Acta neurochirurgica. Supplementum最新文献_第5页

A novel aspect of thrombin in the tissue reaction following central nervous system injury. 凝血酶在中枢神经系统损伤后组织反应中的新作用。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_22

A Nishino, M Suzuki, T Yoshimoto, H Otani, H Nagura

引用次数: 27

The effect of leukotriene C4 on the permeability of brain capillary endothelial cell monolayer. 白三烯C4对脑毛细血管内皮细胞单层通透性的影响。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_14

T Nagashima, W Shigin, A Mizoguchi, M Arakawa, M Yamaguchi, N Tamaki

{"title":"The effect of leukotriene C4 on the permeability of brain capillary endothelial cell monolayer.","authors":"T Nagashima, W Shigin, A Mizoguchi, M Arakawa, M Yamaguchi, N Tamaki","doi":"10.1007/978-3-7091-9334-1_14","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_14","url":null,"abstract":"The role of leukotrienes as mediator of brain edema is still controversial. Recently, the ability of gamma-GTP to act as enzymatic barrier and to inactivate leukotrienes in normal brain capillaries was pointed out. A hypothesis tested in our experiments was that Leukotriene C4 (LTC4) increases permeability of a cerebral capillary endothelial monolayer which lacks gamma-GTP activity. Brain capillary endothelial cells were obtained of 10 rats from cerebral cortex by an enzymatic isolation procedure. The cells have an intact function, however, lack gamma-GTP activity. The endothelial cells were cultured on an optically clear collagen membrane mounted on a plastic frame. Effects of bradykinin (1 x 10(-5) M) and LTC4 (1 x 10(-7) M, 1 x 10(-6) M, 5 x 10(-6) M, 1 x 10(-5) M) were tested on permeability of the endothelial cell monolayer by measuring leakage of 14C-sucrose. The effect of LTC4 and bradykinin on intracellular calcium was studied by laser scanning confocal microscopy. LTC4 did not increase permeability of the brain capillary endothelial cell monolayer which lacked gamma-GTP activity. LTC4 did neither increase the concentration of intracellular calcium. Differences of LTC4 receptor function in normal brain capillaries and tumor capillaries remain to be studied.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"55-7"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18972106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Pharmacokinetics and pharmacodynamics of serum glycerol in patients with brain edema: comparison of oral and intravenous administration. 脑水肿患者血清甘油的药代动力学和药效学:口服和静脉给药的比较。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_152

H Tsuyusaki, R Kondo, S Murase, Y Yoshiyama, T Kobayashi, H Takagi, Y Kitahara, S Morii, F Tomonaga, T Ohwada

引用次数: 2

Sequential change of brain edema by semiquantitative measurement on MRI in patients with hypertensive intracerebral hemorrhage. 高血压脑出血患者MRI半定量测量脑水肿的顺序变化。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_156

S Suga, S Sato, K Yunoki, B Mihara

{"title":"Sequential change of brain edema by semiquantitative measurement on MRI in patients with hypertensive intracerebral hemorrhage.","authors":"S Suga, S Sato, K Yunoki, B Mihara","doi":"10.1007/978-3-7091-9334-1_156","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_156","url":null,"abstract":"The progression of brain edema in seven patients with hypertensive intracerebral hemorrhage (ICH) was evaluated. Five were of putaminal and two were of thalamic hemorrhage. The hematoma volume in the patients was 4 approximately 40 ml (18.9 +/- 8.0 ml). Sequential MRI (SE: 2000/40) was performed at one, two and four weeks after onset. The edema volume (EV) was calculated as 1/2.(long diameter).(short diameter).(thickness) of the high intensity area (HIA) on MRI. In comparison with the EV at one week after onset, the EV at two weeks was increased and the EV at four weeks returned to the same level of that at one week (132.3 +/- 26.1%, 100 +/- 10.6%, respectively). In contrast, the consciousness level and motor weakness of the patients had already improved at two weeks after onset. Our results demonstrate that progression of brain edema after small or medium size ICH may not bring about a deterioration of the clinical course. Moreover, progression of brain edema to the cerebral cortex and ventricle as indicated by MRI suggested an absorption pathway for the edema fluid, and implying that brain edema following ICH could play a part in the healing process after ICH.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"564-7"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-7091-9334-1_156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18972111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Do N-methyl-D-aspartate antagonists have disproportionately greater effects on brain swelling than on ischemic damage in focal cerebral infarction? n -甲基- d -天冬氨酸拮抗剂对局灶性脑梗死的脑肿胀的影响是否不成比例地大于对缺血性损伤的影响?

