Acta neurochirurgica. Supplementum最新文献_第5页

Blocking of interleukin-1 activity is a beneficial approach to ischemia brain edema formation. 阻断白细胞介素-1活性是缺血性脑水肿形成的有益途径。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_80

Y Yamasaki, H Shozuhara, H Onodera, K Kogure

引用次数: 34

Complete cerebral ischemia, prostacyclin deficiency, and therapeutic possibilities. 完全性脑缺血，前列环素缺乏和治疗可能性。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_81

R Pluta

引用次数: 6

Morphological changes of cultured neuronal and endothelial cells by human albumin. 人白蛋白对培养的神经细胞和内皮细胞形态学的影响。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_10

K Akiyama, M Yamamoto, M Haida, H Ohsuga, N Shinohara, Y Shinohara

{"title":"Morphological changes of cultured neuronal and endothelial cells by human albumin.","authors":"K Akiyama, M Yamamoto, M Haida, H Ohsuga, N Shinohara, Y Shinohara","doi":"10.1007/978-3-7091-9334-1_10","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_10","url":null,"abstract":"The role of plasma proteins in the mechanisms of brain tissue damage in ischemic events remains to be clarified. The purpose of this study was to investigate whether the presence of albumin in the extracellular fluid could induce damage to endothelial and neuronal cells. Neuronal cells from rat fetal brain (15 days) were cultured by using RPMI-1640 containing 10% Serum-Plus and endothelial cells from umbilical vein were also cultured in 96-well plates. The studies were made by using neuronal cells after 4 days of culture (N group) and endothelial cells after 4 days of culture (E4 group) and at confluence (EC group). After discarding the culture fluid, 200 microliters of 5-25% human albumin was added to each well. Microscopic observations were made up to 20 minutes, and then immunostaining was done with anti-human albumin antibody. The swelling of neurons was observed immediately after application of albumin solution, and the cells became circular after 10 minutes. In the E4 group, similar morphological changes were observed, but no such changes were seen in the EC group. Immunostaining revealed the presence of albumin in the intracellular space in both the N and E4 groups, but not the EC group. Our results suggest that albumin in extravasated fluid can induce damage to neuronal cells and endothelial cells in the non-confluent state.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"38-40"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18973992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Temporal profiles of Ca2+/calmodulin-dependent and -independent nitric oxide synthase activity in the rat brain microvessels following cerebral ischemia. 脑缺血后大鼠脑微血管中Ca2+/钙调素依赖性和非依赖性一氧化氮合酶活性的时间谱

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_76

T Nagafuji, M Sugiyama, T Matsui

引用次数: 33

Selective increase in blood-tumor barrier permeability by calcium antagonists in transplanted rat brain tumors. 钙拮抗剂选择性增加移植大鼠脑肿瘤血肿瘤屏障通透性。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_109

K Matsukado, T Nomura, K Ikezaki, M Fukui

引用次数: 12

Modulation of edema by dizocilpine, kynurenate, and NBQX in respiring brain slices after exposure to glutamate. 二唑西平、养尿酸和NBQX对暴露于谷氨酸后呼吸脑切片水肿的调节作用。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_15

M T Espanol, Y Xu, L Litt, L H Chang, T L James, P R Weinstein, P H Chan

{"title":"Modulation of edema by dizocilpine, kynurenate, and NBQX in respiring brain slices after exposure to glutamate.","authors":"M T Espanol, Y Xu, L Litt, L H Chang, T L James, P R Weinstein, P H Chan","doi":"10.1007/978-3-7091-9334-1_15","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_15","url":null,"abstract":"Brain edema caused by glutamate excitotoxicity was studied in well oxygenated neonatal cerebrocortical brain slices (350 mu thick). Slices exposed to 60 minutes of 2 mM glutamate, with or without glutamate antagonists (dizocilpine, kynurenate, or NBQX), were allowed to recover for 60 minutes. The protocol was identical to that in noninvasive multinuclear NMR spectroscopy studies (31P/1H/19F) of live slices. Percent water and swelling were determined invasively in isolated slices by wet and dry weight measurements before and after glutamate exposure. Edema was detectable within minutes in all experiments with glutamate exposures, but not in untreated control slices. Dizocilpine, kynurenate, and NBQX differently affected swelling, which correlated with PCr and ATP loss in separate NMR studies. Synaptic glutamate receptor activation appears to initiate events causing both edema and energy failure. Multiple glutamate receptor types seem to be involved. No glutamate antagonist provided greater protection against both edema and energy loss than dizocilpine. Dizocilpine might also block voltage-dependent Na+ channels, and provide protection via mechanisms other than NMDA-receptor dependent channel antagonism.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"58-61"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18973996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Pharmacokinetics and pharmacodynamics of serum glycerol in patients with brain edema: comparison of oral and intravenous administration. 脑水肿患者血清甘油的药代动力学和药效学:口服和静脉给药的比较。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_152

