M Bhargava, R Kumar, P U Iyer, S Ramji, V Kapani, S K Bhargava
{"title":"Effect of maternal anaemia and iron depletion on foetal iron stores, birthweight and gestation.","authors":"M Bhargava, R Kumar, P U Iyer, S Ramji, V Kapani, S K Bhargava","doi":"10.1111/j.1651-2227.1989.tb11080.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb11080.x","url":null,"abstract":"India is considered to have the highest prevalence of nutritional anaemia in women. Between 6040% of pregnant women have been found to be anaemic, mainly due to iron deficiency (1). There are also reports on the development of iron deficiency anaemia in Indian infants already at 6 months of age (2). In view of this, it was considered pertinent to study the effect not only of anaemia but also of iron depletion in the mother on fetal iron stores. The influence of these factors on birth weight and gestation was also determined.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"78 2","pages":"321-2"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb11080.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14065606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N P Huttunen, M Knip, M L Käär, R Puukka, H K Akerblom
{"title":"Clinical significance of urinary C-peptide excretion in children with insulin-dependent diabetes mellitus.","authors":"N P Huttunen, M Knip, M L Käär, R Puukka, H K Akerblom","doi":"10.1111/j.1651-2227.1989.tb11069.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb11069.x","url":null,"abstract":"<p><p>In order to evaluate the accuracy of urinary C-peptide determination and the clinical significance of C-peptiduria for the early course of insulin-dependent diabetes (IDDM), the rate of urinary excretion of C-peptide was determined in 32 children and adolescents with IDDM and correlated with serum C-peptide concentration, urinary excretion of albumin and beta 2-microgloublin and with the glomerular filtration rate (GFR) measured in terms of the clearance of 99mTc-DTPA. The age of the subjects ranged from 9.1 to 17.1 years (mean 13.1) and the duration of diabetes from 0.3 to 11.9 years (mean 4.6). There was a good correlation between postprandial serum C-peptide concentration and the 24-hour urinary C-peptide excretion rate (r = 0.81; p less than 0.001). GFR and urinary albumin excretion were slightly elevated in the diabetic patients as compared with non-diabetic subjects (p less than 0.05 and p less than 0.001, respectively), but C-peptide excretion was unrelated to the degree of hyperfiltration or albuminuria, neither was there any correlation between the excretion rate of beta 2-microglobulin and C-peptide. Glycaemic control was poorer in the diabetic children who had only trace amounts of C-peptide in their urine (less than 0.05 nmol/m2/24 h) than in those with minimal (0.05-1.0 nmol/m2) or moderate 24-hour urinary C-peptide excretion (greater than 1.0 nmol/m2). It is concluded that urinary C-peptide excretion serves very well to reflect residual beta-cell function and is unrelated to the slight renal hyperfunction and albuminuria often seen in diabetic subjects.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"78 2","pages":"271-7"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb11069.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13790814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The changing panorama of cerebral palsy in Sweden. V. The birth year period 1979-82.","authors":"B Hagberg, G Hagberg, I Olow, L von Wendt","doi":"10.1111/j.1651-2227.1989.tb11071.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb11071.x","url":null,"abstract":"<p><p>The prevalence of cerebral palsy (CP) in Swedish infants born in the four-year period 1979-82 is reported and related to the prevalence in infants born during the twenty-year period 1959-78. In 1979-82 it was 2.17 per 1,000 livebirths, 1.23 for children born at term and 0.94 for preterms, which means that the rising trend since the beginning of the 1970s persisted. The most pronounced rise, from 0.18 per 1,000 livebirths in the period 1967-70 to 0.67 in 1979-82 was found in the subgroup of preterms with spastic/ataxic diplegia. The severity of motor disability and the relative frequency of mental retardation, infantile hydrocephalus and epilepsy among preterm CP children successively increased over the same period of time. The livebirth prevalence of CP in term infants increased slightly but non-significantly during the period 1967-82. The birthweight-specific prevalence of CP per 1,000 newborns surviving the first week of life increased in all birthweight groups during the period 1967-82, significantly for birthweights below 1,500 g and over 2,500 g. The rising prevalence of CP was concomitant with a parallel fall in perinatal mortality, especially in very preterm infants. In the 1980s, severely multi-handicapped, very preterm children, only exceptionally seen among CP children born in the 1960s and 1970s, has become a matter of concern.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"78 2","pages":"283-90"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb11071.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13922569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The ceruloplasmin and transferrin system in cerebrospinal fluid of acute leukemia patients.","authors":"D Del Principe, A Menichelli, C Colistra","doi":"10.1111/j.1651-2227.1989.tb11083.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb11083.x","url":null,"abstract":"There are evidences indicating that some long-term neurologic disabilities seen in the children surviving acute lymphoblastic leukemia (ALL) could be attributed to the aggressive treatment rather than to the disease itself (1). We demonstrated, by isotachophoresis, that cerebrospinal fluid (CSF) from ALL children during standard central nervous system (CNS) prophylaxis, showed alterations in the protein profile (2). The most remarkable finding was the presence of oligoclonal immunoglobulins in CSF of children treated with aggressive protocols. Since a similar pattern occurs in neurologic diseases characterized by intrathecal immunologic and inflammatory reactions (3), we assayed in CSF ceruloplasmin and transfemn, which are generally considered markers of inflammatory processes.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"78 2","pages":"327-8"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb11083.