Surgery open science最新文献

{"title":"NIH funding for the pediatric surgeon-scientist: A stable entity, but for how long?","authors":"Troy A. Markel MD, FACS, FAAP","doi":"10.1016/j.sopen.2025.02.008","DOIUrl":"10.1016/j.sopen.2025.02.008","url":null,"abstract":"","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"24 ","pages":"Pages 72-73"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the necessity of simultaneous cholecystectomy in patients undergoing liver hydatid cyst surgery","authors":"Hüseyin Fahri Martlı ,&nbsp;Arzu Hazal Aydın ,&nbsp;Eda Şahingöz ,&nbsp;Derviş Duru ,&nbsp;Sadettin Er ,&nbsp;Nesrin Turhan ,&nbsp;Mesut Tez","doi":"10.1016/j.sopen.2025.02.009","DOIUrl":"10.1016/j.sopen.2025.02.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Liver hydatid cysts remain a significant public health issue in Turkey, the Middle East, East Asia, and Russia. Surgical treatments are often employed for certain stages of this disease. However, the necessity of simultaneous cholecystectomy during these procedures remains unclear. Treating symptoms related to subsequent cholelithiasis can become more challenging. This study investigates the necessity of simultaneous cholecystectomy by following patients who underwent hydatid cyst surgery with or without concurrent cholecystectomy.</div></div><div><h3>Materials and methods</h3><div>Patients who underwent surgery for hydatid cysts between 2019 and 2024 at the General Surgery Clinic of Ankara Bilkent City Hospital were retrospectively reviewed. A total of 97 patients were included, with 56 (54.32 %) undergoing cholecystectomy along with hydatid cyst surgery (Group 1) and 41 (45.68 %) not undergoing cholecystectomy (Group 2).</div><div>Preoperative clinical, laboratory, and radiological findings, as well as intraoperative data, morbidity, mortality, and postoperative symptoms, were analyzed.</div></div><div><h3>Results</h3><div>Patients in Group 1 had longer hospital stays, higher blood loss, and significantly higher Clavien-Dindo complication scores. In the postoperative follow-up of Group 2, 8 patients (19.51 %) developed stones or sludge, and 1 patient (2.4 %) developed polyps. Four patients (9.75 %) presented to the emergency department with cholecystitis symptoms. A total of 5 patients (12.19 %), including 4 with symptomatic cholelithiasis (9.7 %) and 1 with gallbladder polyps (2.4 %), underwent elective cholecystectomy. Two (40 %) of these cholecystectomies were performed laparoscopically, while three (60 %) were converted to open cholecystectomy.</div></div><div><h3>Conclusion</h3><div>Simultaneous cholecystectomy during liver hydatid cyst surgery may prevent difficulties associated with treating symptoms related to subsequent cholelithiasis.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"24 ","pages":"Pages 61-65"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A technical note of flex video-assisted anal fistula treatment procedure: Utilizing modified flexible fistuloscope in video-assisted approach for anal fistula laser treatment","authors":"Okkian Wijaya Kotamto ,&nbsp;Tery Nehemia Nugraha Joseph ,&nbsp;Clement Dewanto ,&nbsp;Natalia Maria Christina ,&nbsp;Nadiska Patricia Artha ,&nbsp;Marsja Ruthfanny Hutapea ,&nbsp;Jeremiah H. Wijaya","doi":"10.1016/j.sopen.2025.03.001","DOIUrl":"10.1016/j.sopen.2025.03.001","url":null,"abstract":"<div><div>This study explores an innovative approach for managing complex anal fistulas, known as the flexible video-assisted anal fistula treatment (flex-VAAFT). This technique uses a modified flexible fistuloscope and a laser diode for precise laser ablation. The flexible fistuloscope offers a wider field of view compared to the traditional VAAFT fistuloscope, allowing for better visualization and accurate assessment of the fistula tract's internal anatomy, enabling meticulous debridement and irrigation. We applied the flex-VAAFT approach in seven male patients aged 36 to 66, documenting the external and internal openings, etiology, and fistula type. Seton placement was used in one case, with follow-up periods ranging from 6 to 12 months. Most patients experienced successful healing, with only one recurrence observed. There were no cases of anal incontinence, and the average hospital stay was brief, lasting between 1 and 2 days. The findings suggest that flex-VAAFT is a promising, minimally invasive method for treating anal fistulas, enhancing surgical precision while preserving anal continence.