Environmental Science: Processes & Impacts最新文献

{"title":"Correction: Responses of CO2 and CH4 in the alpine wetlands of the Tibetan Plateau to warming and nitrogen and phosphorus additions","authors":"Wenbao Zhang, Huijuan Xin, Zongxing Li, Qiao Cui, Bin Xu, Biao Tang, Yaning Wang, Chong Xu and Jian Xue","doi":"10.1039/D5EM90001H","DOIUrl":"10.1039/D5EM90001H","url":null,"abstract":"<p >Correction for ‘Responses of CO<small>₂</small> and CH<small>₄</small> in the alpine wetlands of the Tibetan Plateau to warming and nitrogen and phosphorus additions’ by Wenbao Zhang <em>et al.</em>,<em>Environ. Sci.: Processes Impacts</em>, 2024, <strong>26</strong>, 1516–1525, https://doi.org/10.1039/D4EM00174E.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" 2","pages":" 513-513"},"PeriodicalIF":4.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/em/d5em90001h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The INGENIOUS project: towards understanding air pollution in homes†","authors":"Nicola Carslaw, Jennifer Aghaji, Sri Hapsari Budisulistiorini, David C. Carslaw, Lia Chatzidiakou, Rachael W. Cheung, Terry J. Dillon, Pete Edwards, Denisa Genes, Chiara Giorio, Jacqueline F. Hamilton, Erika Ikeda, Roderic L. Jones, James Lee, Alastair C. Lewis, Ashish Kumar, Rosemary McEachan, Gordon McFiggans, Tim Murrels, Nicholas Pleace, Athina Ruangkanit, Yunqi Shao, Simon P. O'Meara, David R. Shaw, Marvin Shaw, Dagmar Waiblinger, Tom Warburton, Sarah West, Chantelle Wood and Tiffany Yang","doi":"10.1039/D4EM00634H","DOIUrl":"10.1039/D4EM00634H","url":null,"abstract":"<p >This paper provides an overview of the INGENIOUS (UnderstandING the sourcEs, traNsformations and fates of IndOor air pollUtantS) project, aiming to better understand air pollution in homes. Although our homes are the microenvironment in which we spend most of our time, we know relatively little about the sources, transformation processes and fates of indoor air pollutants, or our exposure to them. INGENIOUS aims to address this knowledge gap by delivering: an indoor emissions inventory for UK homes; comprehensive air pollutant measurements in 310 homes in Bradford using a combination of low cost-sensors and more advanced air quality instrumentation; an analysis of the impact of indoor air pollution on outdoor air quality and <em>vice versa</em> using mobile measurements; insight into future indoor air quality using detailed air pollution models; identification of indoor air pollutants that warrant further toxicological study; and better understanding of the barriers and facilitators for behaviour that drives improved indoor air quality. Median daily PM<small>_2.5</small> and CO<small>₂</small> concentrations varied from 7.8 μg m<small>⁻³</small> and 666 ppm in the summer, to 16.4 μg m<small>⁻³</small> and 857 ppm in the winter respectively in our sampled homes. Peak daily PM<small>_2.5</small> concentrations above 150 μg m<small>⁻³</small> were frequently observed across all seasons, and were driven by cooking. Cooking activities also generated high concentrations of volatile organic compounds during emissions measurements, such as harmful aldehydes (up to ∼50 ppb), and alcohols (up to ∼600 ppb) from a chicken stir-fry. Our sampled homes displayed a wide variation in indoor pollutant concentrations, with a strong link to behaviour, including frequency and type of cooking activities, and use of ventilation.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" 2","pages":" 355-372"},"PeriodicalIF":4.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/em/d4em00634h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143031679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key role of persistent free radicals in soil for persulfate activation: impacts on benzo[a]pyrene degradation†","authors":"Yiwen Ou, Xintong Li, Shixu Feng and Hongxia Zhao","doi":"10.1039/D4EM00437J","DOIUrl":"10.1039/D4EM00437J","url":null,"abstract":"<p >Environmentally persistent free radicals (EPFRs) have been widely detected in polycyclic aromatic hydrocarbon (PAH)-contaminated soils, but the activation of persulfate by inherent EPFRs in PAH-contaminated soil for the transformation of PAHs remains unclear. In the present study, benzo[<em>a</em>]pyrene (B[<em>a</em>]P) was selected as a representative PAH and its transformation in a persulfate/B[<em>a</em>]P-contaminated soil system was studied without the addition of any other activator. Results indicated that EPFRs in the soil activated persulfate to produce reactive oxygen species (ROS) and degraded B[<em>a</em>]P. It was found that the decomposition of persulfate was accompanied with the decay of EPFRs in the soil, which was quantified using electron paramagnetic resonance (EPR) technique. Correspondingly, combined with EPR and quenching experiments, it was confirmed that sulfate radicals (SO<small>₄</small>˙<small>⁻</small>), hydroxyl radicals (˙OH), superoxide radicals (˙O<small>₂</small><small>⁻</small>) and singlet oxygen (<small>¹</small>O<small>₂</small>) coexist in the reaction system, and ˙O<small>₂</small><small>⁻</small> and <small>¹</small>O<small>₂</small> play major roles in the degradation of B[<em>a</em>]P. Primary intermediates were identified <em>via</em> gas chromatography-mass spectrometry (GC-MS), and the transformation pathway underlying B[<em>a</em>]P degradation was proposed. Furthermore, the acute and chronic toxicities of seven intermediates to aquatic organisms were predicted using Ecological Structure Activity Relationships (ECOSAR) software, and the corresponding results showed that the seven intermediates detected were very toxic to the environment. This study provides new insights into the activation of persulfate by EPFRs in the degradation of refractory pollutants.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" 2","pages":" 390-400"},"PeriodicalIF":4.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary insight into the intracellular behaviour of rare earths and other technology-critical elements (TCEs) in northern pike liver: study of TCE-binding biomolecules via size-exclusion HPLC-ICP-MS†","authors":"Zrinka Dragun, Zoran Kiralj, Željka Fiket and Dušica Ivanković","doi":"10.1039/D4EM00674G","DOIUrl":"10.1039/D4EM00674G","url":null,"abstract":"<p >Technology-critical elements (TCEs) refer to the elements that play an important role in many emerging technologies and the production of advanced materials, and these include lanthanides, tungsten and vanadium. Actinides, Tl, and Pb, which also belong to TCEs, are abundantly used in power generation, industrial applications, and modern agricultural practices. The information on the influence of these elements on the aquatic environment and biota is still rather scarce. Thus, the distributions of the above-mentioned metals among cytosolic biomolecules of different molecular masses in the liver of the northern pike (<em>Esox lucius</em>) from the Mrežnica River (Croatia) were studied to obtain an insight into their intracellular behaviour and potential for toxicity. The applied method was a hyphenated system of size-exclusion high-performance liquid chromatography and inductively coupled plasma mass spectrometry. In the samples with lower cytosolic concentrations, the obtained distributions of several TCEs (lanthanides, W, Th, and U) and Pb, among biomolecules of a wide range of molecular masses, which covered the entire column separation range (&lt;10 to &gt;600 kDa), indicated their nonspecific binding to various intracellular components. In the sample with the highest cytosolic concentration, a shift towards the highest molecular masse (&gt;600 kDa) was observed for lanthanides and actinides, which is a sign of their possible binding to protein aggregates. In contrast, W and Pb showed a preference for medium molecular mass biomolecules (30–100 kDa). Moreover, it was hypothesized that prominent elution of U and Pb observed in the low molecular mass region (&lt;10 kDa) possibly indicated their partial detoxification. Potential Pb associations with metallothionein-like proteins were also recorded (∼6–7 kDa). The remaining two elements, V and Tl, exhibited more specific intracellular binding, as they were eluted within one/two narrow peaks in the high molecular mass region (575 kDa/100–400 kDa). The tendency of the studied TCEs and other potentially toxic elements to bind to medium and high molecular mass intracellular proteins necessitates further research of their specific targets.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" 1","pages":" 262-276"},"PeriodicalIF":4.