World journal of experimental medicine最新文献

{"title":"Genetic factors that predict response and failure of biologic therapy in inflammatory bowel disease.","authors":"Milena Peruhova, Daniela Stoyanova, Dimitrina Georgieva Miteva, Meglena Kitanova, Milko Bozhidarov Mirchev, Tsvetelina Velikova","doi":"10.5493/wjem.v15.i1.97404","DOIUrl":"10.5493/wjem.v15.i1.97404","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) represents a significant disease burden marked by chronic inflammation and complications that adversely affect patients' quality of life. Effective diagnostic strategies involve clinical assessments, endoscopic evaluations, imaging studies, and biomarker testing, where early diagnosis is essential for effective management and prevention of long-term complications, highlighting the need for continual advancements in diagnostic methods. The intricate interplay between genetic factors and the outcomes of biological therapy is of critical importance. Unraveling the genetic determinants that influence responses and failures to biological therapy holds significant promise for optimizing treatment strategies for patients with IBD on biologics. Through an in-depth examination of current literature, this review article synthesizes critical genetic markers associated with therapeutic efficacy and resistance in IBD. Understanding these genetic actors paves the way for personalized approaches, informing clinicians on predicting, tailoring, and enhancing the effectiveness of biological therapies for improved outcomes in patients with IBD.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 1","pages":"97404"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 proteins show great binding affinity to resin composite monomers and polymerized chains.","authors":"Pedro Henrique Sette-de-Souza, Moan Jéfter Fernandes Costa, Boniek Castillo Dutra Borges","doi":"10.5493/wjem.v15.i1.94022","DOIUrl":"10.5493/wjem.v15.i1.94022","url":null,"abstract":"<p><strong>Background: </strong>Due to saliva and salivary glands are reservoir to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), aerosols and saliva droplets are primary sources of cross-infection and are responsible for the high human-human transmission of SARS-CoV-2. However, there is no evidence about how SARS-CoV-2 interacts with oral structures, particularly resin composites.</p><p><strong>Aim: </strong>To evaluate the interaction of SARS-CoV-2 proteins with monomers present in resin composites using in silico analysis.</p><p><strong>Methods: </strong>Four SARS-CoV-2 proteins [<i>i.e.</i> main protease, 3C-like protease, papain-like protease (PLpro), and glycoprotein spike] were selected along with salivary amylase as the positive control, and their binding affinity with bisphenol-A glycol dimethacrylate, bisphenol-A ethoxylated dimethacrylate, triethylene glycol dimethacrylate, and urethane dimethacrylate was evaluated. Molecular docking was performed using AutoDock Vina and visualised in Chimera UCSF 1.14. The best ligand-protein model was identified based on the binding energy (ΔG-kcal/moL).</p><p><strong>Results: </strong>Values for the binding energies ranged from -3.6 kcal/moL to -7.3 kcal/moL. The 3-monomer chain had the lowest binding energy (<i>i.e.</i> highest affinity) to PLpro and the glycoprotein spike. Non-polymerised monomers and polymerised chains interacted with SARS-CoV-2 proteins <i>via</i> hydrogen bonds and hydrophobic interactions. Those findings suggest an interaction between SARS-CoV-2 proteins and resin composites.</p><p><strong>Conclusion: </strong>SARS-CoV-2 proteins show affinity to non-polymerised and polymerised resin composite chains.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 1","pages":"94022"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial on amylase and the acini-islet-acinar reflex: A new frontier in metabolic health research.","authors":"Opeyemi Deji-Oloruntoba, Uchenna E Okpete, Haewon Byeon","doi":"10.5493/wjem.v15.i1.101289","DOIUrl":"10.5493/wjem.v15.i1.101289","url":null,"abstract":"<p><p>This editorial comments on the study by Pierzynowska <i>et al</i> investigating the acini-islet-acinar (AIA) reflex, which integrates the exocrine and endocrine functions of the pancreas. The study investigates whether exogenous amylase introduced to the interstitial fluid surrounding pancreatic islets can inhibit insulin release. Historically, high serum amylase levels were associated with pancreatitis, but recent findings suggest that low amylase levels are more linked to metabolic diseases like diabetes and obesity. In their experiment, six pigs were used to examine the effects of amylase infusion on insulin release during an intravenous glucose tolerance test. The pigs received different treatments (amylase, saline, or bovine serum albumin), and blood samples were taken over two hours to measure insulin and glucose levels. The results showed amylase delayed glucose-stimulated insulin release, whereas bovine serum albumin increased insulin levels supporting the existence of the AIA reflex and suggesting amylase as a key metabolic regulator. Enzyme supplementation, particularly with α-amylases, may offer therapeutic benefits in preventing and managing metabolic disorders, including diabetes and obesity. Further research is warranted to explore the full scope of amylase's role in metabolic health and its therapeutic potential.