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"24 ","pages":"Pages 80-85"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the dynamics of postoperative steatosis in the regenerating liver: An animal study","authors":"Andrea Lund ,&nbsp;Katrine Holm Andersen ,&nbsp;Kasper Jarlhelt Andersen ,&nbsp;Jakob Kirkegård ,&nbsp;Jens Randel Nyengaard ,&nbsp;Frank Viborg Mortensen","doi":"10.1016/j.sopen.2025.02.005","DOIUrl":"10.1016/j.sopen.2025.02.005","url":null,"abstract":"<div><h3>Introduction</h3><div>The rat model of 70 % partial hepatectomy (PH) is commonly used to investigate liver regeneration processes. The aim of this study was to explore the dynamics of hepatic lipid accumulation and its correlation with the proliferation response during the entire regeneration phase after 70 % PH in rats.</div></div><div><h3>Methods</h3><div>Sixty-four rats underwent 70 % PH and were randomly divided into eight groups for evaluation on post-operative day (POD) 1 to 8. Hepatocyte volume, relative lipid content, and lipid volume per hepatocyte were assessed by stereological analysis.</div><div><strong>Results:</strong> Lipid volume per hepatocyte reached its peak on POD 1 and POD 2, with mean values of 2895 μm³ (95 % CI: 1756–4034 μm³) and 3090 μm³ (95 % CI: 2277–3903 μm³), respectively. A marked decline was observed by POD 4, with a mean of 1323 μm³ (95 % CI: 985–1741 μm³), which continued through POD 5, reaching 619 μm³ (95 % CI: 136–1102 μm³). From POD 5 onwards, lipid volume remained consistently low, with no significant differences detected between POD 5 and POD 8.</div></div><div><h3>Conclusion</h3><div>Lipid accumulation and proliferation peak and decline concurrently, suggesting a strong correlation.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"24 ","pages":"Pages 66-69"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERAS protocol in colorectal surgery is effective in octogenarians: A retrospective cohort study","authors":"Justin Dourado MD ,&nbsp;Ariel Wolf MD ,&nbsp;Maria Herrera Rodriguez DO ,&nbsp;Shruti Agarwal BS ,&nbsp;Karin Blumofe MD ,&nbsp;Jordan Moseson DO ,&nbsp;Jose Yeguez MD ,&nbsp;Andrew Ross MD ,&nbsp;Avraham Belizon MD","doi":"10.1016/j.sopen.2025.03.004","DOIUrl":"10.1016/j.sopen.2025.03.004","url":null,"abstract":"<div><h3>Purpose</h3><div>Evaluate the effectiveness of implementing an ERAS protocol in octogenarians.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed patients undergoing colorectal surgery under the ERAS protocol at Boca Raton Regional Hospital from December 1, 2019 to October 30, 2021. Patients under the age of 18, undergoing emergency surgery, and with incomplete data were excluded. A <em>p</em> &lt; 0.05 was considered statistically significant and analyses were done using EZR and R software.</div></div><div><h3>Results</h3><div>299 patients met inclusion criteria with 60 (20.1 %) over the age of 80 and 239 (79.9 %) younger than 80. 140 (46.8 %) of the cohort were male. When comparing octogenarians with younger patients there were no differences in compliance with ERAS protocols such as pre-operative medication (<em>p</em> = 1) and oral carbohydrate drink consumption (<em>p</em> = 0.574), oral intake in PACU (<em>p</em> = 0.832), PACU sit and dangle (<em>p</em> = 0.619), or adherence to a narcotic sparing regimen (<em>p</em> = 0.365). Additionally, there were no differences in complications (p = 1), time until bowel function (<em>p</em> = 0.401), or time to first ambulation (<em>p</em> = 0.883). Octogenarians were more likely to have a longer LOS (4.89 v 3.0 days; <em>p</em> = 0.006), disposition requiring either home health care or a skilled nursing facility (SNF) (52.5 % v 28.3 %; <em>p</em> = 0.008), and readmission (42.3 % v 20.8 %; <em>p</em> = 0.042).