Acta neurochirurgica. Supplementum最新文献_第6页

Excitatory amino acid release from contused brain tissue into surrounding brain areas. 兴奋性氨基酸从挫伤的脑组织释放到周围的脑区。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_144

H Tanaka, Y Katayama, T Kawamata, T Tsubokawa

{"title":"Excitatory amino acid release from contused brain tissue into surrounding brain areas.","authors":"H Tanaka, Y Katayama, T Kawamata, T Tsubokawa","doi":"10.1007/978-3-7091-9334-1_144","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_144","url":null,"abstract":"The EAA release from contused brain tissue and its effect on the extracellular EAA levels in brain areas surrounding the contusion were investigated with microdialysis technique in the rat. A significant increase in extracellular EAA levels was observed in the contused brain tissue. The EAA increase was significantly greater in the contused brain tissue than in the isolated but non-contused brain tissue. It was further demonstrated that EAAs were released from non-contused brain areas 1-2 mm distant from contused brain tissue. No such EAA release from surrounding brain areas was demonstrated when the cavity was filled with isolated but non-contused brain tissue. The increase in EAAs was attenuated by KYN administered through microdialysis, suggesting that the EAA release from the surrounding brain areas appears to be a consequence that is secondary to the EAA release from the contused brain tissue. Such a diffusion-reaction process is probably mediated by the neurotransmitter actions of EAAs. The results of the present study are of clinical importance, since surgical removal of contused brain tissue and administration of EAA antagonists may serve to protect the surrounding brain areas from EAA neurotoxicity.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"524-7"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18971573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

A novel aspect of thrombin in the tissue reaction following central nervous system injury. 凝血酶在中枢神经系统损伤后组织反应中的新作用。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_22

A Nishino, M Suzuki, T Yoshimoto, H Otani, H Nagura

引用次数: 27

Differences in wound healing pattern between mature and immature brain behavior of extravasated serum protein. 成熟与不成熟脑外渗血清蛋白伤口愈合模式的差异。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_118

M Suzuki, O Motohashi, A Nishino, K Umezawa, N Shida, T Yoshimoto

{"title":"Differences in wound healing pattern between mature and immature brain behavior of extravasated serum protein.","authors":"M Suzuki, O Motohashi, A Nishino, K Umezawa, N Shida, T Yoshimoto","doi":"10.1007/978-3-7091-9334-1_118","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_118","url":null,"abstract":"To clarify the fate of extravasated serum protein and tissue reaction following blood brain-barrier breakdown in mature and immature brain, we produced cryogenic injury in the cortices of adult and post natal day 2 rats, and immunohistochemical examination with GFAP, vimentin and albumin, endogenous tracer of serum proteins, antibodies. Mature and immature brain showed the same histological changes by day 3. However, fibrotic scar, cyst formation and GFAP, vimentin-positive astrocytosis were main features in mature brain, fusion of adjoining cortical plate without scar and astrocytosis was typical in the immature brain. In adult rats, presence of albumin was observed near the lesion on day 1, evidently extending to the contralateral hemisphere on day 7 and localized again around scar and cyst on day 14. In the P2 rats, albumin was present in both hemispheres on day 1, but was localized to molecular layer periventricular region and choroid plexus on day 7. No albumin was detected on day 14. These results suggest that rapid spreading and clearance of extravasted serum proteins may take place in the immature brain and this may be deeply involved in the characteristic wound healing pattern.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"434-6"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18971244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparison of the effects of glycerol, mannitol, and urea on ischemic hippocampal damage in gerbils. 甘油、甘露醇和尿素对沙鼠缺血性海马损伤影响的比较。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_86

K Otsubo, Y Katayama, F Kashiwagi, H Muramatsu, A Terashi

引用次数: 4

Combined treatment with nicardipine, phenobarbital, and methylprednisolone ameliorates vasogenic brain edema. 尼卡地平、苯巴比妥和甲基强的松龙联合治疗可改善血管源性脑水肿。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_145

