Acta neurochirurgica. Supplementum最新文献_第10页

Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology. 神经保护性NMDA拮抗剂:对皮质神经元形态学潜在不利影响的争议。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_4

R J Hargreaves, R G Hill, L L Iversen

{"title":"Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology.","authors":"R J Hargreaves, R G Hill, L L Iversen","doi":"10.1007/978-3-7091-9334-1_4","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_4","url":null,"abstract":"It has been reported that several uncompetitive NMDA receptor ion channel blocking agents (phencyclidine, ketamine, dizocilpine, dextrorphan) cause transient reversible vacuolation in neurons in the posterior cingulate cortex of rats. Similar effects have also been observed with competitive glutamate antagonists such as CPP, CGS 19755 and CGP 37849. This transient morphological change has been noted to be coincident anatomically with brain regions showing hypermetabolism after administration of uncompetitive NMDA receptor ion channel blockers and competitive glutamate antagonists. These results therefore indicate that the functional consequences of NMDA receptor blockade with competitive glutamate and uncompetitive channel antagonists are ultimately the same. These changes do not appear to be a prelude to irreversible damage except after relatively high doses of the receptor ion channel antagonists but they have given rise to concern over the safety in use of NMDA antagonists as neuroprotective agents. In contrast, vacuolation has not yet been demonstrated with agents acting at the glycine (L-687,414) or polyamine (eliprodil) modulatory sites of the NMDA receptor complex suggesting that agents acting at these sites may have a greater potential therapeutic window.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"15-9"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18975714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Endogenous opioid system activity following temporary focal cerebral ischemia. 暂时性局灶性脑缺血后内源性阿片系统活性。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_67

P Ting, S Xu, S Krumins

引用次数: 13

Monitoring of rectal, epidural, and intraventricular temperature in neurosurgical patients. 神经外科病人直肠、硬膜外和脑室温度的监测。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_133

P Mellergård

引用次数: 35

A high-field magnetic resonance imaging study of experimental vasogenic brain edema and its response to AVS: 1,2-bis (nicotinamido)-propane. 实验性血管源性脑水肿的高场磁共振成像研究及其对AVS: 1,2-双(烟酰胺)-丙烷的反应。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_134

K Kamada, K Houkin, Y Iwasaki, H Abe

{"title":"A high-field magnetic resonance imaging study of experimental vasogenic brain edema and its response to AVS: 1,2-bis (nicotinamido)-propane.","authors":"K Kamada, K Houkin, Y Iwasaki, H Abe","doi":"10.1007/978-3-7091-9334-1_134","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_134","url":null,"abstract":"We clearly represented brain structures of rats and permitted a rapid assessment of water gradient of the brain edema by cortical freezing utilizing a high-field (7T) proton magnetic resonance imaging (MRI). The typical time course of vasogenic edema and the efficacy of AVS; 1,2-bis (nicotinamide)-propane upon the edema were presented. Twelve rats with edema induced by cortical freezing were divided into two groups; one group of animals received 0.5 ml of physiological saline with 100 mg (/kg) AVS every eight hours intraperitoneally. The other group of untreated animals received only saline. One three, six, 12, and 24 hours after lesion production, the profiles of edema fluid spreading and the maximum signal intensity (MI) of some regions of interest (ROI) were assessed by T2 weighted images (TE = 70 ms, TR = 3500 ms). One hour after lesion production in the untreated group, a low heterogeneous intensity area was seen mainly in the primarily injured cortex. Two hours later, the margin of the lesion gradually increased in intensity and MI of ROIs around the lesion also gradually increased. Twenty-four h after lesion production edema extended contralaterally via corpus callosum. AVS reduced edema fluid spreading beginning from about six hours after lesion production. The MIs of the AVS treated group were significantly lower than in the untreated group (p < 0.01). We conclude that sequential observation of edema using MRI is a quite practical technique for evaluation of the efficacy of any therapeutic agent.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"491-3"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18975729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Detection of endogenous albumin as an index of blood parenchymal border alteration. 内源性白蛋白检测作为血实质边界改变的指标。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_32

