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Acta pathologica et microbiologica Scandinavica. Section C, Immunology最新文献

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Mitogenic stimulation of human lymphocyte subpopulations by Lathyrus odoratus lectin. 香菖蒲凝集素对人淋巴细胞亚群有丝分裂的刺激作用。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-08-01
J Kolberg, T E Michaelsen
{"title":"Mitogenic stimulation of human lymphocyte subpopulations by Lathyrus odoratus lectin.","authors":"J Kolberg,&nbsp;T E Michaelsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Investigation was made of the mitogenic activation by Lathyrus odoratus (LATH) lectin and phytohaemagglutinin (PHA) of human T-enriched and non-T lympohcytes isolated by nylon wool filtration and sheep erythrocyte rosette depletion, respectively. LATH stimulated only weakly the T-enriched and non-T fractions as compared to PHA which strongly stimulated the T-enriched population and weakly stimulated the non-T cells. Removal of phagocytic cells from the unfractionated lymphocytes caused only a slight reduction in the response to LATH. The responses of mixtures of T-enriched and non-T lymphocytes were similar to that of unfractionated lymphocytes. The LATH lectin seems, therefore, to be neither a pure T nor a pure non-T cell mitogen, since both populations must be present for optimal response. When alpha-methyl-D-mannoside was added to unfractionated lymphocytes together with LATH, there was a strong inhibition of thymidine incorporation. D-glucose and N-acetyl-D-glucosamine diminished the stimulation effect to a lesser degree.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 4","pages":"275-9"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11528206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do bursa-derived T cells exist? 法氏囊衍生的T细胞存在吗?
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-08-01
O Lassila
{"title":"Do bursa-derived T cells exist?","authors":"O Lassila","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In order to study the bursal origin of T cells, 18-d chromosomally-marked bursa cells were transplanted into 18-d chick embryos treated with cyclophosphamide (CY). Transfer of bursa cells restored not only the humoral immune functions but also the mitogenic responses of peripheral blood lymphocytes against phytohaemagglutinin and concanavalin A (Con A). Transplanted bursa cells proliferated primarily in the recipients' bursa. Only 8 out of 209 Con A responsive spleen cells were of donor origin, but no donor-derived cells were observed in the thymus. These findings suggest that cells in the 18-d embryonic bursa are already committed to the B cell lineage, and are not capable of migrating into thymus and of developing into mature T cells.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 4","pages":"287-92"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11528207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electron microscopy of treponemes subjected to the Treponema pallidum immobilization (TPI) test. II. Immunoelectron microscopy. 梅毒螺旋体固定(TPI)试验的螺旋体电子显微镜。2Immunoelectron显微镜。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-08-01
K Hovind-Hougen, A Birch-Andersen, H A Nielsen
{"title":"Electron microscopy of treponemes subjected to the Treponema pallidum immobilization (TPI) test. II. Immunoelectron microscopy.","authors":"K Hovind-Hougen,&nbsp;A Birch-Andersen,&nbsp;H A Nielsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The experiments were carried out in order to investigate whether human IgG globulin is absorbed on to the surface of T. pallidum cells during incubation with human syphilis serum in the Treponema pallidum immobilization (TPI) test. Cells of T. pallidum Nichols subjected to the TPI test were further incubated with ferritin conjugated rabbit antihuman IgG globulin. Human IgG globulin could only be demonstrated on immunoimmobilized cells, i.e. cells incubated with human syphilis serum and unheated guinea pig serum (GPS). The surface of the swollen cells was completely covered by a fuzzy layer on to which the ferritin molecules appeared to be attached. In ultrathin sections of cells obtained from the same suspensions the surface of the outer cell membrane was outlined by ferritin molecules. In these cells a rather wide gap was observed between the outer membrane and the cytoplasmic membrane. The ribosomes seemed to have disappeared from the cytoplasm of the immunoimmobilized treponemes, but were present in motile cells obtained from control incubations.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 4","pages":"263-8"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11595095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of heat eluates of human malignant tissues. 人恶性组织热洗脱液的表征。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-08-01
F Wesenberg
