Acta neurochirurgica. Supplementum最新文献_第10页

Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology. 神经保护性NMDA拮抗剂:对皮质神经元形态学潜在不利影响的争议。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_4

R J Hargreaves, R G Hill, L L Iversen

{"title":"Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology.","authors":"R J Hargreaves, R G Hill, L L Iversen","doi":"10.1007/978-3-7091-9334-1_4","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_4","url":null,"abstract":"It has been reported that several uncompetitive NMDA receptor ion channel blocking agents (phencyclidine, ketamine, dizocilpine, dextrorphan) cause transient reversible vacuolation in neurons in the posterior cingulate cortex of rats. Similar effects have also been observed with competitive glutamate antagonists such as CPP, CGS 19755 and CGP 37849. This transient morphological change has been noted to be coincident anatomically with brain regions showing hypermetabolism after administration of uncompetitive NMDA receptor ion channel blockers and competitive glutamate antagonists. These results therefore indicate that the functional consequences of NMDA receptor blockade with competitive glutamate and uncompetitive channel antagonists are ultimately the same. These changes do not appear to be a prelude to irreversible damage except after relatively high doses of the receptor ion channel antagonists but they have given rise to concern over the safety in use of NMDA antagonists as neuroprotective agents. In contrast, vacuolation has not yet been demonstrated with agents acting at the glycine (L-687,414) or polyamine (eliprodil) modulatory sites of the NMDA receptor complex suggesting that agents acting at these sites may have a greater potential therapeutic window.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"15-9"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18975714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Endogenous opioid system activity following temporary focal cerebral ischemia. 暂时性局灶性脑缺血后内源性阿片系统活性。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_67

P Ting, S Xu, S Krumins

引用次数: 13

Monitoring of rectal, epidural, and intraventricular temperature in neurosurgical patients. 神经外科病人直肠、硬膜外和脑室温度的监测。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_133

P Mellergård

引用次数: 35

A high-field magnetic resonance imaging study of experimental vasogenic brain edema and its response to AVS: 1,2-bis (nicotinamido)-propane. 实验性血管源性脑水肿的高场磁共振成像研究及其对AVS: 1,2-双(烟酰胺)-丙烷的反应。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_134

K Kamada, K Houkin, Y Iwasaki, H Abe

{"title":"A high-field magnetic resonance imaging study of experimental vasogenic brain edema and its response to AVS: 1,2-bis (nicotinamido)-propane.","authors":"K Kamada, K Houkin, Y Iwasaki, H Abe","doi":"10.1007/978-3-7091-9334-1_134","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_134","url":null,"abstract":"We clearly represented brain structures of rats and permitted a rapid assessment of water gradient of the brain edema by cortical freezing utilizing a high-field (7T) proton magnetic resonance imaging (MRI). The typical time course of vasogenic edema and the efficacy of AVS; 1,2-bis (nicotinamide)-propane upon the edema were presented. Twelve rats with edema induced by cortical freezing were divided into two groups; one group of animals received 0.5 ml of physiological saline with 100 mg (/kg) AVS every eight hours intraperitoneally. The other group of untreated animals received only saline. One three, six, 12, and 24 hours after lesion production, the profiles of edema fluid spreading and the maximum signal intensity (MI) of some regions of interest (ROI) were assessed by T2 weighted images (TE = 70 ms, TR = 3500 ms). One hour after lesion production in the untreated group, a low heterogeneous intensity area was seen mainly in the primarily injured cortex. Two hours later, the margin of the lesion gradually increased in intensity and MI of ROIs around the lesion also gradually increased. Twenty-four h after lesion production edema extended contralaterally via corpus callosum. AVS reduced edema fluid spreading beginning from about six hours after lesion production. The MIs of the AVS treated group were significantly lower than in the untreated group (p < 0.01). We conclude that sequential observation of edema using MRI is a quite practical technique for evaluation of the efficacy of any therapeutic agent.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"491-3"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18975729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Dysfunction of the medullary cardiovascular center may cause acute spinal cord swelling. 髓系心血管中心功能障碍可引起急性脊髓肿胀。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_46