</div></div><div><h3>Conclusion</h3><div>The ERAS protocol is safe and effective when used in the octogenarian without decreased compliance or increased complications. Increased LOS, care needed on disposition, and readmission are in-line with other published data of all patients and are likely related to increased frailty among this group and not to the addition of the ERAS protocol.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"24 ","pages":"Pages 86-91"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2589-8450(25)00023-5","DOIUrl":"10.1016/S2589-8450(25)00023-5","url":null,"abstract":"","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"24 ","pages":"Page i"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building an international network of young surgeons across surgical specialties – Introducing the Young Surgeons Publications Committee","authors":"Louisa Bolm ,&nbsp;Martina Nebbia ,&nbsp;Thomas F. Stoop ,&nbsp;Mara R. Goetz ,&nbsp;Lena Conradi ,&nbsp;Nathanael Raschzok ,&nbsp;Hannes Jansson ,&nbsp;Patrik Larsson ,&nbsp;Sarah Gerber ,&nbsp;Jorge Roldàn ,&nbsp;Theodoros Michelakos ,&nbsp;Meike ten Winkel ,&nbsp;Benedict Kinny-Köster ,&nbsp;Ingmar F. Rompen ,&nbsp;Oskar Franklin ,&nbsp;Ioannis A. Ziogas ,&nbsp;Hiroyuki Ishida ,&nbsp;Andrii Khomiak ,&nbsp;Daisuke Hashimoto ,&nbsp;Vincent P. Groot ,&nbsp;Nicholas Joseph Zyromski","doi":"10.1016/j.sopen.2025.02.003","DOIUrl":"10.1016/j.sopen.2025.02.003","url":null,"abstract":"","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"24 ","pages":"Pages 70-71"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Impact of regional data reporting and feedback on rectal cancer surgery quality metrics in the Surgical Care Outcomes Assessment Program (SCOAP)”","authors":"Alex J. Charboneau MD, MS ,&nbsp;Chad Cragle MD, PhD ,&nbsp;Joseph Frankhouse MD ,&nbsp;Shalini Kanneganti MD ,&nbsp;Jenny A. Kaplan MD ,&nbsp;Ravi Moonka MD ,&nbsp;Laila Rashidi MD ,&nbsp;Vlad V. Simianu MD, MPH","doi":"10.1016/j.sopen.2025.03.002","DOIUrl":"10.1016/j.sopen.2025.03.002","url":null,"abstract":"<div><h3>Background</h3><div>Management of rectal cancer is increasingly complex. Leading societies describe metrics of high-quality perioperative rectal cancer care with the goal of reducing variation in practice and improving outcomes. This study was designed to describe the impact of targeted feedback at the institutional level on improving achievement of rectal cancer quality metrics.</div></div><div><h3>Methods</h3><div>Adult elective rectal cancer resections performed at institutions that continuously participated in SCOAP between 2011 and 2022 were included for analysis. Quality metrics evaluated were preoperative MRI (MRI), determination of tumor location (TL), use of neoadjuvant chemoradiation (NAC), performance of a total mesorectal excision (TME), 12+ lymph nodes resected (LN), and composite negative margins (NM). In-depth feedback on these metrics was provided by SCOAP at the end of 2015 and 2019. Achievement of the metrics was evaluated before (2011–2016), between (2017–2019), and after (2020−2022) feedback events to determine effect on achievement.</div></div><div><h3>Results</h3><div>1962 resections were performed at 19 institutions. There were statistically significant increases in MRI(2011–2016 = 32 %, 2017–2019 = 88 %, 2020–2022 = 92 %;<em>p</em> &lt; 0.01), TME(47 %, 68 %, 80 %;p &lt; 0.01), and LN(76 %, 86 %, 86 %;p &lt; 0.01) after one or both feedback events. TL(67 %, 69 %, 70 %;<em>p</em> = 0.558), NAC(62 %, 63 %, 67 %;<em>p</em> = 0.124), and NM(98 %, 97 %, 96 %;<em>p</em> = 0.39) were not significantly different. Mean composite score for metrics increased after each feedback (2011–2016 = 3.8±1.4; 2017–2019 = 4.3±1.4; 2020–2022 = 4.5±1.5;<em>p</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>Interval, in-depth feedback on rectal cancer quality process metrics was associated with increased achievement of several metrics and overall number of metrics achieved. Broader implementation of this feedback method could further advance the quality of rectal cancer surgical care.