Thrombosis最新文献

Pathogenesis of Thromboembolism and Endovascular Management 血栓栓塞的发病机制和血管内治疗

Thrombosis Pub Date : 2017-01-05 DOI: 10.1155/2017/3039713

Sasan Behravesh, Peter Hoang, A. Nanda, A. Wallace, R. Sheth, A. Deipolyi, Adnan Memić, S. Naidu, R. Oklu

引用次数: 34

Referral Patterns and Diagnostic Yield of Lung Scintigraphy in the Diagnosis of Acute Pulmonary Embolism. 肺显像在急性肺栓塞诊断中的转诊模式和诊断率。

Thrombosis Pub Date : 2017-01-01 Epub Date: 2017-04-11 DOI: 10.1155/2017/1623868

Matthieu Pelletier-Galarneau, Erik Zannier, Lionel S Zuckier, Gregoire Le Gal

{"title":"Referral Patterns and Diagnostic Yield of Lung Scintigraphy in the Diagnosis of Acute Pulmonary Embolism.","authors":"Matthieu Pelletier-Galarneau, Erik Zannier, Lionel S Zuckier, Gregoire Le Gal","doi":"10.1155/2017/1623868","DOIUrl":"https://doi.org/10.1155/2017/1623868","url":null,"abstract":"Introduction. The purpose of this study is to assess referral patterns and the yield of ventilation-perfusion (V/Q) scintigraphy in patients referred for acute pulmonary embolism (PE). Methods. We retrospectively reviewed the charts of all patients who underwent V/Q studies between April 1, 2008, and March 31, 2010. Patients were subdivided into 4 groups based on their referral source: emergency department (ED), hospital inpatient ward, outpatient thrombosis clinic, and all other outpatient sources. Results. A total of 1008 patients underwent V/Q scintigraphy to exclude acute PE. The number of ED, inpatient, thrombosis clinic, and outpatient studies was 43 (4.3%), 288 (28.6%), 351 (34.8%), and 326 (32.3%). Proportion of patients with contrast contraindication varied significantly among the different groups. Of the 1,008 studies, 331 (32.8%) were interpreted as normal, 408 (40.5%) as low, 158 (15.7%) as intermediate, and 111 (11.0%) as high probability for PE. 68 (6.7%) patients underwent CTPA within 2 weeks following V/Q. Conclusion. The rate of nondiagnostic studies is lower than that reported in previously published data, with a relatively low rate of intermediate probability studies. Only a small fraction of patients undergoing a V/Q scan will require a CTPA.","PeriodicalId":75222,"journal":{"name":"Thrombosis","volume":"2017 ","pages":"1623868"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1623868","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34985396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

miR-19a and miR-20a and Tissue Factor Expression in Activated Human Peripheral Blood Mononuclear Cells. 活化的人外周血单核细胞中miR-19a、miR-20a与组织因子的表达

Thrombosis Pub Date : 2017-01-01 Epub Date: 2017-10-30 DOI: 10.1155/2017/1076397

Cristina Balia, Mirella Giordano, Valentina Scalise, Tommaso Neri, Gabriella Fontanini, Fulvio Basolo, Alessandro Celi, Roberto Pedrinelli

