.0,"publicationDate":"1979-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11639521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of carcinoembryonic antigen (CEA): comparison of two different assays. 癌胚抗原(CEA)测定:两种不同测定方法的比较。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1978-12-01
H Orjasaeter
{"title":"Determination of carcinoembryonic antigen (CEA): comparison of two different assays.","authors":"H Orjasaeter","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A comparison was made of CEA determination by the CEA-RIAKIT and our slightly modified CEA-Roche assays. The normal levels (mean + 2 SD) found in 63 blood donors were 2.3 microgram/1 and 3.3 microgram/1, respectively. The inter-assay reproducibility was similar in the range below 15 microgram/1, with variations from 0.3 microgram/1 (1 SD, less than 5 microgram/1) to 1.4 microgram/1 (1 SD, 10--15 microgram/1). Both methods measured CEA concentrations down to 1 microgram/1. The ability of the two assays to discriminate between positive and negative values in patients with urogenital and gastrointestinal cancer was similar. The response to recurrences of colorectal carcinoma was also similar, and the CEA fluctuation was parallel after surgery. The CEA-Roche assay generally showed good correlation between measured and theoretical values at both low and high levels. Under our test conditions, the disparity between indirect and direct values was 14 microgram/1 +/- 8 (n = 4) in the range 18--32 microgram/1, and this must be taken into consideration in interpreting the CEA-Roche test. The CEA-RIAKIT measured too low values as compared to both the CEA-Roche and the theoretical values. The discrepancy increased with increasing CEA values, and the ability to distinguish between high CEA concentrations (greater than 15 microgram/1) was poor. The explanation seems to be that the anti-CEA sera used in this assay show a lower affinity for plasma CEA than for tumour-extracted CEA. Immunochemical differences between sample CEA and CEA used for calibration of the standard curves must be considered in evaluation of CEA assays.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"86C 6","pages":"265-75"},"PeriodicalIF":0.0,"publicationDate":"1978-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11928537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunochemistry of Salmonella O-antigens: characterization of the antibody response to Tyvelose 1 leads to 3 alpha mannose 1 leads to bovine serum albumin representative of Salmonella 0-antigen 9. 沙门氏菌o型抗原的免疫化学:鉴定对Tyvelose 1的抗体反应导致3 α -甘露糖1导致代表沙门氏菌0抗原9的牛血清白蛋白。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1978-10-01
H E Carlsson, A A Lindberg
{"title":"Immunochemistry of Salmonella O-antigens: characterization of the antibody response to Tyvelose 1 leads to 3 alpha mannose 1 leads to bovine serum albumin representative of Salmonella 0-antigen 9.","authors":"H E Carlsson,&nbsp;A A Lindberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunization of rabbits with the synthetic disaccharide-protein conjugate, tyvelose 1 leads to alpha 3 mannose 1 leads to bovine serum albumin (TM-BSA) in Freund's complete adjuvant, gave rise to antibodies directed against both the disaccharide hapten and the carrier protein. The hapten antibodies were specific for O-antigen 9 of Salmonella and were superior in terms of specificity to conventional O factor 9 antibodies, as judged by passive haemagglutination and enzyme-linked immunosorbent assay (ELISA). A complement dependent bactericidal assay demonstrated that the TM-BSA antibodies had bacteriolytic activity also directed against the O-antigen 9 Salmonella. The high specificity was evident in both the IgG and IgM antibody classes. In the bactericidal assay the IgM antibodies were more active than antibodies of the IgG class. The results suggested that IgG antibodies in hyperimmune serum blocked the complement dependent bactericidal activity of IgM antibodies.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"86C 5","pages":"237-44"},"PeriodicalIF":0.0,"publicationDate":"1978-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11570917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immuno-suppressive effect of human macrophages. II. Influence of macrophages on the kinetics of DNA, RNA and protein synthesis in PHA-stimulated lymphocytes. 人巨噬细胞的免疫抑制作用。2巨噬细胞对pha刺激淋巴细胞DNA、RNA和蛋白质合成动力学的影响。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1978-08-01
G Unsgaard