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"24 ","pages":"Pages 74-79"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perineural invasion in pancreatic cancer: Current biological function in R status, prognosis, and pain","authors":"Federico Selvaggi ,&nbsp;Elisa Bannone ,&nbsp;Eugenia Melchiorre ,&nbsp;Michele Diana ,&nbsp;Roberto Cotellese ,&nbsp;Gitana Maria Aceto","doi":"10.1016/j.sopen.2025.02.007","DOIUrl":"10.1016/j.sopen.2025.02.007","url":null,"abstract":"<div><div>Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second leading cause of death in 2030 and it is characterized by poor prognosis, recurrence and resistance to therapies. Several factors contribute to the complexity of this disease, among those the invasion of nerves by PDAC cells. This condition, defined as perineural invasion (PNI), is responsible of PDAC progression and pain generation. To date, PNI emerges as a hallmark feature of PDAC, showing the same oncological weight of lymph node metastasis in terms of prognosis. Targeting PNI could help improve prognosis and pain relief in PDAC patients. Only recently, a severity scoring system has been proposed to quantify PNI in histological samples although prospective validation and standardization are strongly advocated. More information about peripancreatic soft tissue infiltration and a “true” curative surgery could be found in understanding the molecular mechanisms of PNI. The incorporation of PNI markers for grading mesopancreas and retroperitoneal invasion is required to overcome current limitations of the histological workup. We discuss the modern understanding of PNI in PDAC, and the state of the art in clinical setting. Although there are still a lot to learn about PDAC, PNI represents one of the biological detonators and an important focus of future research.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"24 ","pages":"Pages 58-60"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of tumor deposit counts in stage III colorectal cancer based on T/N staging and chemotherapy status: A retrospective cohort study","authors":"Chenxiao Zheng MD ,&nbsp;Lingsha Xu MD ,&nbsp;Binbin Ou MD ,&nbsp;Ibrahim Mohamed Bakour Abdourahaman MD ,&nbsp;Xuanqin Chen MD ,&nbsp;Hangjia Xu MD ,&nbsp;Yating Zheng MD ,&nbsp;Yifei Pan MD","doi":"10.1016/j.sopen.2025.02.004","DOIUrl":"10.1016/j.sopen.2025.02.004","url":null,"abstract":"<div><h3>Background</h3><div>We aimed to evaluate the impact of tumor deposit (TD) count on cancer-specific survival (CSS) and disease-free survival (DFS) in stage III colorectal cancer (CRC) patients stratified by T and N staging, and further explore its impact on chemotherapy effect.</div></div><div><h3>Method</h3><div>We determined the optimal TD cut-off value for stage III CRC patients from the SEER database utilizing X-tile analysis, and retrospectively analyzed the clinicopathological data of 443 patients from the First Affiliated Hospital of Wenzhou Medical University from 2019 to 2020. Chi-square (χ2) tests compared categorical variables. Kaplan–Meier assessed CSS and DFS. Cox regression model evaluated prognostic factors on CSS and DFS.</div></div><div><h3>Results</h3><div>2TD is the optimal cutoff value for prognosis in Stage III CRC, in the low-risk group (T1-T3 and N1), ≥3TD patients faced higher cancer-specific mortality (HR = 3.445, 95%CI = 1.254–9.465, P = 0.017) and recurrence risks (HR = 1.934, 95%CI = 1.095–3.416, P = 0.024) vs. 1-2TD, while 1-2TD and no-TD patients showed no difference in survival. In the high-risk group (T4 or N2), both ≥3TD and 1-2TD patients had poor prognosis. Chemotherapy reduced cancer-specific mortality in both groups (1-2TD: HR = 0.347, 95%CI = 0.138–0.870, P = 0.024; ≥3TD: HR = 0.272, 95%CI = 0.077–0.960, P = 0.043) but did not significantly improve recurrence risk (1-2TD: P = 0.177; ≥3TD: P = 0.058).</div></div><div><h3>Conclusion</h3><div>TD indicates poor prognosis in stage III CRC, with ≥3 TD significantly worsening survival, yet the prognosis remains poor in TD-positive patients with high-risk (T4 or N2) regardless of TD count. Moreover, TD count does not influence chemotherapy's mortality benefit.</div></div>","PeriodicalId":74892,"journal":{"name":"Surgery open science","volume":"24 ","pages":"Pages 42-50"},"PeriodicalIF":1.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}