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 1","pages":"101289"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol and alcoholism associated neurological disorders: Current updates in a global perspective and recent recommendations.","authors":"Prashanti Sahu, Henu Kumar Verma, Lvks Bhaskar","doi":"10.5493/wjem.v15.i1.100402","DOIUrl":"10.5493/wjem.v15.i1.100402","url":null,"abstract":"<p><p>Alcohol use disorder (AUD) is a medical condition that impairs a person's ability to stop or manage their drinking in the face of negative social, occupational, or health consequences. AUD is defined by the National Institute on Alcohol Abuse and Alcoholism as a \"severe problem\". The central nervous system is the primary target of alcohol's adverse effects. It is crucial to identify various neurological disorders associated with AUD, including alcohol withdrawal syndrome, Wernicke-Korsakoff syndrome, Marchiafava-Bignami disease, dementia, and neuropathy. To gain a better understanding of the neurological environment of alcoholism and to shed light on the role of various neurotransmitters in the phenomenon of alcoholism. A comprehensive search of online databases, including PubMed, EMBASE, Web of Science, and Google Scholar, was conducted to identify relevant articles. Several neurotransmitters (dopamine, gamma-aminobutyric acid, serotonin, and glutamate) have been linked to alcoholism due to a brain imbalance. Alcoholism appears to be a complex genetic disorder, with variations in many genes influencing risk. Some of these genes have been identified, including two alcohol metabolism genes, <i>alcohol dehydrogenase 1B gene</i> and <i>aldehyde dehydrogenase 2 gene</i>, which have the most potent known effects on the risk of alcoholism. Neuronal degeneration and demyelination in people with AUD may be caused by neuronal damage, nutrient deficiencies, and blood brain barrier dysfunction; however, the underlying mechanism is unknown. This review will provide a detailed overview of the neurobiology of alcohol addiction, followed by recent studies published in the genetics of alcohol addiction, molecular mechanism and detailed information on the various acute and chronic neurological manifestations of alcoholism for the Future research.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 1","pages":"100402"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of microRNA profiles in cavitatory and non-cavitatory pulmonary tuberculosis: Research protocol.","authors":"Swathy Moorthy, Emmanuel Bhaskar, Shivakumar Singh, Santhi Silambanan","doi":"10.5493/wjem.v15.i1.97460","DOIUrl":"10.5493/wjem.v15.i1.97460","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) is a common infection causing huge morbidity and mortality to mankind. The analytical methods used in diagnosing TB are not sensitive in paucibacillary infections and also require trained technical personnel. MicroRNAs are stable in serum and other body fluids, and hold great potential in the diagnosis of TB.</p><p><strong>Aim: </strong>To analyze the dysregulated microRNA profiles among patients with cavitatory and non-cavitatory pulmonary TB.</p><p><strong>Methods: </strong>The prospective study will be conducted in a tertiary care center in India. Adult patients with newly diagnosed pulmonary TB will be included. There will be two groups: Patients with sputum positive pulmonary TB with cavity and without cavity (group1), and apparently healthy individuals (group 2). The participants will undergo sputum examination, Xpert <i>Mycobacterium TB</i> complex/resistance to rifampin (<i>Mtb</i>/RIF) assay, chest X-ray, and blood investigations and serum microRNA detection. Ethics approval has been obtained. Written informed consent will be obtained. Appropriate statistical analyses will be used.</p><p><strong>Results: </strong>MicroRNAs will be correlated with sputum positivity, Xpert <i>Mtb</i>/RIF assay, radiological involvement, inflammatory markers, and course of the disease among cases and controls.</p><p><strong>Conclusion: </strong>MicroRNAs could serve as potential diagnostic biomarkers in diagnostically challenging TB patients.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 1","pages":"97460"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What would Hippocrates have sworn upon witnessing the COVID-19 mandates and mortality paradox.","authors":"Mina Thabet Kelleni","doi":"10.5493/wjem.v15.i1.98575","DOIUrl":"10.5493/wjem.v15.i1.98575","url":null,"abstract":"<p><p>For the first time in human history, hundreds of millions of people all over the world have been subjected to compulsory vaccination with a new type of nucleic acid based vaccines in order to keep their jobs or be able to travel due to some notorious coronavirus disease 2019 (COVID-19) mandates. The vast majority of African countries were either initially deprived of these vaccines, or later, a majority of the population was too skeptical to receive them and preferred a safe early treatment pharmacological approach. Yet, Africa had the lowest COVID-19 mortality rate compared to those countries that adopted mass vaccination. This letter to the editor adds African insights that should be helpful in future pandemics to save millions of precious lives.