H Tsuyusaki, R Kondo, S Murase, Y Yoshiyama, T Kobayashi, H Takagi, Y Kitahara, S Morii, F Tomonaga, T Ohwada

引用次数: 2

In vivo differentiation of edematous changes after stroke in spontaneously hypertensive rats using diffusion weighted MRI. 弥散加权MRI对自发性高血压大鼠脑卒中后水肿变化的体内分化研究。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_60

M Takahashi, B Fritz-Zieroth, T Chikugo, H Ogawa

引用次数: 3

Effect of mannitol on focal cerebral ischemia evaluated by magnetic resonance imaging. 磁共振成像评价甘露醇对局灶性脑缺血的影响。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_61

H Kobayashi, H Ide, T Kodera, Y Handa, M Kabuto, T Kubota, M Maeda

{"title":"Effect of mannitol on focal cerebral ischemia evaluated by magnetic resonance imaging.","authors":"H Kobayashi, H Ide, T Kodera, Y Handa, M Kabuto, T Kubota, M Maeda","doi":"10.1007/978-3-7091-9334-1_61","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_61","url":null,"abstract":"We have evaluated the effect of mannitol on focal cerebral ischemia using T2-weighted magnetic resonance (MR) imaging and intravoxel incoherent motion (IVIM) MR imaging. The left middle cerebral artery (MCA) was exposed via the transorbital approach in 20 adult cats and occluded just proximal to the origin of the perforating arteries. Seven cats in treatment group received mannitol (0.5 g/kg i.v.) at 0, 6, 12 and 18 hours after MCA occlusion. The other 13 cats received saline and served as controls. Sequential MR coronal images were obtained at 2, 4, 6, and 24 hours after MCA occlusion using a GE Signa (1.5 tesla) system. IVIM MR imaging demonstrated ischemic cerebral injury as a sharply demarcated area at 2 hours after MCA occlusion in control group, while T2-weighted MR imaging failed to show clear evidence of the injury until 2-6 hours. At 24 hours after MCA occlusion, the infarcted area in the mannitol treatment group was 36.9 +/- 7.7% (S.E.M) of the left hemisphere, as compared to 57.3 +/- 5.3% in control group (p < 0.05). Mannitol has beneficial effect on ischemic injury.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"228-30"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18970435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Histochemical demonstration of free radicals (H2O2) in ischemic brain edema and protective effects of human recombinant superoxide dismutase on ischemic neuronal damage. 自由基(H2O2)在缺血性脑水肿中的组织化学表现及人重组超氧化物歧化酶对缺血性神经元损伤的保护作用。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_82

H Morooka, N Hirotsune, T Wani, T Ohmoto

{"title":"Histochemical demonstration of free radicals (H2O2) in ischemic brain edema and protective effects of human recombinant superoxide dismutase on ischemic neuronal damage.","authors":"H Morooka, N Hirotsune, T Wani, T Ohmoto","doi":"10.1007/978-3-7091-9334-1_82","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_82","url":null,"abstract":"A new histofluorescence method by HPAA (p-hydroxyphenyl acetic acid) for free radicals in the brain tissue was devised to study neuronal damage induced by ischemia. Cerebral ischemia was produced in rats by injection of plastic microspheres and arachidonic acid (AA) into the right carotid artery. The concentration of malondialdehyde (MDA; free radical) in cerebral cortex of aminotriazol (an H2O2-dependent inhibitor of catalase) treated rats 2 h after stroke was 6.33 times the level before infarction, while the concentration of MDA in h-r SOD (free radical-scavenging enzyme) treated rats 2 h after stroke was significantly lower than in untreated rats. The histochemical findings demonstrated marked H2O2 production around blood vessels occluded by microspheres in the cerebral cortex of the aminotriazole treated rats 2 h after stroke together with disruption of the BBB. Light microscopical findings demonstrated extensive edematous changes in the aminotriazole treated rats 2 h after stroke, while pathological damage in SOD treated rat brains was absent or minimal. We conclude that free radicals are formed during ischemia, and that AA appears to be a major source of activated oxygen radicals. The findings indicate that SOD is protective against ischemia-induced neuronal damage.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"307-9"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18971565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10