{"title":"miR-19a and miR-20a and Tissue Factor Expression in Activated Human Peripheral Blood Mononuclear Cells.","authors":"Cristina Balia, Mirella Giordano, Valentina Scalise, Tommaso Neri, Gabriella Fontanini, Fulvio Basolo, Alessandro Celi, Roberto Pedrinelli","doi":"10.1155/2017/1076397","DOIUrl":"https://doi.org/10.1155/2017/1076397","url":null,"abstract":"Background and aims: To investigate the behaviour of miR-19a and miR-20a, two microRNAs involved in posttranscriptional modulation of TF expression in peripheral blood mononuclear cells (PBMCs) exposed to high glucose (HG) and lipopolysaccharide (LPS), and to evaluate the involvement of angiotensin II in that process.Methods: TF Procoagulant Activity (PCA, one-stage clotting assay), antigen (Ag, ELISA), and miR-19a and miR-20a levels (specific TaqMan® MicroRNA Assays) were evaluated in PBMCs exposed to high glucose (HG, 50 mM), LPS (100 ng/mL), and Olmesartan (OLM, 10-6 M), an angiotensin II type 1 receptor antagonist.Results: HG increased TF expression and decreased both miRs as compared to control glucose conditions (11.1 mM). In HG-activated PBMCs, LPS stimulated TF expression and downregulated miR-20a, an effect reverted by OLM (10-6 M); miR-19a expression was unchanged by LPS in both CG and HG conditions.Conclusions: miR-19a and miR-20a are inhibited by inflammatory stimuli active on TF expression and their response differs by the stimulus under investigation; angiotensin II may participate in that mechanism.","PeriodicalId":75222,"journal":{"name":"Thrombosis","volume":"2017 ","pages":"1076397"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1076397","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35228570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Medicinal Herbals with Antiplatelet Properties Benefit in Coronary Atherothrombotic Diseases 具有抗血小板特性的草药对冠状动脉粥样硬化性疾病有益

Thrombosis Pub Date : 2016-03-14 DOI: 10.1155/2016/5952910

N. H. Mohd Nor, F. Othman, Eusni Rahayu Mohd Tohit, S. Md Noor

引用次数: 20

The Incidence of Peripheral Catheter-Related Thrombosis in Surgical Patients 手术患者外周导管相关血栓的发生率

Thrombosis Pub Date : 2016-01-24 DOI: 10.1155/2016/6043427

Amy Leung, C. Heal, Jennifer Banks, Breanna Abraham, Gianmarco Capati, C. Pretorius

{"title":"The Incidence of Peripheral Catheter-Related Thrombosis in Surgical Patients","authors":"Amy Leung, C. Heal, Jennifer Banks, Breanna Abraham, Gianmarco Capati, C. Pretorius","doi":"10.1155/2016/6043427","DOIUrl":"https://doi.org/10.1155/2016/6043427","url":null,"abstract":"Background. Central venous catheters and peripherally inserted central catheters are well established risk factors for upper limb deep vein thrombosis. There is limited literature on the thrombosis rates in patients with peripheral catheters. A prospective observational study was conducted to determine the incidence of peripheral catheter-related thrombosis in surgical patients. Methods. Patients deemed high risk for venous thrombosis with a peripheral catheter were considered eligible for the study. An ultrasound was performed on enrolment into the study and at discharge from hospital. Participants were reviewed twice a day for clinical features of upper limb deep vein thrombosis during their admission and followed up at 30 days. Results. 54 patients were included in the study. The incidence of deep vein thrombosis and superficial venous thrombosis was 1.8% and 9.2%, respectively. All cases of venous thrombosis were asymptomatic. Risk factor analysis was limited by the low incidence of thrombosis. Conclusion. This study revealed a low incidence of deep vein thrombosis in surgical patients with peripheral catheters (1.8%). The study was underpowered; therefore the association between peripheral catheters and thrombosis is unable to be established. Future studies with larger sample sizes are required to determine the association between peripheral catheters and thrombosis.","PeriodicalId":75222,"journal":{"name":"Thrombosis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89537558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

The Typical Presentation Spectrum of Deep Vein Thrombosis Associated with Inferior Vena Cava Malformations. 与下腔静脉畸形相关的深静脉血栓的典型表现谱。

Thrombosis Pub Date : 2016-01-01 Epub Date: 2016-07-10 DOI: 10.1155/2016/4965458

Agostino Pozzi, Mustapha A El Lakis, Jad Chamieh, Beatriz Barberà Carbonell, Fabio Villa

引用次数: 0

Out of Sight, out of Mind? An Audit Which Proposes a Follow-Up and Management Pathway for Inferior Vena Cava Filters. 眼不见，心不烦?下腔静脉过滤器的审计及后续处理途径。

Thrombosis Pub Date : 2016-01-01 Epub Date: 2016-03-27 DOI: 10.1155/2016/6538456

Caitriona Logan, Niamh O'Connell, John Kavanagh, Niall McEniff, Mark Ryan, Michael Guiney, Orla Seery, James O'Donnell, Kevin Ryan, Barry White