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/em/d4em00674g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissolved phosphorous through dry–wet–dry transitions in a small-dammed river basin: integrated understanding on transport patterns, export controls, and fate†","authors":"H. K. M. Mihiranga, Yan Jiang, M. G. S. Sathsarani and Xuyong Li","doi":"10.1039/D4EM00686K","DOIUrl":"10.1039/D4EM00686K","url":null,"abstract":"<p >An integrated understanding of dissolved phosphorous (DP) export mechanism and controls on export over dry and wet periods is crucial for riverine ecological restorations in dammed river basins considering its high bioavailability and retention rates at dams. Riverine DP transport patterns (composition, sources, and transport pathways), export controls, and fate were investigated over the 2020 wet season (5 events) and dry seasons before and after it (2 events: dry<small>_(before)</small> and dry<small>_(after)</small>) in a semi-arid, small-dammed watershed to comprehend the links between terrestrial DP sources and aquatic DP sinks. Close spatiotemporal monitoring of the full range of phosphorous and total suspended solids (TSSs) and subsequent analyses (hysteresis, hierarchical partitioning, and coefficient of variation) provided the basis for the study. Total-DP (TDP) shared 13–39% (25%) of total-P (TP) through storms, dissolved organic-P (DOP) shared 6–21% (12%), and phosphate-P shared (PO<small>₄</small>-P) 7–22% (13%). DP forms displayed strong connections with discharge trends across the wet season, and marked changes in the shares were reported over dry–wet and wet–dry transitions. The DOP fraction of TDP increased from 4% in dry<small>_(before)</small> baseflow to 64% at the end of the wet season. The DOP flux increment in stormflow was 20 folds compared to dry<small>_(before)</small> baseflow, while that of PO<small>₄</small>-P was 2 folds. DOP displayed the least spatial source heterogeneity with minimum anthropogenic pressure on inherent fluxes. DOP originated from overland and near-stream soil sources and was transported <em>via</em> surface runoff and soil water runoff, respectively. Across the wet season, the attrition of overland DOP sources and activation of near-stream soil DOP sources through strengthened hydrological connectivity governed the seasonal DOP trends. Surface and groundwater runoff pathways were important for PO<small>₄</small>-P delivery during stormflow; nonetheless, wastewater treatment plant (WWTP) effluent was the main PO<small>₄</small>-P source under both baseflow and stormflow regimes, followed by near-stream traditional agriculture lands. The interaction patterns of small dam systems with DP inputs through dry–wet periods were explained. The riverine PO<small>₄</small>-P fluxes were profoundly impacted by in-stream biogeochemical and physical processes and small dam systems, while riverine DOP fluxes were relatively less influenced.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" 2","pages":" 373-389"},"PeriodicalIF":4.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental drivers of monomethylmercury photodegradation along the land-to-ocean aquatic continuum†","authors":"Sonja Gindorf, Johannes West, Andrew Graham and Sofi Jonsson","doi":"10.1039/D4EM00636D","DOIUrl":"10.1039/D4EM00636D","url":null,"abstract":"<p >In surface waters, photodegradation is a major abiotic removal pathway of the neurotoxin monomethylmercury (MMHg), acting as a key control on the amounts of MMHg available for biological uptake. Different environmental factors can alter the rate of MMHg photodegradation. However, our understanding of how MMHg photodegradation pathways in complex matrixes along the land-to-ocean aquatic continuum respond to changes in salinity, dissolved organic carbon (DOC) concentration and dissolved organic matter (DOM) composition is incomplete. In a set of laboratory experiments combining several artificial and natural waters, we demonstrate that the interplay of DOC concentration, DOM composition, and salinity affects the photodegradation rate of MMHg. The presence of DOM was found to facilitate MMHg photodegradation, but degradation rates were not altered by varying DOC concentrations over two orders of magnitude. We found DOM composition to have a stronger effect on MMHg photodegradation rates than DOC concentration. However, at high DOC levels, where most UV radiation was lost within the first cm of the reaction vessels, lower MMHg photodegradation rates were observed. When moving from terrestrially influenced waters, characterized by a high degree of humification, towards marine conditions with a protein-rich DOM pool, MMHg photodegradation rates increased. In contrast, salinity had a stabilizing effect on MMHg. Hence, especially in systems with low salt and DOC concentrations, changes in either salinity or DOC concentration can impact the photodegradation rates of MMHg.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" 2","pages":" 401-411"},"PeriodicalIF":4.