Acta pathologica et microbiologica Scandinavica. Section C, Immunology最新文献_第7页

IgA and IgG antibodies against surface antigens of Pseudomonas aeruginosa in sputum and serum from patients with cystic fibrosis. 囊性纤维化患者痰液及血清中抗铜绿假单胞菌表面抗原的IgA和IgG抗体。

Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-06-01

P O Schiøtz, N Høiby, H Permin, A Wiik

引用次数: 0

Complement activation by pneumococci associated with acute otitis media. 与急性中耳炎相关的肺炎球菌补体激活。

Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-06-01

K Prellner

引用次数: 0

Effect of pregnancy zone protein on leucocyte migration inhibition, lymphoycte transformation and rosette formation by lymphocytes. 妊娠带蛋白对白细胞迁移抑制、淋巴细胞转化和淋巴细胞花环形成的影响。

Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-06-01

S A Birkeland, B Teisner, W Schilling, E Kemp, G T Pedersen, S E Svehag

引用次数: 0

Human macrophage differentiation in vivo and in vitro. A comparison of human peritoneal macrophages and monocytes. 人巨噬细胞在体内和体外的分化。人腹膜巨噬细胞和单核细胞的比较。

Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-04-01

J Hammerstrøm

{"title":"Human macrophage differentiation in vivo and in vitro. A comparison of human peritoneal macrophages and monocytes.","authors":"J Hammerstrøm","doi":"","DOIUrl":"","url":null,"abstract":"Human mononuclear phagocytes isolated from venous blood or sterile peritoneal exudate were cultured in an in vitro system known to induce differentiation of monocytes to macrophages. Morphological and functional studies were performed at different stages of in vitro differentiation, in order to compare the two macrophage populations. Freshly-isolated human peritoneal macrophages (PEC), which are presumed to represent monocytes which have differentiated in vivo in the peritoneal exudate for 1--2 days, showed several signs of increased effector cell function, as compared to the relatively immature blood monocytes. Cell adherence after phagocytosis, ability to degrade ingested 125I-labelled Candida albicans, and ability to suppress DNA-synthesis in a target cell line of human origin, were all found to be greater in the peritoneal cells in early culture. During in vitro differentiation in this system, both PEC and monocytes developed remarkable morphological and functional changes. Cell size and granule content increased considerably. Cell function, measured as phagocytic, digestive and cytostatic ability, increased for both macrophage populations. The differences between the two cell populations in early culture suggest that the functional and morphological changes induced by in vivo differentiation in peritoneal exudate involve changes of the same kind as those induced by in vitro differentiation in our system. The lodging of mononuclear phagocytes in sterile peritoneal exudate does not seem to impair the capacity for further differentiation to any great extent.","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 2","pages":"113-20"},"PeriodicalIF":0.0,"publicationDate":"1979-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11583837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytotoxicity to tumour cells induced in human monocytes cultured in vitro in the presence of different sera. 不同血清存在下体外培养的人单核细胞对肿瘤细胞的细胞毒性。

Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-04-01

G Unsgaard

{"title":"Cytotoxicity to tumour cells induced in human monocytes cultured in vitro in the presence of different sera.","authors":"G Unsgaard","doi":"","DOIUrl":"","url":null,"abstract":"Rodent macrophages can be stimulated in vivo and in vitro to become cytotoxic to neoplastic cells. It is shown in the present paper that cytotoxicity to a human tumour cell line is induced in human monocytes cultured in vitro in the presence of human serum. The cytotoxic ability is defined as including cytostatic ability, measured as inhibition of 3H-thymidine (3H-TdR) incorporation in tumour cells, and cytocidal ability, measured as release of radioactivity from 3H-TdR-labelled tumour cells. Monocytes cultured in medium containing 25 per cent human serum (HS-M) developed both a cytostatic and a cytocidal ability. When tumour cells were separated from these monocytes by a membrane, allowing factor-mediated interactions, a cytostatic effect was found, thus indicating that secretion of soluble factor(s) may be an important mechanism. The development of cytotoxic ability in the monocytes was accompanied by development of high capacity for phagocytosis of 125I-labelled Candida albicans, increased protein synthesis in the monocytes and microscopically observed alteration into large, well-spread monocytes with accumulation of phase-dense granules in the perinuclear region. Culture of monocytes in the presence of bovine sera induced less cytotoxic and phagocytic ability, as well as a smaller increase in protein synthesis and less morphological alterations, as compared to culture in HS-M.","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 2","pages":"141-9"},"PeriodicalIF":0.0,"publicationDate":"1979-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11646921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uptake of non-opsonized E. coli by unstimulated mouse peritoneal macrophages. 未受刺激的小鼠腹腔巨噬细胞对非调理大肠杆菌的摄取。

Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-04-01

H Rollag

引用次数: 0

In vitro effect of R 17934, a new drug with antitubulin activity, on neutrophil granulocyte locomotion and orientation. 抗微管蛋白新药r17934对中性粒细胞运动和定向的体外影响。

Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-04-01

N H Valerius

{"title":"In vitro effect of R 17934, a new drug with antitubulin activity, on neutrophil granulocyte locomotion and orientation.","authors":"N H Valerius","doi":"","DOIUrl":"","url":null,"abstract":"R 17934 is a new synthetic antimicrotubule drug, which binds to tubulin at the same site as does colchicine. The interaction of this drug with human neutrophil granulocyte locomotion and orientation was examined, using a modified reversible Boyden chamber and a gradient chamber offering a direct visual assay of cell orientation. R 17934 at concentrations as low as 5 x 10(-6) M was found to inhibit chemokinesis to an equal degree in gradient chambers, and in Boyden chambers using checkerboard experiments, in which the absolute concentrations and the concentration gradients of the chemotactic agent were varied. At higher concentrations (10(-5) M) R 17934 also inhibited chemotaxis in Boyden chambers. Much lower concentrations of R 17934 (10(-7) M) were found to affect the ability of neutrophils to orient in gradient chambers. This finding may show that filters form a more suitable substrate for oriented pseudopod formation of microtubule-deficient cells than do glass or plastic slides. In conclusion this study has provided evidence that in the absence of functioning microtubules neutrophils can still orient and migrate directionally towards the source of a concentration gradient, but that they do so less precisely. The finding that R 17934 inhibited chemokinesis suggests that this drug may interfere with the mechanism translating a recognition signal into locomotion. The previous finding that colchicine also had this effect supports the hypothesis that this process may be microtubule-dependent.","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 2","pages":"83-9"},"PeriodicalIF":0.0,"publicationDate":"1979-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11646922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphocyte blast transformation response of seropositive and seronegative subjects to herpes simplex, rubella, mumps and measles virus antigens. 血清阳性和血清阴性受试者对单纯疱疹、风疹、腮腺炎和麻疹病毒抗原的淋巴细胞转化反应。

Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-04-01

J Ilonen

引用次数: 0

Purification and characterization of rabbit anti-mouse renin specific Fab fragments. 兔抗小鼠肾素特异性Fab片段的纯化与鉴定。

Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-04-01

S Lykkegård

引用次数: 0

Cytological events in allo-stimulated lymphocytes triggered by exposure to stimulatory alloantigens. I. Changes in cell size, the mitochondrial areal density, and numerical density of the endoplasmic reticulum and the Golgi apparatus. 暴露于刺激性同种异体抗原引发的同种异体刺激淋巴细胞的细胞学事件。1 .细胞大小、线粒体面密度、内质网和高尔基体数值密度的变化。

Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-04-01

P B Poulsen

引用次数: 0