Neonicotinoid insecticide sulfoxaflor in the environment: a critical review of environmental fate, degradation mechanism, and toxic effects†

In recent decades, neonicotinoids (NEOs) have become widely adopted in agriculture for the control of crop pests and plant pathogens, leading to improved crop yields and enhanced agricultural productivity. However, the prolonged and widespread use of NEOs has raised significant concerns regarding their environmental persistence, food safety, and public health risks. These pesticides have been shown to contaminate various environmental compartments, including soil, surface water, and groundwater, posing potential hazards to ecosystems and human health. Microbes play a crucial role in mitigating the environmental impact of toxic pesticides, with microbial degradation emerging as a promising, cost-effective strategy for degrading pesticide residues. Several sulfoxaflor (SUL)-degrading microbes have been isolated and characterized, yet the identification of microbes, genes, and enzymes responsible for the degradation of NEOs remains an area requiring further investigation. Despite some progress, few reviews have comprehensively addressed the underlying mechanisms of NEOs degradation. This paper provides a detailed review of research on the environmental distribution, exposure risks, and ecotoxicological effects of NEOs, with a particular focus on the environmental fate of SUL. It aims to offer a novel perspective on the fate of NEOs in the environment, their potential toxicological effects, and the role of microbes in mitigating their impact.