{"title":"Out of Sight, out of Mind? An Audit Which Proposes a Follow-Up and Management Pathway for Inferior Vena Cava Filters.","authors":"Caitriona Logan, Niamh O'Connell, John Kavanagh, Niall McEniff, Mark Ryan, Michael Guiney, Orla Seery, James O'Donnell, Kevin Ryan, Barry White","doi":"10.1155/2016/6538456","DOIUrl":"https://doi.org/10.1155/2016/6538456","url":null,"abstract":"Insertion of an IVC filter can be a safe and effective way to avoid PE in thrombosis patients who cannot be anticoagulated. If temporary filters are not promptly removed they can become difficult to remove, causing avoidable complications and often requiring lifelong warfarin. In this study, two sequential audits of retrieval of temporary IVC filters were conducted before and after the implementation of a coordinated management strategy for IVC filter follow-up. 33 filter placements were examined over a 15-month period (Group A). Following implementation of the strategy a comparable 15-month period in which 33 IVC filters were placed was audited (Group B). Following implementation, failed retrievals dropped from 15% to 9%. The number successfully retrieved did not change at 45%. The number made permanent from the outset following expert discussion increased from 12% to 39%. The number of filters with no attempted retrieval and no consultation about retrieval decreased from 27% to 9% (these patients were lost to follow-up with multiple contact attempts made). In Group B 100% of placed IVC filters were followed up appropriately. The proposed model is an easily implemented plan to avoid patient morbidity caused by temporary IVC filters made unintentionally permanent by loss to follow-up. ","PeriodicalId":75222,"journal":{"name":"Thrombosis","volume":"2016 ","pages":"6538456"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6538456","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34429116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Length of Stay Comparison between Rivaroxaban and Warfarin in the Treatment of Pulmonary Embolism: Results from a Real-World Observational Cohort Study 利伐沙班和华法林治疗肺栓塞的住院时间比较:来自真实世界观察队列研究的结果

Thrombosis Pub Date : 2015-12-31 DOI: 10.1155/2015/414523

K. Roberts, Tamara B Knight, Eimeira Padilla-Tolentino, Manasa S. Murthy, Evan J. Peterson

{"title":"Length of Stay Comparison between Rivaroxaban and Warfarin in the Treatment of Pulmonary Embolism: Results from a Real-World Observational Cohort Study","authors":"K. Roberts, Tamara B Knight, Eimeira Padilla-Tolentino, Manasa S. Murthy, Evan J. Peterson","doi":"10.1155/2015/414523","DOIUrl":"https://doi.org/10.1155/2015/414523","url":null,"abstract":"Background. Trials have shown that novel oral anticoagulants may decrease length of stay versus warfarin. A comparison of length of stay in the treatment of pulmonary embolism (PE) has not been performed outside post hoc analysis of a large clinical trial. Objective. To evaluate if rivaroxaban decreases length of stay compared to warfarin plus enoxaparin in the treatment of PE. Methods. This was a multicenter, retrospective, observational cohort study. Patients were identified based on discharge diagnosis of PE and were excluded if they received anticoagulants prior to admission and had additional indications for anticoagulation or reduced creatinine clearance. The primary endpoint was length of stay. Secondary endpoints included time from initial dose of oral anticoagulant to discharge and length of stay comparison between subgroups. Results. Inclusion criterion was met by 158 patients (82 warfarin, 76 rivaroxaban). The median length of stay was 4.5 days (interquartile range [IQR], 2.7, 5.9) in the warfarin group and 1.8 days (IQR, 1.2, 3.7) in the rivaroxaban group (P < 0.001). Time interval from first dose of oral anticoagulant to discharge was shorter with rivaroxaban (P < 0.001). Conclusions. Patients given rivaroxaban had decreased length of stay versus those given warfarin plus enoxaparin for the treatment of PE.","PeriodicalId":75222,"journal":{"name":"Thrombosis","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84347805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Comparison of Chemical and Mechanical Prophylaxis of Venous Thromboembolism in Nonsurgical Mechanically Ventilated Patients 非手术机械通气患者静脉血栓栓塞化学预防与机械预防的比较