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_74

C K Park, J McCulloch, D S Jung, J K Kang, C R Choi

引用次数: 6

Blocking of interleukin-1 activity is a beneficial approach to ischemia brain edema formation. 阻断白细胞介素-1活性是缺血性脑水肿形成的有益途径。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_80

Y Yamasaki, H Shozuhara, H Onodera, K Kogure

引用次数: 34

Complete cerebral ischemia, prostacyclin deficiency, and therapeutic possibilities. 完全性脑缺血，前列环素缺乏和治疗可能性。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_81

R Pluta

引用次数: 6

Morphological changes of cultured neuronal and endothelial cells by human albumin. 人白蛋白对培养的神经细胞和内皮细胞形态学的影响。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_10

K Akiyama, M Yamamoto, M Haida, H Ohsuga, N Shinohara, Y Shinohara

{"title":"Morphological changes of cultured neuronal and endothelial cells by human albumin.","authors":"K Akiyama, M Yamamoto, M Haida, H Ohsuga, N Shinohara, Y Shinohara","doi":"10.1007/978-3-7091-9334-1_10","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_10","url":null,"abstract":"The role of plasma proteins in the mechanisms of brain tissue damage in ischemic events remains to be clarified. The purpose of this study was to investigate whether the presence of albumin in the extracellular fluid could induce damage to endothelial and neuronal cells. Neuronal cells from rat fetal brain (15 days) were cultured by using RPMI-1640 containing 10% Serum-Plus and endothelial cells from umbilical vein were also cultured in 96-well plates. The studies were made by using neuronal cells after 4 days of culture (N group) and endothelial cells after 4 days of culture (E4 group) and at confluence (EC group). After discarding the culture fluid, 200 microliters of 5-25% human albumin was added to each well. Microscopic observations were made up to 20 minutes, and then immunostaining was done with anti-human albumin antibody. The swelling of neurons was observed immediately after application of albumin solution, and the cells became circular after 10 minutes. In the E4 group, similar morphological changes were observed, but no such changes were seen in the EC group. Immunostaining revealed the presence of albumin in the intracellular space in both the N and E4 groups, but not the EC group. Our results suggest that albumin in extravasated fluid can induce damage to neuronal cells and endothelial cells in the non-confluent state.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"38-40"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18973992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Modulation of edema by dizocilpine, kynurenate, and NBQX in respiring brain slices after exposure to glutamate. 二唑西平、养尿酸和NBQX对暴露于谷氨酸后呼吸脑切片水肿的调节作用。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_15

M T Espanol, Y Xu, L Litt, L H Chang, T L James, P R Weinstein, P H Chan

{"title":"Modulation of edema by dizocilpine, kynurenate, and NBQX in respiring brain slices after exposure to glutamate.","authors":"M T Espanol, Y Xu, L Litt, L H Chang, T L James, P R Weinstein, P H Chan","doi":"10.1007/978-3-7091-9334-1_15","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_15","url":null,"abstract":"Brain edema caused by glutamate excitotoxicity was studied in well oxygenated neonatal cerebrocortical brain slices (350 mu thick). Slices exposed to 60 minutes of 2 mM glutamate, with or without glutamate antagonists (dizocilpine, kynurenate, or NBQX), were allowed to recover for 60 minutes. The protocol was identical to that in noninvasive multinuclear NMR spectroscopy studies (31P/1H/19F) of live slices. Percent water and swelling were determined invasively in isolated slices by wet and dry weight measurements before and after glutamate exposure. Edema was detectable within minutes in all experiments with glutamate exposures, but not in untreated control slices. Dizocilpine, kynurenate, and NBQX differently affected swelling, which correlated with PCr and ATP loss in separate NMR studies. Synaptic glutamate receptor activation appears to initiate events causing both edema and energy failure. Multiple glutamate receptor types seem to be involved. No glutamate antagonist provided greater protection against both edema and energy loss than dizocilpine. Dizocilpine might also block voltage-dependent Na+ channels, and provide protection via mechanisms other than NMDA-receptor dependent channel antagonism.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"58-61"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18973996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Role of serotonin and prostaglandins in brain edema induced by heat stress. An experimental study in the young rat. 血清素和前列腺素在热应激性脑水肿中的作用。一项对幼鼠的实验研究。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_17

H S Sharma, J Westman, F Nyberg, J Cervos-Navarro, P K Dey

{"title":"Role of serotonin and prostaglandins in brain edema induced by heat stress. An experimental study in the young rat.","authors":"H S Sharma, J Westman, F Nyberg, J Cervos-Navarro, P K Dey","doi":"10.1007/978-3-7091-9334-1_17","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_17","url":null,"abstract":"The possibility that serotonin and prostaglandins participate in edema formation following heat stress (HS) was examined in young rats. Exposure of conscious young animals (8-9 weeks old) to heat at 38 degrees C in a biological oxygen demand (BOD) incubator (relative humidity 50-55%; wind velocity 20-25 cm/s) for 4 h resulted in marked increase in the whole brain water content (about 3%) as compared to animals kept at room temperature (21 degrees C). A marked extravasation of Evans blue and 131I-sodium occurred in the brain of heat exposed animals as compared to normal animals. Morphological examination using electron microscopy of selected brain regions of heat stressed animals showed profound cell changes. Thus perivascular edema, swollen neuronal and glial cells, membrane damage, vesiculation of myelin, axonal swelling and synaptic damage was frequent in this group of untreated animals. Pretreatment with ketanserin (a selective serotonin2 receptor antagonist) or indomethacin (an inhibitor of prostaglandin synthesis) markedly reduced edema formation after 4 h HS in young animals. These heat stressed animals had considerably less extravasation of protein tracers as compared to the untreated group. Cell changes and edema at the ultrastructural level were mainly absent. Our results suggest that serotonin and prostaglandins are involved in heat stress induced breakdown of the BBB permeability, edema formation, and cell damage.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"65-70"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18973998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 57