{"title":"Characterization of heat eluates of human malignant tissues.","authors":"F Wesenberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Eluates of 13 malignant and 17 normal tissues were prepared at 56 degrees C using the continuous flow technique. Albumin was detected in all the eluates. IgG, IgA, C3 or haptoglobin were detected in most of the malignant and some of the normal tissues. Carcinoembryonic antigen, beta 2-microglobulin, alpha 1-antitrypsin or alpha 1-antichymotrypsin were detected in some of the eluates of the malignant tissues only. IgM, IgD, C1q, C4, Cl-INH, alpha 1-macroglobulin, beta 2-lipoprotein, fibrinogen and alpha 1-foetoprotein were not detected in any of the eluates. The ratio of the concentration of albumin to the concentration of IgG was similar in extracts and eluates of all the normal tissue and in 3 of the malignant tissues indicating non-specific binding of IgG.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 4","pages":"301-6"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11595097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formation of germinal centres during neonatal tolerance in the chicken. 鸡新生期萌发中心的形成。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-08-01
O Vainio, M K Viljanen
{"title":"Formation of germinal centres during neonatal tolerance in the chicken.","authors":"O Vainio,&nbsp;M K Viljanen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chickens were made tolerant to BSA at the time of hatching. During the tolerance, antigenic stimulation with BSA resulted in poor germinal centre formation as compared to normal immunized control birds. The tolerance persisted for at least 6 weeks. Its breakdown had hardly started at the age of 12 weeks, both IgM and IgG antibody responses against BSA remaining negligible. Stimulation with the unrelated antigens SRBC and Brucella abortus resulted in good antibody responses, but the number of germinal centres was smaller in the tolerant birds than in normal controls.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 4","pages":"313-7"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11700003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic control of the spontaneous hypertension in the NZB/Cr strain of mice. Immunogenetic considerations. 小鼠NZB/Cr株自发性高血压的遗传控制。免疫遗传的因素。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-08-01
U G Svendsen, C M Koch, B Rubin
{"title":"Genetic control of the spontaneous hypertension in the NZB/Cr strain of mice. Immunogenetic considerations.","authors":"U G Svendsen,&nbsp;C M Koch,&nbsp;B Rubin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>NZB/Cr mice spontaneously develop a high blood pressure. This hypertension is developed during the first two months of age. F1-hybrids between NZB/Cr and C57/B1/6J (a normotensive mouse strain which does not spontaneously develop hypertension) also develop a high blood pressure, showing that the phenomenon is inherited as a dominant trait. The gene(s) responsive for the phenotypic high blood pressure is localised outside the MHC of the mouse (the H-2 complex). However, H-2 typing of backcrosses and F2-hybrids gave a weak evidence that genes located in or closely linked to the H-2 complex do influence the spontaneously developed high blood pressure in the NZB/Cr strain of mice. It is emphasized that further studies in larger populations of mice is necessary to establish the importance of linkage of genes to the H-2 comlex for the spontaneous hypertension in the NZB/Cr strain of mice.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 4","pages":"269-73"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11700002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct effects of Corynebacterium parvum and BCG on human monocyte-mediated tumour cell cytostasis in vitro. 小棒状杆菌和卡介苗对体外单核细胞介导的肿瘤细胞抑制的直接影响。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-08-01
J Hammerstrøm
{"title":"Direct effects of Corynebacterium parvum and BCG on human monocyte-mediated tumour cell cytostasis in vitro.","authors":"J Hammerstrøm","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Four strains of Corynebacterium parvum (Cp) and BCG induced low levels of cytostatic ability to a human tumour cell line in human monocytes when added directly to conventional monocyte cultures. The cytostatic ability induced by mediators from autologous lymphocytes stimulated with the same agents was greater than that produced by direct addition to monocytes. BCG was more efficient in stimulating lymphocyte DNA-synthesis and lymphokine release than any of the Cp strains tested. In order to test the influence of contaminating adherent lymphocytes on the direct induction of cytostasis, monocyte cultures of greater than 99.9% purity were prepared by adherence purification. Cp induced low levels of cytostatic ability in such highly purified monocytes when added directly to the monocytes. Addition of BCG and Candida albicans had an adverse effect on the cytostatic ability of purified monocytes. A morphological study of Cp interaction with purified monocytes was performed. Cp, but not BCG, would seem to be able to induce low levels of cytostatic ability in human monocytes without lympohcyte cooperation. Human monocyte activation by the more effective lymphokine pathway is more efficiently triggered in vitro by BCG than by Cp.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 4","pages":"293-300"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11595096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytological events in allo-stimulated lymphocytes triggered by exposure to stimulatory alloantigens. III. Changes in the areal density of cytoplasmic vacuoles containing endocytized Thorotrast. 暴露于刺激性同种异体抗原引发的同种异体刺激淋巴细胞的细胞学事件。3含有内吞化胸透的细胞质空泡面密度的变化。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-08-01
P B Poulsen, L H Nielsen