Thrombosis Pub Date : 2015-11-22 DOI: 10.1155/2015/849142

Dany Gaspard, K. Vito, C. Schorr, K. Hunter, D. Gerber

{"title":"Comparison of Chemical and Mechanical Prophylaxis of Venous Thromboembolism in Nonsurgical Mechanically Ventilated Patients","authors":"Dany Gaspard, K. Vito, C. Schorr, K. Hunter, D. Gerber","doi":"10.1155/2015/849142","DOIUrl":"https://doi.org/10.1155/2015/849142","url":null,"abstract":"Background. Thromboembolic events are major causes of morbidity, and prevention is important. We aimed to compare chemical prophylaxis (CP) and mechanical prophylaxis (MP) as methods of prevention in nonsurgical patients on mechanical ventilation. Methods. We performed a retrospective study of adult patients admitted to the Cooper University Hospital ICU between 2002 and 2010. Patients on one modality of prophylaxis throughout their stay were included. The CP group comprised 329 patients and the MP group 419 patients. The primary outcome was incidence of thromboembolic events. Results. Acuity measured by APACHE II score was comparable between the two groups (p = 0.215). Univariate analysis showed 1 DVT/no PEs in the CP group and 12 DVTs/1 PE in the MP group (p = 0.005). Overall mortality was 34.3% and 50.6%, respectively. ICU LOS was similar. Hospital LOS was shorter in the MP group. Multivariate analysis showed a significantly higher incidence of events in the MP prophylaxis group (odds ratio 9.9). After excluding patients admitted for bleeding in both groups, repeat analysis showed again increased events in the MP group (odds ratio 2.9) but this result did not reach statistical significance. Conclusion. Chemical methods for DVT/PE prophylaxis seem superior to mechanical prophylaxis in nonsurgical patients on mechanical ventilation and should be used when possible.","PeriodicalId":75222,"journal":{"name":"Thrombosis","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83471302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

The Perception of Evidence for Venous Thromboembolism Prophylaxis Current Practices after Cardiac Surgery: A Canadian Cross-Sectional Survey 心脏手术后静脉血栓栓塞预防的证据感知:加拿大横断面调查

Thrombosis Pub Date : 2015-11-02 DOI: 10.1155/2015/795645

H. Mufti, R. Baskett, R. Arora, J. Légaré

{"title":"The Perception of Evidence for Venous Thromboembolism Prophylaxis Current Practices after Cardiac Surgery: A Canadian Cross-Sectional Survey","authors":"H. Mufti, R. Baskett, R. Arora, J. Légaré","doi":"10.1155/2015/795645","DOIUrl":"https://doi.org/10.1155/2015/795645","url":null,"abstract":"Background. Venous thromboembolism (VTE) is the third leading cause of cardiovascular death in patients undergoing surgery. However, VTE prophylaxis practices in cardiac surgery are based on noncardiac surgical literature. The objective of our study was to extract current patterns of VTE prophylaxis practices in cardiac surgery patients. We also aimed to identify health care professionals knowledge of available evidence supporting VTE prophylaxis in adult cardiac surgery patients. Methods. A web-based survey was developed and sent to all Canadian cardiac surgery centers with the intent to have the survey distributed to all personnel involved in the perioperative care of adult cardiac surgery patients. Participation in the questionnaire was voluntary and anonymized. Results. Thirty-five responses were obtained. Sixty-nine percent reported having an established protocol for VTE prophylaxis. However, 83% reported using VTE prophylaxis in their daily practice despite lack of protocol. The majority (60%) believed that the class of recommendation was high despite the lack of evidence. Conclusions. Our survey demonstrated the following. (a) Majority of Canadian centers employ VTE prophylaxis, with considerable variability. (b) There is a misconception among health care professionals about the strength of evidence supporting VTE prophylaxis in cardiac surgery. Our findings highlight the need for appropriately designed studies to fill this knowledge gap.","PeriodicalId":75222,"journal":{"name":"Thrombosis","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85241849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1