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The outcomes of right and left complicated colonic diverticulitis 左、右合并结肠憩室炎的预后
IF 1.4
Surgery open science Pub Date : 2025-06-15 DOI: 10.1016/j.sopen.2025.06.005
Anh Tuan Nguyen , Quang Tien Pham , Hoi Van Tran , Hoang Viet Truong , Loc Huynh Tran
{"title":"The outcomes of right and left complicated colonic diverticulitis","authors":"Anh Tuan Nguyen ,&nbsp;Quang Tien Pham ,&nbsp;Hoi Van Tran ,&nbsp;Hoang Viet Truong ,&nbsp;Loc Huynh Tran","doi":"10.1016/j.sopen.2025.06.005","DOIUrl":"10.1016/j.sopen.2025.06.005","url":null,"abstract":"<div><h3>Background</h3><div>The incidence of complicated colonic diverticulitis is increasing in Asia, with notable differences in management between right-sided (RCD) and left-sided (LCD) cases. This study compared treatment outcomes and identified risk factors for complications.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 181 patients diagnosed with complicated colonic diverculitis from January 2022 to September 2024, including 99 RCD and 82 LCD cases.</div></div><div><h3>Results</h3><div>The mean age in the RCD group was 43.31 ± 14.6 years, compared to 63.9 ± 12.9 years in the LCD group. Recurrence rates were higher in LCD than RCD (19.5 % vs. 7.1 %). Surgical intervention was more frequent in LCD cases (63.4 % vs. 9.2 %), with longer hospital stay (9.3 vs 4.9 days). All RCD perforations were managed with primary anastomosis. Hartmann's procedure was the most common approach for LCD, with primary resection and anastomosis performed in 26.9 %. Postoperative complications occurred in 27.8 % of LCD patients, including wound infections, intra-abdominal abscesses, and pneumonia. Three patients in the LCD group died during hospitalization. Fever, elevated CRP levels, surgery type, and prolonged hospital stays were independent risk factors.</div></div><div><h3>Conclusion</h3><div>Patients with complicated RCD were younger than those with LCD. Conservative treatment for RCD had a high success rate, while complicated LCD often required surgery due to peritonitis. Fever, CRP level, type of surgery, and hospital stay were independent risk factors for complications.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"27 ","pages":"Pages 31-35"},"PeriodicalIF":1.4,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of hospital for-profit status with clinical and financial outcomes following emergency general surgery 医院盈利状况与急诊普通外科手术后临床和财务结果的关系
IF 1.4
Surgery open science Pub Date : 2025-06-12 DOI: 10.1016/j.sopen.2025.06.003
Izhar Mbarani MD , Sara Sakowitz MD, MBA , Amulya Vadlakonda MD , Troy Coaston MSCR , Esteban Aguayo MD , Syed Shaheer Ali , Konmal Ali , Saad Mallick MD , Peyman Benharash MD MS
{"title":"Association of hospital for-profit status with clinical and financial outcomes following emergency general surgery","authors":"Izhar Mbarani MD ,&nbsp;Sara Sakowitz MD, MBA ,&nbsp;Amulya Vadlakonda MD ,&nbsp;Troy Coaston MSCR ,&nbsp;Esteban Aguayo MD ,&nbsp;Syed Shaheer Ali ,&nbsp;Konmal Ali ,&nbsp;Saad Mallick MD ,&nbsp;Peyman Benharash MD MS","doi":"10.1016/j.sopen.2025.06.003","DOIUrl":"10.1016/j.sopen.2025.06.003","url":null,"abstract":"<div><h3>Background</h3><div>The impact of for-profit (FP) hospital ownership on healthcare outcomes has garnered increasing attention in recent years with limited work linking FP status with lower quality of care and higher costs. However, outcomes emergency general surgery (EGS) at FP hospitals remains unknown.</div></div><div><h3>Methods</h3><div>All non-elective adult (≥18 years) hospitalizations entailing EGS (appendectomy, cholecystectomy, laparotomy, large bowel resection, perforated ulcer repair, or small bowel resection), within 2 days of admission, were tabulated from the 2016 to 2021 National Inpatient Sample. Multivariable models were constructed to evaluate the independent associations between hospital FP status with key clinical and financial outcomes.