{"title":"Cytological events in allo-stimulated lymphocytes triggered by exposure to stimulatory alloantigens. III. Changes in the areal density of cytoplasmic vacuoles containing endocytized Thorotrast.","authors":"P B Poulsen,&nbsp;L H Nielsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>H-2b lymphocytes were sensitized against H-2d alloantigens by a lymphocyte culture reaction (MLR) and incubated with H-2d mastocytoma cells. Thirty minutes before incubation with the mastocytoma cells Thorotrast was added to the lymphocyte culture medium. The interaction between lymphoid cells and mastocytoma cells was stopped by fixation with glutaraldehyde. The areal densities of the cytoplasmic vacuoles were examined by electron microscopy. Two populations of lymphocytes were observed, small lymphocytes with heterochromatic nuclei and larger lymphocytes (lymphoblasts) with euchromatic nuclei. Only the lymphoblasts showed changes following interaction with target cells. The areal density of Thorotrast containing vacuoles in sensitized lymphoblasts increased during the three hour observation period, but the percentage of vacuoles containing Thorotrast in the total area of cytoplasmic vacuoles decreased in the first thirty minutes of interaction with target cells. This observation may indicate greater formation of vacuoles from the Golgi apparatus compared with the formation of vacuoles from the cytoplasmic membrane at the onset of interaction with target cells. In the multivesicular bodies (MVB) the Thorotrast was first observed inside the small vesicles and later on it was also observed in the matrix of the MVB. After three hours of interaction Thorotrast was observed laying \"free\" in the matrix of phagosomes along with myelin figures.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 4","pages":"281-6"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11378126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sendai virus haemolysis: mechanism of the increased haemolysis obtained by pretreatment of the virus with antibody and complement. 仙台病毒溶血:用抗体和补体预处理病毒后溶血增强的机制。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-06-01
P Fadnes, G Haukenes
{"title":"Sendai virus haemolysis: mechanism of the increased haemolysis obtained by pretreatment of the virus with antibody and complement.","authors":"P Fadnes,&nbsp;G Haukenes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sendai virus is haemolytic against erythrocytes from various species. Pretreatment of the virus with antibody and complement (C) resulted in a sixfold increase in the haemolysis. The viral haemolysin (HL) could be inactivated by heating the virus at 37 degrees C for 5 h. HL-inactivated virus became haemolytic again when pre-treated with antibody and C. This acquired haemolytic capacity corresponded to the enhanced haemolysis shown by intact virus. It is concluded that the enhanced haemolytic activity is due to a C-mediated indirect haemolysis and is not dependent on the fusion process. The possibility of cell damage in vivo from virus-antibody-C complexes is discussed.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 3","pages":"223-7"},"PeriodicalIF":0.0,"publicationDate":"1979-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11440155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytostatic effect on tumour cells induced in human monocytes by mediators from BCG-stimulated lymphocytes and MLC. bcg刺激淋巴细胞和MLC介质对人单核细胞诱导肿瘤细胞的细胞抑制作用。
Acta pathologica et microbiologica Scandinavica. Section C, Immunology Pub Date : 1979-06-01
G Unsgaard, J Hammerström, J Lamvik
{"title":"Cytostatic effect on tumour cells induced in human monocytes by mediators from BCG-stimulated lymphocytes and MLC.","authors":"G Unsgaard,&nbsp;J Hammerström,&nbsp;J Lamvik","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human monocytes activated by mediators (lymphokines) from BCG-stimulated, sensitized lymphocytes (from BCG-vaccinated donors) were cytostatic to a human cell line. Mediators from allogeneic lymphocytes activated the cytostatic ability of monocytes to the same degree as mediators from autologous lymphocytes. Mediators from BCG-stimulated lymphocytes from tuberculin-negative donors not vaccinated with BCG, activated the monocytes only to a small extent. Culture of lymphocytes in a membrane chamber (MC) proximate to monocytes, or incubation of monocytes with filtered supernatants of lymphocyte cultures, were equally effective procedures for inducing cytostatic ability in monocytes. Supernatants of sensitized lymphocytes cultured on BCG for four hours did not activate the monocytes, while supernatants collected after 24 hours activated the cytostatic ability to the same extent as 72-hour supernatants. Supernatants of mixed lymphocyte cultures (MLC) collected after 24 hours did not activate the monocyte cytostatic ability at all. Forty-eight and 72-hour supernatants of MLC showed a small but increasing activity. There was no significant difference between BCG-stimulated lymphocytes and MLC in their maximum DNA synthesis or in the kinetics of their DNA synthesis. Thus, the DNA synthesis and secretion of lymphocyte mediators may be independent phenomena resulting from the same stimulus.</p>","PeriodicalId":75411,"journal":{"name":"Acta pathologica et microbiologica Scandinavica. Section C, Immunology","volume":"87C 3","pages":"159-66"},"PeriodicalIF":0.0,"publicationDate":"1979-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11376384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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