M Maeda, M Nakai, A J Krieger, H N Sapru

{"title":"Dysfunction of the medullary cardiovascular center may cause acute spinal cord swelling.","authors":"M Maeda, M Nakai, A J Krieger, H N Sapru","doi":"10.1007/978-3-7091-9334-1_46","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_46","url":null,"abstract":"Acute brain swelling is well known to be acute vasodilatation of cerebral vessels and sometimes results from brain injury. One of the causes of acute brain swelling may be disturbance of central control mechanisms of cerebral vessels. However, the presence of acute spinal cord swelling is little noticed. We present here a possibility that acute spinal cord swelling may be occur following the dysfunction of the cardiovascular center of the medulla. In urethane-anesthetized, paralyzed and artificially ventilated rats, the neurons in the rostral ventrolateral pressor area (VLPA), origin of the sympathetic nerve activities in the brain stem, were chemically stimulated by microinjection of L-glutamate and the spinal cord blood flow (SCBF) was determined using labeled microspheres. The SCBFs of cervical, thoracic, and lumbar cord decreased significantly from 27 +/- 3 (mean +/- S.E.M.) to 20 +/- 2 (p < 0.01), from 22 +/- 1 to 17 +/- 2 (p < 0.05), and from 41 +/- 5 to 26 +/- 3 (p < 0.05) ml.min-1.(100 g)-1, respectively (n = 12). The spinal cord vascular resistances (SCVRs) of cervical, thoracic, and lumbar cord increased significantly from 3.7 +/- 0.4 to 5.0 +/- 0.6 (p < 0.05), from 4.2 +/- 0.2 to 5.9 +/- 0.7 (p < 0.05), and from 2.5 +/- 0.2 to 3.8 +/- 0.4 (p < 0.05) mmHg per [ml.min-1.(100 g)-1], respectively (n = 12). These results suggest that the neurons within the VLPA may play a role in the control of spinal cord circulation. There is a possibility that the dysfunction of the VLPA may cause acute spinal cord swelling.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"171-3"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-7091-9334-1_46","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18971641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

CSF dynamics in patients with meningiomas. 脑膜瘤患者脑脊液动力学。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_47

N Pliushcheva, A Shakhnovich

引用次数: 3

Abnormalities of the blood-brain barrier in global cerebral ischemia in rats due to experimental cardiac arrest. 实验性心脏骤停致全脑缺血大鼠血脑屏障异常。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_73

M J Mossakowski, A S Lossinsky, R Pluta, H M Wisniewski

{"title":"Abnormalities of the blood-brain barrier in global cerebral ischemia in rats due to experimental cardiac arrest.","authors":"M J Mossakowski, A S Lossinsky, R Pluta, H M Wisniewski","doi":"10.1007/978-3-7091-9334-1_73","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_73","url":null,"abstract":"The aim of the study was to characterize the impact of global cerebral ischemia resulting from cardiac arrest on the BBB permeability. Survival time of experimental animals after 3.5, 5 or 10 min ischemia range from 3.5-10 min to 24 h. Vascular permeability was evaluated with horseradish peroxidase (HRP). BBB disturbances were of biphasic nature. In the first phase, appearing immediately after ischemia and persisting till 1st postischemic hour, HRP extravasation involved mainly venous site of microcirculation and was limited to the cerebral and cerebellar cortex and the central periventricular structures. The second phase covering the period between 6 and 24 h after resuscitation was characterized by random HRP leakage in all the CNS structures. HRP penetrated through increased microvesicular and canalicular endothelial systems, through interendothelial junctions and via disintegrated endothelial cells. Distribution and perivenous localization of BBB changes in early phase suggests their connection with venostasis resulting from cardiac arrest. The second phase seems to be pathogenetically related with the consequences of the ischemic process.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"274-6"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-7091-9334-1_73","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18971643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Detection of endogenous albumin as an index of blood parenchymal border alteration. 内源性白蛋白检测作为血实质边界改变的指标。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_32

T Fukuhara, M Gotoh, M Kawauchi, S Asari, T Ohmoto, K Tsutsui, T Shohmori

{"title":"Detection of endogenous albumin as an index of blood parenchymal border alteration.","authors":"T Fukuhara, M Gotoh, M Kawauchi, S Asari, T Ohmoto, K Tsutsui, T Shohmori","doi":"10.1007/978-3-7091-9334-1_32","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_32","url":null,"abstract":"We used a microdialysis technique to establish a method to detect sequential changes in disruption of the blood parenchymal border. Twelve cats were divided into two groups; one group underwent occlusion of the middle cerebral artery for 60 minutes, the other a cold injury model. Microdialysis probes were implanted bilaterally into the white matter, and dialysates were collected successively at 30 minute intervals for 6 hours in the occlusion model and 4 hours in the cold injury model. Regional cerebral blood flow was measured simultaneously using the hydrogen clearance method. The water content of the white matter was measured using specific gravity. The proteins in the dialysate were analyzed using electrophoresis with silver stain, and, with densitometric analysis, the density of the 66.2 kDa band was quantified as albumin. The ratio of this density to the preoperative density was defined as the \"albumin index.\" On the side of the lesion in the cold injury model, this index significantly increased 3 hours after the cold injury compared with the contralateral side, and a correlation between the water content and this index was observed. The albumin index was believed to indicate the severity of disruption of the blood parenchymal border.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"121-3"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18970429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Mechanisms of brain injury associated with partial and complete occlusion of the MCA in cat. 脑损伤与脑中动脉部分和完全闭塞的机制。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_57

Z S Vexler, T P Roberts, N Derugin, E Kozniewska, A I Arieff, J Kucharczyk

引用次数: 6

Blood-damaged tissue interaction in experimental brain ischemia. 实验性脑缺血中血损伤组织的相互作用。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_62

J M Hallenbeck

引用次数: 14