T Fukuhara, M Gotoh, M Kawauchi, S Asari, T Ohmoto, K Tsutsui, T Shohmori

{"title":"Detection of endogenous albumin as an index of blood parenchymal border alteration.","authors":"T Fukuhara, M Gotoh, M Kawauchi, S Asari, T Ohmoto, K Tsutsui, T Shohmori","doi":"10.1007/978-3-7091-9334-1_32","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_32","url":null,"abstract":"We used a microdialysis technique to establish a method to detect sequential changes in disruption of the blood parenchymal border. Twelve cats were divided into two groups; one group underwent occlusion of the middle cerebral artery for 60 minutes, the other a cold injury model. Microdialysis probes were implanted bilaterally into the white matter, and dialysates were collected successively at 30 minute intervals for 6 hours in the occlusion model and 4 hours in the cold injury model. Regional cerebral blood flow was measured simultaneously using the hydrogen clearance method. The water content of the white matter was measured using specific gravity. The proteins in the dialysate were analyzed using electrophoresis with silver stain, and, with densitometric analysis, the density of the 66.2 kDa band was quantified as albumin. The ratio of this density to the preoperative density was defined as the \"albumin index.\" On the side of the lesion in the cold injury model, this index significantly increased 3 hours after the cold injury compared with the contralateral side, and a correlation between the water content and this index was observed. The albumin index was believed to indicate the severity of disruption of the blood parenchymal border.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"121-3"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18970429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Mechanisms of brain injury associated with partial and complete occlusion of the MCA in cat. 脑损伤与脑中动脉部分和完全闭塞的机制。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_57

Z S Vexler, T P Roberts, N Derugin, E Kozniewska, A I Arieff, J Kucharczyk

引用次数: 6

Blood-damaged tissue interaction in experimental brain ischemia. 实验性脑缺血中血损伤组织的相互作用。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_62

J M Hallenbeck

引用次数: 14

The relationship between cerebral ischemic edema and monoamines: revisited. 脑缺血水肿与单胺的关系:重访。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_63

H Ishii, N Bertrand, D Stanimirovic, A Strasser, B B Mrsulja, M Spatz

引用次数: 5

Massive astrocytic swelling in response to extracellular glutamate--a possible mechanism for post-traumatic brain swelling? 大量星形细胞肿胀对细胞外谷氨酸的反应——创伤后脑肿胀的可能机制?

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_127

W L Maxwell, R Bullock, H Landholt, H Fujisawa

引用次数: 31

Resolution of peritumoral brain edema following excision of meningioma. 脑膜瘤切除术后瘤周脑水肿的消退。

Acta neurochirurgica. Supplementum Pub Date : 1994-01-01 DOI: 10.1007/978-3-7091-9334-1_113

T Shirotani, K Shima, H Chigasaki

{"title":"Resolution of peritumoral brain edema following excision of meningioma.","authors":"T Shirotani, K Shima, H Chigasaki","doi":"10.1007/978-3-7091-9334-1_113","DOIUrl":"https://doi.org/10.1007/978-3-7091-9334-1_113","url":null,"abstract":"We studied the resolution of peritumoral brain edema after meningioma excision. In twenty-nine patients with meningioma, the total volume of tumor and the peritumoral edema were measured planimetrically by serial CT scans and MRI with or without contrast enhancement. Four different patterns of postoperative resolution of hypodense volume on CT were observed: Group A: a large hypodensity rapidly decreased and disappeared, which may be related to the clearance of the real peritumoral edema in meningioma. Group B: a small hypodensity gradually disappeared. Group C: the hypodensity remained unchanged, which may result from the damaged brain tissue. Group D: the hypodensity progressively decreased but persisted, which may represent both the peritumoral edema and damaged brain tissue. We have calculated the resolution rate of edema fluid using the clearance curve of Groups A and D. The average resolution rate of edema fluid during the passage through 1 cm3 of the peritumoral white matter was 0.0493 ml/day. We speculate that 50% of edematous white matter, which presented as hypodensity on a CT scan, may be resolved in 4 days after total removal, and that 90% may be resolved in 14 days.","PeriodicalId":75393,"journal":{"name":"Acta neurochirurgica. Supplementum","volume":"60 ","pages":"416-8"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18971239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12