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14065608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GH responsiveness to GHRH in obese children before and after weight loss.","authors":"A Sartorio, D Bochicchio, F Morabito, G Faglia","doi":"10.1111/j.1651-2227.1989.tb11084.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb11084.x","url":null,"abstract":"It is well known that obese children show impaired growth hormone (GH) responses to provocative stimuli, such as insulin-induced hypoglycemia (l) , arginine (2) and sleep (2). In addition, Pertzelan et al. (3) have recently demonstrated that obese children show an impaired GH response to GH releasing hormone (GHRH). In this work, we compare GH response to GHRH in obese children before and after weight loss.","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"78 2","pages":"329-30"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb11084.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13639581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W A Cutting, N R Belton, J A Gray, R P Brettle, P D Welsby, W T Todd, R A Elton, A Westwood, S Davidson
{"title":"Safety and efficacy of three oral rehydration solutions for children with diarrhoea (Edinburgh 1984-85).","authors":"W A Cutting, N R Belton, J A Gray, R P Brettle, P D Welsby, W T Todd, R A Elton, A Westwood, S Davidson","doi":"10.1111/j.1651-2227.1989.tb11065.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb11065.x","url":null,"abstract":"<p><p>Of 357 children with acute diarrhoea admitted to the City Hospital, Edinburgh, over a 12-month period, only 5 (1.4%) required IV infusions. Three hundred and nineteen were treated with oral rehydration (OR). Of these 269 were studied in detail and 43% had signs of dehydration, but in none of them was it severe. There were no fatalities. Patients were randomly allocated to treatment with one of three OR solutions in a double blind trial. The solutions had sodium concentrations of 35, 50 and 90 mmol (mEq)/l, and dextrose of 200 (36 g/l), 111 (20 g/l) and 110 (19.8 g/l) mmol/l, respectively. Hypernatraemia was not a clinical problem and only 5 children (2%) were biochemically hypernatraemic on admission. Treatment did not cause clinical hypernatraemia. At the second assessment only 3 children were biochemically hypernatraemic, one from each treatment group, and no one had clinical signs. All three solutions were safe and effective in the relatively mildly dehydrated patients currently seen in the UK.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"78 2","pages":"253-8"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb11065.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13790813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plasma amino acids in relation to metabolic control in insulin-dependent diabetic children.","authors":"L Hagenfeldt, G Dahlquist, B Persson","doi":"10.1111/j.1651-2227.1989.tb11070.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb11070.x","url":null,"abstract":"<p><p>The influence of metabolic control (estimated by blood glucose, 3-hydroxybutyrate and glycosylated hemoglobin levels) on plasma amino acids was determined in a group of 56 insulin-dependent diabetic children. A multiple correlation analysis revealed significant positive partial correlations between most amino acids and blood glucose. Alanine, methionine, tyrosine, phenylalanine and arginine showed negative partial correlations to the 3-hydroxybutyrate level. The results are consistent with the postulate that ketone body inhibition of muscle proteolysis is one of the factors regulating substrate flows during insulin deficiency.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"78 2","pages":"278-82"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb11070.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14065598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Autistic behaviour in Moebius syndrome.","authors":"C Gillberg, S Steffenburg","doi":"10.1111/j.1651-2227.1989.tb11076.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb11076.x","url":null,"abstract":"<p><p>Seventeen children and young adults with Moebius syndrome were examined with a view to finding symptoms of autism. Some 40% of the group showed all or many of the symptoms typical of autistic disorder. The high frequency of autistic symptoms in Moebius syndrome might be a marked overrepresentation and could be suggestive of a common underlying neurobiological deficit at the brainstem level.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"78 2","pages":"314-6"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb11076.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14065603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O Brunser, M Araya, J Espinoza, P R Guesry, M C Secretin, I Pacheco
{"title":"Effect of an acidified milk on diarrhoea and the carrier state in infants of low socio-economic stratum.","authors":"O Brunser, M Araya, J Espinoza, P R Guesry, M C Secretin, I Pacheco","doi":"10.1111/j.1651-2227.1989.tb11066.x","DOIUrl":"https://doi.org/10.1111/j.1651-2227.1989.tb11066.x","url":null,"abstract":"<p><p>The effect on diarrhoeal disease of an acidified, modified powdered cow's milk infant formula (Pelargon) was evaluated in 82 infants (Group I) for six months; 104 infants who received the same formula but non acidified, served as controls (Group II). Nutritional status remained satisfactory in both groups throughout the observation period. Some children rejected the taste of the acidified milk. The incidence of diarrhoea was lower in Group I (p less than 0.001). The proportion of days in which the children suffered from acute diarrhoea, and the duration of the episodes were also lower in the children given the acidified milk (p less than 0.001). The rate of detection of enteropathogens and the species identified were comparable in both groups. Carrier rates for bacterial enteropathogens fell over time in Group I while they rose in Group II (p less than 0.001). Carrier rates for enteric parasites were comparable to those expected in our setting for this age group. These results suggest that acidified milk exerts a protective effect against diarrhoeal disease.</p>","PeriodicalId":75407,"journal":{"name":"Acta paediatrica Scandinavica","volume":"78 2","pages":"259-64"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1651-2227.1989.tb11066.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14064921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}