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 1","pages":"98575"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haematology results, inflammatory haematological ratios, and inflammatory indices in cervical cancer: How is the difference between cancer stage?","authors":"Phey Liana, Hanif Gusneri Syahbiran, Nurmalia Purnama Sari, Kemas Yakub Rahadiyanto, Raissa Nurwany, Wahyudi Nurhidayat, Tungki Pratama Umar","doi":"10.5493/wjem.v15.i1.96988","DOIUrl":"10.5493/wjem.v15.i1.96988","url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer is a prevalent form of cancer affecting women worldwide and it is the second most common cancer among women in Indonesia, accounting for 8.5% of all cancer-related deaths. Cervical cancer progression can be evaluated through laboratory tests to detect anaemia, an increased platelet count, and elevated inflammatory markers, therefore, effective laboratory examination is crucial for early detection and treatment of cervical cancer.</p><p><strong>Aim: </strong>To evaluate the association between laboratory findings (haematology, haematology index, and inflammatory index) and the clinical stage of cervical cancer.</p><p><strong>Methods: </strong>This cross-sectional study analyzed adult cervical cancer patients' data from medical records and laboratory results including sociodemographic status, histopathological finding, clinical stage, and complete haematology examination. Numerical data was analyzed by the one-way ANOVA (normal data distribution), while the Kruskal-Wallis test was used for non-parametric data (abnormal distribution), followed by appropriate post-hoc analysis. The categorical data was analyzed by the Chi-square or Fisher Exact tests. The significance level was established at a <i>P</i> value < 0.05.</p><p><strong>Results: </strong>This study involved the data of 208 adult cervical cancer patients and found no association between age, marital history, parity history, hormonal contraceptive use and cervical cancer stages. There were significant differences in the clinical laboratory test results based on the clinical stage of cervical cancer, including haemoglobin levels (<i>P</i> < 0.001), leucocytes (<i>P</i> < 0.001), neutrophils (<i>P</i> < 0.001), monocytes (<i>P</i> = 0.002), lymphocytes (<i>P</i> = 0.006), platelets (<i>P</i> < 0.001), neutrophil-lymphocyte ratio/NLR (<i>P</i> < 0.001), lymphocyte-monocyte ratio/LMR (<i>P</i> < 0.001), and platelet-lymphocyte ratio/PLR (<i>P</i> < 0.001). There were also significant differences in the systemic inflammatory index (SII) and systematic inflammatory response index (SIRI) between stage III + IV cervical cancer and stage II (SII <i>P</i> < 0.001; SIRI <i>P</i> = 0.001) and stage I (SII <i>P</i> < 0.001; SIRI <i>P</i> = 0.016), associated with the shifts in previously mentioned complete haematological values with cancer advancement.</p><p><strong>Conclusion: </strong>The haematological parameters, inflammatory haematological ratios, and inflammatory indices exhibited significant differences between cervical cancer stages, therefore these tests can be utilized to evaluate cervical cancer progression.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 1","pages":"96988"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of curcumin on gut microbiome.","authors":"Sangeetha Balaji, Naveen Jeyaraman, Madhan Jeyaraman, Swaminathan Ramasubramanian, Sathish Muthu, Gabriel Silva Santos, Lucas Furtado da Fonseca, José Fábio Lana","doi":"10.5493/wjem.v15.i1.100275","DOIUrl":"10.5493/wjem.v15.i1.100275","url":null,"abstract":"<p><p>The intricate interplay between natural compounds like curcumin and the gut microbiome has gained significant attention in recent years due to their potential therapeutic implications in various health conditions. Curcumin, a polyphenolic compound derived from turmeric, exhibits diverse pharmacological properties, including anti-inflammatory, antioxidant, and anticancer effects. Understanding how curcumin modulates gut microbiota composition and function is crucial for elucidating its therapeutic mechanisms. This review examines the current literature on the interactions between curcumin and the gut microbiome. A systematic search of relevant databases was conducted to identify studies investigating the effects of curcumin on gut microbial diversity and abundance. Key findings from studies exploring curcumin's efficacy in neurological disorders, gastrointestinal diseases, and metabolic dysfunction are synthesized and discussed. Studies have demonstrated that curcumin supplementation can modulate gut microbiota composition and function, leading to beneficial effects on gut health and homeostasis. Mechanisms underlying curcumin's therapeutic effects include immune modulation, neuroprotection, and inflammation regulation. However, challenges such as poor bioavailability and safety concerns remain significant hurdles to overcome. The interactions between curcumin and the gut microbiome hold promise for therapeutic interventions in a diverse range of health conditions. Further research is needed to optimize curcumin formulations, improve bioavailability, and address safety concerns.