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/em/d4em00636d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accounting for <i>in situ</i> air cleaner utilization and performance to improve interpretation of patient outcomes in real-world indoor air cleaner intervention trials.","authors":"Saeed Farhoodi, Insung Kang, Yicheng Zeng, Kaveeta Jagota, Nancy Karpen, Mohammad Heidarinejad, Zane Elfessi, Israel Rubinstein, Brent Stephens","doi":"10.1039/d4em00648h","DOIUrl":"https://doi.org/10.1039/d4em00648h","url":null,"abstract":"<p><p>There is an increasing number of randomized clinical trials intended to assess the effectiveness of indoor air cleaners for improving participant outcomes in real-world settings. In this communication, we synthesize the current state of registered air cleaner intervention trials and call attention to the critical importance of conducting measurements to characterize the performance and <i>in situ</i> utilization of air cleaners in such trials to improve interpretation of exposure measurements and patient outcomes. We draw upon the existing literature and preliminary findings from our ongoing one-year, randomized, single-blind, placebo-controlled case-control trial of stand-alone air filtration in the homes of U.S. military Veterans to inform our recommendations. We demonstrate how to conduct industry-standard performance testing and how to use long-term measurements of air cleaner power draw to assess air cleaner operation. In our analysis of interim data from 53 homes to date with a mean data collection period of 275 days, we found that most air cleaners, whether active or sham, were operated predominantly at low or medium fan speeds, and most participants operated their air cleaner on predominantly one fan speed. In a few homes, air cleaners were mostly off. We estimate that air cleaner operation in these homes is providing a median additional equivalent particle loss rate of ∼0.7/h (ranging ∼0-2.8/h). Accordingly, we recommend that air cleaner intervention trials adopt the steps described herein to account for the amount of clean air delivered in real-world settings and to provide important context alongside indoor exposure measurements and analysis of patient outcomes.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of volatile organic compound metabolites with hearing loss: unveiling their potential mechanism and intervention target†","authors":"Jingcheng Zhou, Guanchao Sun, Houming Zhao, Handai Qin, Yiming Bi and Xuemin Chen","doi":"10.1039/D4EM00644E","DOIUrl":"10.1039/D4EM00644E","url":null,"abstract":"<p >Hearing loss (HL) is an otolaryngology disease susceptible to environmental pollutants. Volatile organic compounds (VOCs), as a class of chemical pollutants with evaporation propensity, pose a great threat to human health. However, the association between VOCs and HL remains unclear. This study aimed to explore the association between urinary-specific VOC metabolites and HL. It included 1048 participants from the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2012. Multivariate linear regression models, smooth curve analysis, and stratified analysis were employed to investigate the relationship between urinary-specific VOC metabolite concentrations and pure tone audiometry (PTA) across three different frequencies. A two-piecewise linear regression model was employed to analyze the threshold effects of urinary-specific VOC metabolites on hearing threshold changes. Furthermore, a comparative toxicogenomics database (CTD) and functional gene enrichment were constructed. An interaction network of transcription factors, genes, and non-coding RNA was constructed to further confirm the upstream and downstream regulatory relationships. Molecular docking analyses were conducted to explore the potential binding modes and critical docking sites. Additionally, a moderation analysis was conducted to investigate the role of oxidative stress in moderating the influence of VOC metabolites on hearing. Multivariate linear regression model discerned a significant correlation between cyanide 2-aminothiazoline-4-carboxylic acid (ATCA) with speech-frequency PTA and <em>N</em>-acetyl-<em>S</em>-(3,4-dihydroxybutyl)-<small>L</small>-cysteine (DHBMA) with high-frequency PTA. The smoothed curve and threshold effect analysis corroborated a positive linear relationship between cyanide ATCA and speech-frequency PTA without a threshold effect only in the 20–34 age group. Additionally, the bioinformatics analysis discovered pathogenic genes related to cyanide-induced HL and suggested that oxidative stress responses play a critical role in this biological process. Furthermore, the moderation effect of total bilirubin (TB), an oxidative stress-associated molecule, was ascertained on the effects of ATCA on hearing. Our findings suggest a potential link between VOC metabolites and hearing and indicate the crucial role of oxidative stress responses in this association.