{"title":"Immuno-suppressive effect of human macrophages. II. Influence of macrophages on the kinetics of DNA, RNA and protein synthesis in PHA-stimulated lymphocytes.","authors":"G Unsgaard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human macrophages obtained by culturing blood monocytes in vitro for 8 days release a soluble factor(s) inhibiting DNA synthesis and cell proliferation in PHA-stimulated lymphocytes. Synthesis of RNA and protein was strongly inhibited in PHA-stimulated lymphocytes sedimented on macrophages, as well as in lymphocytes separeted from the macrophages by a membrane, thus demomatrating that inhibition of RNA and protein synthesis was also mediated by a soluble factor(s). The kinetics of the factor-mediated inhibition showed that RNA synthesis was readily inhibited, whereas there was a delay in the inhibition of protein synthesis, thus indicating that the inhibition of protein synthesis and cell proliferation is a result of a blocking effect on the nucleic acid synthesis. The kinetics of DNA and protein synthesis in lymphocytes relieved from macrophage-mediated inhibition indicate a cytostatic effect.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"86C 4","pages":"187-92"},"PeriodicalIF":0.0,"publicationDate":"1978-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11897475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immuno-suppressive effect of human macrophages. I. Evidence for an unstable soluble factor(s) inhibiting DNA synthesis and proliferation in PHA-stimulated lymphocytes. 人巨噬细胞的免疫抑制作用。一种不稳定可溶性因子抑制pha刺激淋巴细胞DNA合成和增殖的证据。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1978-08-01
G Unsgaard
{"title":"Immuno-suppressive effect of human macrophages. I. Evidence for an unstable soluble factor(s) inhibiting DNA synthesis and proliferation in PHA-stimulated lymphocytes.","authors":"G Unsgaard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Macrophages obtained by culturing blood monocytes in vitro for 8 days showed capacity to inhibit DNA synthesis and cell proliferation in PHA-stimulated lymphocytes separated from the macrophages by a membrane with pore size 0.2 micron. The DNA synthesis was measured as 3H thymidine incorporation and the proliferation as cell counts. The depression was reduced when the distance between macrophages and lymphocytes was increased concomitant with increased culture volume. Heat-killing of macrophages abolished their lymphocyte depressing capacity. Full inhibitory effect was established within 4 hours when lymphocytes were cultured in the proximity of macrophages. The effect was blocked by molecular filtration membranes with nominal molecular weight limits (nmwl) 1,000 and 10,000 whereas membranes with nmwl 25,000 only partially blocked the effect. No inhibitory effect was registered in the supernatants from macrophage-depressed lymphocyte cultures. Presumably the lymphocyte depressing effect is mediated via an unstable soluble factor(s).</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"86C 4","pages":"179-86"},"PeriodicalIF":0.0,"publicationDate":"1978-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11897474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Freezing of rat lymphocytes. V. The effect of suppressor cells in phytohaemagglutinin-stimulated spleen cell cultures before and after freeze-thawing. 大鼠淋巴细胞冷冻。五、植物血凝素刺激脾细胞冻融前后抑制细胞的作用。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1978-08-01
E Hem
{"title":"Freezing of rat lymphocytes. V. The effect of suppressor cells in phytohaemagglutinin-stimulated spleen cell cultures before and after freeze-thawing.","authors":"E Hem","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Spleen lymphocyte proliferation, as measured by 3H-thymidine incorporation induced by phytohaemagglutinin (PHA), was increased after freeze-thawing with 10% dimethyl sulphoxide. Depletion or intoxication of macrophages in fresh spleen cell preparations also increased lymphocyte proliferation in response to PHA. On the other hand, freezing of macrophage-depleted spleen cell suspensions lowered 3H-thymidine uptake of stimulated cultures. At concntrations above 3%, macrophages added to cultures of fresh purified lymphocytes showed a dose-dependent inhibitory effect on the PHA response, and fresh macrophages were more inhibitory than frozen-thawed macrophages. Purified lymphocytes mixed with 10% macrophages showed a higher response after freeze-thawing. It is concluded that macrophages suppress the lymphoproliferative response to PHA in rat spleen cell cultures, and that these macrophages are more sensitive than lymphocytes to the present freeze-thaw process.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"86C 4","pages":"153-8"},"PeriodicalIF":0.0,"publicationDate":"1978-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11522311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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