S Z Lin, T L Chiou, Y H Chiang, W S Song

{"title":"Combined treatment with nicardipine, phenobarbital, and methylprednisolone ameliorates vasogenic brain edema.","authors":"S Z Lin, T L Chiou, Y H Chiang, W S Song","doi":"10.1007/978-3-7091-9334-1_145","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_145","url":null,"abstract":"Free radicals formed around the edematous areas of the brain can cause lipoperoxidation of the cellular membrane, followed by calcium influx into the cell through calcium channels. These secondary insults may aggravate vasogenic brain edema. Since phenobarbital is a free radical scavenger, methylprednisolone has an antilipoperoxidation effect; and nicardipine is a calcium channel blocker, we hypothesized that combined treatment with phenobarbital, methylprednisolone, and nicardipine would be beneficial in vasogenic brain edema. This hypothesis was tested in Sprague-Dawley rats with a transdural cold-injury on the right parietal cortex. The animals were randomly divided into two groups. Animals in the treatment group were injected intraperitoneally with phenobarbital (4 mg/kg), methylprednisolone (50 mg/kg), and nicardipine (10 micrograms/kg) at 5 min and 8 hours after the cold-injury. The control animals were injected with saline. These animals were sacrificed 24 hours after the injury. The extent of brain edema was assessed by measuring the water content, the inulin distribution volume, and the distribution area of Evans blue in the brain. Our results showed that the water content of the edematous hemisphere was similar in the control and the treatment groups. However, Evans blue distribution area and inulin distribution volume of the treatment group were less than those of the control group by 12% and 31%, respectively. In conclusion, the combined treatment with phenobarbital, methylprednisolone and nicardipine is beneficial in vasogenic brain edema.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"528-30"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18971574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Quantitation of peritumoural oedema and the effect of steroids using NMR-relaxation time imaging and blood-brain barrier analysis. 利用核磁共振弛豫时间成像和血脑屏障分析定量肿瘤周围水肿和类固醇的作用。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_112

C Andersen, J Astrup, C Gyldensted

{"title":"Quantitation of peritumoural oedema and the effect of steroids using NMR-relaxation time imaging and blood-brain barrier analysis.","authors":"C Andersen, J Astrup, C Gyldensted","doi":"10.1007/978-3-7091-9334-1_112","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_112","url":null,"abstract":"A new method of in vivo quantitation of peritumoural brain oedema using NMR relaxation time imaging (T1-maps) and Gd-DTPA-enhanced Blood-Tumour-Barrier (BTB) analysis is presented. The method is based on image pixel histogram analysis and a fast imaging method combined with arterial [Gd-DTPA]-measurement. The method was applied in 26 brain tumour patients, studied prior to--and 1, 3 and 7 days after initiation of dexamethasone. Oedema resorption rate following dexamethasone treatment was almost equal in glioblastomas and metastases, mean T1 being reduced by ca. 12% in 7 days. In meningiomas no significant changes in peritumoural oedema could be detected. Simultaneous BTB-analysis was obtained in 4 patients showing correlation between oedema resorption in vivo and reduction of BTB transport rate constant Ki after 7 days of steroid treatment. This method is a powerful tool in quantitation and monitoring of brain oedema in vivo, as both steroid influence on oedema resorption and on BTB-defect can be monitored simultaneously.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"413-5"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-7091-9334-1_112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18971916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Simultaneous measurement of bidirectional capillary permeability, vascular volume, extracellular space, and rCBF in experimental gliomas and surrounding edema. 同时测量实验性胶质瘤和周围水肿的双向毛细血管通透性、血管体积、细胞外空间和rCBF。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_91

P C Warnke, F J Hans, A Korst, C Mall, C B Ostertag

引用次数: 2

Proton MR spectroscopy of experimental brain tumors in vivo. 体内实验性脑肿瘤的质子磁共振光谱。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_94

M L Gyngell, T Els, M Hoehn-Berlage, K A Hossmann

引用次数: 15

Effect of a new calcium antagonist (SM-6586) on experimental cerebral ischemia. 一种新型钙拮抗剂SM-6586对实验性脑缺血的影响。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_77

F Kashiwagi, Y Katayama, H Igarashi, S Iida, H Muramatsu, A Terashi

引用次数: 3

Naloxone reduces alterations in evoked potentials and edema in trauma to the rat spinal cord. 纳洛酮可减少大鼠脊髓损伤诱发电位和水肿的改变。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_140

T Winkler, H S Sharma, E Stålberg, Y Olsson, F Nyberg

{"title":"Naloxone reduces alterations in evoked potentials and edema in trauma to the rat spinal cord.","authors":"T Winkler, H S Sharma, E Stålberg, Y Olsson, F Nyberg","doi":"10.1007/978-3-7091-9334-1_140","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_140","url":null,"abstract":"The influence of naloxone (an opioid receptor antagonist) on spinal cord conduction and edema formation as a result of trauma to the cord was investigated in a rat model. The spinal cord injury (SCI) was inflicted in urethane anesthetized animals by a longitudinal incision into the right dorsal horn of the T10-11 segments, about 2 mm deep and 5 mm long. Spinal cord evoked potentials (SCEP) were recorded epidurally from the T9 (rostral) and T12 (caudal) segments after stimulation of the ipsilateral tibial and sural nerves at the ankle. The edema was measured by determining water content of the cord at s h after injury. In rats not given naloxone SCI resulted in an immediate long-lasting depression of the rostral maximal negative peak (MNP) amplitude (about 60%) and a significant increase in the latency of the rostral maximal positive peak (MPP). Pretreatment with naloxone inhibited the immediate post-injury decrease of the rostral MNP and some of the increase of MPP latency. The water content in the traumatized spinal cord was reduced by 3% in naloxone treated animals compared with untreated injured controls. Our results indicate that endogenous opioid peptides participate in changes of spinal cord conduction after trauma and influence edema formation probably via multiple opioid receptors.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"511-5"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18972231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16