</div></div><div><h3>Results</h3><div>Of an estimated 2,124,394 patients, 337,950 (16 %) were classified as FP. Compared to others, the FP cohort was younger, of lower comorbidity burden, and more frequently in the lowest income quartile. After risk adjustment, care at FP hospitals was associated with a greater likelihood of in-hospital mortality or any major complication (Adjusted Odds Ratio [AOR] 1.15, 95 % Confidence Interval [CI] 1.12–1.18), including infectious (AOR 1.22, 95 % CI 1.18–1.26), respiratory (AOR 1.26, 95 % CI 1.21–1.31), and renal sequelae (AOR 1.12, 95 % CI 1.08–1.16). While associated with reduced per-patient hospitalization costs (β -$2910, 95 % CI -3180,-2640), treatment at FP institutions was associated with increased odds of non-home discharge (AOR 1.09, 95 % CI 1.05–1.13).</div></div><div><h3>Conclusions</h3><div>Care at for-profit hospitals appears to be associated with greater risk of morbidity and nonhome discharge. Future work is needed to consider the factors contributing to greater morbidity, and developing interventions aimed at improving quality of care.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"27 ","pages":"Pages 1-7"},"PeriodicalIF":1.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of online teaching curricula on undergraduate basic surgical skills acquisition 网络教学课程对本科外科基本技能习得的影响
IF 1.4
Surgery open science Pub Date : 2025-06-06 DOI: 10.1016/j.sopen.2025.06.002
Devansh Tandon , Ayush Gupta , Rhianna Patel , Anushka Shukla , Saran Singh Gill , Rhea Elise Patel , Keshav Krishnan , Bishoy Yassa , Shivansh Tandon , Amar Rai , Matt Boal , Nader Francis
{"title":"The impact of online teaching curricula on undergraduate basic surgical skills acquisition","authors":"Devansh Tandon ,&nbsp;Ayush Gupta ,&nbsp;Rhianna Patel ,&nbsp;Anushka Shukla ,&nbsp;Saran Singh Gill ,&nbsp;Rhea Elise Patel ,&nbsp;Keshav Krishnan ,&nbsp;Bishoy Yassa ,&nbsp;Shivansh Tandon ,&nbsp;Amar Rai ,&nbsp;Matt Boal ,&nbsp;Nader Francis","doi":"10.1016/j.sopen.2025.06.002","DOIUrl":"10.1016/j.sopen.2025.06.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Despite the growing use of online teaching in medical education, undergraduate surgical skills training remains predominantly face-to-face, with limited structured curricula and resources. Consequently, many students lack confidence performing basic procedures independently. While online programmes offer a potential alternative, comparative evidence is limited. This service evaluation assessed the effectiveness of online surgical skills teaching on student skill acquisition and confidence.</div></div><div><h3>Methods</h3><div>Medical students who participated in five UK national surgical skills programmes between 2022 and 2024 were selected, having received either online or face-to-face instruction. Skill acquisition was measured using the Objective Structured Assessment of Technical Skills (OSATS) tool and confidence was measured pre- and post-training via a Likert scale. Non-parametric data were analysed using the Mann-Whitney <em>U</em> test, with significance set at <em>p</em> &lt; 0.05.</div></div><div><h3>Results</h3><div>Of 133 participants, 82 received online and 51 face-to-face training. Fifty-six percent were in their first or second year of study. No significant differences were found in continuous (<em>p</em> = 0.0652) or mattress suturing (<em>p</em> = 0.143), while interrupted suturing scores were significantly higher in the online group (<em>p</em> = 0.0143). Both modalities significantly improved confidence (<em>p</em> &lt; 0.0001), with no significant difference between groups (<em>p</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study demonstrates that online surgical skills teaching is as effective as face-to-face methods, with both positively impacting skill acquisition and confidence. A hybrid approach, integrating online and face-to-face teaching, could optimise learning by combining the scalability of online instruction with essential practical experience, enhancing medical students' confidence and technical proficiency in surgical skills.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"27 ","pages":"Pages 8-14"},"PeriodicalIF":1.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Board Page 编委会页面
IF 1.4
Surgery open science Pub Date : 2025-06-01 DOI: 10.1016/S2589-8450(25)00052-1
{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2589-8450(25)00052-1","DOIUrl":"10.1016/S2589-8450(25)00052-1","url":null,"abstract":"","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"26 ","pages":"Page i"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of cholecystectomy in hyperkinetic biliary dyskinesia: A systematic review and meta-analysis 胆囊切除术在高运动性胆道运动障碍中的作用:一项系统综述和荟萃分析