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 1","pages":"100275"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic strategies and prognostic challenges in linitis plastica.","authors":"Grigorios Christodoulidis, Sara Eirini Agko, Konstantinos Eleftherios Koumarelas, Marina Nektaria Kouliou","doi":"10.5493/wjem.v15.i1.96318","DOIUrl":"10.5493/wjem.v15.i1.96318","url":null,"abstract":"<p><p>Gastric cancer ranks fifth as the most common cancer and third as the leading cause of death worldwide. Risk factors include advancing age, low-fiber diets, high salt intake and <i>Helicobacter pylori</i> infection. Diagnosis relies on histological examination following endoscopic biopsy with staging accomplished through various imaging modalities. Early gastric cancer is primarily managed <i>via</i> endoscopic resection, while non-early operable cases typically undergo surgery. Advanced cases are addressed through sequential chemotherapy lines, with initial treatment usually comprising a platinum and fluoropyrimidine combination. Linitis plastica (LP) is a rare, aggressive form of gastric cancer characterized by diffuse infiltration of the gastric wall, resulting in poor outcomes even after curative resection. The absence of a standardized definition contributes to uncertainty regarding the precise incidence of these tumors. LP is often diagnosed at advanced stages, with a reported median survival rate of approximately 4%-29%, despite \"curative resection\". Its distinctive biological behavior includes perineural invasion, nodal metastasis, and peritoneal dissemination. The bleak prognosis for LP patients partly stems from delayed diagnosis and its aggressive biological nature, posing significant challenges for clinical management. Currently, no specialized treatment strategy exists for LP, and clinical approaches typically align with those used for general gastric cancer treatment. Surgical resection is the primary treatment, but the optimal surgical approach remains contentious. Recent studies have investigated the efficacy of neoadjuvant chemotherapy and radiotherapy in improving survival outcomes for LP patients. However, controversies persist regarding the role of adjuvant chemotherapy and postoperative radiotherapy. LP requires a multidisciplinary approach and personalized treatment strategies tailored to each patient's condition. Further research is needed to elucidate optimal therapeutic interventions and improve outcomes for LP patients.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 1","pages":"96318"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bile acid therapy for primary biliary cholangitis: Pathogenetic validation.","authors":"Vasiliy I Reshetnyak, Igor V Maev","doi":"10.5493/wjem.v15.i1.101771","DOIUrl":"10.5493/wjem.v15.i1.101771","url":null,"abstract":"<p><p>Knowledge of the etiological and pathogenetic mechanisms of the development of any disease is essential for its treatment. Because the cause of primary biliary cholangitis (PBC), a chronic, slowly progressive cholestatic liver disease, is still unknown, treatment remains symptomatic. Knowledge of the physicochemical properties of various bile acids and the adaptive responses of cholangiocytes and hepatocytes to them has provided an important basis for the development of relatively effective drugs based on hydrophilic bile acids that can potentially slow the progression of the disease. Advances in the use of hydrophilic bile acids for the treatment of PBC are also associated with the discovery of pathogenetic mechanisms of the development of cholangiocyte damage and the appearance of the first signs of this disease. For 35 years, ursodeoxycholic acid (UDCA) has been the unique drug of choice for the treatment of patients with PBC. In recent years, the list of hydrophilic bile acids used to treat cholestatic liver diseases, including PBC, has expanded. In addition to UDCA, the use of obeticholic acid, tauroursodeoxycholic acid and norursodeoxycholic acid as drugs is discussed. The pathogenetic rationale for treatment of PBC with various bile acid drugs is discussed in this review. Emphasis is made on the mechanisms explaining the beneficial therapeutic effects and potential of each of the bile acid as a drug, based on the understanding of the pathogenesis of the initial stages of PBC.</p>","PeriodicalId":75340,"journal":{"name":"World journal of experimental medicine","volume":"15 1","pages":"101771"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}