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" 2","pages":" 437-452"},"PeriodicalIF":4.3,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on environmental contamination of petroleum hydrocarbons, its effects and remediation approaches","authors":"Bzhwen Khalid Majeed, Dler M.S Shwan and Khasraw Abdullah Rashid","doi":"10.1039/D4EM00548A","DOIUrl":"10.1039/D4EM00548A","url":null,"abstract":"<p >Oil leakage into soil is a major environmental concern, affecting its physical, chemical, biological, and geotechnical properties, which threatens soil fertility. Remediating contaminated sites helps mitigate risks to human health, the environment, and the economy, while also enabling land reuse for development or agriculture. Petroleum spills generally occur during production, processing, transportation, and storage. This review discusses the impact of hydrocarbon contamination on soil and its surrounding environment and examines various remediation techniques, including physical–chemical methods (soil excavation, soil washing, soil vapor extraction, thermal treatment, and chemical oxidation), biological methods (bioremediation and phytoremediation), nanotechnology-based approaches, and integrated methods. The effectiveness, limitations, and applicability of these techniques are critically analyzed, providing a comprehensive framework for managing soil contamination by petroleum hydrocarbons.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" 3","pages":" 526-548"},"PeriodicalIF":4.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal effect of PM_2.5 exposure in patients with COPD: a multicentre panel study.","authors":"Jin-Young Huh, Hajeong Kim, Shinhee Park, Seung Won Ra, Sung-Yoon Kang, Bock Hyun Jung, Mihye Kim, Sang Min Lee, Sang Pyo Lee, Dirga Kumar Lamichhane, Young-Jun Park, Seon-Jin Lee, Jae Seung Lee, Yeon-Mok Oh, Hwan-Cheol Kim, Sei Won Lee","doi":"10.1039/d4em00376d","DOIUrl":"https://doi.org/10.1039/d4em00376d","url":null,"abstract":"<p><p><i>Background</i>: Exposure to particulate matter <2.5 μm (PM_2.5) is linked to chronic obstructive pulmonary disease (COPD), but most studies lack individual PM_2.5 measurements. Seasonal variation and their impact on clinical outcomes remain understudied. <i>Objective</i>: This study investigated the impact of PM_2.5 concentrations on COPD-related clinical outcomes and their seasonal changes. <i>Methods</i>: A multicentre panel study enrolled 105 COPD patients (age range: 46-82) from July 2019 to August 2020. Their mean forced expiratory volume in 1 second after bronchodilation was 53.9%. Individual PM_2.5 levels were monitored continuously with indoor measurements at residences and outdoor data from the National Ambient Air Quality Monitoring Information System. Clinical parameters, including pulmonary function tests, symptom questionnaires (CAT and SGRQ-C), and impulse oscillometry (IOS), were assessed every three months over the course of one year. Statistical analysis was conducted using a linear mixed-effect model to account for repeated measurements and control for confounding variables, including age, sex, smoking status and socioeconomic status. <i>Results</i>: The mean indoor and outdoor PM_2.5 concentrations were 16.2 ± 8.4 μg m^-3 and 17.2 ± 5.0 μg m^-3, respectively. Winter had the highest PM_2.5 concentrations (indoor, 18.8 ± 11.7 μg m³; outdoor, 22.5 ± 5.0 μg m^-3). Higher PM_2.5 concentrations significantly correlated with poorer St. George's Respiratory Questionnaire for COPD (SGRQ-C) scores and increased acute exacerbations, particularly in winter. Patients of lower socioeconomic status were more vulnerable. Increased PM_2.5 concentrations were also associated with amplified small airway resistance (<i>R</i>5-<i>R</i>20). <i>Conclusions</i>: PM_2.5 concentration changes are positively correlated with poorer SGRQ-C scores and increased acute exacerbations in COPD patients with significant seasonal variations, especially in winter.</p>","PeriodicalId":74,"journal":{"name":"Environmental Science: Processes & Impacts","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}