IF 1.4
Surgery open science Pub Date : 2025-06-01 DOI: 10.1016/j.sopen.2025.06.001
Duyen Quach MD , Kayla Nguyen MD , Gabriella Tavera BS , Rachel Wright MD , Zuhair Ali MD , Mike Liang MD
{"title":"Role of cholecystectomy in hyperkinetic biliary dyskinesia: A systematic review and meta-analysis","authors":"Duyen Quach MD ,&nbsp;Kayla Nguyen MD ,&nbsp;Gabriella Tavera BS ,&nbsp;Rachel Wright MD ,&nbsp;Zuhair Ali MD ,&nbsp;Mike Liang MD","doi":"10.1016/j.sopen.2025.06.001","DOIUrl":"10.1016/j.sopen.2025.06.001","url":null,"abstract":"<div><h3>Background</h3><div>Biliary dyskinesia is disorder characterized by reduced gallbladder ejection fraction, which have shown a good response to cholecystectomy. In contrast, hyperkinetic biliary dyskinesia (HBD), as defined by ejection fraction ≥80 %, is an emerging phenomenon, and the role of cholecystectomy is not yet clearly defined. This review investigates the effectiveness of cholecystectomy in alleviating symptoms of HBD.</div></div><div><h3>Material and methods</h3><div>A comprehensive literature search was conducted to retrieve studies based on predefined inclusion criteria. Data were extracted by two-independent reviewers. A random-effects model was used for meta-analysis. Risk ratios (RR) were calculated to estimate the impact of cholecystectomy on symptom improvement. Heterogeneity was calculated using the I<sup>2</sup> statistic and Q-test, with subgroup analyses performed based on study design.</div></div><div><h3>Results</h3><div>Fourteen studies involving 416 patients with HBD were included. Overall, the pooled RR for symptom relief post-cholecystectomy was 3.72 (95 % CI: 2.57–5.38). A subgroup analysis of retrospective reviews showed an RR of 3.9 (95 % CI: 2.57–5.92). Moderate heterogeneity (I<sup>2</sup> = 30.01 %) was observed.</div></div><div><h3>Conclusion</h3><div>Based on existing evidence, cholecystectomy appeared to be a promising and effective treatment for HBD in select patients.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"26 ","pages":"Pages 128-134"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of body mass index and outcomes in surgical and transcatheter aortic valve replacement 体质量指数与手术和经导管主动脉瓣置换术预后的关系
IF 1.4
Surgery open science Pub Date : 2025-06-01 DOI: 10.1016/j.sopen.2025.05.008
Bennet S. Cho MD , Troy N. Coaston BS , Amulya Vadlakonda BS , Sara Sakowitz MPH, MS , Syed Shaheer Ali , Esteban Aguayo MD , Peyman Benharash MD
{"title":"Association of body mass index and outcomes in surgical and transcatheter aortic valve replacement","authors":"Bennet S. Cho MD ,&nbsp;Troy N. Coaston BS ,&nbsp;Amulya Vadlakonda BS ,&nbsp;Sara Sakowitz MPH, MS ,&nbsp;Syed Shaheer Ali ,&nbsp;Esteban Aguayo MD ,&nbsp;Peyman Benharash MD","doi":"10.1016/j.sopen.2025.05.008","DOIUrl":"10.1016/j.sopen.2025.05.008","url":null,"abstract":"<div><h3>Background</h3><div>The association between body mass index (BMI) and outcomes in surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) is not well understood. This study assessed the nuanced relationship between BMI and clinical outcomes in a nationally representative cohort undergoing aortic valve replacement.</div></div><div><h3>Methods</h3><div>Adult (≥18 years) admissions for elective SAVR or TAVR from the 2016–2021 National Inpatient Sample were analyzed. BMI was categorized as underweight (&lt;20), ideal weight (20–30), obesity class I (30–34.9), class II (35–39.9), and class III (≥40). The primary outcome was in-hospital mortality. Secondary outcomes included major adverse events (MAE), a composite of mortality and complications (e.g., stroke, thromboembolic, cardiac, respiratory, infection, renal).</div></div><div><h3>Results</h3><div>Among 103,000 patients, 61.2 % underwent TAVR. TAVR patients were older (76 vs. 64 years; p &lt; 0.001) and more frequently underweight (3.1 % vs. 1.5 %; p &lt; 0.001) compared to SAVR patients. In TAVR, BMI &lt; 20 was associated with higher mortality (AOR 2.99, 95 % CI 1.16–7.74) and MAE (AOR 1.74, 95 % CI 1.30–2.34) compared to ideal BMI. Obesity did not increase the overall incidence of MAE in patients undergoing TAVR. In SAVR, mortality was not associated with BMI, but underweight (AOR 2.05, 95 % CI 1.33–3.15) and class III obesity (AOR 1.34, 95 % CI 1.09–1.65) were linked to higher MAE risk.</div></div><div><h3>Conclusions</h3><div>Extremes of BMI results in poorer outcomes in SAVR and TAVR. Underweight patients had increased risks across both approaches, while severe obesity elevated MAE risk in SAVR. These findings underscore the need for tailored perioperative strategies and risk counseling.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"26 ","pages":"Pages 135-139"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical trainee education in benign anorectal disease: a scoping review 良性肛肠疾病的外科培训生教育:范围综述
IF 1.4
Surgery open science Pub Date : 2025-06-01 DOI: 10.1016/j.sopen.2025.05.001
Eleanor G.R. Watson BSc (Hons), MD , Tony Y. Zhang BBMed , Hwa Ian Ong MBChB, FRACS , David M. Proud MBBS (Hons), FRACS , Helen M. Mohan PhD, FRCSI
{"title":"Surgical trainee education in benign anorectal disease: a scoping review","authors":"Eleanor G.R. Watson BSc (Hons), MD ,&nbsp;Tony Y. Zhang BBMed ,&nbsp;Hwa Ian Ong MBChB, FRACS ,&nbsp;David M. Proud MBBS (Hons), FRACS ,&nbsp;Helen M. Mohan PhD, FRCSI","doi":"10.1016/j.sopen.2025.05.001","DOIUrl":"10.1016/j.sopen.2025.05.001","url":null,"abstract":"<div><h3>Background</h3><div>Benign anorectal diseases such as haemorrhoids, perianal abscesses and fistulas are prevalent and disabling conditions that can be difficult to diagnose and treat.</div><div>This review aims to evaluate current education for training doctors around these diseases to inform the revision and development of surgical curricula.</div></div><div><h3>Materials and methods</h3><div>A literature search was conducted in MEDLINE, Embase and Google Scholar and data from included articles were charted in a semi-structured table. Quantitative outcomes were presented using simple descriptive statistics. Qualitative data were analysed using a reflexive thematic analysis framework.</div></div><div><h3>Results</h3><div>Ten studies were included. Most education was centred around haemorrhoids and delivered in the format of lectures and simulations. Harnessing the benefits of both on-demand and in-person content was key to optimising education delivery. In simulation studies, low-fidelity models were generally sufficient to meet educational objectives. There was universal agreement that the purpose of education was to supplement or prepare for clinical exposure, rather than to replace or ‘bridge gaps’ in experience. Education was found to be most useful and relevant when delivered to junior surgical or non-surgical cohorts.</div></div><div><h3>Conclusions</h3><div>This review elucidates gaps in current literature on benign anorectal disease education and provides recommendations for the development and implementation of future education for surgical trainees. There is a need for education that addresses a broader range of anorectal conditions and has a greater focus on the retention and clinical translation of acquired knowledge and skills. Interventions should be designed to enhance clinical exposure and maintain relevance throughout training progression.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"26 ","pages":"Pages 119-127"},"PeriodicalIF":1.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic review and meta-analysis of Transanal Opening of Intersphincteric Space (TROPIS) versus conventional treatments for anal fistula 经肛门括约肌间隙(TROPIS)与传统治疗肛瘘的系统回顾和荟萃分析
IF 1.4
Surgery open science Pub Date : 2025-05-30 DOI: 10.1016/j.sopen.2025.05.010
Yang-Tao Chen , Zhao-Chu Wang, Ya-Meng Xie, Xun Wang, Xu-Xiong Wu, Yang Li, Rong Shi, Jing Wang
{"title":"Systematic review and meta-analysis of Transanal Opening of Intersphincteric Space (TROPIS) versus conventional treatments for anal fistula","authors":"Yang-Tao Chen ,&nbsp;Zhao-Chu Wang,&nbsp;Ya-Meng Xie,&nbsp;Xun Wang,&nbsp;Xu-Xiong Wu,&nbsp;Yang Li,&nbsp;Rong Shi,&nbsp;Jing Wang","doi":"10.1016/j.sopen.2025.05.010","DOIUrl":"10.1016/j.sopen.2025.05.010","url":null,"abstract":"<div><div>Transanal Opening of Intersphincteric Space (TROPIS) has emerged as a promising surgical approach for anal fistula management over recent years. This meta-analysis comprehensively evaluates the comparative efficacy and safety of TROPIS versus conventional treatments through systematic analysis of 24 clinical studies involving 2813 patients. Through systematic searches across 7 major biomedical databases (including PubMed, EMBASE, and Chinese repositories) from inception to March 2024, we identified comparative studies assessing TROPIS against six established interventions: incision-thread-drawing, seton placement, LIFT, EAFR, fistulotomy, and incision-suture techniques. Pooled analysis demonstrated TROPIS achieved superior clinical outcomes, with a 3.15-fold higher total efficacy rate (95 % CI 1.22–8.13, <em>p</em> = 0.02) and 64 % lower complication risk compared to conventional methods (OR 0.28, 95 % CI 0.18–0.42, <em>p</em> &lt; 0.00001). Sensitivity analyses confirmed result stability across study designs, while publication bias assessment via funnel plots and Egger's test revealed no significant distortion. Importantly, TROPIS maintained its advantage across various complication subtypes including incontinence (OR 0.31), infection (OR 0.27), and recurrence (OR 0.19). These findings establish TROPIS as a clinically superior alternative that significantly improves therapeutic outcomes while reducing procedure-related risks, suggesting its potential to become the new reference standard in anal fistula management. The consistent results across diverse patient populations and comparator procedures underscore the robustness of this evidence synthesis.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"27 ","pages":"Pages 15-30"},"PeriodicalIF":1.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Searching for bacteria within acute cholecystitis using next-generation sequencers 使用新一代测序仪寻找急性胆囊炎中的细菌
IF 1.4
Surgery open science Pub Date : 2025-05-26 DOI: 10.1016/j.sopen.2025.05.006
Tomohiro Otsuka , Yoichi Ishizaki , Jiro Yoshimoto , Kenji Takamori , Shin Watanabe
{"title":"Searching for bacteria within acute cholecystitis using next-generation sequencers","authors":"Tomohiro Otsuka ,&nbsp;Yoichi Ishizaki ,&nbsp;Jiro Yoshimoto ,&nbsp;Kenji Takamori ,&nbsp;Shin Watanabe","doi":"10.1016/j.sopen.2025.05.006","DOIUrl":"10.1016/j.sopen.2025.05.006","url":null,"abstract":"<div><h3>Introduction</h3><div>A biliary microbiome comprising flora within normal gallbladders was recently uncovered through analyses targeting the bacterial 16S ribosomal RNA (16S rRNA) gene, despite the gallbladder previously being regarded as a sterile environment. In the present study, we subjected bile samples from patients with acute cholecystitis to gene analysis targeting bacterial flora.</div></div><div><h3>Methods</h3><div>We targeted patients diagnosed as having Grade I or Grade II acute cholecystitis (in accordance with the Tokyo Guidelines 2018 established by the Japanese Society of Hepato-Biliary-Pancreatic Surgery) who underwent laparoscopic cholecystectomy within 24 h of diagnosis at Juntendo University Urayasu Hospital between July 2021 and January 2024 for evaluation. We drew bile sample from the gallbladder of each patient to confirm the presence of biliary bacterial flora, using both standard bacteriology (culture test) and 16S rRNA gene sequence.</div></div><div><h3>Results</h3><div>Of the 29 samples, 15 yielded cultures positive for bacterial flora, and gene analysis revealed the presence of bacterial biliary flora in all 14 samples that had tested negative in standard bacteriology. Considering the bacterial flora of a normal gallbladder without lesions as “normal flora,” bacteria other than normal flora—<em>Propionibacterium</em> spp., <em>Coprococcus</em> spp., <em>Prevotella</em> spp., <em>Sediminibacterium</em> spp., and <em>Collinesella</em> spp.—were detected in 25 of the 29 cases (86 %).</div></div><div><h3>Conclusions</h3><div>Bacteria not detected in non-inflammatory gallbladders such as <em>Propiobacterium</em> spp., <em>Coprococcus</em> spp., <em>Prevotella</em> spp., <em>Sediminibacterium</em> spp., and <em>Collinesella</em> spp. may play a role in the mechanism underlying development of acute cholecystitis.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"26 ","pages":"Pages 113-118"},"PeriodicalIF":1.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pancreaticoduodenectomy on soft-embalmed human cadavers according to Dodge – a pilot feasibility report 根据道奇的试点可行性报告,对软防腐尸体进行胰十二指肠切除术
IF 1.4
Surgery open science Pub Date : 2025-05-21 DOI: 10.1016/j.sopen.2025.05.005
Dariya Jaeger , Eric Hinrichs , Ralf Schoppe , Gebhard Reiss , Georg Feigl , Benno Mann
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